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The map label for this gene is lpxD [H]

Identifier: 89898334

GI number: 89898334

Start: 618700

End: 619779

Strand: Direct

Name: lpxD [H]

Synonym: CF0527

Alternate gene names: 89898334

Gene position: 618700-619779 (Clockwise)

Preceding gene: 89898333

Following gene: 89898336

Centisome position: 53.05

GC content: 40.09

Gene sequence:

>1080_bases
ATGCCTCAAGAACTGGTCTATACTCTTCAACAGTTAGCAGACTTATTAAAAGTTGAAGTTCAAGGAAATACAGAAACTCC
TATTTCTGGAGTTGAAGAAATAAGTGAGGCTCAATCTCATCACGTCACTTTTCTGGATAACGAAAAGTATTCGCGTTTTA
TAAAAAATACCGAAGCTGGAGCGATTATTCTATCAAAAGCTCAGGCTCAAAAGTACGGTCATTTAAATAAGAACTTTCTT
ATAGTTTCTGAGTTCCCTTCAATAGCTTTTCAAAAATGTATAGAGTTATTTATTCCTCCCATTGATTCAGGATTCCCGGG
AATTCATCCTACAGCAGTTATTCATCCCACAGCACATATTGGCAAAGATGTTTTTCTTGAACCCTATGCTGTAATATGCC
AACACGCGCAAATTGGAGATTCTTCTCATATTGGAGCAGGAAGTGTTATAGGCGCTTTTTCAACTCTTGGGGAACATTGC
TATGTTCATCCTAAAGTAGTAATTCGCGAACGTGTGGTAATAGGTAAGCGTGTTATCGTTCAACCCGGAGCTATTATCGG
CGCTTGTGGTTTTGGTTATATCACCAATGCTTTTGGGCGTCATAAACATCTCAAACATCTAGGCCAGGTAATCATTGAAG
ACGATGTCGAGATTGGAGCAAACACTACGATAGATAGGGGCCGCTTCAAGAATAGTGTTATACGTGAGGGCACTAAAATC
GACAACCAAGTTCAAATAGCTCATCATGTGGAGGTTGGAAAACACAGCATGATTGTTGCTCAAGCAGGAATCGCTGGTTC
TACGAAAATCGGAAACCACGTAATTATTGGAGGTCAAACAGGAATTACGGGTCATATTTCAATAACAGATCACGTAATCA
TGATGGCTCAAACAGGGGTTACAAAATCGATTAGTTCTCCAGGAATCTATGGAGGAGCTCCTGCTCGTCCTTATCAAGAG
ATTCATCGTCAAGTTGCGAAAATCCGCGGCCTACCTAAATTAGAAGAACGTTTGGGAATGCTAGAAGAAAAAGTTAAGGG
ATTATCTGCACAATCCGAAGAAGCTCAAATAACCCCTTAA

Upstream 100 bases:

>100_bases
CTCTATTGATTCTAGCGCTGATATAACTAATGAAATTATCAAAATTCTTGATGAATCTTTCAAAAATAATTAAGATACCT
CAAGAACCAAGGAGTTTTGT

Downstream 100 bases:

>100_bases
TCAAATTACACGTACACGGATTTAAAACGCCTTTTCAAGGTTAAAACCTTGATTACGCTTTTGTTAACGATTGCAGGGCT
TATTTTCCCTGCTGAAATTA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MPQELVYTLQQLADLLKVEVQGNTETPISGVEEISEAQSHHVTFLDNEKYSRFIKNTEAGAIILSKAQAQKYGHLNKNFL
IVSEFPSIAFQKCIELFIPPIDSGFPGIHPTAVIHPTAHIGKDVFLEPYAVICQHAQIGDSSHIGAGSVIGAFSTLGEHC
YVHPKVVIRERVVIGKRVIVQPGAIIGACGFGYITNAFGRHKHLKHLGQVIIEDDVEIGANTTIDRGRFKNSVIREGTKI
DNQVQIAHHVEVGKHSMIVAQAGIAGSTKIGNHVIIGGQTGITGHISITDHVIMMAQTGVTKSISSPGIYGGAPARPYQE
IHRQVAKIRGLPKLEERLGMLEEKVKGLSAQSEEAQITP

Sequences:

>Translated_359_residues
MPQELVYTLQQLADLLKVEVQGNTETPISGVEEISEAQSHHVTFLDNEKYSRFIKNTEAGAIILSKAQAQKYGHLNKNFL
IVSEFPSIAFQKCIELFIPPIDSGFPGIHPTAVIHPTAHIGKDVFLEPYAVICQHAQIGDSSHIGAGSVIGAFSTLGEHC
YVHPKVVIRERVVIGKRVIVQPGAIIGACGFGYITNAFGRHKHLKHLGQVIIEDDVEIGANTTIDRGRFKNSVIREGTKI
DNQVQIAHHVEVGKHSMIVAQAGIAGSTKIGNHVIIGGQTGITGHISITDHVIMMAQTGVTKSISSPGIYGGAPARPYQE
IHRQVAKIRGLPKLEERLGMLEEKVKGLSAQSEEAQITP
>Mature_358_residues
PQELVYTLQQLADLLKVEVQGNTETPISGVEEISEAQSHHVTFLDNEKYSRFIKNTEAGAIILSKAQAQKYGHLNKNFLI
VSEFPSIAFQKCIELFIPPIDSGFPGIHPTAVIHPTAHIGKDVFLEPYAVICQHAQIGDSSHIGAGSVIGAFSTLGEHCY
VHPKVVIRERVVIGKRVIVQPGAIIGACGFGYITNAFGRHKHLKHLGQVIIEDDVEIGANTTIDRGRFKNSVIREGTKID
NQVQIAHHVEVGKHSMIVAQAGIAGSTKIGNHVIIGGQTGITGHISITDHVIMMAQTGVTKSISSPGIYGGAPARPYQEI
HRQVAKIRGLPKLEERLGMLEEKVKGLSAQSEEAQITP

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=339, Percent_Identity=34.2182890855457, Blast_Score=191, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 38886; Mature: 38755

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQELVYTLQQLADLLKVEVQGNTETPISGVEEISEAQSHHVTFLDNEKYSRFIKNTEAG
CCHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCEEEEECHHHHHHHHCCCCC
AIILSKAQAQKYGHLNKNFLIVSEFPSIAFQKCIELFIPPIDSGFPGIHPTAVIHPTAHI
EEEEEHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHC
GKDVFLEPYAVICQHAQIGDSSHIGAGSVIGAFSTLGEHCYVHPKVVIRERVVIGKRVIV
CCHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEECCHHHHHHHHHHCCEEEE
QPGAIIGACGFGYITNAFGRHKHLKHLGQVIIEDDVEIGANTTIDRGRFKNSVIREGTKI
CCCCEEEECCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHCCCCC
DNQVQIAHHVEVGKHSMIVAQAGIAGSTKIGNHVIIGGQTGITGHISITDHVIMMAQTGV
CCEEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCEEEEEECCEEEEEECCCC
TKSISSPGIYGGAPARPYQEIHRQVAKIRGLPKLEERLGMLEEKVKGLSAQSEEAQITP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PQELVYTLQQLADLLKVEVQGNTETPISGVEEISEAQSHHVTFLDNEKYSRFIKNTEAG
CHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHCCEEEEECHHHHHHHHCCCCC
AIILSKAQAQKYGHLNKNFLIVSEFPSIAFQKCIELFIPPIDSGFPGIHPTAVIHPTAHI
EEEEEHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHC
GKDVFLEPYAVICQHAQIGDSSHIGAGSVIGAFSTLGEHCYVHPKVVIRERVVIGKRVIV
CCHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEECCHHHHHHHHHHCCEEEE
QPGAIIGACGFGYITNAFGRHKHLKHLGQVIIEDDVEIGANTTIDRGRFKNSVIREGTKI
CCCCEEEECCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHCCCCC
DNQVQIAHHVEVGKHSMIVAQAGIAGSTKIGNHVIIGGQTGITGHISITDHVIMMAQTGV
CCEEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCEEEEEECCEEEEEECCCC
TKSISSPGIYGGAPARPYQEIHRQVAKIRGLPKLEERLGMLEEKVKGLSAQSEEAQITP
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA