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The map label for this gene is phhA [H]

Identifier: 91786079

GI number: 91786079

Start: 182345

End: 183244

Strand: Reverse

Name: phhA [H]

Synonym: Bpro_0168

Alternate gene names: 91786079

Gene position: 183244-182345 (Counterclockwise)

Preceding gene: 91786080

Following gene: 91786078

Centisome position: 3.52

GC content: 64.56

Gene sequence:

>900_bases
ATGCAGACACTCCCAGACACCAGCAGCAAACACGGCCTGGCGGCCGGCGACACGGCCCAGCCGGAGCGGGCCGACTGGAC
CATGGACCAGGGCTGGGAACACTACAGCGCCGAAGAGCACGGCATCTGGAAGACGCTGTTCGAACGCCAGCGCCGCCTGC
TGCCCGGGCGCGCCTGCGATGCTTTCGTGGAGGGCATGGCCCGGCTGCCGATAGGCGCAGACCAGATTCCCGATTTCCGG
CGCCTGTCCGACACCTTGATGCAGCGCACCGGCTGGCAGGTGGTTGCCGTGCCGGGCCTGGTGCCCGATGATGTGTTCTT
TGAACACTTGGCGAACCGCCGCTTTCCCGCGGGCCAGTTCATCCGCGGGCGGCACCAGCTGGACTACCTGGAAGAGCCCG
ATGTTTTTCACGACGTATTCGGCCACGTGCCCATGCTGATGAACCCGGCCATTGCGGACTACATCCAGGCCTATGGCGTG
GGTGGGCTGCGCGCGCAGAAGCTGGGCGTGCTCGACAAGCTGGCGCGCGTCTACTGGTACACGGTCGAATTCGGCCTGGT
GCAGCAACAGGACGGCTTGCGTATTTATGGCGCCGGCATCGCCTCGTCCGCCGCGGAAAGCGTGTTTGCGCTCGATGATG
CCTCGCCGAACCGGCTGGGCTTTGAGCTGGAGCGGGTGATGCGCACGCAGTACCGGATTGACGATTTCCAGGAAAGCTAC
TTTGTGATTGACGACCTGGACGAATTGCTGGCACTGGCGAAGATCGATTTTGCGGCCAGCTACGCGCGGGTGCAGGACCA
GCCCGACCACACGCCGGGAACGGTGCTGCCAACAGACCGGATGTTCACCCGCGGATCGGGCCATTACCACCACGCCAAAC
GGCAGGGAGCAGCAGCATGA

Upstream 100 bases:

>100_bases
CACGACGTCCAGGGCCTGTCGACCAACGACGTCGACCTGGCACAACAGGTCGATGCCATCTACGCCCCCTTGAACACCCC
GCGCGCTTAGGCAAGACACC

Downstream 100 bases:

>100_bases
ACTTCAAGCATCGCACCGTGATGGTGACCGGCGCCGCAGGCAACCTGGGGCAAGCGGTGGCGGCCGCATTTTCGGCACAG
GGCGCACAACTGGTGCTGCT

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MQTLPDTSSKHGLAAGDTAQPERADWTMDQGWEHYSAEEHGIWKTLFERQRRLLPGRACDAFVEGMARLPIGADQIPDFR
RLSDTLMQRTGWQVVAVPGLVPDDVFFEHLANRRFPAGQFIRGRHQLDYLEEPDVFHDVFGHVPMLMNPAIADYIQAYGV
GGLRAQKLGVLDKLARVYWYTVEFGLVQQQDGLRIYGAGIASSAAESVFALDDASPNRLGFELERVMRTQYRIDDFQESY
FVIDDLDELLALAKIDFAASYARVQDQPDHTPGTVLPTDRMFTRGSGHYHHAKRQGAAA

Sequences:

>Translated_299_residues
MQTLPDTSSKHGLAAGDTAQPERADWTMDQGWEHYSAEEHGIWKTLFERQRRLLPGRACDAFVEGMARLPIGADQIPDFR
RLSDTLMQRTGWQVVAVPGLVPDDVFFEHLANRRFPAGQFIRGRHQLDYLEEPDVFHDVFGHVPMLMNPAIADYIQAYGV
GGLRAQKLGVLDKLARVYWYTVEFGLVQQQDGLRIYGAGIASSAAESVFALDDASPNRLGFELERVMRTQYRIDDFQESY
FVIDDLDELLALAKIDFAASYARVQDQPDHTPGTVLPTDRMFTRGSGHYHHAKRQGAAA
>Mature_299_residues
MQTLPDTSSKHGLAAGDTAQPERADWTMDQGWEHYSAEEHGIWKTLFERQRRLLPGRACDAFVEGMARLPIGADQIPDFR
RLSDTLMQRTGWQVVAVPGLVPDDVFFEHLANRRFPAGQFIRGRHQLDYLEEPDVFHDVFGHVPMLMNPAIADYIQAYGV
GGLRAQKLGVLDKLARVYWYTVEFGLVQQQDGLRIYGAGIASSAAESVFALDDASPNRLGFELERVMRTQYRIDDFQESY
FVIDDLDELLALAKIDFAASYARVQDQPDHTPGTVLPTDRMFTRGSGHYHHAKRQGAAA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI31795563, Length=235, Percent_Identity=34.8936170212766, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI4557819, Length=234, Percent_Identity=33.7606837606838, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI4759248, Length=218, Percent_Identity=33.0275229357798, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI88900501, Length=235, Percent_Identity=33.1914893617021, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI88900505, Length=235, Percent_Identity=33.1914893617021, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI88900503, Length=235, Percent_Identity=33.1914893617021, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71980736, Length=278, Percent_Identity=31.6546762589928, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17531391, Length=216, Percent_Identity=34.2592592592593, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI115532103, Length=231, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI115533973, Length=231, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71980731, Length=189, Percent_Identity=29.6296296296296, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI62472054, Length=233, Percent_Identity=34.3347639484979, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24660393, Length=233, Percent_Identity=34.3347639484979, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136774, Length=218, Percent_Identity=30.2752293577982, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136776, Length=218, Percent_Identity=30.2752293577982, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24654994, Length=221, Percent_Identity=32.1266968325792, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33712; Mature: 33712

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLPDTSSKHGLAAGDTAQPERADWTMDQGWEHYSAEEHGIWKTLFERQRRLLPGRACD
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHCCCCCCHHHHHHHHHHHHCCCCHHHH
AFVEGMARLPIGADQIPDFRRLSDTLMQRTGWQVVAVPGLVPDDVFFEHLANRRFPAGQF
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCHH
IRGRHQLDYLEEPDVFHDVFGHVPMLMNPAIADYIQAYGVGGLRAQKLGVLDKLARVYWY
HHCCHHCCCCCCCHHHHHHHCCCHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
TVEFGLVQQQDGLRIYGAGIASSAAESVFALDDASPNRLGFELERVMRTQYRIDDFQESY
HEEECEEECCCCCEEEECCHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCE
FVIDDLDELLALAKIDFAASYARVQDQPDHTPGTVLPTDRMFTRGSGHYHHAKRQGAAA
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MQTLPDTSSKHGLAAGDTAQPERADWTMDQGWEHYSAEEHGIWKTLFERQRRLLPGRACD
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHCCCCCCHHHHHHHHHHHHCCCCHHHH
AFVEGMARLPIGADQIPDFRRLSDTLMQRTGWQVVAVPGLVPDDVFFEHLANRRFPAGQF
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCHH
IRGRHQLDYLEEPDVFHDVFGHVPMLMNPAIADYIQAYGVGGLRAQKLGVLDKLARVYWY
HHCCHHCCCCCCCHHHHHHHCCCHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
TVEFGLVQQQDGLRIYGAGIASSAAESVFALDDASPNRLGFELERVMRTQYRIDDFQESY
HEEECEEECCCCCEEEECCHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCE
FVIDDLDELLALAKIDFAASYARVQDQPDHTPGTVLPTDRMFTRGSGHYHHAKRQGAAA
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]