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The map label for this gene is phoP [H]

Identifier: 91787833

GI number: 91787833

Start: 2022508

End: 2023179

Strand: Direct

Name: phoP [H]

Synonym: Bpro_1956

Alternate gene names: 91787833

Gene position: 2022508-2023179 (Clockwise)

Preceding gene: 91787832

Following gene: 91787834

Centisome position: 38.89

GC content: 68.3

Gene sequence:

>672_bases
ATGCGCCTGTTACTGATCGAGGACGATGCCGCGCTGCGGCTCACACTGGCCCGCCAGCTGGAGGCCGATGGCTACCGGGT
CGACCAGGCCAAGGACGGCGAAGAGGGCCTGTTCCTGGCGCGCGAGTACCCGGTCGACCTGGTCATCGTCGACCTGGGGC
TGCCCAAGCTGAACGGGCTGACCATCGTGCAGCGCCTGCGCCAGGAGGGGCGTGCCATACCCATCCTGATCCTCACCGCA
CGCGGCAGCTGGCAAGACAAGGTTGTGGGGCTGGAGGCCGGGGCCGACGACTACCTGGTCAAGCCTTTCGAATACCCGGA
GCTGGCGGCGCGGCTCAAGGCCTTGTTGCGGCGCTCGCTCAAGACTGCCTCTGACGTGCTGACGCTCGGCCCCCTCAGCA
TTGACCTGTCGGCGCAGGCGGCGCGGCTCAATGGCGCGGCGTTGGAGCTCACGGCGTTCGAGTACCGCCTGCTCGAGTAT
CTGGTGCGCCAGCGCCCGGGCATCGTCACCAAGCAGGCGCTGTCGGACTACCTGTACCCGCACGGGGAAGACCGCGACAG
CAACGTGCTGGAGGTGCTGGTGGGTCGGCTGCGGCGCAAGCTCGACCCGGACGGCAGCCTCGGCCCGATCGAGACCGTGC
GAGGGCGTGGCTACCGGTTCACCCTGGAATGA

Upstream 100 bases:

>100_bases
CGCGTCAAGGTGGTCACGCCGGCTGGTGAGGTCCGCGTGATCCAGGTGGACGTCGCCACCGGCCAGGTCCGATAGGGCCG
GCCTGCGGCAGCTTTAACCC

Downstream 100 bases:

>100_bases
GAGCCAGCTATTCCATCCGTGCCCGCCTGCTTCTGGGGGCTGCGCTGGTACTGCTGGCCTTTATGGCCGGCGCCGGGCTG
GCGGTGCAGCGCGCCCATGA

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRLLLIEDDAALRLTLARQLEADGYRVDQAKDGEEGLFLAREYPVDLVIVDLGLPKLNGLTIVQRLRQEGRAIPILILTA
RGSWQDKVVGLEAGADDYLVKPFEYPELAARLKALLRRSLKTASDVLTLGPLSIDLSAQAARLNGAALELTAFEYRLLEY
LVRQRPGIVTKQALSDYLYPHGEDRDSNVLEVLVGRLRRKLDPDGSLGPIETVRGRGYRFTLE

Sequences:

>Translated_223_residues
MRLLLIEDDAALRLTLARQLEADGYRVDQAKDGEEGLFLAREYPVDLVIVDLGLPKLNGLTIVQRLRQEGRAIPILILTA
RGSWQDKVVGLEAGADDYLVKPFEYPELAARLKALLRRSLKTASDVLTLGPLSIDLSAQAARLNGAALELTAFEYRLLEY
LVRQRPGIVTKQALSDYLYPHGEDRDSNVLEVLVGRLRRKLDPDGSLGPIETVRGRGYRFTLE
>Mature_223_residues
MRLLLIEDDAALRLTLARQLEADGYRVDQAKDGEEGLFLAREYPVDLVIVDLGLPKLNGLTIVQRLRQEGRAIPILILTA
RGSWQDKVVGLEAGADDYLVKPFEYPELAARLKALLRRSLKTASDVLTLGPLSIDLSAQAARLNGAALELTAFEYRLLEY
LVRQRPGIVTKQALSDYLYPHGEDRDSNVLEVLVGRLRRKLDPDGSLGPIETVRGRGYRFTLE

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=45.945945945946, Blast_Score=201, Evalue=4e-53,
Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=38.8127853881278, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=42.0814479638009, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=33.6322869955157, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35.4545454545455, Blast_Score=133, Evalue=7e-33,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=38.9140271493213, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=38.5650224215247, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=34.3891402714932, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=37.4449339207048, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=244, Percent_Identity=32.3770491803279, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=33.7837837837838, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=30.2222222222222, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=30.3418803418803, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1790437, Length=117, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788550, Length=157, Percent_Identity=25.4777070063694, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=34.3137254901961, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788905, Length=144, Percent_Identity=31.9444444444444, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=109, Percent_Identity=31.1926605504587, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=33.0434782608696, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=30.0970873786408, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=27.2727272727273, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24893; Mature: 24893

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLLIEDDAALRLTLARQLEADGYRVDQAKDGEEGLFLAREYPVDLVIVDLGLPKLNGL
CEEEEEECCCEEEEHHHHHHCCCCEECCCCCCCCCCEEEEEECCEEEEEEECCCCCCCCH
TIVQRLRQEGRAIPILILTARGSWQDKVVGLEAGADDYLVKPFEYPELAARLKALLRRSL
HHHHHHHHCCCEEEEEEEECCCCCCCEEEEEECCCCCCEECCCCCHHHHHHHHHHHHHHH
KTASDVLTLGPLSIDLSAQAARLNGAALELTAFEYRLLEYLVRQRPGIVTKQALSDYLYP
HHHHHEEEECCEEEECCCHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
HGEDRDSNVLEVLVGRLRRKLDPDGSLGPIETVRGRGYRFTLE
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEEC
>Mature Secondary Structure
MRLLLIEDDAALRLTLARQLEADGYRVDQAKDGEEGLFLAREYPVDLVIVDLGLPKLNGL
CEEEEEECCCEEEEHHHHHHCCCCEECCCCCCCCCCEEEEEECCEEEEEEECCCCCCCCH
TIVQRLRQEGRAIPILILTARGSWQDKVVGLEAGADDYLVKPFEYPELAARLKALLRRSL
HHHHHHHHCCCEEEEEEEECCCCCCCEEEEEECCCCCCEECCCCCHHHHHHHHHHHHHHH
KTASDVLTLGPLSIDLSAQAARLNGAALELTAFEYRLLEYLVRQRPGIVTKQALSDYLYP
HHHHHEEEECCEEEECCCHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHCCC
HGEDRDSNVLEVLVGRLRRKLDPDGSLGPIETVRGRGYRFTLE
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA