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The map label for this gene is ilvD [H]

Identifier: 91787928

GI number: 91787928

Start: 2132690

End: 2134384

Strand: Reverse

Name: ilvD [H]

Synonym: Bpro_2052

Alternate gene names: 91787928

Gene position: 2134384-2132690 (Counterclockwise)

Preceding gene: 91787930

Following gene: 91787926

Centisome position: 41.04

GC content: 63.48

Gene sequence:

>1695_bases
ATGGAAACCAAGACCATTCAGCTCAACCCCCGCAGCAAAAACATCACCGAAGGCAAATCGCGCGCGCCCAACCGCTCGAT
GTACTACGCCATGGGCTATGAAGAGGCCGACTTCAAGAAGCCCATGATTGGTGTGGCCAACGGGCACAGCACCATCACCC
CCTGCAACAGCGGCCTGCAAAAGCTGGCGGACGCGGCCATTGCCGGCATTGAAGAAGCCGGCGGCAACGCCCAGGTGTTC
GGCACGCCCACCATCTCGGACGGCATGGCCATGGGCACCGAGGGCATGAAGTACTCGCTGGTCAGCCGCGAAGTGATCTC
CGACTGCATCGAAACCTGCGTGCAGGGCCAGTGGATGGACGGCGTGCTGGTGATCGGCGGCTGCGACAAGAACATGCCCG
GCGGCCTGATGGGCATGCTGCGCGCCAACGTGCCGGCCATCTACGTCTATGGCGGTACCATTTTGCCGGGCAGCTACAAG
GGCAAAGACCTCAACATCGTCAGCGTGTTTGAAGCCGTCGGCGAAAACGCAGCAGGCCGCATGAGCGATGAAGACCTGCT
GCAAATCGAGCGCCGCGCCATTCCCGGCACCGGTAGCTGCGGCGGCATGTACACGGCCAACACCATGTCCAGCGCCTTCG
AGGCGCTCGGCATTTCGCTGCCCTACTCCAGCACCATGGCCAATCCGCACGACGAGAAAATGAACTCGGCCAGGGAGTCC
GCCAAGGTCCTGGTCGAAGCCATCAAGAAAGACATCAAGCCGCGCGATCTCGTCACGAAGAAAGCCATTGAAAACGCCGT
GGCAGTGATCATGGCCACGGGCGGCTCCACCAATGCCGTGCTGCACTTCCTGGCGATTGCGCATGCCGCCGGCGTGGACT
GGACAATCGACGACTTCGAACGCGTGCGCCAAAGAACGCCGGTGCTGTGCGACCTGAAGCCGTCCGGCAAGTACCTGGCC
GTGGACCTGCACCGCGCCGGCGGCATTCCGCAGGTCATGAAGATGCTGCTGGCGGCCGGCCTGCTGCATGGCGACTGCCT
GACGATCACCGGCCAAACCATTGCCGAGGTGCTGAAGGATGTGCCCGAAGCGCCGCGCGCCGACCAGGACGTGATTCGCC
CCATCAGCAACCCCATGTACGCCCAGGGCCACCTGGCCATCCTGAAGGGCAACCTCTCGCCTGAAGGCTGCGTGGCCAAA
ATCACCGGCCTGAAAAACCCGGTCATGACGGGCCCGGCCCGCGTATTTGACGACGAGCAGTCGGCGCTGGCCGCCATCCT
GGCCGGCAAGATCAAGGCGGGCGACGTGATGGTGCTGCGTTACCTCGGCCCCAAGGGCGGTCCCGGCATGCCTGAAATGC
TGGCGCCTACCGGTGCGCTGATTGGCGCCGGCCTGGGCGAAAGCGTGGGCCTGATCACCGACGGCCGCTTCTCCGGCGGC
ACCTGGGGCATGGTAGTCGGCCATGTGGCCCCCGAAGCGGCCGCCGGCGGCAATATCGCATTCATCAACGAAGGCGACTC
CATCACCATTGACTCAAAACAGTTGCTGCTGCAACTGAACATCAGCGACGCGGAGCTGGAAAAACGCAAGGTCGGCTGGA
AAGCACCGGCACCGCGCTACAACCGCGGCGTGCAGGCCAAGTTTGCCTTCAACGCGTCGAGTGCCAGCAAGGGTGCGGTG
CTGGACGACTATTGA

Upstream 100 bases:

>100_bases
CATACTCGGCTTTCCGGTAAAAATATCCCACATGCATCCGCCCGTGCCCGCGTGTGAAGCGCATGACATCCGGTGCGACA
ACAAACCTCACGAGACATCC

Downstream 100 bases:

>100_bases
TGCCGGCTGACCGGTAAAACAAAAAAGAGCCCGTAAGTCACAGACTTCACGGGCTCTTTACTTTGGTAACAGGGCAACTC
CTGGCGGCCCGAAATGCAGT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
METKTIQLNPRSKNITEGKSRAPNRSMYYAMGYEEADFKKPMIGVANGHSTITPCNSGLQKLADAAIAGIEEAGGNAQVF
GTPTISDGMAMGTEGMKYSLVSREVISDCIETCVQGQWMDGVLVIGGCDKNMPGGLMGMLRANVPAIYVYGGTILPGSYK
GKDLNIVSVFEAVGENAAGRMSDEDLLQIERRAIPGTGSCGGMYTANTMSSAFEALGISLPYSSTMANPHDEKMNSARES
AKVLVEAIKKDIKPRDLVTKKAIENAVAVIMATGGSTNAVLHFLAIAHAAGVDWTIDDFERVRQRTPVLCDLKPSGKYLA
VDLHRAGGIPQVMKMLLAAGLLHGDCLTITGQTIAEVLKDVPEAPRADQDVIRPISNPMYAQGHLAILKGNLSPEGCVAK
ITGLKNPVMTGPARVFDDEQSALAAILAGKIKAGDVMVLRYLGPKGGPGMPEMLAPTGALIGAGLGESVGLITDGRFSGG
TWGMVVGHVAPEAAAGGNIAFINEGDSITIDSKQLLLQLNISDAELEKRKVGWKAPAPRYNRGVQAKFAFNASSASKGAV
LDDY

Sequences:

>Translated_564_residues
METKTIQLNPRSKNITEGKSRAPNRSMYYAMGYEEADFKKPMIGVANGHSTITPCNSGLQKLADAAIAGIEEAGGNAQVF
GTPTISDGMAMGTEGMKYSLVSREVISDCIETCVQGQWMDGVLVIGGCDKNMPGGLMGMLRANVPAIYVYGGTILPGSYK
GKDLNIVSVFEAVGENAAGRMSDEDLLQIERRAIPGTGSCGGMYTANTMSSAFEALGISLPYSSTMANPHDEKMNSARES
AKVLVEAIKKDIKPRDLVTKKAIENAVAVIMATGGSTNAVLHFLAIAHAAGVDWTIDDFERVRQRTPVLCDLKPSGKYLA
VDLHRAGGIPQVMKMLLAAGLLHGDCLTITGQTIAEVLKDVPEAPRADQDVIRPISNPMYAQGHLAILKGNLSPEGCVAK
ITGLKNPVMTGPARVFDDEQSALAAILAGKIKAGDVMVLRYLGPKGGPGMPEMLAPTGALIGAGLGESVGLITDGRFSGG
TWGMVVGHVAPEAAAGGNIAFINEGDSITIDSKQLLLQLNISDAELEKRKVGWKAPAPRYNRGVQAKFAFNASSASKGAV
LDDY
>Mature_564_residues
METKTIQLNPRSKNITEGKSRAPNRSMYYAMGYEEADFKKPMIGVANGHSTITPCNSGLQKLADAAIAGIEEAGGNAQVF
GTPTISDGMAMGTEGMKYSLVSREVISDCIETCVQGQWMDGVLVIGGCDKNMPGGLMGMLRANVPAIYVYGGTILPGSYK
GKDLNIVSVFEAVGENAAGRMSDEDLLQIERRAIPGTGSCGGMYTANTMSSAFEALGISLPYSSTMANPHDEKMNSARES
AKVLVEAIKKDIKPRDLVTKKAIENAVAVIMATGGSTNAVLHFLAIAHAAGVDWTIDDFERVRQRTPVLCDLKPSGKYLA
VDLHRAGGIPQVMKMLLAAGLLHGDCLTITGQTIAEVLKDVPEAPRADQDVIRPISNPMYAQGHLAILKGNLSPEGCVAK
ITGLKNPVMTGPARVFDDEQSALAAILAGKIKAGDVMVLRYLGPKGGPGMPEMLAPTGALIGAGLGESVGLITDGRFSGG
TWGMVVGHVAPEAAAGGNIAFINEGDSITIDSKQLLLQLNISDAELEKRKVGWKAPAPRYNRGVQAKFAFNASSASKGAV
LDDY

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=607, Percent_Identity=40.1976935749588, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI2367371, Length=485, Percent_Identity=35.6701030927835, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1786464, Length=517, Percent_Identity=34.4294003868472, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1788157, Length=482, Percent_Identity=31.5352697095436, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6322476, Length=564, Percent_Identity=47.1631205673759, Blast_Score=519, Evalue=1e-148,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59344; Mature: 59344

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKTIQLNPRSKNITEGKSRAPNRSMYYAMGYEEADFKKPMIGVANGHSTITPCNSGLQ
CCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCEECCHHHHHH
KLADAAIAGIEEAGGNAQVFGTPTISDGMAMGTEGMKYSLVSREVISDCIETCVQGQWMD
HHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCCCCEEHHHHHHHHHHHHHHHHCCCCCC
GVLVIGGCDKNMPGGLMGMLRANVPAIYVYGGTILPGSYKGKDLNIVSVFEAVGENAAGR
CEEEEECCCCCCCCHHHHHHHCCCCEEEEECCEECCCCCCCCCCHHHHHHHHHCCCCCCC
MSDEDLLQIERRAIPGTGSCGGMYTANTMSSAFEALGISLPYSSTMANPHDEKMNSARES
CCHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHH
AKVLVEAIKKDIKPRDLVTKKAIENAVAVIMATGGSTNAVLHFLAIAHAAGVDWTIDDFE
HHHHHHHHHHCCCCHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHH
RVRQRTPVLCDLKPSGKYLAVDLHRAGGIPQVMKMLLAAGLLHGDCLTITGQTIAEVLKD
HHHHCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
VPEAPRADQDVIRPISNPMYAQGHLAILKGNLSPEGCVAKITGLKNPVMTGPARVFDDEQ
CCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCHHHCCCHH
SALAAILAGKIKAGDVMVLRYLGPKGGPGMPEMLAPTGALIGAGLGESVGLITDGRFSGG
HHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHCCCCHHHCCCCCCCCCEEECCCCCCC
TWGMVVGHVAPEAAAGGNIAFINEGDSITIDSKQLLLQLNISDAELEKRKVGWKAPAPRY
EEEEEEECCCCCCCCCCCEEEEECCCEEEEECCEEEEEECCCHHHHHHHHCCCCCCCCCC
NRGVQAKFAFNASSASKGAVLDDY
CCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
METKTIQLNPRSKNITEGKSRAPNRSMYYAMGYEEADFKKPMIGVANGHSTITPCNSGLQ
CCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCEECCHHHHHH
KLADAAIAGIEEAGGNAQVFGTPTISDGMAMGTEGMKYSLVSREVISDCIETCVQGQWMD
HHHHHHHHHHHHCCCCEEEEECCCCCCCCEECCCCCEEHHHHHHHHHHHHHHHHCCCCCC
GVLVIGGCDKNMPGGLMGMLRANVPAIYVYGGTILPGSYKGKDLNIVSVFEAVGENAAGR
CEEEEECCCCCCCCHHHHHHHCCCCEEEEECCEECCCCCCCCCCHHHHHHHHHCCCCCCC
MSDEDLLQIERRAIPGTGSCGGMYTANTMSSAFEALGISLPYSSTMANPHDEKMNSARES
CCHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHH
AKVLVEAIKKDIKPRDLVTKKAIENAVAVIMATGGSTNAVLHFLAIAHAAGVDWTIDDFE
HHHHHHHHHHCCCCHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHH
RVRQRTPVLCDLKPSGKYLAVDLHRAGGIPQVMKMLLAAGLLHGDCLTITGQTIAEVLKD
HHHHCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
VPEAPRADQDVIRPISNPMYAQGHLAILKGNLSPEGCVAKITGLKNPVMTGPARVFDDEQ
CCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCCHHHCCCHH
SALAAILAGKIKAGDVMVLRYLGPKGGPGMPEMLAPTGALIGAGLGESVGLITDGRFSGG
HHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHCCCCHHHCCCCCCCCCEEECCCCCCC
TWGMVVGHVAPEAAAGGNIAFINEGDSITIDSKQLLLQLNISDAELEKRKVGWKAPAPRY
EEEEEEECCCCCCCCCCCEEEEECCCEEEEECCEEEEEECCCHHHHHHHHCCCCCCCCCC
NRGVQAKFAFNASSASKGAVLDDY
CCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA