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The map label for this gene is pcaR [H]

Identifier: 91787125

GI number: 91787125

Start: 1274059

End: 1274862

Strand: Reverse

Name: pcaR [H]

Synonym: Bpro_1228

Alternate gene names: 91787125

Gene position: 1274862-1274059 (Counterclockwise)

Preceding gene: 91787134

Following gene: 91787123

Centisome position: 24.52

GC content: 62.69

Gene sequence:

>804_bases
ATGGCAAATCCCGCCTCCACACGCATCGCAGACCTTAAACCCGGCGACGGGTATGTGCAATCCTTTGCACGCGGGTTACA
GGTCATCCGCTCCTTCAGTGCCAGCGCACCGCGCCAGACACTGACCGAAGTGGCGCAACGCAGCGAGCTGAGCCGCGCCG
GTGCGCGCCGCATCCTGCTGACGCTGGAGTCGCTGGGCTATGTGCGCAGTGAAGGCAAGCTGTTCAGCCTGACACCACGC
ATTCTCGATTTGGGGTTTGCCTACCTCTCGTCCATGCCAATCTGGAACCTAGCCGAGCCGGTCATGGAAACGCTGGTCGC
GCAGGTCAAGGAGTCCTGCTCGGCAGCGGTGCTGGACGGCACGGACATTGTGTATGTGCTGCGCGTGTCCACCCACAAGA
TCATGAGCATCAGCCTGGGCATCGGCTCCCGGCTACCCGCCTACTGCACCTCGATGGGCCGCATGCTGCTGTCTGCCTTG
CCAGAAACCGAGTTGATGGAGTGCCTGGAACGCTCGGAGCGGACGGCCCGGACCAAGTACACCGCGGTCGATGTGAAGGA
GATCGCGGCCCGGATTGCGCAGGTTCGCAAACAGGGCTGGTCGCTGGTGAATCAGGAACTCGAAGAAGGACTGGTGTCGA
TGGCCGCGCCCATCACCAACCGGGCCGGCCAGATGGTGGCGGCGCTGAACATCAGTGGCCAGGCCAACCGTACCAGTGCC
AAGGTGATGCAGGAAACCATGCTGCCGCAACTGCTCGCGGCTGCACAAGCGATATCGCGCATGCTGAGTGTTCAGCGCAG
CTGA

Upstream 100 bases:

>100_bases
GCATACCGGGCGCGAATCCAGCAGAGTTTCCGGTCCACCAGATTTTGTTCGACATTAGAACAAGAGTTCGTATAATGAAT
TTTAGGAGATTTTTACAGCC

Downstream 100 bases:

>100_bases
GTTAGCTGCGCTGAAACGAAGGGAGCGCGGACTTTCGGCCTTTCAGGGCTTGCGGAACCCCACCACCAGCAAAACCCCAC
CCAGGGCCATGGCGCCTATG

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MANPASTRIADLKPGDGYVQSFARGLQVIRSFSASAPRQTLTEVAQRSELSRAGARRILLTLESLGYVRSEGKLFSLTPR
ILDLGFAYLSSMPIWNLAEPVMETLVAQVKESCSAAVLDGTDIVYVLRVSTHKIMSISLGIGSRLPAYCTSMGRMLLSAL
PETELMECLERSERTARTKYTAVDVKEIAARIAQVRKQGWSLVNQELEEGLVSMAAPITNRAGQMVAALNISGQANRTSA
KVMQETMLPQLLAAAQAISRMLSVQRS

Sequences:

>Translated_267_residues
MANPASTRIADLKPGDGYVQSFARGLQVIRSFSASAPRQTLTEVAQRSELSRAGARRILLTLESLGYVRSEGKLFSLTPR
ILDLGFAYLSSMPIWNLAEPVMETLVAQVKESCSAAVLDGTDIVYVLRVSTHKIMSISLGIGSRLPAYCTSMGRMLLSAL
PETELMECLERSERTARTKYTAVDVKEIAARIAQVRKQGWSLVNQELEEGLVSMAAPITNRAGQMVAALNISGQANRTSA
KVMQETMLPQLLAAAQAISRMLSVQRS
>Mature_266_residues
ANPASTRIADLKPGDGYVQSFARGLQVIRSFSASAPRQTLTEVAQRSELSRAGARRILLTLESLGYVRSEGKLFSLTPRI
LDLGFAYLSSMPIWNLAEPVMETLVAQVKESCSAAVLDGTDIVYVLRVSTHKIMSISLGIGSRLPAYCTSMGRMLLSALP
ETELMECLERSERTARTKYTAVDVKEIAARIAQVRKQGWSLVNQELEEGLVSMAAPITNRAGQMVAALNISGQANRTSAK
VMQETMLPQLLAAAQAISRMLSVQRS

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=221, Percent_Identity=33.0316742081448, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI87082359, Length=230, Percent_Identity=30, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786468, Length=247, Percent_Identity=28.3400809716599, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1786715, Length=220, Percent_Identity=24.5454545454545, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789999, Length=250, Percent_Identity=26.4, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788581, Length=188, Percent_Identity=25.531914893617, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693096, Length=230, Percent_Identity=27.8260869565217, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29051; Mature: 28920

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANPASTRIADLKPGDGYVQSFARGLQVIRSFSASAPRQTLTEVAQRSELSRAGARRILL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TLESLGYVRSEGKLFSLTPRILDLGFAYLSSMPIWNLAEPVMETLVAQVKESCSAAVLDG
HHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCEEEECC
TDIVYVLRVSTHKIMSISLGIGSRLPAYCTSMGRMLLSALPETELMECLERSERTARTKY
CCEEEEEEECHHHHEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
TAVDVKEIAARIAQVRKQGWSLVNQELEEGLVSMAAPITNRAGQMVAALNISGQANRTSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHH
KVMQETMLPQLLAAAQAISRMLSVQRS
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ANPASTRIADLKPGDGYVQSFARGLQVIRSFSASAPRQTLTEVAQRSELSRAGARRILL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TLESLGYVRSEGKLFSLTPRILDLGFAYLSSMPIWNLAEPVMETLVAQVKESCSAAVLDG
HHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCEEEECC
TDIVYVLRVSTHKIMSISLGIGSRLPAYCTSMGRMLLSALPETELMECLERSERTARTKY
CCEEEEEEECHHHHEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
TAVDVKEIAARIAQVRKQGWSLVNQELEEGLVSMAAPITNRAGQMVAALNISGQANRTSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHH
KVMQETMLPQLLAAAQAISRMLSVQRS
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]