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The map label for this gene is kefC [H]

Identifier: 91787134

GI number: 91787134

Start: 1283362

End: 1285188

Strand: Reverse

Name: kefC [H]

Synonym: Bpro_1237

Alternate gene names: 91787134

Gene position: 1285188-1283362 (Counterclockwise)

Preceding gene: 91787135

Following gene: 91787125

Centisome position: 24.71

GC content: 66.06

Gene sequence:

>1827_bases
ATGGAACACGCCCCCGCCTGGCTTACCAACAGCTTCATCTACCTGGCAGCTGCCGTTGTCGCCGTGCCGCTGGCCAAGAA
ATTCGGCCTGGGCTCCATCATTGGCTACCTGGCCGCGGGCATTGCCATCGGCCCCTGGGGCATGGGCCTGGTCACCAATG
TCCAGGACATTCTTCACTTCGCCGAATTTGGCGTGGTGCTGATGCTGTTTCTGGTCGGCCTGGAACTGGAGCCCCAGCGC
CTGTGGAATTTGCGCCGCCCCATCTTTGGCTGGGGCAGCGCGCAGGTGCTCGGCTGCGCCGCCCTGCTGACCGGCGCGGC
CATGCTGTTTGGCGTGGGCTGGCAGACGGCGCTGGTGGCCGGCCTGGGCCTGGCGCTGTCGTCCACCGCGATCGCGCTGC
AGTCCATGGGCGAGCGCAACCTGCTGCCCACGTCCAGCGGGCAGGCCGGGTTTTCCATTTTGCTGTTCCAGGACGTTGCG
GCCATCCCGATTCTGGCGCTGCTGCCGCTGCTGGGTGCGGTGGCCGGCGAAAACGAGGCCGCAGCCCAATCACATCGAGC
GATTGAAGCTCTTAAAATCATAGCAGTCATCGGCGGCATCATTCTCGGCGGCCGGTTGCTGCTGCGCCCGCTGCTGCGCT
GGATCGCCAACAGCGGCACACCCGAGATCTTCACGGCCGCATCGCTGCTGCTGGTGGTCGGCATTGCCGCGCTGATGCAG
CTGGTCGGCCTGTCCATGGCGCTGGGTGCTTTTCTGGCCGGCGTGCTGCTCGCGGAAAGCGAATACCGGCGCGAACTGGA
AACCGACATCGAACCCTTCAAGGGTTTGCTGCTGGGCCTGTTTTTCATCGCGGTGGGCATGAGCATCGACTTTGGCGTGC
TGTGGAAATCGCCCGGCCTGATGGCGGCCATTCTGCTGGGCTTCCTGGGCCTGAAGCTGGCGGTGATCTACGGCCTGGCC
TGGCGCATGAAGCTGCCCTACCAGGAGCGCCCGGTGTTCACGGTGCTGCTGGCGCAAGGCGGTGAATTTGCCTTCGTGGT
ATTCCAGGCCGCGGCGGGCGCGCAGGTGTTTTCCGCCGAAACCGCCTCGCTGCTGATCGGCGCGGTGGCGCTGTCCATGC
TGATCAGCCCCCTCCTGCTGGTGGCTGTCGACAAGCTGCTGCTGCCGCGCTGGGCCAACTGCAGCACGCCGCAGCTCGAA
GAAATCTCCGAGCCGCAGCAGGCCTCCATCATCATTGCCGGCTTTGGCCGCTACGGCCAGATCGTCGGCCGCATGCTGCT
GGCGCAAGGCATTCCGGCGACGGTGCTGGAGCACGACGCCGACATGGTGGAAACCGTGCGGGCCTTCGGTTACCGCGTCT
TTTACGGCGATGCCACACGGCTGGACCTGCTGCGCACGGCCGGCGCCGCCAGCGCCAGAATTCTGGTGCTGGCGGTCGAC
AGCATGGAGCAGTCGCTGAAGATCGTGGACCTGGCGAAGGAGCACTTCCCGAACCTGGAGATCGTGGCCCGCGCGCATGA
CGTGACGCACTGGAATGCGCTGCGGGACCGCGGTGTGATGCGTGTGGAGCGCGAGGTCTTCGAGTCCAGCCTGCGCAGCG
CGCGCACCGTGCTGGAACTGCTCGGCCAGCCGCCGCATGAAGCACGGCAGGCCGCCATGCGTTTTCGGCAGCACAACCTT
GAATTGTTCGAGCGGATGTACCCGCACCGCAAGGACCGCACCAAGGTCATCGCCGTCGCCACCCAGGGGCGGCTGCAACT
GGAAGAGCAAATGGCGCAGGAGCGCGCTCAAGCGGCGCAGCCCCGGCCCCAGGACTGGCACGGCTGA

Upstream 100 bases:

>100_bases
TGCCCATGAAAGACCGCTTGCCCAGGGACGAGGCCAGCATCGAAGCGGACCCGGAAAGCAAGGACGCAGGTACAACGACG
AACGTGGGAGCCACCCGCTA

Downstream 100 bases:

>100_bases
CTTTCAGGAAAAAATGGCTTTACCCCAATAACTATTTGGGGAAATAACTATAAAAACGATAGCACAACTCCTGCTCAAAC
CGCACCCGATCCGGCCCCCC

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MEHAPAWLTNSFIYLAAAVVAVPLAKKFGLGSIIGYLAAGIAIGPWGMGLVTNVQDILHFAEFGVVLMLFLVGLELEPQR
LWNLRRPIFGWGSAQVLGCAALLTGAAMLFGVGWQTALVAGLGLALSSTAIALQSMGERNLLPTSSGQAGFSILLFQDVA
AIPILALLPLLGAVAGENEAAAQSHRAIEALKIIAVIGGIILGGRLLLRPLLRWIANSGTPEIFTAASLLLVVGIAALMQ
LVGLSMALGAFLAGVLLAESEYRRELETDIEPFKGLLLGLFFIAVGMSIDFGVLWKSPGLMAAILLGFLGLKLAVIYGLA
WRMKLPYQERPVFTVLLAQGGEFAFVVFQAAAGAQVFSAETASLLIGAVALSMLISPLLLVAVDKLLLPRWANCSTPQLE
EISEPQQASIIIAGFGRYGQIVGRMLLAQGIPATVLEHDADMVETVRAFGYRVFYGDATRLDLLRTAGAASARILVLAVD
SMEQSLKIVDLAKEHFPNLEIVARAHDVTHWNALRDRGVMRVEREVFESSLRSARTVLELLGQPPHEARQAAMRFRQHNL
ELFERMYPHRKDRTKVIAVATQGRLQLEEQMAQERAQAAQPRPQDWHG

Sequences:

>Translated_608_residues
MEHAPAWLTNSFIYLAAAVVAVPLAKKFGLGSIIGYLAAGIAIGPWGMGLVTNVQDILHFAEFGVVLMLFLVGLELEPQR
LWNLRRPIFGWGSAQVLGCAALLTGAAMLFGVGWQTALVAGLGLALSSTAIALQSMGERNLLPTSSGQAGFSILLFQDVA
AIPILALLPLLGAVAGENEAAAQSHRAIEALKIIAVIGGIILGGRLLLRPLLRWIANSGTPEIFTAASLLLVVGIAALMQ
LVGLSMALGAFLAGVLLAESEYRRELETDIEPFKGLLLGLFFIAVGMSIDFGVLWKSPGLMAAILLGFLGLKLAVIYGLA
WRMKLPYQERPVFTVLLAQGGEFAFVVFQAAAGAQVFSAETASLLIGAVALSMLISPLLLVAVDKLLLPRWANCSTPQLE
EISEPQQASIIIAGFGRYGQIVGRMLLAQGIPATVLEHDADMVETVRAFGYRVFYGDATRLDLLRTAGAASARILVLAVD
SMEQSLKIVDLAKEHFPNLEIVARAHDVTHWNALRDRGVMRVEREVFESSLRSARTVLELLGQPPHEARQAAMRFRQHNL
ELFERMYPHRKDRTKVIAVATQGRLQLEEQMAQERAQAAQPRPQDWHG
>Mature_608_residues
MEHAPAWLTNSFIYLAAAVVAVPLAKKFGLGSIIGYLAAGIAIGPWGMGLVTNVQDILHFAEFGVVLMLFLVGLELEPQR
LWNLRRPIFGWGSAQVLGCAALLTGAAMLFGVGWQTALVAGLGLALSSTAIALQSMGERNLLPTSSGQAGFSILLFQDVA
AIPILALLPLLGAVAGENEAAAQSHRAIEALKIIAVIGGIILGGRLLLRPLLRWIANSGTPEIFTAASLLLVVGIAALMQ
LVGLSMALGAFLAGVLLAESEYRRELETDIEPFKGLLLGLFFIAVGMSIDFGVLWKSPGLMAAILLGFLGLKLAVIYGLA
WRMKLPYQERPVFTVLLAQGGEFAFVVFQAAAGAQVFSAETASLLIGAVALSMLISPLLLVAVDKLLLPRWANCSTPQLE
EISEPQQASIIIAGFGRYGQIVGRMLLAQGIPATVLEHDADMVETVRAFGYRVFYGDATRLDLLRTAGAASARILVLAVD
SMEQSLKIVDLAKEHFPNLEIVARAHDVTHWNALRDRGVMRVEREVFESSLRSARTVLELLGQPPHEARQAAMRFRQHNL
ELFERMYPHRKDRTKVIAVATQGRLQLEEQMAQERAQAAQPRPQDWHG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=416, Percent_Identity=27.6442307692308, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1786232, Length=603, Percent_Identity=50.0829187396352, Blast_Score=566, Evalue=1e-162,
Organism=Escherichia coli, GI1789749, Length=595, Percent_Identity=47.0588235294118, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1786685, Length=566, Percent_Identity=30.9187279151943, Blast_Score=195, Evalue=6e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 65662; Mature: 65662

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHAPAWLTNSFIYLAAAVVAVPLAKKFGLGSIIGYLAAGIAIGPWGMGLVTNVQDILHF
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
AEFGVVLMLFLVGLELEPQRLWNLRRPIFGWGSAQVLGCAALLTGAAMLFGVGWQTALVA
HHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
GLGLALSSTAIALQSMGERNLLPTSSGQAGFSILLFQDVAAIPILALLPLLGAVAGENEA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHH
AAQSHRAIEALKIIAVIGGIILGGRLLLRPLLRWIANSGTPEIFTAASLLLVVGIAALMQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LVGLSMALGAFLAGVLLAESEYRRELETDIEPFKGLLLGLFFIAVGMSIDFGVLWKSPGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHH
MAAILLGFLGLKLAVIYGLAWRMKLPYQERPVFTVLLAQGGEFAFVVFQAAAGAQVFSAE
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCEEEEEEEHHCCCHHHHHH
TASLLIGAVALSMLISPLLLVAVDKLLLPRWANCSTPQLEEISEPQQASIIIAGFGRYGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEEECCHHHH
IVGRMLLAQGIPATVLEHDADMVETVRAFGYRVFYGDATRLDLLRTAGAASARILVLAVD
HHHHHHHHCCCCHHHHHCCHHHHHHHHHHCEEEEECCCHHHHHHHHCCCCCCEEEEEEEC
SMEQSLKIVDLAKEHFPNLEIVARAHDVTHWNALRDRGVMRVEREVFESSLRSARTVLEL
CHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LGQPPHEARQAAMRFRQHNLELFERMYPHRKDRTKVIAVATQGRLQLEEQMAQERAQAAQ
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
PRPQDWHG
CCCCCCCC
>Mature Secondary Structure
MEHAPAWLTNSFIYLAAAVVAVPLAKKFGLGSIIGYLAAGIAIGPWGMGLVTNVQDILHF
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
AEFGVVLMLFLVGLELEPQRLWNLRRPIFGWGSAQVLGCAALLTGAAMLFGVGWQTALVA
HHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
GLGLALSSTAIALQSMGERNLLPTSSGQAGFSILLFQDVAAIPILALLPLLGAVAGENEA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHH
AAQSHRAIEALKIIAVIGGIILGGRLLLRPLLRWIANSGTPEIFTAASLLLVVGIAALMQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LVGLSMALGAFLAGVLLAESEYRRELETDIEPFKGLLLGLFFIAVGMSIDFGVLWKSPGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHH
MAAILLGFLGLKLAVIYGLAWRMKLPYQERPVFTVLLAQGGEFAFVVFQAAAGAQVFSAE
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCEEEEEEEHHCCCHHHHHH
TASLLIGAVALSMLISPLLLVAVDKLLLPRWANCSTPQLEEISEPQQASIIIAGFGRYGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEEECCHHHH
IVGRMLLAQGIPATVLEHDADMVETVRAFGYRVFYGDATRLDLLRTAGAASARILVLAVD
HHHHHHHHCCCCHHHHHCCHHHHHHHHHHCEEEEECCCHHHHHHHHCCCCCCEEEEEEEC
SMEQSLKIVDLAKEHFPNLEIVARAHDVTHWNALRDRGVMRVEREVFESSLRSARTVLEL
CHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LGQPPHEARQAAMRFRQHNLELFERMYPHRKDRTKVIAVATQGRLQLEEQMAQERAQAAQ
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
PRPQDWHG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA