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The map label for this gene is hisA [H]

Identifier: 91211310

GI number: 91211310

Start: 2233529

End: 2234269

Strand: Direct

Name: hisA [H]

Synonym: UTI89_C2297

Alternate gene names: 91211310

Gene position: 2233529-2234269 (Clockwise)

Preceding gene: 91211309

Following gene: 91211311

Centisome position: 44.09

GC content: 56.01

Gene sequence:

>741_bases
GTGATGATTATTCCGGCATTAGATTTAATCGACGGCACCGTGGTGCGTCTCCATCAGGGCGATTACGGCAAACAACGCGA
TTACGGTAACAACCCGCTGCCGCGCTTACAGGATTACGCTGCGCAAGGTGCCGAAGTGTTGCACCTGGTGGATCTGACCG
GGGCAAAAGATCCGGCTAAGCGTCAAATCCCGCTGATTAAAACCCTGGTCGCGGGCGTTAACGTCCCGGTGCAGGTTGGC
GGCGGTGTGCGTAGTGAAAAAGACGTAGCGGCGTTACTGGAAGCGGGCGTTGCGCGCGTGGTGGTCGGCTCCACCGCGGT
GAAATCACCAGAAATGGTGAAAGGTTGGTTTGAACGTTTCGGTGCGGATGCCTTAGTGCTGGCGCTGGATGTCCGTATTG
ACGAGCAAGGCAACAAGCAGGTGGCGGTCAGCGGCTGGCAAGAGAACTCGGGCGTTTCACTGGAACAACTGGTGGAAACC
TATCTGCCCGTCGGCCTGAAACATGTGCTATGTACCGATATCTCGCGCGACGGCACGCTGGCGGGATCTAACGTCTCTTT
ATATGAAGAAGTGTGCGCCAGATATCCACAGGTGGCATTTCAGTCCTCCGGCGGTATTGGCGACATTAACGATGTGGCGG
CCCTGCGTGGTACTGGTGTACGCGGCGTAATAGTTGGTCGTGCATTACTGGAAGGTAAATTCACCGTGAAGGAGGCCATC
GCATGCTGGCAAAACGCATAA

Upstream 100 bases:

>100_bases
TCACCGCGGCGGTACAAAAAGATAACTTCTACGGCGTGCAGTTCCACCCGGAGCGTTCTGGTGCCGCTGGAGCTAAGTTG
CTGAAAAACTTCCTGGAGAT

Downstream 100 bases:

>100_bases
TCCCTTGTCTCGACGTTCGTGATGGTCAGGTGGTGAAAGGCGTACAGTTTCGCAACCATGAAATCATTGGCGATATCGTG
CCACTGGCAAAACGCTACGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MMIIPALDLIDGTVVRLHQGDYGKQRDYGNNPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVG
GGVRSEKDVAALLEAGVARVVVGSTAVKSPEMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVET
YLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDINDVAALRGTGVRGVIVGRALLEGKFTVKEAI
ACWQNA

Sequences:

>Translated_246_residues
MMIIPALDLIDGTVVRLHQGDYGKQRDYGNNPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVG
GGVRSEKDVAALLEAGVARVVVGSTAVKSPEMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVET
YLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDINDVAALRGTGVRGVIVGRALLEGKFTVKEAI
ACWQNA
>Mature_246_residues
MMIIPALDLIDGTVVRLHQGDYGKQRDYGNNPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVG
GGVRSEKDVAALLEAGVARVVVGSTAVKSPEMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVET
YLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDINDVAALRGTGVRGVIVGRALLEGKFTVKEAI
ACWQNA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=245, Percent_Identity=97.9591836734694, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1788336, Length=231, Percent_Identity=25.5411255411255, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26144; Mature: 26144

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIIPALDLIDGTVVRLHQGDYGKQRDYGNNPLPRLQDYAAQGAEVLHLVDLTGAKDPAK
CEEECCHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCH
RQIPLIKTLVAGVNVPVQVGGGVRSEKDVAALLEAGVARVVVGSTAVKSPEMVKGWFERF
HCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCHHHEEECCHHCCCHHHHHHHHHHH
GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL
CCCEEEEEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCC
AGSNVSLYEEVCARYPQVAFQSSGGIGDINDVAALRGTGVRGVIVGRALLEGKFTVKEAI
CCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
ACWQNA
HHHCCC
>Mature Secondary Structure
MMIIPALDLIDGTVVRLHQGDYGKQRDYGNNPLPRLQDYAAQGAEVLHLVDLTGAKDPAK
CEEECCHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCH
RQIPLIKTLVAGVNVPVQVGGGVRSEKDVAALLEAGVARVVVGSTAVKSPEMVKGWFERF
HCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCHHHEEECCHHCCCHHHHHHHHHHH
GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL
CCCEEEEEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCC
AGSNVSLYEEVCARYPQVAFQSSGGIGDINDVAALRGTGVRGVIVGRALLEGKFTVKEAI
CCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
ACWQNA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA