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The map label for this gene is rrm4 [H]

Identifier: 89898159

GI number: 89898159

Start: 415516

End: 416367

Strand: Direct

Name: rrm4 [H]

Synonym: CF0352

Alternate gene names: 89898159

Gene position: 415516-416367 (Clockwise)

Preceding gene: 89898158

Following gene: 89898160

Centisome position: 35.63

GC content: 40.49

Gene sequence:

>852_bases
ATGGAAACGAAGAGAATTCTTAGCAAAGCTTCTGCATATTTAAAATATCATGGCGTTGCTTTCTCCGATAGAGAGGCTTC
TGATATTTTGATGGATTTTCTTGGAATAAGTTCTCGGGCGCAATTAGCGTCTGTAGTTCTAGATGCAGATTCTTTAGAAA
CTTATTGGAAACGTGTTCAACAAAGGGCAGCGCGAGTCCCTACGTCCTACATTCATGGTAGCGTGAGTTTTTTAGGTCTG
CATTTAGATGTGGATTCTCGCGTGCTTATTCCTAGAATGGAAACAGAATTGCTTGCTGAGCGGATCATAAAGTATTTAAC
CCAGCATCCTCATATTCGGACGTTTTATGACGTGTGTTGTGGTAGTGGGTGTCTAGGATTGTCTGTAAAAAAATATTGTC
CTGAGATTCAGGTTGTTCTTTCAGATATTTGTCCAAAAGCTGTGGCTGTAGCTAAGGCAAATGCTTCTATAAATAATTTA
AAAGTGGAAATTCTTCTTGGGGACTTATTTTCTCCCTACTCTTATCCGGCAGATGCTTTTGTCTGTAATCCGCCCTATCT
TTCTTTTAGTGAGATCATGTACGTGGACCCTGAGGTGCGTTGTCATGAACCATGGAAAGCTTTGGTTGGAGGAAGTTCTG
GAGTCGAGTTCTATGAAAGAATAGCTCAAGATTTAGACCTTGTTTTATGCCCCGGAGGTGTGGGATGGTTAGAAATTGGC
TATCGGCAAGGAGAACTAATAAAAAAAATTTTTGCAGGCCGTGGTGTTTCTGGAACTATATACCAAGATCTCTCAGGTTG
CGATAGGATTTTTTTTCTTGAAAATCAAGCAAGTGATGCTGTATCCTCATGA

Upstream 100 bases:

>100_bases
ATAGGCCTTACTCTGTACAATTTAGATAAAGTTATGGAAGGGGATTTAGACACCATTACTTCAGCATTAGTTAGCCACGC
TTATCACCAGCTCTTTCAAA

Downstream 100 bases:

>100_bases
GATTATTCTTGATTTTTGCTGAGTAGATGATCAGTTCTTTATCGCAAAAACTATCCTCGATTTTTTCTTCGCTGATTTCC
TCTCGTAGAATTACTGAAGA

Product: N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase

Products: NA

Alternate protein names: M.AaoHemKP [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
METKRILSKASAYLKYHGVAFSDREASDILMDFLGISSRAQLASVVLDADSLETYWKRVQQRAARVPTSYIHGSVSFLGL
HLDVDSRVLIPRMETELLAERIIKYLTQHPHIRTFYDVCCGSGCLGLSVKKYCPEIQVVLSDICPKAVAVAKANASINNL
KVEILLGDLFSPYSYPADAFVCNPPYLSFSEIMYVDPEVRCHEPWKALVGGSSGVEFYERIAQDLDLVLCPGGVGWLEIG
YRQGELIKKIFAGRGVSGTIYQDLSGCDRIFFLENQASDAVSS

Sequences:

>Translated_283_residues
METKRILSKASAYLKYHGVAFSDREASDILMDFLGISSRAQLASVVLDADSLETYWKRVQQRAARVPTSYIHGSVSFLGL
HLDVDSRVLIPRMETELLAERIIKYLTQHPHIRTFYDVCCGSGCLGLSVKKYCPEIQVVLSDICPKAVAVAKANASINNL
KVEILLGDLFSPYSYPADAFVCNPPYLSFSEIMYVDPEVRCHEPWKALVGGSSGVEFYERIAQDLDLVLCPGGVGWLEIG
YRQGELIKKIFAGRGVSGTIYQDLSGCDRIFFLENQASDAVSS
>Mature_283_residues
METKRILSKASAYLKYHGVAFSDREASDILMDFLGISSRAQLASVVLDADSLETYWKRVQQRAARVPTSYIHGSVSFLGL
HLDVDSRVLIPRMETELLAERIIKYLTQHPHIRTFYDVCCGSGCLGLSVKKYCPEIQVVLSDICPKAVAVAKANASINNL
KVEILLGDLFSPYSYPADAFVCNPPYLSFSEIMYVDPEVRCHEPWKALVGGSSGVEFYERIAQDLDLVLCPGGVGWLEIG
YRQGELIKKIFAGRGVSGTIYQDLSGCDRIFFLENQASDAVSS

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=284, Percent_Identity=27.112676056338, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1787463, Length=203, Percent_Identity=31.5270935960591, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI87082085, Length=225, Percent_Identity=29.7777777777778, Blast_Score=82, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24582226, Length=215, Percent_Identity=29.7674418604651, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 31364; Mature: 31364

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKRILSKASAYLKYHGVAFSDREASDILMDFLGISSRAQLASVVLDADSLETYWKRVQ
CCHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHH
QRAARVPTSYIHGSVSFLGLHLDVDSRVLIPRMETELLAERIIKYLTQHPHIRTFYDVCC
HHHHHCCHHHHCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHC
GSGCLGLSVKKYCPEIQVVLSDICPKAVAVAKANASINNLKVEILLGDLFSPYSYPADAF
CCCCCCCCHHHHCCHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCE
VCNPPYLSFSEIMYVDPEVRCHEPWKALVGGSSGVEFYERIAQDLDLVLCPGGVGWLEIG
EECCCCCCCCCEEEECCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCEEEEC
YRQGELIKKIFAGRGVSGTIYQDLSGCDRIFFLENQASDAVSS
CCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
METKRILSKASAYLKYHGVAFSDREASDILMDFLGISSRAQLASVVLDADSLETYWKRVQ
CCHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHH
QRAARVPTSYIHGSVSFLGLHLDVDSRVLIPRMETELLAERIIKYLTQHPHIRTFYDVCC
HHHHHCCHHHHCCCEEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHC
GSGCLGLSVKKYCPEIQVVLSDICPKAVAVAKANASINNLKVEILLGDLFSPYSYPADAF
CCCCCCCCHHHHCCHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCE
VCNPPYLSFSEIMYVDPEVRCHEPWKALVGGSSGVEFYERIAQDLDLVLCPGGVGWLEIG
EECCCCCCCCCEEEECCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCEEECCCCCCEEEEC
YRQGELIKKIFAGRGVSGTIYQDLSGCDRIFFLENQASDAVSS
CCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]