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The map label for this gene is hemA

Identifier: 91786753

GI number: 91786753

Start: 872022

End: 873302

Strand: Reverse

Name: hemA

Synonym: Bpro_0851

Alternate gene names: 91786753

Gene position: 873302-872022 (Counterclockwise)

Preceding gene: 91786755

Following gene: 91786752

Centisome position: 16.79

GC content: 65.81

Gene sequence:

>1281_bases
ATGTCAGTCTGGGCCCTGGGGCTAAACCATACCACCGCACCGCTCGATTTGCGCGGGCGATTCGCCTATGCCCTGGACCA
AATCGAGCCCACGCTGCGCGGCTTGCGCGAGTCGCTGGCCCGCCAGCCCGAGGCCACCCTGCTCTCGACCTGCAACCGGA
CCGAGATTTATTGCGCAGGCGACCACAACGATCTGGAACACACGCTGGAGTGGCTGGCGCACAACGGTGGCGTCTCGCCT
GCCCTGCTGCGTTCGCACGCCTACACACTGCAGGACGACCAGGCAGCCCGCCACGCTTTCCGCGTCGCCAGTGGGCTCGA
CTCCATGGTGCTCGGCGAGCCGCAGATTCTGGGCCAGCTGAAAGACGCGGTGCGTGCCGCGGAGGACGCGGGCGCCATGG
GCAGCACACTGCACCAGCTGTTCCAGCGCTCCTTCGCCGTCGCCAAGGAAGTACGCACCAGCACGGAGATTGGCGCGCAC
AGCATCAGCATGGCGGCCGCCAGCGTGCGGCTGGCCGGGCAGCTGTTTGAAAACCTGGGCGACATCAGGGTGTTGTTTGT
CGGCGCCGGTGAAATGATTGACCTGGCGGCCACCCACTTTGCCGCAAAAACCCCCAAGTCCATGGCAATTGCCAACCGCA
CGCTGGAGCGTGGCGAAAAGCTCGCCAGCCGCTTCGGCGCCGAAGTCATGCGCCTGGCCGATCTGCCCAGCCGCCTGCAT
GAGTTTGACGCGGTGATCAGCTGCACGGCCAGCACCCTGCCCATCATTGGCCTGGGTGCGGTGGAACGTGCGGTCAAGCT
ACGCAAACACCGCCCCATGTTCATGGTTGACCTGGCCGTGCCGCGCGACATCGAGCCCGAGGTCAAGGACCTGCCTGACA
TCTACCTGTACACCGTGGACGACCTGGCGCACGTCGTCCAGACCGGCAAGGACAACCGCCAGGCCGCAGTGGCGCAGGCC
GAGGTGATCATCGATGCCGGCGTGCAGAACTTCATGCACTGGCTGGGCCAGCGCCGCACGGTGCCCCTGATCCAGCAGCT
CAATGCGCAAACCGACGAGTGGCGCGCCGCGGAAATTGCGCGGGCCAAAAAACTGATCGCCAAAGGCGAGCCGATGGATG
CCGTGCTGGATGCGCTGACGCGCGGCCTCACGCAGAAAATGCTGCATGGCGCGCTGGCGGAACTGCACGCGGGAGACGCC
GCCAGCCGCGAGGCCACGGCGCACACGGTGTCCCGGCTGTTTTTGCGCGGCCAACCGCCCAAAGAACACAAAGAGCGTTA
G

Upstream 100 bases:

>100_bases
GGGTCACGGGGCACACCCTGCAAGCGGCCCGAGAAAGACGGTTGAGGGTGTTTGATCCAGGCCAAATGCCTGTCCCGCAC
TTCAATTTTATAATCGGGGA

Downstream 100 bases:

>100_bases
CGCCGGCCTTGCGCGCTGCCGCAGCCGCCAGAACGGTTGCCATCCTGCCGGCGGCTTCGCCGGTGTGCCCCCCCCATTTA
TCGCCGCCCCGGCCCCCTCG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSVWALGLNHTTAPLDLRGRFAYALDQIEPTLRGLRESLARQPEATLLSTCNRTEIYCAGDHNDLEHTLEWLAHNGGVSP
ALLRSHAYTLQDDQAARHAFRVASGLDSMVLGEPQILGQLKDAVRAAEDAGAMGSTLHQLFQRSFAVAKEVRTSTEIGAH
SISMAAASVRLAGQLFENLGDIRVLFVGAGEMIDLAATHFAAKTPKSMAIANRTLERGEKLASRFGAEVMRLADLPSRLH
EFDAVISCTASTLPIIGLGAVERAVKLRKHRPMFMVDLAVPRDIEPEVKDLPDIYLYTVDDLAHVVQTGKDNRQAAVAQA
EVIIDAGVQNFMHWLGQRRTVPLIQQLNAQTDEWRAAEIARAKKLIAKGEPMDAVLDALTRGLTQKMLHGALAELHAGDA
ASREATAHTVSRLFLRGQPPKEHKER

Sequences:

>Translated_426_residues
MSVWALGLNHTTAPLDLRGRFAYALDQIEPTLRGLRESLARQPEATLLSTCNRTEIYCAGDHNDLEHTLEWLAHNGGVSP
ALLRSHAYTLQDDQAARHAFRVASGLDSMVLGEPQILGQLKDAVRAAEDAGAMGSTLHQLFQRSFAVAKEVRTSTEIGAH
SISMAAASVRLAGQLFENLGDIRVLFVGAGEMIDLAATHFAAKTPKSMAIANRTLERGEKLASRFGAEVMRLADLPSRLH
EFDAVISCTASTLPIIGLGAVERAVKLRKHRPMFMVDLAVPRDIEPEVKDLPDIYLYTVDDLAHVVQTGKDNRQAAVAQA
EVIIDAGVQNFMHWLGQRRTVPLIQQLNAQTDEWRAAEIARAKKLIAKGEPMDAVLDALTRGLTQKMLHGALAELHAGDA
ASREATAHTVSRLFLRGQPPKEHKER
>Mature_425_residues
SVWALGLNHTTAPLDLRGRFAYALDQIEPTLRGLRESLARQPEATLLSTCNRTEIYCAGDHNDLEHTLEWLAHNGGVSPA
LLRSHAYTLQDDQAARHAFRVASGLDSMVLGEPQILGQLKDAVRAAEDAGAMGSTLHQLFQRSFAVAKEVRTSTEIGAHS
ISMAAASVRLAGQLFENLGDIRVLFVGAGEMIDLAATHFAAKTPKSMAIANRTLERGEKLASRFGAEVMRLADLPSRLHE
FDAVISCTASTLPIIGLGAVERAVKLRKHRPMFMVDLAVPRDIEPEVKDLPDIYLYTVDDLAHVVQTGKDNRQAAVAQAE
VIIDAGVQNFMHWLGQRRTVPLIQQLNAQTDEWRAAEIARAKKLIAKGEPMDAVLDALTRGLTQKMLHGALAELHAGDAA
SREATAHTVSRLFLRGQPPKEHKER

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=401, Percent_Identity=43.3915211970075, Blast_Score=308, Evalue=4e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_POLSJ (Q12F85)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_547705.1
- ProteinModelPortal:   Q12F85
- SMR:   Q12F85
- STRING:   Q12F85
- GeneID:   4011354
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_0851
- NMPDR:   fig|296591.1.peg.3083
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q12F85
- ProtClustDB:   PRK00045
- BioCyc:   PSP296591:BPRO_0851-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46574; Mature: 46443

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00747 GLUTR; PS00012 PHOSPHOPANTETHEINE

Important sites: ACT_SITE 51-51 BINDING 108-108 BINDING 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVWALGLNHTTAPLDLRGRFAYALDQIEPTLRGLRESLARQPEATLLSTCNRTEIYCAG
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEECC
DHNDLEHTLEWLAHNGGVSPALLRSHAYTLQDDQAARHAFRVASGLDSMVLGEPQILGQL
CCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCCHHHHHHH
KDAVRAAEDAGAMGSTLHQLFQRSFAVAKEVRTSTEIGAHSISMAAASVRLAGQLFENLG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCC
DIRVLFVGAGEMIDLAATHFAAKTPKSMAIANRTLERGEKLASRFGAEVMRLADLPSRLH
CEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFDAVISCTASTLPIIGLGAVERAVKLRKHRPMFMVDLAVPRDIEPEVKDLPDIYLYTVD
HHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCCCEEEEEHH
DLAHVVQTGKDNRQAAVAQAEVIIDAGVQNFMHWLGQRRTVPLIQQLNAQTDEWRAAEIA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHH
RAKKLIAKGEPMDAVLDALTRGLTQKMLHGALAELHAGDAASREATAHTVSRLFLRGQPP
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
KEHKER
HHHCCC
>Mature Secondary Structure 
SVWALGLNHTTAPLDLRGRFAYALDQIEPTLRGLRESLARQPEATLLSTCNRTEIYCAG
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEECC
DHNDLEHTLEWLAHNGGVSPALLRSHAYTLQDDQAARHAFRVASGLDSMVLGEPQILGQL
CCCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHCCCHHHHHHH
KDAVRAAEDAGAMGSTLHQLFQRSFAVAKEVRTSTEIGAHSISMAAASVRLAGQLFENLG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCC
DIRVLFVGAGEMIDLAATHFAAKTPKSMAIANRTLERGEKLASRFGAEVMRLADLPSRLH
CEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EFDAVISCTASTLPIIGLGAVERAVKLRKHRPMFMVDLAVPRDIEPEVKDLPDIYLYTVD
HHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCCCEEEEEHH
DLAHVVQTGKDNRQAAVAQAEVIIDAGVQNFMHWLGQRRTVPLIQQLNAQTDEWRAAEIA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHH
RAKKLIAKGEPMDAVLDALTRGLTQKMLHGALAELHAGDAASREATAHTVSRLFLRGQPP
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
KEHKER
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA