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The map label for this gene is aceA [H]

Identifier: 91787974

GI number: 91787974

Start: 2189167

End: 2190486

Strand: Direct

Name: aceA [H]

Synonym: Bpro_2101

Alternate gene names: 91787974

Gene position: 2189167-2190486 (Clockwise)

Preceding gene: 91787973

Following gene: 91787975

Centisome position: 42.1

GC content: 61.36

Gene sequence:

>1320_bases
ATGCCACAGACCCTCACTGAACAATTGAGCCGCGACCAGCAGATTTCCGCCCTCGAAAAAGACTGGGCCACCAACCCGCG
CTGGAAAGGCATCAAGCGCGGCTACAGCGCCGCCGACGTGGTTCGCCTGCGTGGCTCGTTCCCGATCGAACACACGCTGG
CCCGCCGTGGTGCCGAAAAGCTGTGGAACATCCTGCACAGCGAGCCTTATGTCAACTGCCTGGGCGCGCTCACCGGCGGT
CAGGCCATGCAGCAGGTCAAGGCCGGCGTGAAGGCCATCTACCTGTCGGGCTGGCAGGTTGCCGCTGACAACAACACCTA
CTCGGCCATGTACCCGGACCAGTCGCTGTACCCGGTGGACTCGGTGCCCAAGGTGGTGGAAACCATCAACAACACTTTCC
GCCGTGCCGACGAAATTCAGCACTCCAAAGGCATTGATGCCGGCGACAAAGGCTACATCGACTATTTCGCCCCCATCGTT
GCAGACGCTGAAGCCGGGTTTGGCGGCGTGCTCAATGCTTTTGAGCTGATGAAGGCCATGATCAAGGCCGGGGCCGGCGG
CGTGCATTGGGAAGACCAGCTGGCGTCCGTCAAGAAGTGCGGCCACATGGGCGGCAAGGTGCTGCTGCCGACGCGCGAGT
CCTGCCAGAAACTGATCGCCGCGCGCATGGCGGCCGACGTGTGCGGCGTGCCTACCCTGGTGATTGCACGTACCGACGCC
GAGGCAGCCGACCTGCTGACCTCCGACTATGACGAGATCGACAAGCCTTTCCTGACGGGTGAGCGCACCGCCGAAGGTTT
CTACAAGACCCGCAAGGGCCTGGAGCAGGCTGTTGCCCGCGCCAACGCCTATGCGCATTACGCCGATCTGGTGTGGTGTG
AAACCGGCACGCCTGACCTTGACTTCGCCAGGAAGTTTGCCGATGCCGTGCACAAGGTCCACCCCGGCAAGATGCTGGCC
TACAACTGCTCGCCTTCGTTCAACTGGAAGAAGAACCTGGACGATGCCACCATCGCCAAGTTCCAGCGCGAACTCGGCGC
GATGGGCTACAAGTACCAGTTCATCACGCTGGCTGGCATTCACTCCATGTGGTACAACATGTACGACCTGTCGCAAGACT
ACGTCAAGCGCGGCATGACGGCCTACATCGAGAAGGTGCAGGAACCCGAGTTCGCAGCGCGTGACCGCGGCTACACCTTT
GTGTCGCACCAGCAGGAAGTGGGCACCGGTTATTTCGATGAAGTGACCACGGCGATCCAGGGCGGCAAGTCCAGCGTGAC
CGCATTGACCGGCTCTACCGAAGAAGAGCAGTTCCATTGA

Upstream 100 bases:

>100_bases
TTTTGTCTTATATAAGACATAAGAGCTTCACAAGGTCTTGTAGAAGACTTAAAGTAGACCTACGTTGTCAGTCACTTTTC
TTCAACCTACGGAGCCCACC

Downstream 100 bases:

>100_bases
GCATTCACCGAGCCTTTACTGAGTTTGCGCTGGGGTATTCCCGGCTCCGACCCTGAGCGCATGGTCCGTATGTCTGGTTC
CTGCCGGATGCGGATTTCAG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MPQTLTEQLSRDQQISALEKDWATNPRWKGIKRGYSAADVVRLRGSFPIEHTLARRGAEKLWNILHSEPYVNCLGALTGG
QAMQQVKAGVKAIYLSGWQVAADNNTYSAMYPDQSLYPVDSVPKVVETINNTFRRADEIQHSKGIDAGDKGYIDYFAPIV
ADAEAGFGGVLNAFELMKAMIKAGAGGVHWEDQLASVKKCGHMGGKVLLPTRESCQKLIAARMAADVCGVPTLVIARTDA
EAADLLTSDYDEIDKPFLTGERTAEGFYKTRKGLEQAVARANAYAHYADLVWCETGTPDLDFARKFADAVHKVHPGKMLA
YNCSPSFNWKKNLDDATIAKFQRELGAMGYKYQFITLAGIHSMWYNMYDLSQDYVKRGMTAYIEKVQEPEFAARDRGYTF
VSHQQEVGTGYFDEVTTAIQGGKSSVTALTGSTEEEQFH

Sequences:

>Translated_439_residues
MPQTLTEQLSRDQQISALEKDWATNPRWKGIKRGYSAADVVRLRGSFPIEHTLARRGAEKLWNILHSEPYVNCLGALTGG
QAMQQVKAGVKAIYLSGWQVAADNNTYSAMYPDQSLYPVDSVPKVVETINNTFRRADEIQHSKGIDAGDKGYIDYFAPIV
ADAEAGFGGVLNAFELMKAMIKAGAGGVHWEDQLASVKKCGHMGGKVLLPTRESCQKLIAARMAADVCGVPTLVIARTDA
EAADLLTSDYDEIDKPFLTGERTAEGFYKTRKGLEQAVARANAYAHYADLVWCETGTPDLDFARKFADAVHKVHPGKMLA
YNCSPSFNWKKNLDDATIAKFQRELGAMGYKYQFITLAGIHSMWYNMYDLSQDYVKRGMTAYIEKVQEPEFAARDRGYTF
VSHQQEVGTGYFDEVTTAIQGGKSSVTALTGSTEEEQFH
>Mature_438_residues
PQTLTEQLSRDQQISALEKDWATNPRWKGIKRGYSAADVVRLRGSFPIEHTLARRGAEKLWNILHSEPYVNCLGALTGGQ
AMQQVKAGVKAIYLSGWQVAADNNTYSAMYPDQSLYPVDSVPKVVETINNTFRRADEIQHSKGIDAGDKGYIDYFAPIVA
DAEAGFGGVLNAFELMKAMIKAGAGGVHWEDQLASVKKCGHMGGKVLLPTRESCQKLIAARMAADVCGVPTLVIARTDAE
AADLLTSDYDEIDKPFLTGERTAEGFYKTRKGLEQAVARANAYAHYADLVWCETGTPDLDFARKFADAVHKVHPGKMLAY
NCSPSFNWKKNLDDATIAKFQRELGAMGYKYQFITLAGIHSMWYNMYDLSQDYVKRGMTAYIEKVQEPEFAARDRGYTFV
SHQQEVGTGYFDEVTTAIQGGKSSVTALTGSTEEEQFH

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=71.5935334872979, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1786525, Length=266, Percent_Identity=28.9473684210526, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982926, Length=419, Percent_Identity=59.9045346062053, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17561814, Length=420, Percent_Identity=59.7619047619048, Blast_Score=507, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6320908, Length=268, Percent_Identity=38.0597014925373, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325263, Length=253, Percent_Identity=36.3636363636364, Blast_Score=147, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 48600; Mature: 48469

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQTLTEQLSRDQQISALEKDWATNPRWKGIKRGYSAADVVRLRGSFPIEHTLARRGAEK
CCCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHH
LWNILHSEPYVNCLGALTGGQAMQQVKAGVKAIYLSGWQVAADNNTYSAMYPDQSLYPVD
HHHHHCCCCHHHHHHHHCCHHHHHHHHHCHHEEEEECEEEEECCCEEEEECCCCCCCCCH
SVPKVVETINNTFRRADEIQHSKGIDAGDKGYIDYFAPIVADAEAGFGGVLNAFELMKAM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IKAGAGGVHWEDQLASVKKCGHMGGKVLLPTRESCQKLIAARMAADVCGVPTLVIARTDA
HHCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCC
EAADLLTSDYDEIDKPFLTGERTAEGFYKTRKGLEQAVARANAYAHYADLVWCETGTPDL
HHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCH
DFARKFADAVHKVHPGKMLAYNCSPSFNWKKNLDDATIAKFQRELGAMGYKYQFITLAGI
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHH
HSMWYNMYDLSQDYVKRGMTAYIEKVQEPEFAARDRGYTFVSHQQEVGTGYFDEVTTAIQ
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCCCCEEECCHHHHCCCHHHHHHHHHH
GGKSSVTALTGSTEEEQFH
CCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
PQTLTEQLSRDQQISALEKDWATNPRWKGIKRGYSAADVVRLRGSFPIEHTLARRGAEK
CCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHH
LWNILHSEPYVNCLGALTGGQAMQQVKAGVKAIYLSGWQVAADNNTYSAMYPDQSLYPVD
HHHHHCCCCHHHHHHHHCCHHHHHHHHHCHHEEEEECEEEEECCCEEEEECCCCCCCCCH
SVPKVVETINNTFRRADEIQHSKGIDAGDKGYIDYFAPIVADAEAGFGGVLNAFELMKAM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IKAGAGGVHWEDQLASVKKCGHMGGKVLLPTRESCQKLIAARMAADVCGVPTLVIARTDA
HHCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCC
EAADLLTSDYDEIDKPFLTGERTAEGFYKTRKGLEQAVARANAYAHYADLVWCETGTPDL
HHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCH
DFARKFADAVHKVHPGKMLAYNCSPSFNWKKNLDDATIAKFQRELGAMGYKYQFITLAGI
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHH
HSMWYNMYDLSQDYVKRGMTAYIEKVQEPEFAARDRGYTFVSHQQEVGTGYFDEVTTAIQ
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCCCCEEECCHHHHCCCHHHHHHHHHH
GGKSSVTALTGSTEEEQFH
CCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]