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The map label for this gene is merR [H]

Identifier: 91788104

GI number: 91788104

Start: 2321822

End: 2322256

Strand: Direct

Name: merR [H]

Synonym: Bpro_2232

Alternate gene names: 91788104

Gene position: 2321822-2322256 (Clockwise)

Preceding gene: 91788093

Following gene: 91788105

Centisome position: 44.65

GC content: 58.85

Gene sequence:

>435_bases
ATGCAAAATATTTTTGGGAATTTGACCATTGGCGTTTTTGCCAAGGCGGCCGGGGTCAACGTGGAGACCATCCGGTTCTA
TCAGCGCAAGGGCCTGCTGCCGGAGCCAGACAAGCCTTACGGCAGCATTCGCCGGTATGGCGAGGCGGATGTAACGCGGG
TGCGGTTTGTGAAATCGGCCCAGCGACTGGGCTTCAGCCTGGACGAGATCGCCGAATTGCTCAGATTGGAGGATGGCACC
CACTGCCGCGAAGCCAGTAACCTGGCCGAGCACAAGCTCCAGGACGTGCGCGAAAAGATGGCTGACCTGGCGCGCATGGA
AACCGTGCTATCCAAGCTTGTGTGCGCCTGCCATGCACGGAAGGGGAACGTTTCCTGTCCGCTGATTGCGTCGCTCCAAG
GGGAGAAAGAAACTTCCAGCTCCGGGGCGAAATAG

Upstream 100 bases:

>100_bases
GCACCACGAACATTTTGTGGTTCAGACATGTGTTTGTGCTTTCGAAACTGGAATGAATGGCGTAACCTTATTTCCGTAGT
AATGTACGGAGTCAAGCGAT

Downstream 100 bases:

>100_bases
TTGAGGAACACGCGGGCCTTAGCGTGCTTTATTTTCCGTTTTTGAGGCGCCCCGAGAAGTTCGGTTGAACCGAAGCGTTC
AGGTAGGTGCGGAGAGGGCT

Product: putative transcriptional regulator MerR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MQNIFGNLTIGVFAKAAGVNVETIRFYQRKGLLPEPDKPYGSIRRYGEADVTRVRFVKSAQRLGFSLDEIAELLRLEDGT
HCREASNLAEHKLQDVREKMADLARMETVLSKLVCACHARKGNVSCPLIASLQGEKETSSSGAK

Sequences:

>Translated_144_residues
MQNIFGNLTIGVFAKAAGVNVETIRFYQRKGLLPEPDKPYGSIRRYGEADVTRVRFVKSAQRLGFSLDEIAELLRLEDGT
HCREASNLAEHKLQDVREKMADLARMETVLSKLVCACHARKGNVSCPLIASLQGEKETSSSGAK
>Mature_144_residues
MQNIFGNLTIGVFAKAAGVNVETIRFYQRKGLLPEPDKPYGSIRRYGEADVTRVRFVKSAQRLGFSLDEIAELLRLEDGT
HCREASNLAEHKLQDVREKMADLARMETVLSKLVCACHARKGNVSCPLIASLQGEKETSSSGAK

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=139, Percent_Identity=34.5323741007194, Blast_Score=82, Evalue=1e-17,
Organism=Escherichia coli, GI1786695, Length=129, Percent_Identity=27.1317829457364, Blast_Score=60, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15924; Mature: 15924

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNIFGNLTIGVFAKAAGVNVETIRFYQRKGLLPEPDKPYGSIRRYGEADVTRVRFVKSA
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
QRLGFSLDEIAELLRLEDGTHCREASNLAEHKLQDVREKMADLARMETVLSKLVCACHAR
HHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KGNVSCPLIASLQGEKETSSSGAK
CCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQNIFGNLTIGVFAKAAGVNVETIRFYQRKGLLPEPDKPYGSIRRYGEADVTRVRFVKSA
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
QRLGFSLDEIAELLRLEDGTHCREASNLAEHKLQDVREKMADLARMETVLSKLVCACHAR
HHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KGNVSCPLIASLQGEKETSSSGAK
CCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666393 [H]