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The map label for this gene is guaB [H]

Identifier: 91788305

GI number: 91788305

Start: 2542510

End: 2543979

Strand: Direct

Name: guaB [H]

Synonym: Bpro_2440

Alternate gene names: 91788305

Gene position: 2542510-2543979 (Clockwise)

Preceding gene: 91788303

Following gene: 91788306

Centisome position: 48.89

GC content: 63.81

Gene sequence:

>1470_bases
ATGCGCCTACTCGGCAAAGCGCTCACCTTCGACGACGTATTGTTGGTGCCAGCGTTCTCCCAGGTCCTGCCCAAGGACAC
CTCACTTTCCACCCAGTTCTCCCGCAACATCCGCCTGAACCTGCCGCTCGTGTCGGCGGCCATGGACACGGTCACCGAAG
CCCGGTTGGCCATTGCCATCGCGCAGGAGGGTGGCATCGGCATCGTCCATAAAAACCTGACGCCCCAGCAGCAGGCCGCA
GAAGTGGCGAAAGTCAAGCGTTACGAGAGCGGCGTGCTCCGCGACCCGGTGGTCATCACGCCCACCCATACTGTCCGGCA
GGTCATGGCCCTGAGTGAGCAGCTCGGCATTTCCGGCTTCCCCGTGATCGACGGCGGCCGGGTTGTCGGTATCGTGACCG
GGCGCGACATGCGCTTCGAATCCCGTATGGATGTGCCGGTCAGCACCATCATGACGCCGCGCGACCGCCTGATCACCATT
TCCGAAACCGCGTCCCTGGCCGACGCCAAGGCGCTGTTGAACAAGCACCGCCTGGAGCGGGTGCTGCTGGTCAATGACAA
CTTCGAGCTCAAGGGCCTGATCACTGTCAAGGACATCACCAAACAGACCACTTTCCCCAATGCGGCACGCGATTCGCATG
GCCAGTTGCGCGTCGGCGCTGCCGTCGGGGTGGGTGAGGGCACCGAAGAGCGTGTCGAGGCGCTGGTCAAGGCCGGGGTG
GACGCCATTGTGGTGGACACCGCCCATGGGCATAGCAAGGGCGTGATCGACCGGGTGCGCTGGGTCAAGCGGAACTACCC
CCAGGTTGATGTCATCGGCGGCAATATTGCCACCGGCGCAGCCGCGCTGGCGCTGGCAGAAGCCGGTGCAGACGGCGTCA
AGGTGGGTATTGGCCCTGGCAGCATCTGTACCACCCGCATCGTTGCGGGTGTCGGGGTGCCGCAGATCATGGCGATCGAC
AACGTGGCGATGGCTTTGCGTGGCACCGGCGTTCCCCTGATTGGGGACGGCGGCATCCGCTACAGCGGTGACATCGCCAA
AGCCATTGCCGCGGGCGCCAATACCGTCATGATGGGCGGGATGTTCGCAGGGACCGAAGAGGCGCCGGGCGAAGTCATCC
TGTACCAGGGGCGCAGCTACAAAAGCTACCGCGGCATGGGAAGCATTGGCGCCATGCAGCAGGGCAGTGCAGACCGCTAT
TTCCAGGAGTCGAGCACCGGCAACCCCAACGCTGACAAGCTGGTCCCCGAGGGCATTGAAGGCCGCGTGCCGTACAAAGG
CTCCATGGTGGCCATCGTGTACCAGATGGCCGGCGGCTTGCGTGCCAGCATGGGCTACTGCGGCTGCGCCACGATTGAAG
ACATGCGCGACAAGGCCGAGTTCGTGGAAATCACCTCCGCCGGCATTCGCGAGAGCCATGTCCACGATGTGCAGATCACC
AAGGAAGCGCCGAACTACCGGGCTGATTGA

Upstream 100 bases:

>100_bases
TTTTGCAACTTGGGCAAAAAGTCAGGCCAAAATAGGCGCCAAGGGTTAGTACCGAGGGTTTTGGGGACAAGGGTACAATC
GTGTTTTTGGAGCTATCCCT

Downstream 100 bases:

>100_bases
TGTGACCCCCACGTTCGCTCACTTCGTGTAGCTCTCTGCCCCCCGAGGGGGCTGGCCTTGCTTGGGGCGGCCCGGCGCGG
CGGCCGCAGTTGGCTTTCAC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MRLLGKALTFDDVLLVPAFSQVLPKDTSLSTQFSRNIRLNLPLVSAAMDTVTEARLAIAIAQEGGIGIVHKNLTPQQQAA
EVAKVKRYESGVLRDPVVITPTHTVRQVMALSEQLGISGFPVIDGGRVVGIVTGRDMRFESRMDVPVSTIMTPRDRLITI
SETASLADAKALLNKHRLERVLLVNDNFELKGLITVKDITKQTTFPNAARDSHGQLRVGAAVGVGEGTEERVEALVKAGV
DAIVVDTAHGHSKGVIDRVRWVKRNYPQVDVIGGNIATGAAALALAEAGADGVKVGIGPGSICTTRIVAGVGVPQIMAID
NVAMALRGTGVPLIGDGGIRYSGDIAKAIAAGANTVMMGGMFAGTEEAPGEVILYQGRSYKSYRGMGSIGAMQQGSADRY
FQESSTGNPNADKLVPEGIEGRVPYKGSMVAIVYQMAGGLRASMGYCGCATIEDMRDKAEFVEITSAGIRESHVHDVQIT
KEAPNYRAD

Sequences:

>Translated_489_residues
MRLLGKALTFDDVLLVPAFSQVLPKDTSLSTQFSRNIRLNLPLVSAAMDTVTEARLAIAIAQEGGIGIVHKNLTPQQQAA
EVAKVKRYESGVLRDPVVITPTHTVRQVMALSEQLGISGFPVIDGGRVVGIVTGRDMRFESRMDVPVSTIMTPRDRLITI
SETASLADAKALLNKHRLERVLLVNDNFELKGLITVKDITKQTTFPNAARDSHGQLRVGAAVGVGEGTEERVEALVKAGV
DAIVVDTAHGHSKGVIDRVRWVKRNYPQVDVIGGNIATGAAALALAEAGADGVKVGIGPGSICTTRIVAGVGVPQIMAID
NVAMALRGTGVPLIGDGGIRYSGDIAKAIAAGANTVMMGGMFAGTEEAPGEVILYQGRSYKSYRGMGSIGAMQQGSADRY
FQESSTGNPNADKLVPEGIEGRVPYKGSMVAIVYQMAGGLRASMGYCGCATIEDMRDKAEFVEITSAGIRESHVHDVQIT
KEAPNYRAD
>Mature_489_residues
MRLLGKALTFDDVLLVPAFSQVLPKDTSLSTQFSRNIRLNLPLVSAAMDTVTEARLAIAIAQEGGIGIVHKNLTPQQQAA
EVAKVKRYESGVLRDPVVITPTHTVRQVMALSEQLGISGFPVIDGGRVVGIVTGRDMRFESRMDVPVSTIMTPRDRLITI
SETASLADAKALLNKHRLERVLLVNDNFELKGLITVKDITKQTTFPNAARDSHGQLRVGAAVGVGEGTEERVEALVKAGV
DAIVVDTAHGHSKGVIDRVRWVKRNYPQVDVIGGNIATGAAALALAEAGADGVKVGIGPGSICTTRIVAGVGVPQIMAID
NVAMALRGTGVPLIGDGGIRYSGDIAKAIAAGANTVMMGGMFAGTEEAPGEVILYQGRSYKSYRGMGSIGAMQQGSADRY
FQESSTGNPNADKLVPEGIEGRVPYKGSMVAIVYQMAGGLRASMGYCGCATIEDMRDKAEFVEITSAGIRESHVHDVQIT
KEAPNYRAD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=454, Percent_Identity=42.0704845814978, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI34328928, Length=454, Percent_Identity=42.0704845814978, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI156616279, Length=454, Percent_Identity=42.0704845814978, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI34328930, Length=458, Percent_Identity=41.4847161572052, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI66933016, Length=488, Percent_Identity=39.7540983606557, Blast_Score=341, Evalue=1e-93,
Organism=Homo sapiens, GI217035152, Length=454, Percent_Identity=41.4096916299559, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI217035148, Length=454, Percent_Identity=41.1894273127753, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI217035150, Length=454, Percent_Identity=38.7665198237885, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI50541956, Length=251, Percent_Identity=36.2549800796813, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI156104880, Length=250, Percent_Identity=36, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI50541954, Length=251, Percent_Identity=36.2549800796813, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI50541952, Length=251, Percent_Identity=36.2549800796813, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI50541948, Length=251, Percent_Identity=36.2549800796813, Blast_Score=159, Evalue=8e-39,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=60.8606557377049, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1786293, Length=227, Percent_Identity=33.4801762114537, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=37.9668049792531, Blast_Score=294, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=40.521327014218, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17560440, Length=280, Percent_Identity=32.5, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=38.6036960985626, Blast_Score=342, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=37.9876796714579, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=487, Percent_Identity=37.9876796714579, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=37.2781065088757, Blast_Score=247, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=122, Percent_Identity=40.9836065573771, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24641071, Length=487, Percent_Identity=40.2464065708419, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24641073, Length=487, Percent_Identity=40.2464065708419, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI28571163, Length=444, Percent_Identity=41.2162162162162, Blast_Score=318, Evalue=7e-87,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51778; Mature: 51778

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLGKALTFDDVLLVPAFSQVLPKDTSLSTQFSRNIRLNLPLVSAAMDTVTEARLAIAI
CCCCCCCCCCCCEEEHHHHHHHCCCCCCCCHHHCCCEEEECCHHHHHHHHHHHCEEEEEE
AQEGGIGIVHKNLTPQQQAAEVAKVKRYESGVLRDPVVITPTHTVRQVMALSEQLGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCCCC
PVIDGGRVVGIVTGRDMRFESRMDVPVSTIMTPRDRLITISETASLADAKALLNKHRLER
EEECCCEEEEEEECCCEEECCCCCCCHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCE
VLLVNDNFELKGLITVKDITKQTTFPNAARDSHGQLRVGAAVGVGEGTEERVEALVKAGV
EEEECCCCEEEEEEEEHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DAIVVDTAHGHSKGVIDRVRWVKRNYPQVDVIGGNIATGAAALALAEAGADGVKVGIGPG
CEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQIMAIDNVAMALRGTGVPLIGDGGIRYSGDIAKAIAAGANTVMMGG
CHHHHHHHHCCCCCCEEECCCCHHEEECCCCEEEECCCEEECCHHHHHHHCCCCEEEECC
MFAGTEEAPGEVILYQGRSYKSYRGMGSIGAMQQGSADRYFQESSTGNPNADKLVPEGIE
EECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCC
GRVPYKGSMVAIVYQMAGGLRASMGYCGCATIEDMRDKAEFVEITSAGIRESHVHDVQIT
CCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHEEHHHCCCCCCCCEEEEEE
KEAPNYRAD
ECCCCCCCC
>Mature Secondary Structure
MRLLGKALTFDDVLLVPAFSQVLPKDTSLSTQFSRNIRLNLPLVSAAMDTVTEARLAIAI
CCCCCCCCCCCCEEEHHHHHHHCCCCCCCCHHHCCCEEEECCHHHHHHHHHHHCEEEEEE
AQEGGIGIVHKNLTPQQQAAEVAKVKRYESGVLRDPVVITPTHTVRQVMALSEQLGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHCCCCCC
PVIDGGRVVGIVTGRDMRFESRMDVPVSTIMTPRDRLITISETASLADAKALLNKHRLER
EEECCCEEEEEEECCCEEECCCCCCCHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCE
VLLVNDNFELKGLITVKDITKQTTFPNAARDSHGQLRVGAAVGVGEGTEERVEALVKAGV
EEEECCCCEEEEEEEEHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
DAIVVDTAHGHSKGVIDRVRWVKRNYPQVDVIGGNIATGAAALALAEAGADGVKVGIGPG
CEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCC
SICTTRIVAGVGVPQIMAIDNVAMALRGTGVPLIGDGGIRYSGDIAKAIAAGANTVMMGG
CHHHHHHHHCCCCCCEEECCCCHHEEECCCCEEEECCCEEECCHHHHHHHCCCCEEEECC
MFAGTEEAPGEVILYQGRSYKSYRGMGSIGAMQQGSADRYFQESSTGNPNADKLVPEGIE
EECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCC
GRVPYKGSMVAIVYQMAGGLRASMGYCGCATIEDMRDKAEFVEITSAGIRESHVHDVQIT
CCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHEEHHHCCCCCCCCEEEEEE
KEAPNYRAD
ECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA