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The map label for this gene is merR [H]

Identifier: 91788105

GI number: 91788105

Start: 2322796

End: 2323212

Strand: Direct

Name: merR [H]

Synonym: Bpro_2233

Alternate gene names: 91788105

Gene position: 2322796-2323212 (Clockwise)

Preceding gene: 91788104

Following gene: 91788106

Centisome position: 44.67

GC content: 56.83

Gene sequence:

>417_bases
ATGCTTACGATCGGCAAACTTGCGGCACTGGCGGGTACCACACCCAACACTTTGCGCTATCACGAGCGCGAGGGCTTGAT
TCCGCCAGCGTCCAAAGGCGACAACGGCTATCGCCTCTACGCGCAAGACGCGGCGCAACGTGTCCACTTCATAAGGCAAG
CGCAGCAATGCGGCTTCGCGCTCGCGGAGATTCGAGCGCTGCTGACTATCCCGCGGCAGGCATCGGCCGGCTGCTCCGAC
GTTCGTACCTTTGCTATCGAAAAGAAACTCGCTCTGGAAGCAAAGATCAAACTGATGAAAGCAATGCCGGCGGAACTCGA
CCAATTGATCGGTGACTGCGTTGATGACAAACGCCCGCTGAATGATTGCCCTATTTTGAATGCGCTGAACCGCGTGCCCG
TGGAGATAACACATTGA

Upstream 100 bases:

>100_bases
GGCGAACGTCAATGACAGGGCAACGCCAGGCACTTGACCTTCGCCTTAGGACGAAGGTTTGCAGTTGTTCTTTTAAACCC
TGTTTAAAGCACCGCTTCCC

Downstream 100 bases:

>100_bases
AGATCGAAGTCTTTTATGCCGATGGCTGCGGCAGTTGCAGCGCGGCCAGGCAAGAATTGAAGCAGGCGGTGCTTGAAGCG
TTCCCCACCGGCGCAGCCTG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MLTIGKLAALAGTTPNTLRYHEREGLIPPASKGDNGYRLYAQDAAQRVHFIRQAQQCGFALAEIRALLTIPRQASAGCSD
VRTFAIEKKLALEAKIKLMKAMPAELDQLIGDCVDDKRPLNDCPILNALNRVPVEITH

Sequences:

>Translated_138_residues
MLTIGKLAALAGTTPNTLRYHEREGLIPPASKGDNGYRLYAQDAAQRVHFIRQAQQCGFALAEIRALLTIPRQASAGCSD
VRTFAIEKKLALEAKIKLMKAMPAELDQLIGDCVDDKRPLNDCPILNALNRVPVEITH
>Mature_138_residues
MLTIGKLAALAGTTPNTLRYHEREGLIPPASKGDNGYRLYAQDAAQRVHFIRQAQQCGFALAEIRALLTIPRQASAGCSD
VRTFAIEKKLALEAKIKLMKAMPAELDQLIGDCVDDKRPLNDCPILNALNRVPVEITH

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=134, Percent_Identity=34.3283582089552, Blast_Score=84, Evalue=2e-18,
Organism=Escherichia coli, GI1786695, Length=129, Percent_Identity=31.0077519379845, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15150; Mature: 15150

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIGKLAALAGTTPNTLRYHEREGLIPPASKGDNGYRLYAQDAAQRVHFIRQAQQCGFA
CCCHHHHHHHCCCCCCHHEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
LAEIRALLTIPRQASAGCSDVRTFAIEKKLALEAKIKLMKAMPAELDQLIGDCVDDKRPL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC
NDCPILNALNRVPVEITH
CCCHHHHHHCCCCEEECC
>Mature Secondary Structure
MLTIGKLAALAGTTPNTLRYHEREGLIPPASKGDNGYRLYAQDAAQRVHFIRQAQQCGFA
CCCHHHHHHHCCCCCCHHEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
LAEIRALLTIPRQASAGCSDVRTFAIEKKLALEAKIKLMKAMPAELDQLIGDCVDDKRPL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC
NDCPILNALNRVPVEITH
CCCHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400173 [H]