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The map label for this gene is hpcH [H]

Identifier: 91786872

GI number: 91786872

Start: 989567

End: 990343

Strand: Reverse

Name: hpcH [H]

Synonym: Bpro_0970

Alternate gene names: 91786872

Gene position: 990343-989567 (Counterclockwise)

Preceding gene: 91786873

Following gene: 91786871

Centisome position: 19.04

GC content: 56.5

Gene sequence:

>777_bases
ATGCAACTGCCAATAAATCACTTCAAACAAGCCCTGCTTCAGGGTACACAGCAGCTCGGGCTTTGGTGCACATTGTCCAG
TCCCTACGCCATTGAGTTGCTTGCAGGCTCCGGGTTCGACTGGCTGCTGATCGACACAGAGCATTCGCCAAGCGATGTTG
TCGGCGTGCTGGCACAGTTGCAAGCGGTCGCACCTTATCCGGTGTCTGCCGTTGTCCGGCCTGCATGGAATGATCCGGTA
CTGATAAAGCGGTACCTGGACATTGGTGCGCAGACCTTGCTGCTGCCCTATATCCAGAACGCTGAAGAAGCTGAAGCGGG
CGTGCGCAGTATTGAATACCCATCCAGCGGCATCCGGGGGGTGTCGGCTTTGACCCGGGCTACCCGATTTGGGCGCATCA
AGAACTACGCGGCCGAGTGCCGCGAGCAACTGTGCTTGCTGGTTCAGGTCGAAACACTCGAAGCCATCAGCCAACTGGAA
TCAATCGCCAGTGTCAAGGGTGTTGACGGGGTATTCATCGGACCGGGCGATCTCGCGGCCAGCATGGGACTTTTGGGACA
GCCTGGGCACCCGGATGTAGTTTCAGTCATCGAAAACGCCATTGCCACCATCAGGAAGCACGGTAAACCCGCCGGCATTC
TGACGGGCGACAAAGCCCTGGCCAAGAAATGCATTGAACTTGGAACCACTTTCACCGCGGTAGGTGTTGACGTTGGAATT
CTGGCTGCGCAAACCACTCTTTTAAGAGATTCATTCACCCGGGAAAGCCCGTGCTGA

Upstream 100 bases:

>100_bases
TTTACCCGGCCAACCGCGGTTGAGGCTGGTGACACCATCCATGCAGACTTCGGCCCCCTGGGCTCCATCGGCCTCTCATT
TTCGTGAGCGGTCGCGCGCC

Downstream 100 bases:

>100_bases
ATCCCCTGCCATCCCCATGATTAACGTATCCGATATCAACAAGCCCGCACCCGTTGGCCGGCTCAGAGCCGCTTCATTGG
GAACGGACATCGACCATGGG

Product: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase

Products: NA

Alternate protein names: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; HHED aldolase; 4-hydroxy-2-ketoheptane-1,7-dioate aldolase; HKHD aldolase [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MQLPINHFKQALLQGTQQLGLWCTLSSPYAIELLAGSGFDWLLIDTEHSPSDVVGVLAQLQAVAPYPVSAVVRPAWNDPV
LIKRYLDIGAQTLLLPYIQNAEEAEAGVRSIEYPSSGIRGVSALTRATRFGRIKNYAAECREQLCLLVQVETLEAISQLE
SIASVKGVDGVFIGPGDLAASMGLLGQPGHPDVVSVIENAIATIRKHGKPAGILTGDKALAKKCIELGTTFTAVGVDVGI
LAAQTTLLRDSFTRESPC

Sequences:

>Translated_258_residues
MQLPINHFKQALLQGTQQLGLWCTLSSPYAIELLAGSGFDWLLIDTEHSPSDVVGVLAQLQAVAPYPVSAVVRPAWNDPV
LIKRYLDIGAQTLLLPYIQNAEEAEAGVRSIEYPSSGIRGVSALTRATRFGRIKNYAAECREQLCLLVQVETLEAISQLE
SIASVKGVDGVFIGPGDLAASMGLLGQPGHPDVVSVIENAIATIRKHGKPAGILTGDKALAKKCIELGTTFTAVGVDVGI
LAAQTTLLRDSFTRESPC
>Mature_258_residues
MQLPINHFKQALLQGTQQLGLWCTLSSPYAIELLAGSGFDWLLIDTEHSPSDVVGVLAQLQAVAPYPVSAVVRPAWNDPV
LIKRYLDIGAQTLLLPYIQNAEEAEAGVRSIEYPSSGIRGVSALTRATRFGRIKNYAAECREQLCLLVQVETLEAISQLE
SIASVKGVDGVFIGPGDLAASMGLLGQPGHPDVVSVIENAIATIRKHGKPAGILTGDKALAKKCIELGTTFTAVGVDVGI
LAAQTTLLRDSFTRESPC

Specific function: Catalyzes the reversible retro-aldol cleavage of 4- hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde [H]

COG id: COG3836

COG function: function code G; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789514, Length=249, Percent_Identity=43.3734939759036, Blast_Score=227, Evalue=5e-61,
Organism=Escherichia coli, GI1788578, Length=233, Percent_Identity=49.3562231759657, Blast_Score=226, Evalue=9e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR012689
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: 4.1.2.-

Molecular weight: Translated: 27474; Mature: 27474

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLPINHFKQALLQGTQQLGLWCTLSSPYAIELLAGSGFDWLLIDTEHSPSDVVGVLAQL
CCCCHHHHHHHHHHHHHHHCEEEEECCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHH
QAVAPYPVSAVVRPAWNDPVLIKRYLDIGAQTLLLPYIQNAEEAEAGVRSIEYPSSGIRG
HHCCCCCHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHH
VSALTRATRFGRIKNYAAECREQLCLLVQVETLEAISQLESIASVKGVDGVFIGPGDLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHH
SMGLLGQPGHPDVVSVIENAIATIRKHGKPAGILTGDKALAKKCIELGTTFTAVGVDVGI
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCEEHHHHHHH
LAAQTTLLRDSFTRESPC
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQLPINHFKQALLQGTQQLGLWCTLSSPYAIELLAGSGFDWLLIDTEHSPSDVVGVLAQL
CCCCHHHHHHHHHHHHHHHCEEEEECCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHH
QAVAPYPVSAVVRPAWNDPVLIKRYLDIGAQTLLLPYIQNAEEAEAGVRSIEYPSSGIRG
HHCCCCCHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHH
VSALTRATRFGRIKNYAAECREQLCLLVQVETLEAISQLESIASVKGVDGVFIGPGDLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHH
SMGLLGQPGHPDVVSVIENAIATIRKHGKPAGILTGDKALAKKCIELGTTFTAVGVDVGI
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCEEHHHHHHH
LAAQTTLLRDSFTRESPC
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA