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The map label for this gene is phoQ [H]

Identifier: 91787834

GI number: 91787834

Start: 2023176

End: 2024507

Strand: Direct

Name: phoQ [H]

Synonym: Bpro_1957

Alternate gene names: 91787834

Gene position: 2023176-2024507 (Clockwise)

Preceding gene: 91787833

Following gene: 91787835

Centisome position: 38.91

GC content: 69.67

Gene sequence:

>1332_bases
ATGAGAGCCAGCTATTCCATCCGTGCCCGCCTGCTTCTGGGGGCTGCGCTGGTACTGCTGGCCTTTATGGCCGGCGCCGG
GCTGGCGGTGCAGCGCGCCCATGAGGACAGTGTGCGCACGGTCCACTTCGGCCGGCTGCAGAGCACTATCTACCTGCTAC
TGGCTGCTGCCGAACTCGATGTCGGCGGTGCGCTGGTGATGCCGCCGGAGTTTGCCGAGCCGCGCCTGTCGCTGCCGGGT
TCCGGCCTGTACGCGGGTATCCATAACGTGTTGCGGGGGGAGCAGTGGCAGTCGGCCTCGACCCTGGGCTTTCAGCCACC
CTTTCGGCGCAGCCTGCAACCCGGTCAATGGCGCAACGAGACGGTGGACGGGACCGGCGGGTCCTTCCTGTCGGTCAGCT
ATGCCGTCACCTGGAAGGCCTCCTCGCGTGAGGTACCGCTGGTGCTCACAGTGCTGGAAGACCGCGCGGCCTTCGACCGC
GAGGTCGGCGCCTTTACCCGCACCCTGTGGCTCTGGCTGGGCGGCGCCGCCGTGCTGCTGTTGCTGGCCCAGCTGTGGCT
GTTGCGATGGGGCCTGGCGCCGCTGCGGCACGTGGCCAGCGAGATCCGGCGTATCGAAGAGGGCGAGCAATCGCGCATTG
AGGGCCGCTACCCCACCGAAATCTCGGGCCTCACGGACAACCTGAACACCCTGATCCAGCAGGAGCGCGAGCGCCAGGCC
CGGCATCGCGACGCACTGAGCTTTTTGGCCCACAGCCTGAAGACTCCGCTGGCCGTGCTGCGCAGCGCCCTGGCCGAGCC
GGCGCAACTGCCGGCCACCGTGGCCCAGCAGGTGAGCCGCATGGACGACATCGTGCAGCACCAGCTGGGGCGCGCCATCG
CCGGGGGCGCCGCGCGCTTTGCGCCGCCGCTTCTGGTGGCGCCGATCCTGGAGCGTATTCGCGACGCGCTGGCCAAGGTG
CATGCCGAGAAGGCGTTGGACTTCAGCGTCGAGTGCCCGGCCGACCTGGCCTGGCGCATCGACGAGGGCGACTTGTTCGA
GATGATGGGCAACCTGCTGGATAACGCGGCCAAGTGGGCGCGCAGCCGGGTCGGGGTGCGGGTGTGGCGCGAAGCCGGGC
GCTTGTGCATCCGCATCGAGGACGATGGCCCCGGGTTCAGCGACACCGAGTCCGTCCTGCGGCTCCACGTGCGGGGGGAC
GAGCGCGTGCCCGGGCACGGCGTCGGGCTGGCCGTGGTGAGCGACCTGGTGGCCAGCCACCAGGGGGAACTGAAGCTCAC
ACGCGGCTCGATGGGCGGCGGGCGGGTCGACATCGTGTTGCCGGTGGCTTGA

Upstream 100 bases:

>100_bases
TGGAGGTGCTGGTGGGTCGGCTGCGGCGCAAGCTCGACCCGGACGGCAGCCTCGGCCCGATCGAGACCGTGCGAGGGCGT
GGCTACCGGTTCACCCTGGA

Downstream 100 bases:

>100_bases
GAGGCATGCTTTTCAAGGTGAAGGCTGGAAGTTCTTAATTTGCCTTGAAGAAGGCGGTCTTGGTGGGTCGGTTTGCGACT
GTCAAGCTCGCCACCACCTC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MRASYSIRARLLLGAALVLLAFMAGAGLAVQRAHEDSVRTVHFGRLQSTIYLLLAAAELDVGGALVMPPEFAEPRLSLPG
SGLYAGIHNVLRGEQWQSASTLGFQPPFRRSLQPGQWRNETVDGTGGSFLSVSYAVTWKASSREVPLVLTVLEDRAAFDR
EVGAFTRTLWLWLGGAAVLLLLAQLWLLRWGLAPLRHVASEIRRIEEGEQSRIEGRYPTEISGLTDNLNTLIQQERERQA
RHRDALSFLAHSLKTPLAVLRSALAEPAQLPATVAQQVSRMDDIVQHQLGRAIAGGAARFAPPLLVAPILERIRDALAKV
HAEKALDFSVECPADLAWRIDEGDLFEMMGNLLDNAAKWARSRVGVRVWREAGRLCIRIEDDGPGFSDTESVLRLHVRGD
ERVPGHGVGLAVVSDLVASHQGELKLTRGSMGGGRVDIVLPVA

Sequences:

>Translated_443_residues
MRASYSIRARLLLGAALVLLAFMAGAGLAVQRAHEDSVRTVHFGRLQSTIYLLLAAAELDVGGALVMPPEFAEPRLSLPG
SGLYAGIHNVLRGEQWQSASTLGFQPPFRRSLQPGQWRNETVDGTGGSFLSVSYAVTWKASSREVPLVLTVLEDRAAFDR
EVGAFTRTLWLWLGGAAVLLLLAQLWLLRWGLAPLRHVASEIRRIEEGEQSRIEGRYPTEISGLTDNLNTLIQQERERQA
RHRDALSFLAHSLKTPLAVLRSALAEPAQLPATVAQQVSRMDDIVQHQLGRAIAGGAARFAPPLLVAPILERIRDALAKV
HAEKALDFSVECPADLAWRIDEGDLFEMMGNLLDNAAKWARSRVGVRVWREAGRLCIRIEDDGPGFSDTESVLRLHVRGD
ERVPGHGVGLAVVSDLVASHQGELKLTRGSMGGGRVDIVLPVA
>Mature_443_residues
MRASYSIRARLLLGAALVLLAFMAGAGLAVQRAHEDSVRTVHFGRLQSTIYLLLAAAELDVGGALVMPPEFAEPRLSLPG
SGLYAGIHNVLRGEQWQSASTLGFQPPFRRSLQPGQWRNETVDGTGGSFLSVSYAVTWKASSREVPLVLTVLEDRAAFDR
EVGAFTRTLWLWLGGAAVLLLLAQLWLLRWGLAPLRHVASEIRRIEEGEQSRIEGRYPTEISGLTDNLNTLIQQERERQA
RHRDALSFLAHSLKTPLAVLRSALAEPAQLPATVAQQVSRMDDIVQHQLGRAIAGGAARFAPPLLVAPILERIRDALAKV
HAEKALDFSVECPADLAWRIDEGDLFEMMGNLLDNAAKWARSRVGVRVWREAGRLCIRIEDDGPGFSDTESVLRLHVRGD
ERVPGHGVGLAVVSDLVASHQGELKLTRGSMGGGRVDIVLPVA

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=327, Percent_Identity=30.8868501529052, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=25, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48378; Mature: 48378

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRASYSIRARLLLGAALVLLAFMAGAGLAVQRAHEDSVRTVHFGRLQSTIYLLLAAAELD
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEHHHHHHHHHHHHHHHHCC
VGGALVMPPEFAEPRLSLPGSGLYAGIHNVLRGEQWQSASTLGFQPPFRRSLQPGQWRNE
CCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCC
TVDGTGGSFLSVSYAVTWKASSREVPLVLTVLEDRAAFDREVGAFTRTLWLWLGGAAVLL
CCCCCCCCEEEEEEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAQLWLLRWGLAPLRHVASEIRRIEEGEQSRIEGRYPTEISGLTDNLNTLIQQERERQA
HHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RHRDALSFLAHSLKTPLAVLRSALAEPAQLPATVAQQVSRMDDIVQHQLGRAIAGGAARF
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
APPLLVAPILERIRDALAKVHAEKALDFSVECPADLAWRIDEGDLFEMMGNLLDNAAKWA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHH
RSRVGVRVWREAGRLCIRIEDDGPGFSDTESVLRLHVRGDERVPGHGVGLAVVSDLVASH
HHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHEEEECCCCCCCCCCHHHHHHHHHHHCC
QGELKLTRGSMGGGRVDIVLPVA
CCCEEEEECCCCCCEEEEEEECC
>Mature Secondary Structure
MRASYSIRARLLLGAALVLLAFMAGAGLAVQRAHEDSVRTVHFGRLQSTIYLLLAAAELD
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEEEHHHHHHHHHHHHHHHHCC
VGGALVMPPEFAEPRLSLPGSGLYAGIHNVLRGEQWQSASTLGFQPPFRRSLQPGQWRNE
CCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCC
TVDGTGGSFLSVSYAVTWKASSREVPLVLTVLEDRAAFDREVGAFTRTLWLWLGGAAVLL
CCCCCCCCEEEEEEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAQLWLLRWGLAPLRHVASEIRRIEEGEQSRIEGRYPTEISGLTDNLNTLIQQERERQA
HHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RHRDALSFLAHSLKTPLAVLRSALAEPAQLPATVAQQVSRMDDIVQHQLGRAIAGGAARF
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
APPLLVAPILERIRDALAKVHAEKALDFSVECPADLAWRIDEGDLFEMMGNLLDNAAKWA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHH
RSRVGVRVWREAGRLCIRIEDDGPGFSDTESVLRLHVRGDERVPGHGVGLAVVSDLVASH
HHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHEEEECCCCCCCCCCHHHHHHHHHHHCC
QGELKLTRGSMGGGRVDIVLPVA
CCCEEEEECCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]