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The map label for this gene is rnc [H]

Identifier: 89898471

GI number: 89898471

Start: 768301

End: 769014

Strand: Direct

Name: rnc [H]

Synonym: CF0664

Alternate gene names: 89898471

Gene position: 768301-769014 (Clockwise)

Preceding gene: 89898462

Following gene: 89898472

Centisome position: 65.88

GC content: 40.9

Gene sequence:

>714_bases
ATGAATAATCTGATCAACATTAAAGAAGTTGAAGCTAAATTAAAATTTACTTTTACTCAACCGCAACTCTTAGTTACAGC
TCTCACCCACCCTTCATATAGGAATGAGACTGTAACTATTACCGAAGATAGCGAGCGTTTAGAATTTTTGGGAGACGCGG
TATTGTGCTTAATTGTCACCGAACACTTATTCCTCTTATTTCCTTCTATGGATGAAGGGACTTTATCTACTGCGCGAGCA
GCATTGATTAATGCAGTTTCTTGCTGCCAATACACTGATGCGTTAGGATTAGGAGAATATTTGCTTATAGGTAAAGGAGA
AAGAATTCAAAATGAGCGGGGGAGAACTTCTGCTTATGCGAATTTATTTGAGGCTATTTTAGGCGCTGTTTATCTCGATG
GAGGTTTAGCCCCAGCGAGACAAATCACAGTTCCTTTACTACCATCAAAAAAGGATATCCTTCCCCTTATGTTAGGAAAT
CCCAAAAACCGCCTACAACAGCTCACGCAAAAACAACTACGAACGTTACCCGTATACCAAAGCACACCGTGGATATCACC
ACAAGGCGCTCCAGGTTACCACATTCGTGTGATAGTAAATGATGAGATCTGGGGAGAGGGATTTGCCTTATCGAAAAAAG
AAGCCGAGAAACTTGCTGCTCAAGAAGCTTTAGACGCCAATGACTACAAAGATAAAAACACAGTGGACCTGTAA

Upstream 100 bases:

>100_bases
TGCAATCAAAAGCACTATAGACTTTAAGCCCTTTTCCGCCTATAAAAAAACTCCGATAACTAATGTGTTATATTGTAATA
GGGCAACATTTCATAATTTT

Downstream 100 bases:

>100_bases
TGAGTGTGGGGCTAGCGCGCCTAAATGGTTAGGCCAATGTCCGGGATGCTTACAATGGAACACTCTTATTGAAGAACACA
TCTCTCCTTCTCAAAATGCA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNNLINIKEVEAKLKFTFTQPQLLVTALTHPSYRNETVTITEDSERLEFLGDAVLCLIVTEHLFLLFPSMDEGTLSTARA
ALINAVSCCQYTDALGLGEYLLIGKGERIQNERGRTSAYANLFEAILGAVYLDGGLAPARQITVPLLPSKKDILPLMLGN
PKNRLQQLTQKQLRTLPVYQSTPWISPQGAPGYHIRVIVNDEIWGEGFALSKKEAEKLAAQEALDANDYKDKNTVDL

Sequences:

>Translated_237_residues
MNNLINIKEVEAKLKFTFTQPQLLVTALTHPSYRNETVTITEDSERLEFLGDAVLCLIVTEHLFLLFPSMDEGTLSTARA
ALINAVSCCQYTDALGLGEYLLIGKGERIQNERGRTSAYANLFEAILGAVYLDGGLAPARQITVPLLPSKKDILPLMLGN
PKNRLQQLTQKQLRTLPVYQSTPWISPQGAPGYHIRVIVNDEIWGEGFALSKKEAEKLAAQEALDANDYKDKNTVDL
>Mature_237_residues
MNNLINIKEVEAKLKFTFTQPQLLVTALTHPSYRNETVTITEDSERLEFLGDAVLCLIVTEHLFLLFPSMDEGTLSTARA
ALINAVSCCQYTDALGLGEYLLIGKGERIQNERGRTSAYANLFEAILGAVYLDGGLAPARQITVPLLPSKKDILPLMLGN
PKNRLQQLTQKQLRTLPVYQSTPWISPQGAPGYHIRVIVNDEIWGEGFALSKKEAEKLAAQEALDANDYKDKNTVDL

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=233, Percent_Identity=29.6137339055794, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI155030234, Length=233, Percent_Identity=29.6137339055794, Blast_Score=91, Evalue=6e-19,
Organism=Escherichia coli, GI1788920, Length=179, Percent_Identity=34.0782122905028, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17506883, Length=96, Percent_Identity=41.6666666666667, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193202651, Length=96, Percent_Identity=41.6666666666667, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137682, Length=145, Percent_Identity=35.8620689655172, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26275; Mature: 26275

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLINIKEVEAKLKFTFTQPQLLVTALTHPSYRNETVTITEDSERLEFLGDAVLCLIVT
CCCCCCHHEEEEEEEEEECCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHH
EHLFLLFPSMDEGTLSTARAALINAVSCCQYTDALGLGEYLLIGKGERIQNERGRTSAYA
HHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHCCCCCCHHHHH
NLFEAILGAVYLDGGLAPARQITVPLLPSKKDILPLMLGNPKNRLQQLTQKQLRTLPVYQ
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCC
STPWISPQGAPGYHIRVIVNDEIWGEGFALSKKEAEKLAAQEALDANDYKDKNTVDL
CCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNNLINIKEVEAKLKFTFTQPQLLVTALTHPSYRNETVTITEDSERLEFLGDAVLCLIVT
CCCCCCHHEEEEEEEEEECCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHH
EHLFLLFPSMDEGTLSTARAALINAVSCCQYTDALGLGEYLLIGKGERIQNERGRTSAYA
HHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHCCCCCCHHHHH
NLFEAILGAVYLDGGLAPARQITVPLLPSKKDILPLMLGNPKNRLQQLTQKQLRTLPVYQ
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCC
STPWISPQGAPGYHIRVIVNDEIWGEGFALSKKEAEKLAAQEALDANDYKDKNTVDL
CCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA