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The map label for this gene is pdhA [H]

Identifier: 89898336

GI number: 89898336

Start: 620984

End: 622009

Strand: Direct

Name: pdhA [H]

Synonym: CF0529

Alternate gene names: 89898336

Gene position: 620984-622009 (Clockwise)

Preceding gene: 89898334

Following gene: 89898337

Centisome position: 53.25

GC content: 40.06

Gene sequence:

>1026_bases
ATGCCCGACTCTTTTCATTACAATATAGCCTCTAAAGAATCAGATGAATCTTCTGTAAAAAATATTATTGATGTATTCGG
CGCCCCTCGCTGTTTAGAGCTCTTAAAACAAATGTTATTGATTCGTGAGTTCGAAACTCGTGGTGAGGAAGCTTATCTGG
AAGGATTAGCTGGAGGTTTTTATCATTCCTATAGTGGTCAAGAAGCTGTTGCCACCGCAGCTTTGGCCAACACAGGATTA
GACCAATGGTTTTTTTCTTCATACCGTTGTCATGCTCTAGCCATATTACTAAACATTCCCTTGCGTTCACTTGCTGCGGA
ATTATTAGGGAAAGAAACGGGCTGTGCTTTAGGCAGAGGTGGATCTATGCATATGTGTGGTCCAAATTTCCCTGGAGGTT
TTGGTATTGTAGGAGGACAAATTCCCCTAGCAGCTGGAGCCGCATTTGCAATAAAATATCGTGGTGAGGATAAAATTTCT
CTAGGTTTTATTGGAGATGGAGCCGTTGCTCAAGGAGTGTTTCACGAAACGTTAAATTTTGCTTCGCTTCATAACCTTCC
GCTTATGCTTATTATAGAGAATAATGGCTGGGGAATGGGAACAGCTCTTAAGCGTGCTATTGCTAAACTGTCTATAGGAG
AATCTCAAGGGTCTTCTTACGGAATACGCTCTTTTACTTTGAATGGTTTTGATCTATTTAACTGTCTCACAGGCTTTAAG
GATGCTTATGAATATATGTTAAAGACTCGCCGACCAATTATTATTGAATGTTTATGTTCGCGATTTAGAGGCCATTCTAT
TTCAGATCCTAACCTCTATAGAAGTAAGGAAGAAATGCAATGCCTTATAAAAAAAGATCCCATTATTTTTGTAAAAAACT
GGTTAATCCGTTTAGGAGTGCTTTCAGAAGAGAATTTCCAAGCGATGCGACAAGAGTGTAGGAGTGAGGTCGTGAAAGCG
TTCACCGAAGCAAAATCAGATCCAGAACCAACGATTGCCACATTAGAAGAAGGTGTTTATGCCTAA

Upstream 100 bases:

>100_bases
TTTTTTAAAAACTTAATTACTTTTTTGGTCTTGTCTTTTCAAATCCATGATTTTATAATGGGGAGGAACTTAATCCTTGA
CGCAACTCACGTATCAAGAT

Downstream 100 bases:

>100_bases
GCACGTTACATTGGAAATCCGAGAAGCTATTAGAGAAGCCATAGACGAAGAGATGGCCAGGGATCCTAATGTATGCATAC
TGGGAGAAGAAGTCGCCGAG

Product: pyruvate dehydrogenase E1 alpha chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MPDSFHYNIASKESDESSVKNIIDVFGAPRCLELLKQMLLIREFETRGEEAYLEGLAGGFYHSYSGQEAVATAALANTGL
DQWFFSSYRCHALAILLNIPLRSLAAELLGKETGCALGRGGSMHMCGPNFPGGFGIVGGQIPLAAGAAFAIKYRGEDKIS
LGFIGDGAVAQGVFHETLNFASLHNLPLMLIIENNGWGMGTALKRAIAKLSIGESQGSSYGIRSFTLNGFDLFNCLTGFK
DAYEYMLKTRRPIIIECLCSRFRGHSISDPNLYRSKEEMQCLIKKDPIIFVKNWLIRLGVLSEENFQAMRQECRSEVVKA
FTEAKSDPEPTIATLEEGVYA

Sequences:

>Translated_341_residues
MPDSFHYNIASKESDESSVKNIIDVFGAPRCLELLKQMLLIREFETRGEEAYLEGLAGGFYHSYSGQEAVATAALANTGL
DQWFFSSYRCHALAILLNIPLRSLAAELLGKETGCALGRGGSMHMCGPNFPGGFGIVGGQIPLAAGAAFAIKYRGEDKIS
LGFIGDGAVAQGVFHETLNFASLHNLPLMLIIENNGWGMGTALKRAIAKLSIGESQGSSYGIRSFTLNGFDLFNCLTGFK
DAYEYMLKTRRPIIIECLCSRFRGHSISDPNLYRSKEEMQCLIKKDPIIFVKNWLIRLGVLSEENFQAMRQECRSEVVKA
FTEAKSDPEPTIATLEEGVYA
>Mature_340_residues
PDSFHYNIASKESDESSVKNIIDVFGAPRCLELLKQMLLIREFETRGEEAYLEGLAGGFYHSYSGQEAVATAALANTGLD
QWFFSSYRCHALAILLNIPLRSLAAELLGKETGCALGRGGSMHMCGPNFPGGFGIVGGQIPLAAGAAFAIKYRGEDKISL
GFIGDGAVAQGVFHETLNFASLHNLPLMLIIENNGWGMGTALKRAIAKLSIGESQGSSYGIRSFTLNGFDLFNCLTGFKD
AYEYMLKTRRPIIIECLCSRFRGHSISDPNLYRSKEEMQCLIKKDPIIFVKNWLIRLGVLSEENFQAMRQECRSEVVKAF
TEAKSDPEPTIATLEEGVYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=312, Percent_Identity=37.1794871794872, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI291084742, Length=312, Percent_Identity=36.2179487179487, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI4505685, Length=312, Percent_Identity=36.2179487179487, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI291084744, Length=319, Percent_Identity=35.423197492163, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI291084757, Length=312, Percent_Identity=31.4102564102564, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI11386135, Length=318, Percent_Identity=29.559748427673, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI258645172, Length=318, Percent_Identity=29.559748427673, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17536047, Length=299, Percent_Identity=38.4615384615385, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI32564172, Length=299, Percent_Identity=38.4615384615385, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI86563355, Length=286, Percent_Identity=26.9230769230769, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI86563357, Length=286, Percent_Identity=26.9230769230769, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321026, Length=314, Percent_Identity=37.8980891719745, Blast_Score=196, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24639744, Length=319, Percent_Identity=38.5579937304075, Blast_Score=200, Evalue=9e-52,
Organism=Drosophila melanogaster, GI28571106, Length=319, Percent_Identity=38.5579937304075, Blast_Score=200, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24639740, Length=314, Percent_Identity=38.5350318471338, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24639748, Length=312, Percent_Identity=38.1410256410256, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=38.8888888888889, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21355903, Length=314, Percent_Identity=25.4777070063694, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37455; Mature: 37324

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSFHYNIASKESDESSVKNIIDVFGAPRCLELLKQMLLIREFETRGEEAYLEGLAGGF
CCCCEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
YHSYSGQEAVATAALANTGLDQWFFSSYRCHALAILLNIPLRSLAAELLGKETGCALGRG
HCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
GSMHMCGPNFPGGFGIVGGQIPLAAGAAFAIKYRGEDKISLGFIGDGAVAQGVFHETLNF
CCEEECCCCCCCCCEECCCCCCHHCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHH
ASLHNLPLMLIIENNGWGMGTALKRAIAKLSIGESQGSSYGIRSFTLNGFDLFNCLTGFK
HHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHH
DAYEYMLKTRRPIIIECLCSRFRGHSISDPNLYRSKEEMQCLIKKDPIIFVKNWLIRLGV
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHCCCEEEEEHHHHHHCC
LSEENFQAMRQECRSEVVKAFTEAKSDPEPTIATLEEGVYA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure 
PDSFHYNIASKESDESSVKNIIDVFGAPRCLELLKQMLLIREFETRGEEAYLEGLAGGF
CCCEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
YHSYSGQEAVATAALANTGLDQWFFSSYRCHALAILLNIPLRSLAAELLGKETGCALGRG
HCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
GSMHMCGPNFPGGFGIVGGQIPLAAGAAFAIKYRGEDKISLGFIGDGAVAQGVFHETLNF
CCEEECCCCCCCCCEECCCCCCHHCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHH
ASLHNLPLMLIIENNGWGMGTALKRAIAKLSIGESQGSSYGIRSFTLNGFDLFNCLTGFK
HHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHH
DAYEYMLKTRRPIIIECLCSRFRGHSISDPNLYRSKEEMQCLIKKDPIIFVKNWLIRLGV
HHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHCCCEEEEEHHHHHHCC
LSEENFQAMRQECRSEVVKAFTEAKSDPEPTIATLEEGVYA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA