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The map label for this gene is hldD

Identifier: 91787666

GI number: 91787666

Start: 1844804

End: 1845811

Strand: Reverse

Name: hldD

Synonym: Bpro_1784

Alternate gene names: 91787666

Gene position: 1845811-1844804 (Counterclockwise)

Preceding gene: 91787667

Following gene: 91787665

Centisome position: 35.49

GC content: 61.21

Gene sequence:

>1008_bases
ATGAAAATCGTAGTGACCGGCGCCGCCGGCTTCATCGGCAGCAACCTCGTGAAGGGACTCAACGACCGCGGCATCGACGA
CATCATCGCCGTCGACGACCTGACCCACGGCGACAAGTTTCGCAACCTGGCAGACCTGCAGATTGCCGACTACATCGATG
CCGACGACTTTTATGACCTGTTTGCCGAAGGCGCTTTTGGCCAGGTAGAAGCGGTGTTCCACGAAGGCGCCTGCAGCGAC
ACCATGGAGCTTGACGGCAAGTACATGATGGACAACAACTACACGCTGTCCTGCGAGCTGTTTCATGCCTGCCAGGAGCA
GGGCACACGCCTGCTGTATGCCTCGTCGGCCGCCACCTATGGCGGCTCCGATACCTTCAGCGAGTCACCCGAGTTCGAGC
GCCCGCTCAACGTCTATGGCTACTCCAAGCTGCTGTTTGACCAGCGGATGCGGCGTGAGCTCGGTGCCCGGTTTGAAAAC
GCCGCCACGCAGGTGGCCGGCTTCCGGTACTTTAACGTCTACGGCCCGCGCGAGCAGCACAAGGGCCGCATGGCCAGCGT
CGCCTTTCACCAGTTCAACCAGTTCCAGGCAGAAGGCAAGGTCAAGCTGTTTGGAGACTACGGCGGTTACCAGGCCGGCG
GACAGATGCGCGACTTTGTGTTCATCGATGACGTGGTGGCAGTCAATCTCTGGTTTCTGGATCACCCGGAGAAGTCCGGC
ATTTTCAACCTGGGTACCGGAAGGGCGCAGCCCTTCAACGATGTGGCCCTGGCCGTCGTCAACACCCTGCGCCAGAGCCA
AAACGCTGCAGCCATGAGCCTCGAAGACGCGGTGCGCGGCGGGCTGATTGACTACATCACCTTCCCCCCCGCGCTGGTGG
GCAAGTACCAGAGCTATACCCAGGCCGACTTGCAAGCCCTGCGCGCGGCCGGCTGCCAGCATGCCTTTGCCGATGTGCAG
ACCGGTGTGGCGGCTTACATGCAGTGGCTGGCGAGTGCAAAGATCTAG

Upstream 100 bases:

>100_bases
TTCGGTACCGCCACCGTGAACTACAGCGAACTCTTTGCCGCCCCCTGAAGCCATTACTGCCATTAGCGCCGTCAGTGCAC
TGAAACCGAGGAATTTCCCC

Downstream 100 bases:

>100_bases
GGTTTCATTCAGGGTTTCCCCGACCGAAAACGCCTGGAGCCGGTCAACCCAGCCTGAAACCGTACGTTATTGAAAAGGAC
ATCCTTATTCACAAGGATGG

Product: ADP-glyceromanno-heptose 6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKIVVTGAAGFIGSNLVKGLNDRGIDDIIAVDDLTHGDKFRNLADLQIADYIDADDFYDLFAEGAFGQVEAVFHEGACSD
TMELDGKYMMDNNYTLSCELFHACQEQGTRLLYASSAATYGGSDTFSESPEFERPLNVYGYSKLLFDQRMRRELGARFEN
AATQVAGFRYFNVYGPREQHKGRMASVAFHQFNQFQAEGKVKLFGDYGGYQAGGQMRDFVFIDDVVAVNLWFLDHPEKSG
IFNLGTGRAQPFNDVALAVVNTLRQSQNAAAMSLEDAVRGGLIDYITFPPALVGKYQSYTQADLQALRAAGCQHAFADVQ
TGVAAYMQWLASAKI

Sequences:

>Translated_335_residues
MKIVVTGAAGFIGSNLVKGLNDRGIDDIIAVDDLTHGDKFRNLADLQIADYIDADDFYDLFAEGAFGQVEAVFHEGACSD
TMELDGKYMMDNNYTLSCELFHACQEQGTRLLYASSAATYGGSDTFSESPEFERPLNVYGYSKLLFDQRMRRELGARFEN
AATQVAGFRYFNVYGPREQHKGRMASVAFHQFNQFQAEGKVKLFGDYGGYQAGGQMRDFVFIDDVVAVNLWFLDHPEKSG
IFNLGTGRAQPFNDVALAVVNTLRQSQNAAAMSLEDAVRGGLIDYITFPPALVGKYQSYTQADLQALRAAGCQHAFADVQ
TGVAAYMQWLASAKI
>Mature_335_residues
MKIVVTGAAGFIGSNLVKGLNDRGIDDIIAVDDLTHGDKFRNLADLQIADYIDADDFYDLFAEGAFGQVEAVFHEGACSD
TMELDGKYMMDNNYTLSCELFHACQEQGTRLLYASSAATYGGSDTFSESPEFERPLNVYGYSKLLFDQRMRRELGARFEN
AATQVAGFRYFNVYGPREQHKGRMASVAFHQFNQFQAEGKVKLFGDYGGYQAGGQMRDFVFIDDVVAVNLWFLDHPEKSG
IFNLGTGRAQPFNDVALAVVNTLRQSQNAAAMSLEDAVRGGLIDYITFPPALVGKYQSYTQADLQALRAAGCQHAFADVQ
TGVAAYMQWLASAKI

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily

Homologues:

Organism=Escherichia coli, GI1790049, Length=330, Percent_Identity=54.8484848484848, Blast_Score=329, Evalue=2e-91,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): HLDD_POLSJ (Q12CM2)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_548618.1
- ProteinModelPortal:   Q12CM2
- SMR:   Q12CM2
- STRING:   Q12CM2
- GeneID:   4015569
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_1784
- NMPDR:   fig|296591.1.peg.2822
- eggNOG:   COG0451
- HOGENOM:   HBG755066
- OMA:   GFIGSAM
- PhylomeDB:   Q12CM2
- ProtClustDB:   CLSK721781
- BioCyc:   PSP296591:BPRO_1784-MONOMER
- HAMAP:   MF_01601
- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF29
- TIGRFAMs:   TIGR02197

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.20

Molecular weight: Translated: 36963; Mature: 36963

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: ACT_SITE 139-139 ACT_SITE 181-181 BINDING 39-39 BINDING 92-92 BINDING 143-143 BINDING 172-172 BINDING 173-173 BINDING 181-181 BINDING 183-183 BINDING 190-190 BINDING 217-217 BINDING 296-296

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVVTGAAGFIGSNLVKGLNDRGIDDIIAVDDLTHGDKFRNLADLQIADYIDADDFYDL
CEEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHCCHHCCHHHHCCCCHHHHHH
FAEGAFGQVEAVFHEGACSDTMELDGKYMMDNNYTLSCELFHACQEQGTRLLYASSAATY
HHCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCEEEEHHHHHHHHHCCCEEEEECCCCCC
GGSDTFSESPEFERPLNVYGYSKLLFDQRMRRELGARFENAATQVAGFRYFNVYGPREQH
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCEEEEEECCCCHHH
KGRMASVAFHQFNQFQAEGKVKLFGDYGGYQAGGQMRDFVFIDDVVAVNLWFLDHPEKSG
CCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEECCEEEEEEEEEECCCCCC
IFNLGTGRAQPFNDVALAVVNTLRQSQNAAAMSLEDAVRGGLIDYITFPPALVGKYQSYT
EEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEHHCCHHHHHHHHHHH
QADLQALRAAGCQHAFADVQTGVAAYMQWLASAKI
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIVVTGAAGFIGSNLVKGLNDRGIDDIIAVDDLTHGDKFRNLADLQIADYIDADDFYDL
CEEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHCCHHCCHHHHCCCCHHHHHH
FAEGAFGQVEAVFHEGACSDTMELDGKYMMDNNYTLSCELFHACQEQGTRLLYASSAATY
HHCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCEEEEHHHHHHHHHCCCEEEEECCCCCC
GGSDTFSESPEFERPLNVYGYSKLLFDQRMRRELGARFENAATQVAGFRYFNVYGPREQH
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCEEEEEECCCCHHH
KGRMASVAFHQFNQFQAEGKVKLFGDYGGYQAGGQMRDFVFIDDVVAVNLWFLDHPEKSG
CCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCEEEECCEEEEEEEEEECCCCCC
IFNLGTGRAQPFNDVALAVVNTLRQSQNAAAMSLEDAVRGGLIDYITFPPALVGKYQSYT
EEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEHHCCHHHHHHHHHHH
QADLQALRAAGCQHAFADVQTGVAAYMQWLASAKI
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA