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The map label for this gene is mscL [H]

Identifier: 91786722

GI number: 91786722

Start: 842733

End: 843188

Strand: Reverse

Name: mscL [H]

Synonym: Bpro_0820

Alternate gene names: 91786722

Gene position: 843188-842733 (Counterclockwise)

Preceding gene: 91786728

Following gene: 91786719

Centisome position: 16.21

GC content: 57.02

Gene sequence:

>456_bases
ATGATTCACCAACAACAGGAGTTGCACATGGGAATGATGCAGGAATTCAGGGAATTTGCGGTCAAGGGCAATGTGATCGA
TCTGGCAGTGGGCGTGATCATAGGCGCGGCGTTCAGCAAGATTGTCGAATCCGTGGTGGGTGACCTGATCATGCCGGTCG
TGGGTGCCGTGGTAGGCAAGCTGGATTTTTCCAACCTGTTTGTGGTGATGGGCAGCGTGCCGCCGGGCACCGCCATGACG
CTGGACGCCCTGAAAAAGGCCGGCGTACCGGTGCTTGCCTATGGCAACTTCATCACCGTCGCCGTCAACTTTGCCATCCT
GGCCTTCATCATTTTCCTGATGATCAAGCAGATCAACCGGCTCAAACGCCGCCAGGAGACCCAGCCTGCGGCGCCCGCAA
CACCACCCGAAGACGTCATGCTGCTGCGCGAAATTCGCGACAGCCTGAAGAAATAA

Upstream 100 bases:

>100_bases
GCAGGGCGAGCGCTCTTTCAGGCCAATCGCAAGATACCGCGTCGAGCATCCGATCCAGCCTTCATAATGACTTTTCGACA
CTCACGAGGGGCGGTCAGCA

Downstream 100 bases:

>100_bases
GCACCCCCCTGTGGCTCGCTCACTTCGTGTAGCGGGCCTCTCCCCTACAGGGGACGGCGCCTGCCGGCTGGCAAAGCCAG
ACCGGCGCCCCCCGCTTGCG

Product: large-conductance mechanosensitive channel

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MIHQQQELHMGMMQEFREFAVKGNVIDLAVGVIIGAAFSKIVESVVGDLIMPVVGAVVGKLDFSNLFVVMGSVPPGTAMT
LDALKKAGVPVLAYGNFITVAVNFAILAFIIFLMIKQINRLKRRQETQPAAPATPPEDVMLLREIRDSLKK

Sequences:

>Translated_151_residues
MIHQQQELHMGMMQEFREFAVKGNVIDLAVGVIIGAAFSKIVESVVGDLIMPVVGAVVGKLDFSNLFVVMGSVPPGTAMT
LDALKKAGVPVLAYGNFITVAVNFAILAFIIFLMIKQINRLKRRQETQPAAPATPPEDVMLLREIRDSLKK
>Mature_151_residues
MIHQQQELHMGMMQEFREFAVKGNVIDLAVGVIIGAAFSKIVESVVGDLIMPVVGAVVGKLDFSNLFVVMGSVPPGTAMT
LDALKKAGVPVLAYGNFITVAVNFAILAFIIFLMIKQINRLKRRQETQPAAPATPPEDVMLLREIRDSLKK

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=143, Percent_Identity=50.3496503496504, Blast_Score=119, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 16464; Mature: 16464

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS01327 MSCL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHQQQELHMGMMQEFREFAVKGNVIDLAVGVIIGAAFSKIVESVVGDLIMPVVGAVVGK
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDFSNLFVVMGSVPPGTAMTLDALKKAGVPVLAYGNFITVAVNFAILAFIIFLMIKQINR
CCHHHHEEEECCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
LKRRQETQPAAPATPPEDVMLLREIRDSLKK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIHQQQELHMGMMQEFREFAVKGNVIDLAVGVIIGAAFSKIVESVVGDLIMPVVGAVVGK
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDFSNLFVVMGSVPPGTAMTLDALKKAGVPVLAYGNFITVAVNFAILAFIIFLMIKQINR
CCHHHHEEEECCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
LKRRQETQPAAPATPPEDVMLLREIRDSLKK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA