Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 91786496

GI number: 91786496

Start: 594070

End: 595314

Strand: Reverse

Name: acdA [H]

Synonym: Bpro_0590

Alternate gene names: 91786496

Gene position: 595314-594070 (Counterclockwise)

Preceding gene: 91786497

Following gene: 91786495

Centisome position: 11.45

GC content: 68.19

Gene sequence:

>1245_bases
ATGAACCCGACGACAGCACATCTGGCACTGCCGTTTTTTGACGGCGTGCACCGTGATCTCGGCCAGCGGCTGGCCGAGTG
GATCCCCCACCAGCACATCGACGAGCGTGACGACCGCCAGGCCTGCCGGGAGTGGGTCCGGCTGCTGGGCGCCCACCAGT
GGCTGCGCTACTGCGTGCCCGCGGGCAAAGACGGCGTGCTGGGCGGCGCGCTCGACCAGCTCGACTCGCGGGCGCTCGTC
ATTTTGCGCGAGATGCTGGCCTTCCACTCGCCGCTGGCCGACTTCGCGTTTGCGATGCAGGGGCTGGGCAGCGGCGCCAT
CACGCTGGCCGGCTCACCCGAGCAGCAGGCCGCCTACCTGCCACAGGTGGCCCGCGGCGAGAAAATCGCCGCCTTTGCGC
TGAGCGAGGCCGACGCCGGCTCCGACGTCGGCGCCATGCAAACCAGCGCCACCCACACGGGCGACGGCTGGGCCCTCAAC
GGCAGCAAGACCTGGATCAGCAACGGCGGCATCGCTGATTTCTACGTCACCTTTGCCAAGACCGAACCCGACGCCGGCAC
GCGCGGCATCACGGCCTTCATCGTCGATGCCCCGACACAGGGCCTGGACAGCGGCGAGGCGATCGCGGTGATCTCGCCCC
ACCCGCTGGCCACGCTGAAATTCACCCATTGCAGGCTGGCCGACAGCACGCAGCTGGGCACGCTGCACGGCGGCTTCAAG
CTGGCGATGCAGACGCTGGACATTTTCCGGGCATCCGTGGCCGGCGCCGCGCTGGGCATGGCGCGCCGCGCGCTCGCCGA
GGCCGTGCAGTTTGCCCAGGCGCGAAAAATGTTCGGTCAGACGCTGGCGGATTTTCAGCTGACCCAGGCCAAACTCGGCG
AGATGGCGGCCCTGGTGGACGCAGCGGCGCTGCTGACCTATCGCGCCGCCTGGATGCGCGACCATCACAACGCTCCGGGC
GAGCATCCGGACAACGCCGCCACCACTGCCACCACTGCCATCACCGCCACCACGGAGGCCGAAGGCCGCCGGGACCGCAC
CGTGGCTGCCGCGATGGCCAAAATGACGGCCACCGAAAACGCCCAGCGGGTGATCGACATGGCGCTGCAGATGCATGGCG
GCCAGGGCGTGAAGGTGGGCAGCAAGGTGGAAAGCCTGTACCGTGACATCCGCTCGCTGCGGATTTACGAAGGCGCCACC
GAGGTCCAGCAACTCATCATCGGCAAGGCGGTGTTGCAATCATGA

Upstream 100 bases:

>100_bases
CTTCACGCGCGCCTACGAAGCCTTTGCCGCCAAACAAAAACCGGTGTTCCAGGGCGACTGAGCGCCGGGCACAGTCCACA
GTCATAAGGAGGTTTTCAGC

Downstream 100 bases:

>100_bases
ATACGCCCACACACGCACCAGCCTCGAAGGCGCCCTCTGCGCAGACCGACTGCTTCGTGCACGACCGCCTGCCAACGCCC
GACCAGTGGCCGAAACTGGT

Product: acyl-CoA dehydrogenase-like protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNPTTAHLALPFFDGVHRDLGQRLAEWIPHQHIDERDDRQACREWVRLLGAHQWLRYCVPAGKDGVLGGALDQLDSRALV
ILREMLAFHSPLADFAFAMQGLGSGAITLAGSPEQQAAYLPQVARGEKIAAFALSEADAGSDVGAMQTSATHTGDGWALN
GSKTWISNGGIADFYVTFAKTEPDAGTRGITAFIVDAPTQGLDSGEAIAVISPHPLATLKFTHCRLADSTQLGTLHGGFK
LAMQTLDIFRASVAGAALGMARRALAEAVQFAQARKMFGQTLADFQLTQAKLGEMAALVDAAALLTYRAAWMRDHHNAPG
EHPDNAATTATTAITATTEAEGRRDRTVAAAMAKMTATENAQRVIDMALQMHGGQGVKVGSKVESLYRDIRSLRIYEGAT
EVQQLIIGKAVLQS

Sequences:

>Translated_414_residues
MNPTTAHLALPFFDGVHRDLGQRLAEWIPHQHIDERDDRQACREWVRLLGAHQWLRYCVPAGKDGVLGGALDQLDSRALV
ILREMLAFHSPLADFAFAMQGLGSGAITLAGSPEQQAAYLPQVARGEKIAAFALSEADAGSDVGAMQTSATHTGDGWALN
GSKTWISNGGIADFYVTFAKTEPDAGTRGITAFIVDAPTQGLDSGEAIAVISPHPLATLKFTHCRLADSTQLGTLHGGFK
LAMQTLDIFRASVAGAALGMARRALAEAVQFAQARKMFGQTLADFQLTQAKLGEMAALVDAAALLTYRAAWMRDHHNAPG
EHPDNAATTATTAITATTEAEGRRDRTVAAAMAKMTATENAQRVIDMALQMHGGQGVKVGSKVESLYRDIRSLRIYEGAT
EVQQLIIGKAVLQS
>Mature_414_residues
MNPTTAHLALPFFDGVHRDLGQRLAEWIPHQHIDERDDRQACREWVRLLGAHQWLRYCVPAGKDGVLGGALDQLDSRALV
ILREMLAFHSPLADFAFAMQGLGSGAITLAGSPEQQAAYLPQVARGEKIAAFALSEADAGSDVGAMQTSATHTGDGWALN
GSKTWISNGGIADFYVTFAKTEPDAGTRGITAFIVDAPTQGLDSGEAIAVISPHPLATLKFTHCRLADSTQLGTLHGGFK
LAMQTLDIFRASVAGAALGMARRALAEAVQFAQARKMFGQTLADFQLTQAKLGEMAALVDAAALLTYRAAWMRDHHNAPG
EHPDNAATTATTAITATTEAEGRRDRTVAAAMAKMTATENAQRVIDMALQMHGGQGVKVGSKVESLYRDIRSLRIYEGAT
EVQQLIIGKAVLQS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=312, Percent_Identity=39.1025641025641, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI21361497, Length=324, Percent_Identity=33.9506172839506, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI187960098, Length=335, Percent_Identity=32.2388059701493, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4557231, Length=335, Percent_Identity=32.2388059701493, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4557235, Length=319, Percent_Identity=34.4827586206897, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI76496475, Length=319, Percent_Identity=34.4827586206897, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI4501859, Length=335, Percent_Identity=31.3432835820896, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI7656849, Length=350, Percent_Identity=29.4285714285714, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI226958412, Length=422, Percent_Identity=28.436018957346, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI226958414, Length=304, Percent_Identity=30.9210526315789, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4501857, Length=363, Percent_Identity=28.3746556473829, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI4503943, Length=311, Percent_Identity=27.6527331189711, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI7669494, Length=192, Percent_Identity=34.375, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI211971008, Length=313, Percent_Identity=25.2396166134185, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI48976061, Length=313, Percent_Identity=25.2396166134185, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786223, Length=304, Percent_Identity=26.6447368421053, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87081958, Length=291, Percent_Identity=26.4604810996564, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17534899, Length=352, Percent_Identity=31.25, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17569725, Length=311, Percent_Identity=30.8681672025724, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17508101, Length=336, Percent_Identity=30.952380952381, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17533517, Length=304, Percent_Identity=32.2368421052632, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=318, Percent_Identity=33.3333333333333, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17570075, Length=344, Percent_Identity=28.7790697674419, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17538396, Length=307, Percent_Identity=32.5732899022801, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17506239, Length=337, Percent_Identity=29.080118694362, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71990804, Length=207, Percent_Identity=34.7826086956522, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71985192, Length=218, Percent_Identity=35.3211009174312, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32563615, Length=213, Percent_Identity=30.9859154929577, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71982178, Length=177, Percent_Identity=35.5932203389831, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17534353, Length=311, Percent_Identity=26.3665594855305, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17551932, Length=318, Percent_Identity=28.6163522012579, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17505929, Length=407, Percent_Identity=25.5528255528256, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17531909, Length=268, Percent_Identity=27.2388059701493, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562446, Length=324, Percent_Identity=27.1604938271605, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356377, Length=305, Percent_Identity=36.7213114754098, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24646207, Length=342, Percent_Identity=34.5029239766082, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24660351, Length=351, Percent_Identity=32.7635327635328, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281363737, Length=319, Percent_Identity=33.5423197492163, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24666513, Length=335, Percent_Identity=31.6417910447761, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=27.5064267352185, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI19920834, Length=342, Percent_Identity=28.3625730994152, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 44228; Mature: 44228

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTTAHLALPFFDGVHRDLGQRLAEWIPHQHIDERDDRQACREWVRLLGAHQWLRYCVP
CCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
AGKDGVLGGALDQLDSRALVILREMLAFHSPLADFAFAMQGLGSGAITLAGSPEQQAAYL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCCHHHHHC
PQVARGEKIAAFALSEADAGSDVGAMQTSATHTGDGWALNGSKTWISNGGIADFYVTFAK
CHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCEEECCCCEEEEEEEEEC
TEPDAGTRGITAFIVDAPTQGLDSGEAIAVISPHPLATLKFTHCRLADSTQLGTLHGGFK
CCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCCCHHH
LAMQTLDIFRASVAGAALGMARRALAEAVQFAQARKMFGQTLADFQLTQAKLGEMAALVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALLTYRAAWMRDHHNAPGEHPDNAATTATTAITATTEAEGRRDRTVAAAMAKMTATEN
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHH
AQRVIDMALQMHGGQGVKVGSKVESLYRDIRSLRIYEGATEVQQLIIGKAVLQS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPTTAHLALPFFDGVHRDLGQRLAEWIPHQHIDERDDRQACREWVRLLGAHQWLRYCVP
CCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
AGKDGVLGGALDQLDSRALVILREMLAFHSPLADFAFAMQGLGSGAITLAGSPEQQAAYL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCCHHHHHC
PQVARGEKIAAFALSEADAGSDVGAMQTSATHTGDGWALNGSKTWISNGGIADFYVTFAK
CHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCEEECCCCEEEEEEEEEC
TEPDAGTRGITAFIVDAPTQGLDSGEAIAVISPHPLATLKFTHCRLADSTQLGTLHGGFK
CCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCCCHHH
LAMQTLDIFRASVAGAALGMARRALAEAVQFAQARKMFGQTLADFQLTQAKLGEMAALVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAALLTYRAAWMRDHHNAPGEHPDNAATTATTAITATTEAEGRRDRTVAAAMAKMTATEN
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHH
AQRVIDMALQMHGGQGVKVGSKVESLYRDIRSLRIYEGATEVQQLIIGKAVLQS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]