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The map label for this gene is thrS [H]

Identifier: 91787975

GI number: 91787975

Start: 2190962

End: 2192869

Strand: Direct

Name: thrS [H]

Synonym: Bpro_2102

Alternate gene names: 91787975

Gene position: 2190962-2192869 (Clockwise)

Preceding gene: 91787974

Following gene: 91787976

Centisome position: 42.13

GC content: 58.91

Gene sequence:

>1908_bases
ATGATTCAAATAACGCTTCCCGATGCATCCAAACGCGAATATCCCCAAGCCGTCACCGTGGCCGAAGTGGCCGCGTCCAT
CGGTGCTGGCCTGGCCAAGGCTGCCCTGGGTGGCAAGGTCGATGGCAAGGTGGTCGACACGAGCTACCTGATCGAGAAAG
ACAGCGCGCTGTCCATCATCACGGCCAAGGATGCCGATGGGCTGGAGCTGATCCGCCACTCGACGGCGCACTTGCTGGCG
TATGCGGTCAAGGAGCTGTTTTCCGAGGCGCAGGTCACCATCGGGCCGGTGATTGAAAACGGGTTTTATTACGACTTTGC
CTACAAGCGTCCTTTCACGCCGGAAGACCTGGCGGCCATTGAAAAACGCATGACCGAGTTGGCGGCCAAAGACGAACCGG
TGACGCGCCGTGTGCTGCCGCGCGATGAAGCCGTGGCGCACTTCAAGAGCATTGGAGAGCATTACAAGGCCGAAATCATT
GCCAGCATCCCTGCCAATGAAGATGTGTCGCTGTACCGGGAGGGGACGTTTGAAGACCTGTGCCGCGGCCCCCACGTACC
CAGCACCGGCAAGCTGAAATTCTTCAAGCTCATGAAAGTGGCTGGCGCCTACTGGCGCGGCGACCATCGCAACGAGATGC
TGCAGCGTGTCTACGGAACGGCGTGGGCCACCAAGGACGAACTGCAGCAGTACCTGACGATGCTGGAGGAAGCCGAAAAG
CGCGACCACCGCAAGCTGGGCAAGGAGCTGGACCTGTTCCATATCGATGACCATGCGCCTGGCCTCGTGTTCTGGCACCC
CAAGGGCTGGACGATCTGGCAGGGCGTGGAGCAGTACATGCGCAAGGTCTACCAGGACAACGGCTACCAGGAGGTCAAGG
GCCCGCAGGTCATCGACAAGACCCTGTGGGAAAAGACCGGCCACTGGGACAAGTACCGCGACAACATGTTCACGACCGAG
AGCGAGAAGCGCGAGTACGCGCTCAAGCCGATGAACTGCCCCGGCCACATCCTGATTTTCAAGCAGGGTATCAAGAGCTA
CCGCGACCTGCCGCTGCGCTACGGTGAATTCGGCCAGTGCCACCGCAATGAACCCTCGGGCGGGTTGCACGGCATCATGC
GGGTGCGCGGCTTCACGCAGGATGACGGCCATATTTTTTGCACGGAAGAGCAGATCCTCAAGGAATGCGTGGACTACACG
ACCTTGCTGCAAAAGGTCTACACCGACTTCGGCTTTAAAAACATCATCTACAAGGTCGCTACCCGGCCCGACGCCCGCAT
TGGCTCTGACGAGAGCTGGGACAAGGCCGAGCAGGCCCTGATCGAAAGCCTGCGCGCTTCAGGCTGTGAATTTGAAATCT
CCCCGGGCGAGGGCGCGTTTTACGGCCCCAAGATCGAGTACACGCTGAAAGATGCGATTGGCCGGCAGTGGCAGTGCGGC
ACCATGCAGGTCGATTTCTCCATGCCGGAGCGTCTGGATGCCGAGTATGTGGGCGAGGATGGCGCCCGCCATCGCCCGGT
GATGCTGCACCGCGCGATTGTGGGCAGCCTGGAGCGATTCATCGGGATTTTGATCGAGGAACACGCTGGTGCGCTGCCAA
CCTGGCTGGCGCCGATTCAGGTTTCGGTGCTCAATATCACCGATTCCCAGGCTGAATATGCCCGGGAAGTTGCCAAAACG
CTGCAAAATCAAGGGCTTAGGGTCAACCTTGACCTGCGCAATGAGAAAATTACGTATAAAATACGGGAGCACTCCTTGCA
AAAGCTGCCTTACATCCTTGTCGTTGGCGACAAAGAGAAGGCGGCTGGAGCCGTAGCAGTGCGCGCCCGGGGTAACAAAG
ACCTTGGAGTAATGTCCATCGAAGCGTTTGCCCAGCAAATTGCCTCCGACATTGCACAAAAAGCCTGA

Upstream 100 bases:

>100_bases
AATTTAATAGCTTAAATTCATAGCAAAAATCCATTTCCCTTATCAAAAGCGCGGCCGGTTCCGCGCTTTTTGTTTGACAG
TCCACTTTCAAAGCCTTCCC

Downstream 100 bases:

>100_bases
ACCGCTGACAAGCTGGATAAGTCTGTCGGCATTAAAGCTTCTCGTCCTTGTGGGACGGGCGCAAGCCGCTATAGCTTTTA
TAGCAAGCATTGAAGGATTA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MIQITLPDASKREYPQAVTVAEVAASIGAGLAKAALGGKVDGKVVDTSYLIEKDSALSIITAKDADGLELIRHSTAHLLA
YAVKELFSEAQVTIGPVIENGFYYDFAYKRPFTPEDLAAIEKRMTELAAKDEPVTRRVLPRDEAVAHFKSIGEHYKAEII
ASIPANEDVSLYREGTFEDLCRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNEMLQRVYGTAWATKDELQQYLTMLEEAEK
RDHRKLGKELDLFHIDDHAPGLVFWHPKGWTIWQGVEQYMRKVYQDNGYQEVKGPQVIDKTLWEKTGHWDKYRDNMFTTE
SEKREYALKPMNCPGHILIFKQGIKSYRDLPLRYGEFGQCHRNEPSGGLHGIMRVRGFTQDDGHIFCTEEQILKECVDYT
TLLQKVYTDFGFKNIIYKVATRPDARIGSDESWDKAEQALIESLRASGCEFEISPGEGAFYGPKIEYTLKDAIGRQWQCG
TMQVDFSMPERLDAEYVGEDGARHRPVMLHRAIVGSLERFIGILIEEHAGALPTWLAPIQVSVLNITDSQAEYAREVAKT
LQNQGLRVNLDLRNEKITYKIREHSLQKLPYILVVGDKEKAAGAVAVRARGNKDLGVMSIEAFAQQIASDIAQKA

Sequences:

>Translated_635_residues
MIQITLPDASKREYPQAVTVAEVAASIGAGLAKAALGGKVDGKVVDTSYLIEKDSALSIITAKDADGLELIRHSTAHLLA
YAVKELFSEAQVTIGPVIENGFYYDFAYKRPFTPEDLAAIEKRMTELAAKDEPVTRRVLPRDEAVAHFKSIGEHYKAEII
ASIPANEDVSLYREGTFEDLCRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNEMLQRVYGTAWATKDELQQYLTMLEEAEK
RDHRKLGKELDLFHIDDHAPGLVFWHPKGWTIWQGVEQYMRKVYQDNGYQEVKGPQVIDKTLWEKTGHWDKYRDNMFTTE
SEKREYALKPMNCPGHILIFKQGIKSYRDLPLRYGEFGQCHRNEPSGGLHGIMRVRGFTQDDGHIFCTEEQILKECVDYT
TLLQKVYTDFGFKNIIYKVATRPDARIGSDESWDKAEQALIESLRASGCEFEISPGEGAFYGPKIEYTLKDAIGRQWQCG
TMQVDFSMPERLDAEYVGEDGARHRPVMLHRAIVGSLERFIGILIEEHAGALPTWLAPIQVSVLNITDSQAEYAREVAKT
LQNQGLRVNLDLRNEKITYKIREHSLQKLPYILVVGDKEKAAGAVAVRARGNKDLGVMSIEAFAQQIASDIAQKA
>Mature_635_residues
MIQITLPDASKREYPQAVTVAEVAASIGAGLAKAALGGKVDGKVVDTSYLIEKDSALSIITAKDADGLELIRHSTAHLLA
YAVKELFSEAQVTIGPVIENGFYYDFAYKRPFTPEDLAAIEKRMTELAAKDEPVTRRVLPRDEAVAHFKSIGEHYKAEII
ASIPANEDVSLYREGTFEDLCRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNEMLQRVYGTAWATKDELQQYLTMLEEAEK
RDHRKLGKELDLFHIDDHAPGLVFWHPKGWTIWQGVEQYMRKVYQDNGYQEVKGPQVIDKTLWEKTGHWDKYRDNMFTTE
SEKREYALKPMNCPGHILIFKQGIKSYRDLPLRYGEFGQCHRNEPSGGLHGIMRVRGFTQDDGHIFCTEEQILKECVDYT
TLLQKVYTDFGFKNIIYKVATRPDARIGSDESWDKAEQALIESLRASGCEFEISPGEGAFYGPKIEYTLKDAIGRQWQCG
TMQVDFSMPERLDAEYVGEDGARHRPVMLHRAIVGSLERFIGILIEEHAGALPTWLAPIQVSVLNITDSQAEYAREVAKT
LQNQGLRVNLDLRNEKITYKIREHSLQKLPYILVVGDKEKAAGAVAVRARGNKDLGVMSIEAFAQQIASDIAQKA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=602, Percent_Identity=41.0299003322259, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI38202255, Length=626, Percent_Identity=39.297124600639, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI20070344, Length=650, Percent_Identity=36.7692307692308, Blast_Score=419, Evalue=1e-117,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=58.0188679245283, Blast_Score=782, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=158, Percent_Identity=27.2151898734177, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71984192, Length=627, Percent_Identity=39.8724082934609, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71984184, Length=627, Percent_Identity=39.8724082934609, Blast_Score=482, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322112, Length=629, Percent_Identity=37.2019077901431, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322654, Length=448, Percent_Identity=37.9464285714286, Blast_Score=310, Evalue=6e-85,
Organism=Drosophila melanogaster, GI24583839, Length=622, Percent_Identity=40.032154340836, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24583842, Length=622, Percent_Identity=40.032154340836, Blast_Score=482, Evalue=1e-136,
Organism=Drosophila melanogaster, GI28574141, Length=622, Percent_Identity=40.032154340836, Blast_Score=482, Evalue=1e-136,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 71726; Mature: 71726

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQITLPDASKREYPQAVTVAEVAASIGAGLAKAALGGKVDGKVVDTSYLIEKDSALSII
CEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCEEECHHHEEECCCCEEEE
TAKDADGLELIRHSTAHLLAYAVKELFSEAQVTIGPVIENGFYYDFAYKRPFTPEDLAAI
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEEEEECCCCCHHHHHHH
EKRMTELAAKDEPVTRRVLPRDEAVAHFKSIGEHYKAEIIASIPANEDVSLYREGTFEDL
HHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCHHEECCCHHHH
CRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNEMLQRVYGTAWATKDELQQYLTMLEEAEK
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGKELDLFHIDDHAPGLVFWHPKGWTIWQGVEQYMRKVYQDNGYQEVKGPQVIDK
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
TLWEKTGHWDKYRDNMFTTESEKREYALKPMNCPGHILIFKQGIKSYRDLPLRYGEFGQC
HHHHHCCCCHHHHCCCCCCCCCCHHHCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCC
HRNEPSGGLHGIMRVRGFTQDDGHIFCTEEQILKECVDYTTLLQKVYTDFGFKNIIYKVA
CCCCCCCHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
TRPDARIGSDESWDKAEQALIESLRASGCEFEISPGEGAFYGPKIEYTLKDAIGRQWQCG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEECCEEEEEEHHHCCCCEECC
TMQVDFSMPERLDAEYVGEDGARHRPVMLHRAIVGSLERFIGILIEEHAGALPTWLAPIQ
EEEECCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEE
VSVLNITDSQAEYAREVAKTLQNQGLRVNLDLRNEKITYKIREHSLQKLPYILVVGDKEK
EEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHHHHCCEEEEECCCCC
AAGAVAVRARGNKDLGVMSIEAFAQQIASDIAQKA
CCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIQITLPDASKREYPQAVTVAEVAASIGAGLAKAALGGKVDGKVVDTSYLIEKDSALSII
CEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCEEECHHHEEECCCCEEEE
TAKDADGLELIRHSTAHLLAYAVKELFSEAQVTIGPVIENGFYYDFAYKRPFTPEDLAAI
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEEEEECCCCCHHHHHHH
EKRMTELAAKDEPVTRRVLPRDEAVAHFKSIGEHYKAEIIASIPANEDVSLYREGTFEDL
HHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCHHEECCCHHHH
CRGPHVPSTGKLKFFKLMKVAGAYWRGDHRNEMLQRVYGTAWATKDELQQYLTMLEEAEK
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGKELDLFHIDDHAPGLVFWHPKGWTIWQGVEQYMRKVYQDNGYQEVKGPQVIDK
HHHHHHCCCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
TLWEKTGHWDKYRDNMFTTESEKREYALKPMNCPGHILIFKQGIKSYRDLPLRYGEFGQC
HHHHHCCCCHHHHCCCCCCCCCCHHHCCCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCC
HRNEPSGGLHGIMRVRGFTQDDGHIFCTEEQILKECVDYTTLLQKVYTDFGFKNIIYKVA
CCCCCCCHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
TRPDARIGSDESWDKAEQALIESLRASGCEFEISPGEGAFYGPKIEYTLKDAIGRQWQCG
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEECCEEEEEEHHHCCCCEECC
TMQVDFSMPERLDAEYVGEDGARHRPVMLHRAIVGSLERFIGILIEEHAGALPTWLAPIQ
EEEECCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEE
VSVLNITDSQAEYAREVAKTLQNQGLRVNLDLRNEKITYKIREHSLQKLPYILVVGDKEK
EEEEEECCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHHHHCCEEEEECCCCC
AAGAVAVRARGNKDLGVMSIEAFAQQIASDIAQKA
CCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA