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The map label for this gene is ilvA [H]

Identifier: 91786645

GI number: 91786645

Start: 758142

End: 759701

Strand: Reverse

Name: ilvA [H]

Synonym: Bpro_0743

Alternate gene names: 91786645

Gene position: 759701-758142 (Counterclockwise)

Preceding gene: 91786647

Following gene: 91786644

Centisome position: 14.61

GC content: 62.95

Gene sequence:

>1560_bases
GTGTCTGCGCAAGGCCTCACGCCCGCGGATTACCTGAAGAAAATCCTCACCGCGCGCGTCTACGACGTCGCGCTGGAATC
GGCCCTGGAGCCCGCCAAAAACCTGGGCCGCCGGCTGAACAACACCGTGCTGCTCAAGCGTGAAGACCAGCAGCCCGTCT
TCAGCTTCAAGCTGCGCGGCGCCTATAACAAGATGGCGCACCTCAGCAGCGCCCAGCTCAAGAAAGGCGTGATTTGCGCC
TCGGCCGGCAACCATGCCCAGGGCGTGGCCCTGAGCGCGCAAAAACTCGGCACCCGCGCCGTGGTGGTGATGCCGACGAC
CACGCCACAGGTCAAGATCGATGCGGTCAAGGGCTGGGGCGCAGAAGTGGTACTGCACGGCGACAGCTACTCGGATGCCT
ACGCCCACGCCGTGCTGCTGGAAAAAAAGCGTGGATTGACCTTTGTACATCCTTTCGACGACCCGGACGTGATTGCCGGC
CAGGGCACGATTGCGATGGAAATCCTGATGCAGCTGCAAAGCCTGGGGTCGCGCCGGCTGGACGCCGTGTTTGTCGCCAT
TGGCGGCGGCGGCCTGATTGCCGGGGTGGCCAACTACATCAAGGCGGTGCGACCCGAGATCAAAGTCATCGGCGTGCAGA
TGAACGACTCCGACGCGATGATGCAGTCGGTGACCGCGAAAAAGCGCGTCACCCTGAATGACGTGGGCCTGTTTTCAGAC
GGCACGGCCGTCAAGCTGGTGGGCGAGGAAACCTTTCGCATCAGCCGCGAACTGGTCGACGAATTCATGACCGTGGACAC
CGATGCGGTGTGCGCCGCCATCAAGGACGTGTTTGTGGACACGCGCAGCATCGTGGAGCCTGCCGGCGCGCTGGCCGTGG
CCGCCATCAAGCAGTACGTGGCCACGCACAAGACCAAAGGGGAAACCTACGCAGCCATTTTGTGCGGCGCCAACATGAAC
TTCGACCGCCTGCGCTTTGTGGCCGAGCGGGCTGAAGTGGGCGAGGAACGCGAGGCGCTGTTTGCCGTGACGATTCCCGA
AGAGCGCGGCAGCTTCCGGCACTTTTGCGAACTGATTGGCGAGTTGCCCGGCGGCCCGCGCAGCGTGACCGAATTCAACT
ACCGCATCAGCGACGACGAGAAAGCCCATGTCTTTGTGGGCCTGACCACCTCGGCCAAGGGCGAGAGCAGCAAGATCGCG
GCCAACTTCTCCCGCCACGGCTTCAAGGCGCTCGACCTCACGCATGACGAGCTCGCCAAGGAACATATCCGCCACATGGT
GGGCGGGCACAGCGCACTGTCCAAGGACGAACGCCTGCTGCGCTTCATCTTTCCCGAGCGGCCCGGCGCGCTGATGAAAT
TTTTGTCCAGCATGCAGCCGGGATGGAACATCAGCCTCTTTCACTACCGCAACCAGGGCGCCGACTACGGCCGCATCCTG
GTGGGCCTGCAGGTGCCCAAGGCCGACAACAAGGCCTTCAAGGCCTTCCTGGACACCCTGGGCTACCCCCACGTGGAAGA
AACCGACAACCCCGTCTACCGGCTGTTTCTGCAGAGCTGA

Upstream 100 bases:

>100_bases
TTTCTTGCCCACTATGATGTTGGACTGCGAGAAAAACATGCCAACCCACACCCCCCCTGCTGCCTACCCCTCCCCTCAAG
CGGCCAAAACCGCACGCAAA

Downstream 100 bases:

>100_bases
CCGGACAAACGCATGACTTCACAAGGCTCGCCATCACCAGAAACACCGGGAGCCGGCTTGCCCGACACCTCGCCCACCTC
GGTGTGCCCGCGCTGCGGCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MSAQGLTPADYLKKILTARVYDVALESALEPAKNLGRRLNNTVLLKREDQQPVFSFKLRGAYNKMAHLSSAQLKKGVICA
SAGNHAQGVALSAQKLGTRAVVVMPTTTPQVKIDAVKGWGAEVVLHGDSYSDAYAHAVLLEKKRGLTFVHPFDDPDVIAG
QGTIAMEILMQLQSLGSRRLDAVFVAIGGGGLIAGVANYIKAVRPEIKVIGVQMNDSDAMMQSVTAKKRVTLNDVGLFSD
GTAVKLVGEETFRISRELVDEFMTVDTDAVCAAIKDVFVDTRSIVEPAGALAVAAIKQYVATHKTKGETYAAILCGANMN
FDRLRFVAERAEVGEEREALFAVTIPEERGSFRHFCELIGELPGGPRSVTEFNYRISDDEKAHVFVGLTTSAKGESSKIA
ANFSRHGFKALDLTHDELAKEHIRHMVGGHSALSKDERLLRFIFPERPGALMKFLSSMQPGWNISLFHYRNQGADYGRIL
VGLQVPKADNKAFKAFLDTLGYPHVEETDNPVYRLFLQS

Sequences:

>Translated_519_residues
MSAQGLTPADYLKKILTARVYDVALESALEPAKNLGRRLNNTVLLKREDQQPVFSFKLRGAYNKMAHLSSAQLKKGVICA
SAGNHAQGVALSAQKLGTRAVVVMPTTTPQVKIDAVKGWGAEVVLHGDSYSDAYAHAVLLEKKRGLTFVHPFDDPDVIAG
QGTIAMEILMQLQSLGSRRLDAVFVAIGGGGLIAGVANYIKAVRPEIKVIGVQMNDSDAMMQSVTAKKRVTLNDVGLFSD
GTAVKLVGEETFRISRELVDEFMTVDTDAVCAAIKDVFVDTRSIVEPAGALAVAAIKQYVATHKTKGETYAAILCGANMN
FDRLRFVAERAEVGEEREALFAVTIPEERGSFRHFCELIGELPGGPRSVTEFNYRISDDEKAHVFVGLTTSAKGESSKIA
ANFSRHGFKALDLTHDELAKEHIRHMVGGHSALSKDERLLRFIFPERPGALMKFLSSMQPGWNISLFHYRNQGADYGRIL
VGLQVPKADNKAFKAFLDTLGYPHVEETDNPVYRLFLQS
>Mature_518_residues
SAQGLTPADYLKKILTARVYDVALESALEPAKNLGRRLNNTVLLKREDQQPVFSFKLRGAYNKMAHLSSAQLKKGVICAS
AGNHAQGVALSAQKLGTRAVVVMPTTTPQVKIDAVKGWGAEVVLHGDSYSDAYAHAVLLEKKRGLTFVHPFDDPDVIAGQ
GTIAMEILMQLQSLGSRRLDAVFVAIGGGGLIAGVANYIKAVRPEIKVIGVQMNDSDAMMQSVTAKKRVTLNDVGLFSDG
TAVKLVGEETFRISRELVDEFMTVDTDAVCAAIKDVFVDTRSIVEPAGALAVAAIKQYVATHKTKGETYAAILCGANMNF
DRLRFVAERAEVGEEREALFAVTIPEERGSFRHFCELIGELPGGPRSVTEFNYRISDDEKAHVFVGLTTSAKGESSKIAA
NFSRHGFKALDLTHDELAKEHIRHMVGGHSALSKDERLLRFIFPERPGALMKFLSSMQPGWNISLFHYRNQGADYGRILV
GLQVPKADNKAFKAFLDTLGYPHVEETDNPVYRLFLQS

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=304, Percent_Identity=33.2236842105263, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=30.2250803858521, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI19923959, Length=309, Percent_Identity=28.8025889967638, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790207, Length=510, Percent_Identity=51.3725490196078, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1789505, Length=318, Percent_Identity=39.622641509434, Blast_Score=174, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI71991565, Length=362, Percent_Identity=29.8342541436464, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17537387, Length=351, Percent_Identity=31.6239316239316, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17508781, Length=294, Percent_Identity=28.5714285714286, Blast_Score=118, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320930, Length=526, Percent_Identity=48.4790874524715, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322631, Length=305, Percent_Identity=33.4426229508197, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319788, Length=266, Percent_Identity=24.812030075188, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355833, Length=315, Percent_Identity=31.4285714285714, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24645328, Length=256, Percent_Identity=28.90625, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56740; Mature: 56609

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQGLTPADYLKKILTARVYDVALESALEPAKNLGRRLNNTVLLKREDQQPVFSFKLRG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECC
AYNKMAHLSSAQLKKGVICASAGNHAQGVALSAQKLGTRAVVVMPTTTPQVKIDAVKGWG
HHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEHHHCCCEEEEEEECCCCCEEEEEECCCC
AEVVLHGDSYSDAYAHAVLLEKKRGLTFVHPFDDPDVIAGQGTIAMEILMQLQSLGSRRL
CEEEEECCCCCHHHHHHHEEECCCCCEEECCCCCCCEEECCCHHHHHHHHHHHHCCCCCE
DAVFVAIGGGGLIAGVANYIKAVRPEIKVIGVQMNDSDAMMQSVTAKKRVTLNDVGLFSD
EEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHCCEEEECCCEECC
GTAVKLVGEETFRISRELVDEFMTVDTDAVCAAIKDVFVDTRSIVEPAGALAVAAIKQYV
CCEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ATHKTKGETYAAILCGANMNFDRLRFVAERAEVGEEREALFAVTIPEERGSFRHFCELIG
HHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHH
ELPGGPRSVTEFNYRISDDEKAHVFVGLTTSAKGESSKIAANFSRHGFKALDLTHDELAK
HCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCCCEEECHHHCCCEEECCCHHHHHH
EHIRHMVGGHSALSKDERLLRFIFPERPGALMKFLSSMQPGWNISLFHYRNQGADYGRIL
HHHHHHHCCCHHHCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEE
VGLQVPKADNKAFKAFLDTLGYPHVEETDNPVYRLFLQS
EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
SAQGLTPADYLKKILTARVYDVALESALEPAKNLGRRLNNTVLLKREDQQPVFSFKLRG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECC
AYNKMAHLSSAQLKKGVICASAGNHAQGVALSAQKLGTRAVVVMPTTTPQVKIDAVKGWG
HHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEHHHCCCEEEEEEECCCCCEEEEEECCCC
AEVVLHGDSYSDAYAHAVLLEKKRGLTFVHPFDDPDVIAGQGTIAMEILMQLQSLGSRRL
CEEEEECCCCCHHHHHHHEEECCCCCEEECCCCCCCEEECCCHHHHHHHHHHHHCCCCCE
DAVFVAIGGGGLIAGVANYIKAVRPEIKVIGVQMNDSDAMMQSVTAKKRVTLNDVGLFSD
EEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHCCEEEECCCEECC
GTAVKLVGEETFRISRELVDEFMTVDTDAVCAAIKDVFVDTRSIVEPAGALAVAAIKQYV
CCEEEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ATHKTKGETYAAILCGANMNFDRLRFVAERAEVGEEREALFAVTIPEERGSFRHFCELIG
HHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHH
ELPGGPRSVTEFNYRISDDEKAHVFVGLTTSAKGESSKIAANFSRHGFKALDLTHDELAK
HCCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCCCCEEECHHHCCCEEECCCHHHHHH
EHIRHMVGGHSALSKDERLLRFIFPERPGALMKFLSSMQPGWNISLFHYRNQGADYGRIL
HHHHHHHCCCHHHCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEE
VGLQVPKADNKAFKAFLDTLGYPHVEETDNPVYRLFLQS
EEEECCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA