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The map label for this gene is guaA [H]

Identifier: 91788306

GI number: 91788306

Start: 2544124

End: 2545743

Strand: Direct

Name: guaA [H]

Synonym: Bpro_2441

Alternate gene names: 91788306

Gene position: 2544124-2545743 (Clockwise)

Preceding gene: 91788305

Following gene: 91788307

Centisome position: 48.92

GC content: 62.47

Gene sequence:

>1620_bases
ATGCAACACCAGAAAATCCTCATCCTCGATTTCGGCTCCCAGGTCACCCAGCTGATTGCCCGCCGCGTGCGCGATGCCCA
TGTGTTTTGCGAAGTCCATCCCTGCGATGTGACTGACGACTGGGTCCGCGACTACGCCAGGGACGGCACGCTCAAGGGCG
TCATCCTGTCCGGCAGCCATGCCAGCATCTACGAAGAAACGACCGACAAAGCGCCCCAGGCCGTGTTTGAGCTGGGCCTT
CCGGTGCTGGGCATCTGCTACGGCATGCAGGCCATGGCGCACCAGCTGGGCGGCAAGGTCGAAGGCGGCCACAAGCGCGA
ATTCGGTTCGGCTGACGTGCGGGCCCGCGGCCACACCGCGCTGCTCAAGGACATCGCCGACTACACCACGCCAGAGGGCC
AGGGCATGCTGGACGTCTGGATGAGCCACGGTGACAAGGTCACCGAAATGCCGCCGGGCTTCAAGCTCATGGCATCCACC
GAGTCCTGCCCGATCGCCGGCATGGCCGATGAAGACCGCCGTTTTTACGCGGTGCAGTTCCACCCGGAAGTCACGCACAC
CAAGCAGGGCAATGCCATTCTCAAGCGCTTTGTGCTTGATATTTGCGGCACCCGGCAAGACTGGGTCATGGGCGACTACA
TCAGCGAAGCGGTTGAAAAAATCCGCCAGCAGGTAGGCGACGAAGAGGTCATCCTCGGCCTGTCGGGCGGTGTCGATTCA
TCGGTGGCGGCGGCACTGATCCACCGCGCCATCGGCGACCAGCTGACCTGCGTATTCGTTGACCATGGCCTGCTGCGCCT
GAACGAAGGCGACATGGTGATGGACATGTTTGTCGGCAAGCTGCATGCCAGAGTGGTCCGCGTCGATGCGAGCGAGCAGT
TTCTAGGCCACCTGGCCGGGGTGAGCGAACCCGAGGCCAAGCGCAAAATCATCGGCCGGGAATTTGTCGAAGTGTTCAAG
GCCGAGGCGGCTCGGCTCAAGGCTGGCGACGGCGGCCACAAGGGCGCCAAATGGCTGGCCCAGGGCACGATTTATCCTGA
TGTGATCGAGTCCGGTGGCGCCAAGAGCAAGAAAGCCGTCACCATCAAAAGCCACCACAACGTCGGCGGCCTGCCCGAGC
AGCTGGGCCTGAAGCTGCTTGAGCCGCTGCGTGAGCTGTTCAAGGACGAGGTCCGCGAACTGGGCGTCGCGCTCGGCCTG
CCGCATGACATGGTGTATCGCCATCCCTTCCCCGGTCCCGGCCTCGGGGTGCGCATCCTGGGCGAAGTCAAAAAAGAGTA
CGCTGACCTGCTGCGCCGCGCCGACGCCATCTTTATCGAAGAACTGCGCAACTTCAGGGATGCCGAGACCGGCAAGACCT
GGTACGACCTGACCAGCCAGGCGTTCACCGTCTTCCTGCCGGTGAAAAGCGTGGGTGTGATGGGCGATGGCCGCACCTAT
GACTATGTGGTGGCGCTGCGCGCTGTGCAAACCAGCGACTTCATGACCGCAGACTGGGCAGAACTGCCCTACGCGTTGCT
CAAAAAGGTCTCCAGCCGCATCATCAACGAGGTGCGCGGCATCAACCGCGTCACTTACGACGTGAGCAGCAAGCCGCCGG
CAACGATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GAGGGGGCTGGCCTTGCTTGGGGCGGCCCGGCGCGGCGGCCGCAGTTGGCTTTCACGTTTCCCCAGGTTTGCCCTTGTCC
GTAGCAACTGACTCAATCAA

Downstream 100 bases:

>100_bases
AGGGCCGAGCCCATGCCCGAGCAACCGTCATTACCCGGGTTCGCCGCCTTGCCGCAGCAGCCGACGGACAGGCTGTTCTT
TGCCATCTTTCCCGACGCGA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MQHQKILILDFGSQVTQLIARRVRDAHVFCEVHPCDVTDDWVRDYARDGTLKGVILSGSHASIYEETTDKAPQAVFELGL
PVLGICYGMQAMAHQLGGKVEGGHKREFGSADVRARGHTALLKDIADYTTPEGQGMLDVWMSHGDKVTEMPPGFKLMAST
ESCPIAGMADEDRRFYAVQFHPEVTHTKQGNAILKRFVLDICGTRQDWVMGDYISEAVEKIRQQVGDEEVILGLSGGVDS
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHARVVRVDASEQFLGHLAGVSEPEAKRKIIGREFVEVFK
AEAARLKAGDGGHKGAKWLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRELFKDEVRELGVALGL
PHDMVYRHPFPGPGLGVRILGEVKKEYADLLRRADAIFIEELRNFRDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGRTY
DYVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE

Sequences:

>Translated_539_residues
MQHQKILILDFGSQVTQLIARRVRDAHVFCEVHPCDVTDDWVRDYARDGTLKGVILSGSHASIYEETTDKAPQAVFELGL
PVLGICYGMQAMAHQLGGKVEGGHKREFGSADVRARGHTALLKDIADYTTPEGQGMLDVWMSHGDKVTEMPPGFKLMAST
ESCPIAGMADEDRRFYAVQFHPEVTHTKQGNAILKRFVLDICGTRQDWVMGDYISEAVEKIRQQVGDEEVILGLSGGVDS
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHARVVRVDASEQFLGHLAGVSEPEAKRKIIGREFVEVFK
AEAARLKAGDGGHKGAKWLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRELFKDEVRELGVALGL
PHDMVYRHPFPGPGLGVRILGEVKKEYADLLRRADAIFIEELRNFRDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGRTY
DYVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE
>Mature_539_residues
MQHQKILILDFGSQVTQLIARRVRDAHVFCEVHPCDVTDDWVRDYARDGTLKGVILSGSHASIYEETTDKAPQAVFELGL
PVLGICYGMQAMAHQLGGKVEGGHKREFGSADVRARGHTALLKDIADYTTPEGQGMLDVWMSHGDKVTEMPPGFKLMAST
ESCPIAGMADEDRRFYAVQFHPEVTHTKQGNAILKRFVLDICGTRQDWVMGDYISEAVEKIRQQVGDEEVILGLSGGVDS
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHARVVRVDASEQFLGHLAGVSEPEAKRKIIGREFVEVFK
AEAARLKAGDGGHKGAKWLAQGTIYPDVIESGGAKSKKAVTIKSHHNVGGLPEQLGLKLLEPLRELFKDEVRELGVALGL
PHDMVYRHPFPGPGLGVRILGEVKKEYADLLRRADAIFIEELRNFRDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGRTY
DYVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=572, Percent_Identity=34.4405594405594, Blast_Score=269, Evalue=6e-72,
Organism=Escherichia coli, GI1788854, Length=539, Percent_Identity=62.5231910946197, Blast_Score=675, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=585, Percent_Identity=34.5299145299145, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI71992710, Length=585, Percent_Identity=34.5299145299145, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=585, Percent_Identity=34.5299145299145, Blast_Score=288, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=537, Percent_Identity=50.6517690875233, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=564, Percent_Identity=33.8652482269504, Blast_Score=273, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59536; Mature: 59536

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHQKILILDFGSQVTQLIARRVRDAHVFCEVHPCDVTDDWVRDYARDGTLKGVILSGSH
CCCCEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCC
ASIYEETTDKAPQAVFELGLPVLGICYGMQAMAHQLGGKVEGGHKREFGSADVRARGHTA
CHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
LLKDIADYTTPEGQGMLDVWMSHGDKVTEMPPGFKLMASTESCPIAGMADEDRRFYAVQF
HHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEE
HPEVTHTKQGNAILKRFVLDICGTRQDWVMGDYISEAVEKIRQQVGDEEVILGLSGGVDS
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHARVVRVDASEQFLGHLAG
HHHHHHHHHHHCCCEEEEEEECCEEEECCCCCHHHHHHHHHHHEEEEECCHHHHHHHHCC
VSEPEAKRKIIGREFVEVFKAEAARLKAGDGGHKGAKWLAQGTIYPDVIESGGAKSKKAV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCHHHHHCCCCCCCEEE
TIKSHHNVGGLPEQLGLKLLEPLRELFKDEVRELGVALGLPHDMVYRHPFPGPGLGVRIL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHH
GEVKKEYADLLRRADAIFIEELRNFRDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEEEHHHCCCCCCCCCE
DYVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE
EEEEEEHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECC
>Mature Secondary Structure
MQHQKILILDFGSQVTQLIARRVRDAHVFCEVHPCDVTDDWVRDYARDGTLKGVILSGSH
CCCCEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCC
ASIYEETTDKAPQAVFELGLPVLGICYGMQAMAHQLGGKVEGGHKREFGSADVRARGHTA
CHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
LLKDIADYTTPEGQGMLDVWMSHGDKVTEMPPGFKLMASTESCPIAGMADEDRRFYAVQF
HHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEE
HPEVTHTKQGNAILKRFVLDICGTRQDWVMGDYISEAVEKIRQQVGDEEVILGLSGGVDS
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVAAALIHRAIGDQLTCVFVDHGLLRLNEGDMVMDMFVGKLHARVVRVDASEQFLGHLAG
HHHHHHHHHHHCCCEEEEEEECCEEEECCCCCHHHHHHHHHHHEEEEECCHHHHHHHHCC
VSEPEAKRKIIGREFVEVFKAEAARLKAGDGGHKGAKWLAQGTIYPDVIESGGAKSKKAV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCHHHHHCCCCCCCEEE
TIKSHHNVGGLPEQLGLKLLEPLRELFKDEVRELGVALGLPHDMVYRHPFPGPGLGVRIL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHH
GEVKKEYADLLRRADAIFIEELRNFRDAETGKTWYDLTSQAFTVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEEEHHHCCCCCCCCCE
DYVVALRAVQTSDFMTADWAELPYALLKKVSSRIINEVRGINRVTYDVSSKPPATIEWE
EEEEEEHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA