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The map label for this gene is ffh [H]

Identifier: 89898160

GI number: 89898160

Start: 416394

End: 417740

Strand: Direct

Name: ffh [H]

Synonym: CF0353

Alternate gene names: 89898160

Gene position: 416394-417740 (Clockwise)

Preceding gene: 89898159

Following gene: 89898161

Centisome position: 35.7

GC content: 40.16

Gene sequence:

>1347_bases
ATGATCAGTTCTTTATCGCAAAAACTATCCTCGATTTTTTCTTCGCTGATTTCCTCTCGTAGAATTACTGAAGAAAACAT
ATCTGAAGCGATCCGAGAAGTCCGCTTGGCTTTGCTAGATGCTGACGTGAATTACCATGTCGTTAAAAGTTTTATTGCTA
AGGTAAAGCAAAAAATTCTTGGAGAGGAGGTGTGGAAACACGTTTCCCCCGGACAACAGTTTATACGACATTTACACGAA
GAATTGACAGAATTGCTCATCAGTAGTGAAGCTGATTTAACGACTTCAGGAAACCCTGGAGTGGTTTTGCTTTGTGGTTT
ACAGGGAACAGGGAAAACTACGACATGCGCTAAACTCGCAGCTTATGTTCTAGAGAAACGTAAGGCAAAGAAAGTGTTGG
TTGTTCCTTGCGATTTGAAGCGCTATGCAGCAGTAGATCAATTAAGAAATTTGATTTCAAAAACCAAAGCAGAGCTGTAT
AATAGCGAAGCGCAAGACCCTGTAAAGGTTGTTTCTCAAGCTTTAGATTATGCAAAACAGAACGGTCATGATCTTGTTTT
AATTGATACAGCCGGTCGATTGCATGTGGATGAGGCTATGATGGAAGAATTGGCTTCCATACAAAAGGCCTCTAAATCCT
GCGAAAGGCTATTTGTAATGAACTTGGCTATGGGGCAAGACGCTGTTACTACAGCCAAAGCATTTGATGATTGTTTAGAT
CTTACTGGAGTTATTATCTCCATGACGGATGGCGATGCTCGCGCAGGTGCTGTTCTGTCAATGAAAAGTTTATTGGGAAA
ACCAATAAAATTTGAAGGGTGTGGTGAGAAAATCCAAGATCTTCGACCTTTTAATGCGGAGTCTATGGCGGATCGCATTT
TGGGTATGGGAGATACTATGCATTTTGTTCAAAAAATGCGCGAATGTATCTCAGAGGAAGAAGACGAAGAACTTGGGAAA
AAGTTAATAGAATCGACCTTCACTTATGAAGATTACTATAAGCAAATGAAGGCGTTTCGACGTATGGGTCCACTCAGAAA
GCTTATGGGGATGATGCCAAGTTTTGGTGGCATGAAACCTAGTGATAAAGAGATTGCGGACTCCGAAGAACATATGAAAA
GAACAGAAGCTATTATCCTCTCTATGACTCCTCAAGAGAGAAGTGAAAAGGTAGAGTTAGATATGAGCCGCATGAAAAGA
ATAGCGGCTGGCTGCGGATTGACTTTAGGTGATGTAAATCAGTTCCGCAAGCGTATGATGCAATCTAAAAAGTTTTTTAA
AAATATGAGTAAAGAAAAAATAGAACAAATGAAAAAGAAAATGTCTGGAGGAAACCTGTGGCGTTAA

Upstream 100 bases:

>100_bases
TATACCAAGATCTCTCAGGTTGCGATAGGATTTTTTTTCTTGAAAATCAAGCAAGTGATGCTGTATCCTCATGAGATTAT
TCTTGATTTTTGCTGAGTAG

Downstream 100 bases:

>100_bases
AAATTCGTTTACGACAACAAGGGCGAAGAAATCACGTAGTCTATAGATTAGTACTTGCTGACGTAGAGTCTCCTCGTGAT
GGTAGATACATAGAATTGTT

Product: signal recognition particle GTPase

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MISSLSQKLSSIFSSLISSRRITEENISEAIREVRLALLDADVNYHVVKSFIAKVKQKILGEEVWKHVSPGQQFIRHLHE
ELTELLISSEADLTTSGNPGVVLLCGLQGTGKTTTCAKLAAYVLEKRKAKKVLVVPCDLKRYAAVDQLRNLISKTKAELY
NSEAQDPVKVVSQALDYAKQNGHDLVLIDTAGRLHVDEAMMEELASIQKASKSCERLFVMNLAMGQDAVTTAKAFDDCLD
LTGVIISMTDGDARAGAVLSMKSLLGKPIKFEGCGEKIQDLRPFNAESMADRILGMGDTMHFVQKMRECISEEEDEELGK
KLIESTFTYEDYYKQMKAFRRMGPLRKLMGMMPSFGGMKPSDKEIADSEEHMKRTEAIILSMTPQERSEKVELDMSRMKR
IAAGCGLTLGDVNQFRKRMMQSKKFFKNMSKEKIEQMKKKMSGGNLWR

Sequences:

>Translated_448_residues
MISSLSQKLSSIFSSLISSRRITEENISEAIREVRLALLDADVNYHVVKSFIAKVKQKILGEEVWKHVSPGQQFIRHLHE
ELTELLISSEADLTTSGNPGVVLLCGLQGTGKTTTCAKLAAYVLEKRKAKKVLVVPCDLKRYAAVDQLRNLISKTKAELY
NSEAQDPVKVVSQALDYAKQNGHDLVLIDTAGRLHVDEAMMEELASIQKASKSCERLFVMNLAMGQDAVTTAKAFDDCLD
LTGVIISMTDGDARAGAVLSMKSLLGKPIKFEGCGEKIQDLRPFNAESMADRILGMGDTMHFVQKMRECISEEEDEELGK
KLIESTFTYEDYYKQMKAFRRMGPLRKLMGMMPSFGGMKPSDKEIADSEEHMKRTEAIILSMTPQERSEKVELDMSRMKR
IAAGCGLTLGDVNQFRKRMMQSKKFFKNMSKEKIEQMKKKMSGGNLWR
>Mature_448_residues
MISSLSQKLSSIFSSLISSRRITEENISEAIREVRLALLDADVNYHVVKSFIAKVKQKILGEEVWKHVSPGQQFIRHLHE
ELTELLISSEADLTTSGNPGVVLLCGLQGTGKTTTCAKLAAYVLEKRKAKKVLVVPCDLKRYAAVDQLRNLISKTKAELY
NSEAQDPVKVVSQALDYAKQNGHDLVLIDTAGRLHVDEAMMEELASIQKASKSCERLFVMNLAMGQDAVTTAKAFDDCLD
LTGVIISMTDGDARAGAVLSMKSLLGKPIKFEGCGEKIQDLRPFNAESMADRILGMGDTMHFVQKMRECISEEEDEELGK
KLIESTFTYEDYYKQMKAFRRMGPLRKLMGMMPSFGGMKPSDKEIADSEEHMKRTEAIILSMTPQERSEKVELDMSRMKR
IAAGCGLTLGDVNQFRKRMMQSKKFFKNMSKEKIEQMKKKMSGGNLWR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=450, Percent_Identity=32.2222222222222, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI226371618, Length=380, Percent_Identity=32.3684210526316, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI23308697, Length=311, Percent_Identity=25.7234726688103, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI295424842, Length=311, Percent_Identity=25.7234726688103, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI89061728, Length=164, Percent_Identity=32.3170731707317, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1788963, Length=421, Percent_Identity=42.2802850356295, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1789874, Length=233, Percent_Identity=34.3347639484979, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17539958, Length=432, Percent_Identity=30.787037037037, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=311, Percent_Identity=27.0096463022508, Blast_Score=111, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=444, Percent_Identity=27.027027027027, Blast_Score=180, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320498, Length=323, Percent_Identity=26.9349845201238, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17647949, Length=357, Percent_Identity=33.6134453781513, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI24641198, Length=319, Percent_Identity=24.7648902821317, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50264; Mature: 50264

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISSLSQKLSSIFSSLISSRRITEENISEAIREVRLALLDADVNYHVVKSFIAKVKQKIL
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVWKHVSPGQQFIRHLHEELTELLISSEADLTTSGNPGVVLLCGLQGTGKTTTCAKLA
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHH
AYVLEKRKAKKVLVVPCDLKRYAAVDQLRNLISKTKAELYNSEAQDPVKVVSQALDYAKQ
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
NGHDLVLIDTAGRLHVDEAMMEELASIQKASKSCERLFVMNLAMGQDAVTTAKAFDDCLD
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LTGVIISMTDGDARAGAVLSMKSLLGKPIKFEGCGEKIQDLRPFNAESMADRILGMGDTM
HHCEEEEECCCCCHHHHHHHHHHHHCCCCEECCCCHHHHHCCCCCHHHHHHHHHCCCHHH
HFVQKMRECISEEEDEELGKKLIESTFTYEDYYKQMKAFRRMGPLRKLMGMMPSFGGMKP
HHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCC
SDKEIADSEEHMKRTEAIILSMTPQERSEKVELDMSRMKRIAAGCGLTLGDVNQFRKRMM
CCCHHCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QSKKFFKNMSKEKIEQMKKKMSGGNLWR
HHHHHHHHCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MISSLSQKLSSIFSSLISSRRITEENISEAIREVRLALLDADVNYHVVKSFIAKVKQKIL
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GEEVWKHVSPGQQFIRHLHEELTELLISSEADLTTSGNPGVVLLCGLQGTGKTTTCAKLA
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHH
AYVLEKRKAKKVLVVPCDLKRYAAVDQLRNLISKTKAELYNSEAQDPVKVVSQALDYAKQ
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
NGHDLVLIDTAGRLHVDEAMMEELASIQKASKSCERLFVMNLAMGQDAVTTAKAFDDCLD
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LTGVIISMTDGDARAGAVLSMKSLLGKPIKFEGCGEKIQDLRPFNAESMADRILGMGDTM
HHCEEEEECCCCCHHHHHHHHHHHHCCCCEECCCCHHHHHCCCCCHHHHHHHHHCCCHHH
HFVQKMRECISEEEDEELGKKLIESTFTYEDYYKQMKAFRRMGPLRKLMGMMPSFGGMKP
HHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCC
SDKEIADSEEHMKRTEAIILSMTPQERSEKVELDMSRMKRIAAGCGLTLGDVNQFRKRMM
CCCHHCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QSKKFFKNMSKEKIEQMKKKMSGGNLWR
HHHHHHHHCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]