Click here to switch to the map view.

The map label for this gene is argA [H]

Identifier: 161936269

GI number: 161936269

Start: 2492137

End: 2493486

Strand: Reverse

Name: argA [H]

Synonym: Bpro_2397

Alternate gene names: 161936269

Gene position: 2493486-2492137 (Counterclockwise)

Preceding gene: 91788266

Following gene: 91788262

Centisome position: 47.95

GC content: 63.19

Gene sequence:

>1350_bases
ATGTCCACCGTTTTCAATTTCACCTTTGTCCCCTGGTTCCGCTCGGTGGCGCCCTACATCCACACGCACCGCGGCAAGAC
CTTTGTCGTGGGCATTGCGGGCGAGGCGATTGCCGCCGGCAAGCTGCCGCACATTGCGCAGGACCTGGCCTTGATCCAGA
GCATGGGCGTGAAGATAGTGCTGGTGCACGGCTTTCGTCCCCAGGTCAATGAACAGCTCAAGGCCAAAGGCCACGCGGCC
AGGTATTCCCACGGCATGCGCATCACCGACGAGGTGGCGCTGGACTGTGCCCAGGAAGCGGCCGGCCAGTTGCGCTATGA
AATCGAGGCGGCCTTCAGCCAGGGCCTGCCCAATACGCCCATGGCGGGCTCCACCGTGCGCGTGATTTCAGGCAACTTCC
TCACCGCGCGTCCGGTGGGCATCCTGGACGGGGTGGATTTCAAGCACTCCGGCATGGTGCGCAAGGTGGATGTGGCGGGC
ATCACCCGCACGCTCGATTTCGGCGCCATGGTGCTGTTGTCGCCGTTCGGCTTCTCGCCGACGGGCGAAGCCTTCAACCT
GACCATGGAAGAAGTCGCCACCTCGGTGGCGATTGCCATGCAGGCCGACAAACTGATTTTCCTGACCGAGATCCCCGGCA
TCCGTATCCACCACGACCAGCCCGCCAGCGAAGACAACCCGATAGACACCGAGTTGCCACTGGCCGCCGCCGAAAAGCTG
CTGACCACCCTGCCCAATGGCGAGCGGCCAACCGACACCGCGTTTTACCTGCAGCACTGCGTCAAGGCCTGCAAGGCGGG
CGTGGAACGCAGCCACATCCTGCCCTTTGCGGTCGACGGCTCCCTGCTGCTCGAAATTTATGTGCACGACGGCATAGGCA
CCATGGTGGTCGATGAGAAGCTGGAGTCCTTGCGCGAGGCCACCGCCGACGACGTGGGCGGCATCCTGCAGCTGATTGAG
CCATTTGAAAAAGACGGCACCCTGGTCAAACGCGGCCGCACGGAAATCGAGCGCGACGCCGACCTGTACACCATCATCGA
ACACGACGGCGTGATCTTTGGCTGCGCCGCGCTCTACCCCTACCCCGAAGCCAAAACCGCCGAGATGGCCGCGCTCACGG
TGTCGCCGCAAAGCCAGGGCCAGGGCGACGGCGAGAAAATCCTCAAACGCATCGAGCAGCGCGCCCGCGCCGCCGGCCTG
CAAAGCATTTTTGTGCTGACCACCCGCACCATGCACTGGTTCATCAAGCGCGGTTTTGTGCAGGTCGACCCGGACTGGCT
GCCCGAAGCGCGCAAGCGCAAGTACAACTGGGACCGGAAAAGCCAGGTGCTGGTGAAGAAGCTGGGTTGA

Upstream 100 bases:

>100_bases
CATTTGCGCAAACGTTTTTGTCGACCTGCTAGTGGCTTTTACCGAGTTGCTTTTTTTCCAATTGCCTGAACCGATTTCTT
ACAGTCCCCGAAAGCGCGCC

Downstream 100 bases:

>100_bases
CGCGAGGCCATACGCACTGCCTCCCACAGACAGTCCGTCTGGCTGTCACTTTCACCGCGAAGAACTCACAGACTCTTACC
AGGAATTGCGCACCCCCTCA

Product: N-acetylglutamate synthase

Products: NA

Alternate protein names: N-acetylglutamate synthase; AGS; NAGS [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSTVFNFTFVPWFRSVAPYIHTHRGKTFVVGIAGEAIAAGKLPHIAQDLALIQSMGVKIVLVHGFRPQVNEQLKAKGHAA
RYSHGMRITDEVALDCAQEAAGQLRYEIEAAFSQGLPNTPMAGSTVRVISGNFLTARPVGILDGVDFKHSGMVRKVDVAG
ITRTLDFGAMVLLSPFGFSPTGEAFNLTMEEVATSVAIAMQADKLIFLTEIPGIRIHHDQPASEDNPIDTELPLAAAEKL
LTTLPNGERPTDTAFYLQHCVKACKAGVERSHILPFAVDGSLLLEIYVHDGIGTMVVDEKLESLREATADDVGGILQLIE
PFEKDGTLVKRGRTEIERDADLYTIIEHDGVIFGCAALYPYPEAKTAEMAALTVSPQSQGQGDGEKILKRIEQRARAAGL
QSIFVLTTRTMHWFIKRGFVQVDPDWLPEARKRKYNWDRKSQVLVKKLG

Sequences:

>Translated_449_residues
MSTVFNFTFVPWFRSVAPYIHTHRGKTFVVGIAGEAIAAGKLPHIAQDLALIQSMGVKIVLVHGFRPQVNEQLKAKGHAA
RYSHGMRITDEVALDCAQEAAGQLRYEIEAAFSQGLPNTPMAGSTVRVISGNFLTARPVGILDGVDFKHSGMVRKVDVAG
ITRTLDFGAMVLLSPFGFSPTGEAFNLTMEEVATSVAIAMQADKLIFLTEIPGIRIHHDQPASEDNPIDTELPLAAAEKL
LTTLPNGERPTDTAFYLQHCVKACKAGVERSHILPFAVDGSLLLEIYVHDGIGTMVVDEKLESLREATADDVGGILQLIE
PFEKDGTLVKRGRTEIERDADLYTIIEHDGVIFGCAALYPYPEAKTAEMAALTVSPQSQGQGDGEKILKRIEQRARAAGL
QSIFVLTTRTMHWFIKRGFVQVDPDWLPEARKRKYNWDRKSQVLVKKLG
>Mature_448_residues
STVFNFTFVPWFRSVAPYIHTHRGKTFVVGIAGEAIAAGKLPHIAQDLALIQSMGVKIVLVHGFRPQVNEQLKAKGHAAR
YSHGMRITDEVALDCAQEAAGQLRYEIEAAFSQGLPNTPMAGSTVRVISGNFLTARPVGILDGVDFKHSGMVRKVDVAGI
TRTLDFGAMVLLSPFGFSPTGEAFNLTMEEVATSVAIAMQADKLIFLTEIPGIRIHHDQPASEDNPIDTELPLAAAEKLL
TTLPNGERPTDTAFYLQHCVKACKAGVERSHILPFAVDGSLLLEIYVHDGIGTMVVDEKLESLREATADDVGGILQLIEP
FEKDGTLVKRGRTEIERDADLYTIIEHDGVIFGCAALYPYPEAKTAEMAALTVSPQSQGQGDGEKILKRIEQRARAAGLQ
SIFVLTTRTMHWFIKRGFVQVDPDWLPEARKRKYNWDRKSQVLVKKLG

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

Organism=Escherichia coli, GI1789181, Length=442, Percent_Identity=44.3438914027149, Blast_Score=404, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6320913, Length=206, Percent_Identity=26.2135922330097, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR001048
- InterPro:   IPR010167 [H]

Pfam domain/function: PF00696 AA_kinase; PF00583 Acetyltransf_1 [H]

EC number: =2.3.1.1 [H]

Molecular weight: Translated: 49286; Mature: 49155

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVFNFTFVPWFRSVAPYIHTHRGKTFVVGIAGEAIAAGKLPHIAQDLALIQSMGVKIV
CCCEEEEEHHHHHHHHHHHHEECCCCEEEEEECCCHHHCCCCCHHHHHHHHHHHCCCEEE
LVHGFRPQVNEQLKAKGHAARYSHGMRITDEVALDCAQEAAGQLRYEIEAAFSQGLPNTP
EEECCCCCHHHHHHHCCCHHHHCCCCEEHHHHHHHHHHHHHHHEEHHHHHHHHCCCCCCC
MAGSTVRVISGNFLTARPVGILDGVDFKHSGMVRKVDVAGITRTLDFGAMVLLSPFGFSP
CCCCEEEEEECCEEEECCCCEECCCCCCCCCCEEEEEHHHHHHHHHHCEEEEECCCCCCC
TGEAFNLTMEEVATSVAIAMQADKLIFLTEIPGIRIHHDQPASEDNPIDTELPLAAAEKL
CCCEEEEEHHHHHHHHHEEEECCCEEEEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHH
LTTLPNGERPTDTAFYLQHCVKACKAGVERSHILPFAVDGSLLLEIYVHDGIGTMVVDEK
HHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEEEEECCCCHHHHHHH
LESLREATADDVGGILQLIEPFEKDGTLVKRGRTEIERDADLYTIIEHDGVIFGCAALYP
HHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHCCCCEEEEEECCCEEEEEEHHCC
YPEAKTAEMAALTVSPQSQGQGDGEKILKRIEQRARAAGLQSIFVLTTRTMHWFIKRGFV
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCHHEEEEHHHHHHHHHHHCCCE
QVDPDWLPEARKRKYNWDRKSQVLVKKLG
EECCCCCCHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
STVFNFTFVPWFRSVAPYIHTHRGKTFVVGIAGEAIAAGKLPHIAQDLALIQSMGVKIV
CCEEEEEHHHHHHHHHHHHEECCCCEEEEEECCCHHHCCCCCHHHHHHHHHHHCCCEEE
LVHGFRPQVNEQLKAKGHAARYSHGMRITDEVALDCAQEAAGQLRYEIEAAFSQGLPNTP
EEECCCCCHHHHHHHCCCHHHHCCCCEEHHHHHHHHHHHHHHHEEHHHHHHHHCCCCCCC
MAGSTVRVISGNFLTARPVGILDGVDFKHSGMVRKVDVAGITRTLDFGAMVLLSPFGFSP
CCCCEEEEEECCEEEECCCCEECCCCCCCCCCEEEEEHHHHHHHHHHCEEEEECCCCCCC
TGEAFNLTMEEVATSVAIAMQADKLIFLTEIPGIRIHHDQPASEDNPIDTELPLAAAEKL
CCCEEEEEHHHHHHHHHEEEECCCEEEEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHH
LTTLPNGERPTDTAFYLQHCVKACKAGVERSHILPFAVDGSLLLEIYVHDGIGTMVVDEK
HHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEEEEEEECCCCHHHHHHH
LESLREATADDVGGILQLIEPFEKDGTLVKRGRTEIERDADLYTIIEHDGVIFGCAALYP
HHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHCCCCEEEEEECCCEEEEEEHHCC
YPEAKTAEMAALTVSPQSQGQGDGEKILKRIEQRARAAGLQSIFVLTTRTMHWFIKRGFV
CCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCHHEEEEHHHHHHHHHHHCCCE
QVDPDWLPEARKRKYNWDRKSQVLVKKLG
EECCCCCCHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]