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The map label for this gene is ndhF [H]

Identifier: 91787375

GI number: 91787375

Start: 1534345

End: 1536060

Strand: Reverse

Name: ndhF [H]

Synonym: Bpro_1481

Alternate gene names: 91787375

Gene position: 1536060-1534345 (Counterclockwise)

Preceding gene: 91787383

Following gene: 91787374

Centisome position: 29.54

GC content: 65.27

Gene sequence:

>1716_bases
ATGGCCATCCGATCTGACACCCAGAACACTGTCAAGCCCATCCGGTTCATCCGGCGTGGTGAAGTGGTAACGCTTGCCAA
TGTACCACCCAGCCGCACCCTGCTGGAGGTACTGCGCGAAGACCTCGCCTGCACCGGCACCAAGGAAGGCTGCGGCGAAG
GCGACTGCGGCGCCTGCACCGTGGTGCTGGGCGAGGCCGACGGCAAGACCATCCGCTACCGCGCCATCAACAGCTGCATC
CGGCTGGCGCATTCGATTGACGGCCTGGCGCTGTGGACGGTGGAAGACATTGCCCCCACGCTTTTCACTTCGCCTTCGGC
TTCGTGTAATGCGCTGCCCCCCGAGGGGGCGCTGCGCCTGCGGCCCGGCAAAGCCGGTTCCGCGGCCCCTACTGGCGAAG
AAGAAAGGGGTAAACCAACACTACACCCCGCACAAGAGGCCATGGTCCAGTTCCACGGTTCCCAATGCGGCTTTTGTACG
CCGGGCTTTGTGATGAGCCTGTTCGGCATGTACCACAACCATGTCGGACGGGGCCAGCCCATCACGCGCGCGCTGGCGCA
GGAAGAACTGTCCGGCAACCTGTGCCGCTGCACCGGCTACCGGCCCATCCTCGACGCCGCGCAAGCCATGGACCAGCTCC
CGCAAGTGGCCGTTGACGAAGCCGGACTGCTGAAAAAAATGAAGCAGCTCGCGCATGCACCGTACCGGCCAGGCCCGGAT
TTCTCCTCGGATTTTTCTTATGAATCGCCCCCCACGCTGGCTGCGCTGCTGAAAGCGCGAGCCGCGCACCCCGAGGCCCA
ACTGGTGGCCGGCTGCACCGACGTGGGCCTGTGGGTGACCAAGCAGCACCAGCAGTTCAGCCGGGTGCTGGACGTGACCA
GGGTTCGGGAGCTGCGCCGCATTGAAGACTACCCGCAGCACATTGCGATAGGCGCCGCGGTGACGCTGGCCGATGCCTAT
GCCGCGCTGGCGAAGGACCGGCCCCAGCTGCACACCTTTGCCGCCCGCTTTGCCGGCCTGCCGGTGCGCAACGCGGGCAC
GATGGGCGGCAATGTCGCCAATGGCTCGCCGATTGGCGACTCCATGCCGCTGCTAATTGCCCTGGGCGCCAACGTCGTGC
TGATGAATGAACGGCAAGGTGTGATGGGCCACCGCGAGATGCCGCTGGAGCAGCTCTACACCGGCTATCGCCAGAGCGTG
ATGGCCCCGGATGAAGTGCTGGCTTGGGTGAAGGTGCCGAGGCCGGCCAGCCCTCACCCTAACCCTCTCCCAGGGGGAGA
GGGGATTGAAGAAAAAGACGGTATTGCTCCCTCGCCCCTCTGGGGAGAGGGCTGGGGTGAGGGGCAGGAGTTGCTGCGCA
TCTACAAAATCTCCAAGCGCTACGACGACGATATCTCCGCGGTCTGCCTGGCCCTGAACCTGCACATCGACAAGGGCATC
GTGACCAGCGCGTCGATAGGCGCGGGCGGTGTCGCCGCAACACCCGTGCGCGCCGTCAAGACCGAGGCAGCGCTGCTCGG
CCAGGCGTGGACTGCCGAGACGGTGCAACAAGCCATCACCACCTTGCGCGCCGAGTTCTCGCCGATCTCGGACATGCGCG
CTTCCGCCGCCTACCGCAGCACGGTGCTGGGCAACCTGCTGCAGCGCTACTGGCTCGAAAGCCAGGGCCTGCAGCAGATC
AACCTGGAATCCTTCCGGCTGGAGGAGCTCGCATGA

Upstream 100 bases:

>100_bases
AAAGCGCCTGATCTTTCATACGCTCTTGCCCATGCGCCTGATACGCGCTTTTGTATGCCGACTGTGGACTGACTGTTTTA
CCCTGAAACTCATGTCTAGC

Downstream 100 bases:

>100_bases
ACGCCCCTGAAATACTGCCGGTTCATGCGGCCGGACCGGCACACCCGCCGGCCGCCGGACGCCCGCACTTTCACGAAAGT
GCCCGCGCGCAGGTGGCCGG

Product: molybdopterin dehydrogenase

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase FAD-subunit; NAH [H]

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MAIRSDTQNTVKPIRFIRRGEVVTLANVPPSRTLLEVLREDLACTGTKEGCGEGDCGACTVVLGEADGKTIRYRAINSCI
RLAHSIDGLALWTVEDIAPTLFTSPSASCNALPPEGALRLRPGKAGSAAPTGEEERGKPTLHPAQEAMVQFHGSQCGFCT
PGFVMSLFGMYHNHVGRGQPITRALAQEELSGNLCRCTGYRPILDAAQAMDQLPQVAVDEAGLLKKMKQLAHAPYRPGPD
FSSDFSYESPPTLAALLKARAAHPEAQLVAGCTDVGLWVTKQHQQFSRVLDVTRVRELRRIEDYPQHIAIGAAVTLADAY
AALAKDRPQLHTFAARFAGLPVRNAGTMGGNVANGSPIGDSMPLLIALGANVVLMNERQGVMGHREMPLEQLYTGYRQSV
MAPDEVLAWVKVPRPASPHPNPLPGGEGIEEKDGIAPSPLWGEGWGEGQELLRIYKISKRYDDDISAVCLALNLHIDKGI
VTSASIGAGGVAATPVRAVKTEAALLGQAWTAETVQQAITTLRAEFSPISDMRASAAYRSTVLGNLLQRYWLESQGLQQI
NLESFRLEELA

Sequences:

>Translated_571_residues
MAIRSDTQNTVKPIRFIRRGEVVTLANVPPSRTLLEVLREDLACTGTKEGCGEGDCGACTVVLGEADGKTIRYRAINSCI
RLAHSIDGLALWTVEDIAPTLFTSPSASCNALPPEGALRLRPGKAGSAAPTGEEERGKPTLHPAQEAMVQFHGSQCGFCT
PGFVMSLFGMYHNHVGRGQPITRALAQEELSGNLCRCTGYRPILDAAQAMDQLPQVAVDEAGLLKKMKQLAHAPYRPGPD
FSSDFSYESPPTLAALLKARAAHPEAQLVAGCTDVGLWVTKQHQQFSRVLDVTRVRELRRIEDYPQHIAIGAAVTLADAY
AALAKDRPQLHTFAARFAGLPVRNAGTMGGNVANGSPIGDSMPLLIALGANVVLMNERQGVMGHREMPLEQLYTGYRQSV
MAPDEVLAWVKVPRPASPHPNPLPGGEGIEEKDGIAPSPLWGEGWGEGQELLRIYKISKRYDDDISAVCLALNLHIDKGI
VTSASIGAGGVAATPVRAVKTEAALLGQAWTAETVQQAITTLRAEFSPISDMRASAAYRSTVLGNLLQRYWLESQGLQQI
NLESFRLEELA
>Mature_570_residues
AIRSDTQNTVKPIRFIRRGEVVTLANVPPSRTLLEVLREDLACTGTKEGCGEGDCGACTVVLGEADGKTIRYRAINSCIR
LAHSIDGLALWTVEDIAPTLFTSPSASCNALPPEGALRLRPGKAGSAAPTGEEERGKPTLHPAQEAMVQFHGSQCGFCTP
GFVMSLFGMYHNHVGRGQPITRALAQEELSGNLCRCTGYRPILDAAQAMDQLPQVAVDEAGLLKKMKQLAHAPYRPGPDF
SSDFSYESPPTLAALLKARAAHPEAQLVAGCTDVGLWVTKQHQQFSRVLDVTRVRELRRIEDYPQHIAIGAAVTLADAYA
ALAKDRPQLHTFAARFAGLPVRNAGTMGGNVANGSPIGDSMPLLIALGANVVLMNERQGVMGHREMPLEQLYTGYRQSVM
APDEVLAWVKVPRPASPHPNPLPGGEGIEEKDGIAPSPLWGEGWGEGQELLRIYKISKRYDDDISAVCLALNLHIDKGIV
TSASIGAGGVAATPVRAVKTEAALLGQAWTAETVQQAITTLRAEFSPISDMRASAAYRSTVLGNLLQRYWLESQGLQQIN
LESFRLEELA

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=611, Percent_Identity=27.3322422258593, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI71773480, Length=606, Percent_Identity=24.9174917491749, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1789231, Length=317, Percent_Identity=24.9211356466877, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17540638, Length=611, Percent_Identity=28.1505728314239, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17539860, Length=409, Percent_Identity=25.1833740831296, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32566215, Length=410, Percent_Identity=24.390243902439, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17737937, Length=592, Percent_Identity=30.4054054054054, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24647199, Length=572, Percent_Identity=27.0979020979021, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24647201, Length=561, Percent_Identity=25.8467023172906, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24647197, Length=353, Percent_Identity=32.2946175637394, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24647195, Length=353, Percent_Identity=32.5779036827195, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24647193, Length=389, Percent_Identity=26.9922879177378, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 61462; Mature: 61331

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00189 LIPOYL ; PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRSDTQNTVKPIRFIRRGEVVTLANVPPSRTLLEVLREDLACTGTKEGCGEGDCGACT
CCCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
VVLGEADGKTIRYRAINSCIRLAHSIDGLALWTVEDIAPTLFTSPSASCNALPPEGALRL
EEEECCCCCEEHHHHHHHHHHHHHCCCCEEEEEHHHHCHHHCCCCCCCCCCCCCCCCEEE
RPGKAGSAAPTGEEERGKPTLHPAQEAMVQFHGSQCGFCTPGFVMSLFGMYHNHVGRGQP
CCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCH
ITRALAQEELSGNLCRCTGYRPILDAAQAMDQLPQVAVDEAGLLKKMKQLAHAPYRPGPD
HHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FSSDFSYESPPTLAALLKARAAHPEAQLVAGCTDVGLWVTKQHQQFSRVLDVTRVRELRR
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCHHCCEEEHHHHHHHHHHHHHHHHHHHH
IEDYPQHIAIGAAVTLADAYAALAKDRPQLHTFAARFAGLPVRNAGTMGGNVANGSPIGD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
SMPLLIALGANVVLMNERQGVMGHREMPLEQLYTGYRQSVMAPDEVLAWVKVPRPASPHP
CCCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHEECCCCCCCCC
NPLPGGEGIEEKDGIAPSPLWGEGWGEGQELLRIYKISKRYDDDISAVCLALNLHIDKGI
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHEEECCCC
VTSASIGAGGVAATPVRAVKTEAALLGQAWTAETVQQAITTLRAEFSPISDMRASAAYRS
EEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TVLGNLLQRYWLESQGLQQINLESFRLEELA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
AIRSDTQNTVKPIRFIRRGEVVTLANVPPSRTLLEVLREDLACTGTKEGCGEGDCGACT
CCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
VVLGEADGKTIRYRAINSCIRLAHSIDGLALWTVEDIAPTLFTSPSASCNALPPEGALRL
EEEECCCCCEEHHHHHHHHHHHHHCCCCEEEEEHHHHCHHHCCCCCCCCCCCCCCCCEEE
RPGKAGSAAPTGEEERGKPTLHPAQEAMVQFHGSQCGFCTPGFVMSLFGMYHNHVGRGQP
CCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCH
ITRALAQEELSGNLCRCTGYRPILDAAQAMDQLPQVAVDEAGLLKKMKQLAHAPYRPGPD
HHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FSSDFSYESPPTLAALLKARAAHPEAQLVAGCTDVGLWVTKQHQQFSRVLDVTRVRELRR
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCHHCCEEEHHHHHHHHHHHHHHHHHHHH
IEDYPQHIAIGAAVTLADAYAALAKDRPQLHTFAARFAGLPVRNAGTMGGNVANGSPIGD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
SMPLLIALGANVVLMNERQGVMGHREMPLEQLYTGYRQSVMAPDEVLAWVKVPRPASPHP
CCCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHEECCCCCCCCC
NPLPGGEGIEEKDGIAPSPLWGEGWGEGQELLRIYKISKRYDDDISAVCLALNLHIDKGI
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHEEECCCC
VTSASIGAGGVAATPVRAVKTEAALLGQAWTAETVQQAITTLRAEFSPISDMRASAAYRS
EEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
TVLGNLLQRYWLESQGLQQINLESFRLEELA
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA