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The map label for this gene is glxR [H]

Identifier: 91787594

GI number: 91787594

Start: 1765466

End: 1766362

Strand: Reverse

Name: glxR [H]

Synonym: Bpro_1712

Alternate gene names: 91787594

Gene position: 1766362-1765466 (Counterclockwise)

Preceding gene: 91787595

Following gene: 91787592

Centisome position: 33.97

GC content: 66.11

Gene sequence:

>897_bases
ATGACCGTTGAAAGCGACCCGTACGCAAGAAAAATCACCTTTTTGGGCACAGGCAGCATGGGCCTGCCCATGGCCCGACG
CCTGTGCGAGGCCGGGTATGCACTGCAGGTGTGGAACCGCACGCCAGCCAGGGCCGCCTCGCTGGCGGCGCTGGGCGCGA
CCATTCACGAGCAGGCCCGCGCAGCGGCCAGGGATGCCGACATCGTGGTCAGCATGCTGGAAAACGGCGCCGTGGTGCAA
GACGTGCTGTTCGCGCAAGGCGTTGCTGCAGCGATGAAACCAGGGTCGCTCTTCCTCGACATGGCATCCATCACGCCCCG
TGAAGCACGTGACCACGCCGCGCGGCTGGGCGCCTTGGGCATCGCCCACCTGGATACGCCGGTCTCTGGCGGCACCGTCG
GCGCCGAGCAGGGCACGCTGGTCATCATGGCGGGCGGCAAGCCGGCCGACTTCGAGCGCTCCCTGCCCTTGCTCAAGGTA
TTCGGCCGCGCCACGCACGTGGGCCCGCACGGCAGCGGGCAGCTCACCAAACTGGCCAACCAGATGATTGTCGGCATCAC
GATAGGCGCGGTGGCCGAAGCCTTGCTGTTCGCCACCAAGGGCGGCGCCGACATGGCCAAGGTCAAGGAAGCCATCACCG
GCGGTTTTGCCGACAGCCGCGTGTTGCAGTTGCACGGCCAGCGCATGGTGGAGCGGGACTTCGCGCCACGCGCGCGCTTG
TCGATACAGCTCAAGGACATGCGCAATGCGCTGGCGACCGCGCAGGAAATCGGCTTTGATGCACCCATCACCGGGCTCTT
CGAGCAGCTCTACGCCGAGGGTGTGGAACACGGCCTGACAGACCTCGACCAGTCGGGACTCTTTGTGGAACTGGCCAGCC
GCAATGGCATGAGCTGA

Upstream 100 bases:

>100_bases
TGGAAACCATGTTCTCGCCGGCCATCAAGAAAGCTGCCTGACAGCCTTCTTGCGCTGCGTGCCGGATGATGGGTACATCT
GCCATTAACCAGGAACCCGA

Downstream 100 bases:

>100_bases
GTTCAAGCCCGCGAAGGCCTTCCGCTACCGTCTCCGATGCCGGGACGGCCGGGGAGGCAGGCCGGCTCAGTAGCCCAGCA
TGTTGCTGCGTACATGCGCC

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTVESDPYARKITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAASLAALGATIHEQARAAARDADIVVSMLENGAVVQ
DVLFAQGVAAAMKPGSLFLDMASITPREARDHAARLGALGIAHLDTPVSGGTVGAEQGTLVIMAGGKPADFERSLPLLKV
FGRATHVGPHGSGQLTKLANQMIVGITIGAVAEALLFATKGGADMAKVKEAITGGFADSRVLQLHGQRMVERDFAPRARL
SIQLKDMRNALATAQEIGFDAPITGLFEQLYAEGVEHGLTDLDQSGLFVELASRNGMS

Sequences:

>Translated_298_residues
MTVESDPYARKITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAASLAALGATIHEQARAAARDADIVVSMLENGAVVQ
DVLFAQGVAAAMKPGSLFLDMASITPREARDHAARLGALGIAHLDTPVSGGTVGAEQGTLVIMAGGKPADFERSLPLLKV
FGRATHVGPHGSGQLTKLANQMIVGITIGAVAEALLFATKGGADMAKVKEAITGGFADSRVLQLHGQRMVERDFAPRARL
SIQLKDMRNALATAQEIGFDAPITGLFEQLYAEGVEHGLTDLDQSGLFVELASRNGMS
>Mature_297_residues
TVESDPYARKITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAASLAALGATIHEQARAAARDADIVVSMLENGAVVQD
VLFAQGVAAAMKPGSLFLDMASITPREARDHAARLGALGIAHLDTPVSGGTVGAEQGTLVIMAGGKPADFERSLPLLKVF
GRATHVGPHGSGQLTKLANQMIVGITIGAVAEALLFATKGGADMAKVKEAITGGFADSRVLQLHGQRMVERDFAPRARLS
IQLKDMRNALATAQEIGFDAPITGLFEQLYAEGVEHGLTDLDQSGLFVELASRNGMS

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=208, Percent_Identity=29.8076923076923, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI40556376, Length=284, Percent_Identity=25, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1786719, Length=279, Percent_Identity=42.6523297491039, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI145693186, Length=279, Percent_Identity=39.426523297491, Blast_Score=190, Evalue=9e-50,
Organism=Escherichia coli, GI1790315, Length=296, Percent_Identity=28.0405405405405, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1789092, Length=283, Percent_Identity=28.6219081272085, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17557316, Length=194, Percent_Identity=30.4123711340206, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24655230, Length=288, Percent_Identity=30.9027777777778, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI19922568, Length=288, Percent_Identity=30.9027777777778, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574115, Length=286, Percent_Identity=24.4755244755245, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31275; Mature: 31144

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVESDPYARKITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAASLAALGATIHEQAR
CCCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
AAARDADIVVSMLENGAVVQDVLFAQGVAAAMKPGSLFLDMASITPREARDHAARLGALG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHEEEHHHCCCHHHHHHHHHHHHHH
IAHLDTPVSGGTVGAEQGTLVIMAGGKPADFERSLPLLKVFGRATHVGPHGSGQLTKLAN
HHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHHHH
QMIVGITIGAVAEALLFATKGGADMAKVKEAITGGFADSRVLQLHGQRMVERDFAPRARL
HHEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHE
SIQLKDMRNALATAQEIGFDAPITGLFEQLYAEGVEHGLTDLDQSGLFVELASRNGMS
EEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
TVESDPYARKITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAASLAALGATIHEQAR
CCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
AAARDADIVVSMLENGAVVQDVLFAQGVAAAMKPGSLFLDMASITPREARDHAARLGALG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHEEEHHHCCCHHHHHHHHHHHHHH
IAHLDTPVSGGTVGAEQGTLVIMAGGKPADFERSLPLLKVFGRATHVGPHGSGQLTKLAN
HHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHCCHHHHHHHHHHCCCCCCCCHHHHHHH
QMIVGITIGAVAEALLFATKGGADMAKVKEAITGGFADSRVLQLHGQRMVERDFAPRARL
HHEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHE
SIQLKDMRNALATAQEIGFDAPITGLFEQLYAEGVEHGLTDLDQSGLFVELASRNGMS
EEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]