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The map label for this gene is uvrD [H]

Identifier: 91787605

GI number: 91787605

Start: 1776930

End: 1779407

Strand: Direct

Name: uvrD [H]

Synonym: Bpro_1723

Alternate gene names: 91787605

Gene position: 1776930-1779407 (Clockwise)

Preceding gene: 91787604

Following gene: 91787606

Centisome position: 34.17

GC content: 62.47

Gene sequence:

>2478_bases
GTGCCGGTTTTCTACAATGGACCCATGTTTCCACAAGTCACCCGAGATTCCCCGCTGCTGCACAACCTCAACCCCGAGCA
ACATGCCGCTGTCACCCTGCCGAATGAGCACGCCCTGATTCTTGCCGGGGCGGGCTCCGGCAAGACCCGCGTGCTGACCA
CCCGCATTGCCTGGCTGCTGCAAACCGGCCAGGTCTCGCCCGGCGGCATCCTGGCCGTGACGTTTACCAACAAGGCTGCC
AAGGAAATGCTGGCCCGCCTGTCTGCCATGCTGCCCGTCAATGTGCGCGGCATGTGGATTGGCACCTTCCATGGCTTGTG
CAACCGTTTTTTGCGCGCGCATTACAAGCTGGCCAATCTGCCGCAGAGTTTCCAGATTCTGGACACGCAAGACCAGCTGT
CGGCCATCAAGCGGCTGTGCAAGCAGTTCAATGTGGACGACGAGCGCTTTCCGCCCAAGCAGCTGGCATGGTTTATTGCC
AGCTGCAAGGAAGACGGCCTGCGTGCCAAGGACGTGCAGGTGCGTGACGAGGAAGGCCGCAAGAAGGTCGAGATCTACGC
GCTGTACGAAGAGCAGTGCCAGCGCGAAGGCGTGGTGGATTTTGGCGAGCTGATGCTGCGCAGCTATGAACTGCTGCGTG
ACAACACCGCCGTGCGCGAGCACTACCAGCGGCGTTTTCGCCACATCCTGATCGATGAGTTCCAGGACACCAACAAGCTG
CAATACGCCTGGATCAAGATGCTGGCGGGCCAGGGCCCCGAAGCCACGCAGGGCGCCGCCGTGATGCCGGGCGGCTCGGT
GGTGGCGGTGGGTGACGACGACCAGAGCATCTACGCCTTTCGCGGTGCGCGCGTGGGCAACATGACCGATTTCGTGCGCG
AATTCGATGTGCAGCACCAGATCAAGCTGGAGCGCAACTACCGCAGCTTCGGCAACATCCTGGATTCGGCCAACGAGCTG
ATCAGCCACAACAGCAAGCGTCTGGGCAAGAACCTGCGCACCGAGGCCGGCCCTGGCGAGCCGGTGCGGGTGTACGAAGC
CACCTCTGATTTTGCCGAGGCCCAGTGGTTTGTCGATGAGGTGAAGCAGCTGGTGCGAGACGGCGCCGAGCGCAAGGAGA
TCGCGCTGCTGTACCGCAGCAATGCGCAAAGCCGGGTGATGGAGACGGCGCTGTTCAACGCTGGTGTGCCTTACCGCGTG
TATGGCGGCCTGCGCTTTTTCGAGCGCGCCGAGATCAAGCATGCGCTGGCCTACCTGCGCCTGCTGGAGAATCCGCACGA
TGACACCAGCTTTTTGCGCGTAGTCAACTTTCCGCCGCGCGGCATTGGCGCACGCAGCATTGAGCAACTGCAGGACATTT
CGCGCGCCTCGGGTTGCTCGCTGCATGACGGTGTCAGTGCGGTGACTGGCAAGGCCGGAGCCAACCTGGGCGCCTTTGTG
GCCAAAATCGATGTGCTGCGCGAGCAGACCACGGGCCTCACCCTGCGCGAAATCATCGAGCTGGTGCTGCAGCACAGCGG
GCTGGAAGAGCATTACAAGCTGGAAAAAGAAGGCCAGGACCGCCTGGAGAACCTGGCCGAACTGGTCAACGCCGCCGAGT
CTTTTGTCAGCCAGGAAGGCTTTGGCCGCGATGCCGTAGCCTTGCCGGTGGACGAACTGGGTTCGCGTGCGAACCTGGCC
CTGGGCCAGTCGCCAGCCAGCCAGGGCCTCGATCCTTCGGCTGCGCTGCTGAGTGAACCCTTGCCGGAATTGCTGGCGCC
CGACACCGAGACCGGTGAAACGCTGTCGCCGCTCGCGGCCTTTCTCACGCACGCCGCGCTGGAGTCCGGCGACAACCAGG
CGCAGGCCGGCCAGGATGCCGTGCAACTGATGACGGTGCACTCGTCCAAGGGGCTGGAGTTTGACTGCGTCTTCGTCACC
GGCATGGAAGAGGGCCTGTTCCCGCATGAAAATTCCATGAGCGACCACGATGGCCTGGAGGAAGAGCGCCGCCTGATGTA
CGTGGCCATCACGCGCGCGCGCAAGCGCCTCTACCTCAGCTATTCACAGACCCGCATGCTGCACGGCCAGACGCGCTACC
ACCTGAAAAGCCGGTTTTTTGACGAGCTGCCGGAAGCGGCGCTCAAATGGATCACGCCCAAAAACCAGGGCTTTGCTTCC
GGCCTGGGCATGGGATCCAGCGGCTGGGGTGGTGCCGGTAATTCAGGTGCGAGTGGCACCCGTGGCGACTGGGCCAGCAA
CGTTTTTTCTTCAAAGTCCGGTTCATCGGAGCGCTTTGCCAATCCACCGGTGCCGCCGCAACGCAACGCGCCTTCGCATG
GGTTCAAGGGCGGCATGCAGGTGTTTCACGCCAAGTTTGGCGAGGGCAAGGTGCTGATGCTCGAAGGCAGTGGTGACGAT
GCGCGGGCGCAGATCAATTTCACCCGGCATGGCGTGAAATGGCTGGCACTGAGTGTGGCCAAGCTGACGGTGGTTTAA

Upstream 100 bases:

>100_bases
TGCAATCATGAAAACCGACATCGCCAGGTTTCGTGAACTGGGGGAGCGGATCAAGATCAGTCTGGATTAACCATTCCCGG
GGTGCGGGGAGGGGGTGTGG

Downstream 100 bases:

>100_bases
GAGCCTTACATGGTTAAGATAGGTCAACCCTTGGTGCTGTGCCCGCATCCCCTTGATCCAGCCGCCCGCGAGAATACATG
AACGAGCCCGAACCGTCCGC

Product: ATP-dependent DNA helicase UvrD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 825; Mature: 824

Protein sequence:

>825_residues
MPVFYNGPMFPQVTRDSPLLHNLNPEQHAAVTLPNEHALILAGAGSGKTRVLTTRIAWLLQTGQVSPGGILAVTFTNKAA
KEMLARLSAMLPVNVRGMWIGTFHGLCNRFLRAHYKLANLPQSFQILDTQDQLSAIKRLCKQFNVDDERFPPKQLAWFIA
SCKEDGLRAKDVQVRDEEGRKKVEIYALYEEQCQREGVVDFGELMLRSYELLRDNTAVREHYQRRFRHILIDEFQDTNKL
QYAWIKMLAGQGPEATQGAAVMPGGSVVAVGDDDQSIYAFRGARVGNMTDFVREFDVQHQIKLERNYRSFGNILDSANEL
ISHNSKRLGKNLRTEAGPGEPVRVYEATSDFAEAQWFVDEVKQLVRDGAERKEIALLYRSNAQSRVMETALFNAGVPYRV
YGGLRFFERAEIKHALAYLRLLENPHDDTSFLRVVNFPPRGIGARSIEQLQDISRASGCSLHDGVSAVTGKAGANLGAFV
AKIDVLREQTTGLTLREIIELVLQHSGLEEHYKLEKEGQDRLENLAELVNAAESFVSQEGFGRDAVALPVDELGSRANLA
LGQSPASQGLDPSAALLSEPLPELLAPDTETGETLSPLAAFLTHAALESGDNQAQAGQDAVQLMTVHSSKGLEFDCVFVT
GMEEGLFPHENSMSDHDGLEEERRLMYVAITRARKRLYLSYSQTRMLHGQTRYHLKSRFFDELPEAALKWITPKNQGFAS
GLGMGSSGWGGAGNSGASGTRGDWASNVFSSKSGSSERFANPPVPPQRNAPSHGFKGGMQVFHAKFGEGKVLMLEGSGDD
ARAQINFTRHGVKWLALSVAKLTVV

Sequences:

>Translated_825_residues
MPVFYNGPMFPQVTRDSPLLHNLNPEQHAAVTLPNEHALILAGAGSGKTRVLTTRIAWLLQTGQVSPGGILAVTFTNKAA
KEMLARLSAMLPVNVRGMWIGTFHGLCNRFLRAHYKLANLPQSFQILDTQDQLSAIKRLCKQFNVDDERFPPKQLAWFIA
SCKEDGLRAKDVQVRDEEGRKKVEIYALYEEQCQREGVVDFGELMLRSYELLRDNTAVREHYQRRFRHILIDEFQDTNKL
QYAWIKMLAGQGPEATQGAAVMPGGSVVAVGDDDQSIYAFRGARVGNMTDFVREFDVQHQIKLERNYRSFGNILDSANEL
ISHNSKRLGKNLRTEAGPGEPVRVYEATSDFAEAQWFVDEVKQLVRDGAERKEIALLYRSNAQSRVMETALFNAGVPYRV
YGGLRFFERAEIKHALAYLRLLENPHDDTSFLRVVNFPPRGIGARSIEQLQDISRASGCSLHDGVSAVTGKAGANLGAFV
AKIDVLREQTTGLTLREIIELVLQHSGLEEHYKLEKEGQDRLENLAELVNAAESFVSQEGFGRDAVALPVDELGSRANLA
LGQSPASQGLDPSAALLSEPLPELLAPDTETGETLSPLAAFLTHAALESGDNQAQAGQDAVQLMTVHSSKGLEFDCVFVT
GMEEGLFPHENSMSDHDGLEEERRLMYVAITRARKRLYLSYSQTRMLHGQTRYHLKSRFFDELPEAALKWITPKNQGFAS
GLGMGSSGWGGAGNSGASGTRGDWASNVFSSKSGSSERFANPPVPPQRNAPSHGFKGGMQVFHAKFGEGKVLMLEGSGDD
ARAQINFTRHGVKWLALSVAKLTVV
>Mature_824_residues
PVFYNGPMFPQVTRDSPLLHNLNPEQHAAVTLPNEHALILAGAGSGKTRVLTTRIAWLLQTGQVSPGGILAVTFTNKAAK
EMLARLSAMLPVNVRGMWIGTFHGLCNRFLRAHYKLANLPQSFQILDTQDQLSAIKRLCKQFNVDDERFPPKQLAWFIAS
CKEDGLRAKDVQVRDEEGRKKVEIYALYEEQCQREGVVDFGELMLRSYELLRDNTAVREHYQRRFRHILIDEFQDTNKLQ
YAWIKMLAGQGPEATQGAAVMPGGSVVAVGDDDQSIYAFRGARVGNMTDFVREFDVQHQIKLERNYRSFGNILDSANELI
SHNSKRLGKNLRTEAGPGEPVRVYEATSDFAEAQWFVDEVKQLVRDGAERKEIALLYRSNAQSRVMETALFNAGVPYRVY
GGLRFFERAEIKHALAYLRLLENPHDDTSFLRVVNFPPRGIGARSIEQLQDISRASGCSLHDGVSAVTGKAGANLGAFVA
KIDVLREQTTGLTLREIIELVLQHSGLEEHYKLEKEGQDRLENLAELVNAAESFVSQEGFGRDAVALPVDELGSRANLAL
GQSPASQGLDPSAALLSEPLPELLAPDTETGETLSPLAAFLTHAALESGDNQAQAGQDAVQLMTVHSSKGLEFDCVFVTG
MEEGLFPHENSMSDHDGLEEERRLMYVAITRARKRLYLSYSQTRMLHGQTRYHLKSRFFDELPEAALKWITPKNQGFASG
LGMGSSGWGGAGNSGASGTRGDWASNVFSSKSGSSERFANPPVPPQRNAPSHGFKGGMQVFHAKFGEGKVLMLEGSGDDA
RAQINFTRHGVKWLALSVAKLTVV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=820, Percent_Identity=42.9268292682927, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI48994965, Length=705, Percent_Identity=35.3191489361702, Blast_Score=343, Evalue=4e-95,
Organism=Escherichia coli, GI1787196, Length=351, Percent_Identity=29.3447293447293, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=779, Percent_Identity=26.7008985879332, Blast_Score=213, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324477, Length=715, Percent_Identity=22.5174825174825, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 91188; Mature: 91057

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVFYNGPMFPQVTRDSPLLHNLNPEQHAAVTLPNEHALILAGAGSGKTRVLTTRIAWLL
CCEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCEEHHHHHHHHH
QTGQVSPGGILAVTFTNKAAKEMLARLSAMLPVNVRGMWIGTFHGLCNRFLRAHYKLANL
HCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCC
PQSFQILDTQDQLSAIKRLCKQFNVDDERFPPKQLAWFIASCKEDGLRAKDVQVRDEEGR
CCCCEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCC
KKVEIYALYEEQCQREGVVDFGELMLRSYELLRDNTAVREHYQRRFRHILIDEFQDTNKL
CEEEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHH
QYAWIKMLAGQGPEATQGAAVMPGGSVVAVGDDDQSIYAFRGARVGNMTDFVREFDVQHQ
HHHHHHHHHCCCCCCCCCCEECCCCCEEEECCCCCCEEEECCCCCCCHHHHHHHHCCHHE
IKLERNYRSFGNILDSANELISHNSKRLGKNLRTEAGPGEPVRVYEATSDFAEAQWFVDE
EEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHH
VKQLVRDGAERKEIALLYRSNAQSRVMETALFNAGVPYRVYGGLRFFERAEIKHALAYLR
HHHHHHCCCCHHEEEEEEECCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHH
LLENPHDDTSFLRVVNFPPRGIGARSIEQLQDISRASGCSLHDGVSAVTGKAGANLGAFV
HHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHH
AKIDVLREQTTGLTLREIIELVLQHSGLEEHYKLEKEGQDRLENLAELVNAAESFVSQEG
HHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FGRDAVALPVDELGSRANLALGQSPASQGLDPSAALLSEPLPELLAPDTETGETLSPLAA
CCCCEEECCHHHCCCCCCEEECCCCHHCCCCHHHHHHHCCCHHHHCCCCCCCCHHHHHHH
FLTHAALESGDNQAQAGQDAVQLMTVHSSKGLEFDCVFVTGMEEGLFPHENSMSDHDGLE
HHHHHHHHCCCCHHHCCHHHEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCH
EERRLMYVAITRARKRLYLSYSQTRMLHGQTRYHLKSRFFDELPEAALKWITPKNQGFAS
HHHHEEHHHHHHHHHHEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
GLGMGSSGWGGAGNSGASGTRGDWASNVFSSKSGSSERFANPPVPPQRNAPSHGFKGGMQ
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
VFHAKFGEGKVLMLEGSGDDARAQINFTRHGVKWLALSVAKLTVV
HHHHCCCCCEEEEEECCCCCCEEEEEEHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVFYNGPMFPQVTRDSPLLHNLNPEQHAAVTLPNEHALILAGAGSGKTRVLTTRIAWLL
CEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCEEHHHHHHHHH
QTGQVSPGGILAVTFTNKAAKEMLARLSAMLPVNVRGMWIGTFHGLCNRFLRAHYKLANL
HCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCC
PQSFQILDTQDQLSAIKRLCKQFNVDDERFPPKQLAWFIASCKEDGLRAKDVQVRDEEGR
CCCCEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCC
KKVEIYALYEEQCQREGVVDFGELMLRSYELLRDNTAVREHYQRRFRHILIDEFQDTNKL
CEEEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHH
QYAWIKMLAGQGPEATQGAAVMPGGSVVAVGDDDQSIYAFRGARVGNMTDFVREFDVQHQ
HHHHHHHHHCCCCCCCCCCEECCCCCEEEECCCCCCEEEECCCCCCCHHHHHHHHCCHHE
IKLERNYRSFGNILDSANELISHNSKRLGKNLRTEAGPGEPVRVYEATSDFAEAQWFVDE
EEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHH
VKQLVRDGAERKEIALLYRSNAQSRVMETALFNAGVPYRVYGGLRFFERAEIKHALAYLR
HHHHHHCCCCHHEEEEEEECCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHH
LLENPHDDTSFLRVVNFPPRGIGARSIEQLQDISRASGCSLHDGVSAVTGKAGANLGAFV
HHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCHHHHH
AKIDVLREQTTGLTLREIIELVLQHSGLEEHYKLEKEGQDRLENLAELVNAAESFVSQEG
HHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FGRDAVALPVDELGSRANLALGQSPASQGLDPSAALLSEPLPELLAPDTETGETLSPLAA
CCCCEEECCHHHCCCCCCEEECCCCHHCCCCHHHHHHHCCCHHHHCCCCCCCCHHHHHHH
FLTHAALESGDNQAQAGQDAVQLMTVHSSKGLEFDCVFVTGMEEGLFPHENSMSDHDGLE
HHHHHHHHCCCCHHHCCHHHEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCH
EERRLMYVAITRARKRLYLSYSQTRMLHGQTRYHLKSRFFDELPEAALKWITPKNQGFAS
HHHHEEHHHHHHHHHHEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
GLGMGSSGWGGAGNSGASGTRGDWASNVFSSKSGSSERFANPPVPPQRNAPSHGFKGGMQ
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
VFHAKFGEGKVLMLEGSGDDARAQINFTRHGVKWLALSVAKLTVV
HHHHCCCCCEEEEEECCCCCCEEEEEEHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]