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The map label for this gene is iscA [H]

Identifier: 91788053

GI number: 91788053

Start: 2276046

End: 2276369

Strand: Direct

Name: iscA [H]

Synonym: Bpro_2180

Alternate gene names: 91788053

Gene position: 2276046-2276369 (Clockwise)

Preceding gene: 91788052

Following gene: 91788054

Centisome position: 43.77

GC content: 56.79

Gene sequence:

>324_bases
ATGTCCGTTACTCTCACCGATGCTGCTGCCCGTCACGTGACCCGCTATATGGCCAAGCGCGGGAAGGGCGTGGGCGTGCG
TTTGGGCGTCAAGACCACAGGCTGCTCGGGTCTGGCATACAAGCTTGAATATGCCGACGAGATCGCGCCTGAAGATGTGG
TGTTTGAAGACAACGGCGTCAAGGTGCTGGTGGATCCCAAAAGCATGGCCTACATCGACGGCACCCAGCTTGATTTTGTG
CGCGAGGGTCTGAACGAAGGCTTCAAGTTCATCAATCCCAACGAGCGTGATCGCTGTGGTTGCGGTGAAAGCTTTCGCGT
TTGA

Upstream 100 bases:

>100_bases
ACTGCTCCATTCTGGCGGAAGACGCCATCAAGGCTGCCGTGAACGACTACAAGCAAAAGCACGCACACTGATAGTCCTGC
CTAATTTTTGAGTCATTGAA

Downstream 100 bases:

>100_bases
CGGGCGCACTTGCGCTAGCCCCGACATCCAGTACAGCCGTTTTTGCAGAGCCGCCTTCACTGACTGTGCTGGCGGCTTTT
TCTTGACATGAACCTTCACT

Product: iron-sulfur cluster assembly protein IscA

Products: NA

Alternate protein names: Iron-sulfur cluster assembly protein [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSVTLTDAAARHVTRYMAKRGKGVGVRLGVKTTGCSGLAYKLEYADEIAPEDVVFEDNGVKVLVDPKSMAYIDGTQLDFV
REGLNEGFKFINPNERDRCGCGESFRV

Sequences:

>Translated_107_residues
MSVTLTDAAARHVTRYMAKRGKGVGVRLGVKTTGCSGLAYKLEYADEIAPEDVVFEDNGVKVLVDPKSMAYIDGTQLDFV
REGLNEGFKFINPNERDRCGCGESFRV
>Mature_106_residues
SVTLTDAAARHVTRYMAKRGKGVGVRLGVKTTGCSGLAYKLEYADEIAPEDVVFEDNGVKVLVDPKSMAYIDGTQLDFVR
EGLNEGFKFINPNERDRCGCGESFRV

Specific function: Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that iscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transi

COG id: COG0316

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesB/iscA family [H]

Homologues:

Organism=Homo sapiens, GI52426768, Length=106, Percent_Identity=37.7358490566038, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI160420328, Length=83, Percent_Identity=40.9638554216867, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788877, Length=107, Percent_Identity=68.2242990654206, Blast_Score=162, Evalue=3e-42,
Organism=Escherichia coli, GI1787974, Length=105, Percent_Identity=53.3333333333333, Blast_Score=117, Evalue=1e-28,
Organism=Escherichia coli, GI1786351, Length=110, Percent_Identity=37.2727272727273, Blast_Score=73, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193209025, Length=106, Percent_Identity=36.7924528301887, Blast_Score=88, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI25146411, Length=106, Percent_Identity=36.7924528301887, Blast_Score=88, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323001, Length=105, Percent_Identity=38.0952380952381, Blast_Score=85, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24642263, Length=104, Percent_Identity=40.3846153846154, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000361
- InterPro:   IPR016092
- InterPro:   IPR017870
- InterPro:   IPR011302 [H]

Pfam domain/function: PF01521 Fe-S_biosyn [H]

EC number: NA

Molecular weight: Translated: 11752; Mature: 11621

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS01152 HESB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTLTDAAARHVTRYMAKRGKGVGVRLGVKTTGCSGLAYKLEYADEIAPEDVVFEDNGV
CEEEECHHHHHHHHHHHHHCCCCCEEEEECEECCCCCEEEEEECCCCCCCCCEEEECCCC
KVLVDPKSMAYIDGTQLDFVREGLNEGFKFINPNERDRCGCGESFRV
EEEECCCCEEEECCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVTLTDAAARHVTRYMAKRGKGVGVRLGVKTTGCSGLAYKLEYADEIAPEDVVFEDNGV
EEEECHHHHHHHHHHHHHCCCCCEEEEECEECCCCCEEEEEECCCCCCCCCEEEECCCC
KVLVDPKSMAYIDGTQLDFVREGLNEGFKFINPNERDRCGCGESFRV
EEEECCCCEEEECCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA