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The map label for this gene is lysA [H]

Identifier: 91786679

GI number: 91786679

Start: 799046

End: 800329

Strand: Reverse

Name: lysA [H]

Synonym: Bpro_0777

Alternate gene names: 91786679

Gene position: 800329-799046 (Counterclockwise)

Preceding gene: 91786682

Following gene: 91786673

Centisome position: 15.39

GC content: 63.71

Gene sequence:

>1284_bases
ATGACAGACCACAAACTCCCCGGCCACCCCCATTTTGCGTACCGTGGCAATGACCTGTTTGCCGAAGACCTGATGGTCAG
CGAGTTGGCGAGCCTGCACGGCACACCGCTATTTGTTTACTCCAAAGCGGCGATGCTGTCGGCCCTGGCCGCTTACCAGC
GCGGCTTTGCGGGGCGCGATGTGCAGATCTGCTATGCCATGAAGGCCAACTCTTCGCTGGGCGTGCTGCAAGTGTTTGCC
GGGGCCGGCTGCGGTTTCGACATTGTCTCGGGCGGCGAACTGGAACGTGTGCTCGCTGCAGGCGGCCAGGCCAACAAGAT
CATCTTCTCCGGGGTCGGCAAGACGCGGGCCGAGATGCGGCAGGCGCTGGCGGCTGGCATTGGCTGCTTCAACGTAGAGA
GCGAGGCCGAGCTGGACGTGCTGTCAGGCGTTGCTGCGGCGATGAACTTGCGTGCGCCGGTAAGCATTCGCGTCAATCCG
AATGTCGACCCCAAGACCCATCCCTATATTTCCACGGGCCTCAAGGGCAATAAATTCGGCGTCGCCCATGAGGATGCCCT
GCGCATTTACCAGCACGCGGCGGCCTTGCCCGGCTTGCAGGTTGCGGGTATCGACTGCCACATTGGCTCGCAGATCACCG
AAACCACACCCTACCTCGACGCGATGGACCGGGTGCTGGACCTGGTCGCGTCCATTGAAAGCGCAGGCATAGAGCTGGAG
CACATCGACTTCGGCGGCGGCCTGGGCATCAATTACAACGGCGACACCCCGCCCGAAGCCGACGTGCTCTGGCGGCAACT
GCTGGCCAAACTCGACGCGCGCGGCTACGGCAGCAAGAAACTGATGATTGAACCGGGCCGCTCGCTGGTGGGCAATGCCG
GCATCTGCCTGACCGAGGTGCTCTACCTGAAACCCGGCGAGCAGAAAAACTTCTGCATCATTGATGCGGCGATGAACGAC
TTGCCGCGACCGGCGATGTACCAAGCTTTTCACGCCATCGTGCCGGCGGTGGCCGGCGGTCCCGCCCCCGCCACGACGTA
TGACGTGGTCGGCCCGGTCTGTGAGAGCGGCGACTGGATAGGCCGTGACAGGCCTCTGGCGGTCAACGCGGGCGACGTGC
TGGCCGTGCTGTCAGCGGGCGCTTACTGCATGAGCATGGCCAGCAACTACAACACGCGCGGCCGCGCTGCCGAGGTGCTG
GTCGACGGCAGCCAGGCGCACCTGATACGCCGCCGCGAAGATGCGCAGGACCAGATGCGCCATGAGCAGCTGGTGGCCGA
ATAA

Upstream 100 bases:

>100_bases
GCGGGTTCGGCTTTGCGCCGTGAATCTGTCATGGCTTTCAAGCCAGGCCCTCCTTAAGATTAATCGCCCCAGACCTCCCG
TATTGACAAGCAGCTCATCC

Downstream 100 bases:

>100_bases
AGCCAGCGAGGGCACTGGCAGGGGCGCCCGCATCAGGCGATGCAGCCAGCCATTCAGGACGATAGCTTGACGCGCCCGCT
GGGCATGGGCAGCGGCCTCT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTDHKLPGHPHFAYRGNDLFAEDLMVSELASLHGTPLFVYSKAAMLSALAAYQRGFAGRDVQICYAMKANSSLGVLQVFA
GAGCGFDIVSGGELERVLAAGGQANKIIFSGVGKTRAEMRQALAAGIGCFNVESEAELDVLSGVAAAMNLRAPVSIRVNP
NVDPKTHPYISTGLKGNKFGVAHEDALRIYQHAAALPGLQVAGIDCHIGSQITETTPYLDAMDRVLDLVASIESAGIELE
HIDFGGGLGINYNGDTPPEADVLWRQLLAKLDARGYGSKKLMIEPGRSLVGNAGICLTEVLYLKPGEQKNFCIIDAAMND
LPRPAMYQAFHAIVPAVAGGPAPATTYDVVGPVCESGDWIGRDRPLAVNAGDVLAVLSAGAYCMSMASNYNTRGRAAEVL
VDGSQAHLIRRREDAQDQMRHEQLVAE

Sequences:

>Translated_427_residues
MTDHKLPGHPHFAYRGNDLFAEDLMVSELASLHGTPLFVYSKAAMLSALAAYQRGFAGRDVQICYAMKANSSLGVLQVFA
GAGCGFDIVSGGELERVLAAGGQANKIIFSGVGKTRAEMRQALAAGIGCFNVESEAELDVLSGVAAAMNLRAPVSIRVNP
NVDPKTHPYISTGLKGNKFGVAHEDALRIYQHAAALPGLQVAGIDCHIGSQITETTPYLDAMDRVLDLVASIESAGIELE
HIDFGGGLGINYNGDTPPEADVLWRQLLAKLDARGYGSKKLMIEPGRSLVGNAGICLTEVLYLKPGEQKNFCIIDAAMND
LPRPAMYQAFHAIVPAVAGGPAPATTYDVVGPVCESGDWIGRDRPLAVNAGDVLAVLSAGAYCMSMASNYNTRGRAAEVL
VDGSQAHLIRRREDAQDQMRHEQLVAE
>Mature_426_residues
TDHKLPGHPHFAYRGNDLFAEDLMVSELASLHGTPLFVYSKAAMLSALAAYQRGFAGRDVQICYAMKANSSLGVLQVFAG
AGCGFDIVSGGELERVLAAGGQANKIIFSGVGKTRAEMRQALAAGIGCFNVESEAELDVLSGVAAAMNLRAPVSIRVNPN
VDPKTHPYISTGLKGNKFGVAHEDALRIYQHAAALPGLQVAGIDCHIGSQITETTPYLDAMDRVLDLVASIESAGIELEH
IDFGGGLGINYNGDTPPEADVLWRQLLAKLDARGYGSKKLMIEPGRSLVGNAGICLTEVLYLKPGEQKNFCIIDAAMNDL
PRPAMYQAFHAIVPAVAGGPAPATTYDVVGPVCESGDWIGRDRPLAVNAGDVLAVLSAGAYCMSMASNYNTRGRAAEVLV
DGSQAHLIRRREDAQDQMRHEQLVAE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=361, Percent_Identity=24.9307479224377, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789203, Length=429, Percent_Identity=34.032634032634, Blast_Score=161, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17562780, Length=365, Percent_Identity=27.6712328767123, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24586472, Length=344, Percent_Identity=26.1627906976744, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45349; Mature: 45218

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDHKLPGHPHFAYRGNDLFAEDLMVSELASLHGTPLFVYSKAAMLSALAAYQRGFAGRD
CCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCC
VQICYAMKANSSLGVLQVFAGAGCGFDIVSGGELERVLAAGGQANKIIFSGVGKTRAEMR
EEEEEEEECCCCCCHHHHHHCCCCCCEECCCCHHHHHHHCCCCCCEEEEECCCHHHHHHH
QALAAGIGCFNVESEAELDVLSGVAAAMNLRAPVSIRVNPNVDPKTHPYISTGLKGNKFG
HHHHHCCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEECCCCCCCCC
VAHEDALRIYQHAAALPGLQVAGIDCHIGSQITETTPYLDAMDRVLDLVASIESAGIELE
CCHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHCCEEE
HIDFGGGLGINYNGDTPPEADVLWRQLLAKLDARGYGSKKLMIEPGRSLVGNAGICLTEV
EEECCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHCCCCHHHHHE
LYLKPGEQKNFCIIDAAMNDLPRPAMYQAFHAIVPAVAGGPAPATTYDVVGPVCESGDWI
EEECCCCCCCEEEEECHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHCCCCCC
GRDRPLAVNAGDVLAVLSAGAYCMSMASNYNTRGRAAEVLVDGSQAHLIRRREDAQDQMR
CCCCCEEECCCHHHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
HEQLVAE
HHHHHCC
>Mature Secondary Structure 
TDHKLPGHPHFAYRGNDLFAEDLMVSELASLHGTPLFVYSKAAMLSALAAYQRGFAGRD
CCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCC
VQICYAMKANSSLGVLQVFAGAGCGFDIVSGGELERVLAAGGQANKIIFSGVGKTRAEMR
EEEEEEEECCCCCCHHHHHHCCCCCCEECCCCHHHHHHHCCCCCCEEEEECCCHHHHHHH
QALAAGIGCFNVESEAELDVLSGVAAAMNLRAPVSIRVNPNVDPKTHPYISTGLKGNKFG
HHHHHCCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEECCCCCCCCC
VAHEDALRIYQHAAALPGLQVAGIDCHIGSQITETTPYLDAMDRVLDLVASIESAGIELE
CCHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHCCEEE
HIDFGGGLGINYNGDTPPEADVLWRQLLAKLDARGYGSKKLMIEPGRSLVGNAGICLTEV
EEECCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHCCCCHHHHHE
LYLKPGEQKNFCIIDAAMNDLPRPAMYQAFHAIVPAVAGGPAPATTYDVVGPVCESGDWI
EEECCCCCCCEEEEECHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHCCCCCC
GRDRPLAVNAGDVLAVLSAGAYCMSMASNYNTRGRAAEVLVDGSQAHLIRRREDAQDQMR
CCCCCEEECCCHHHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
HEQLVAE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]