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The map label for this gene is bioF1 [C]

Identifier: 89897977

GI number: 89897977

Start: 201505

End: 202611

Strand: Direct

Name: bioF1 [C]

Synonym: CF0170

Alternate gene names: 89897977

Gene position: 201505-202611 (Clockwise)

Preceding gene: 89897976

Following gene: 89897980

Centisome position: 17.28

GC content: 41.28

Gene sequence:

>1107_bases
ATGAGCGAATGTCCGATCGATTTTGTAACTAACGATTTTCTTGGTTTTTCTCGTTCTACAATACTAGTTAATGAAGTTGA
GAAACGCTATCGTGCTTACTGTGAGCAATTTTCTCATGCACAGCTTGGAGCGAGTGGCTCTCGTGCTATTTTGGGACCTT
CCCAAATCCAGCAGGATTTAGAAGAAAAAATTGCCAAGTTCCATAATTCTGAGTCTGCTTTTGTAGTCCATAGCGGCTAT
ATGGCAAATTTAGGCCTCTGCTATCACATCTCGAAAAATACCGATATAGTGTTTTGGGATGAGTCTGTGCATATATCTGT
TGCACAAAGTTTGAGAGTGATCTCTGGGGAACATCAAGCATTCCCCCACAATGATCTATGCGCTCTAGAGTCATTATTAA
TATCTCACAGGGCAGTCTCATCGGGAAGAATCTTCATTTTTGTTTGTTCAGTATACTCTTTTTCGGGAACTTTGGCTCCT
CTTGAAGAACTCATAGCTCTTTCAAAAAAATATAACGCCCATCTCATTGTAGATGAAGCTCATGCTATGGGCATTTTAGG
AGAAGAAGGACGTGGATTATGTCACAAATGGGGATACGAAAATTTTTATGCTGTGCTTGTGACCTATAGCAAGGCTATGG
GAGCTATGGGCGCTGCACTTCTTTCTTCCTTAGAAGTGAAAACAGAATTGATGTTGAGTTCTCCTCCCCTGCGTTATACT
ACCGCGTTAGCTCCTCATGCACTGATCACCATAGGAGCTTCCTACGATCATCTAGTTCTGGAGGGAGAGCGTGCACGTCA
GAAAATATTCAACCTAAAGGCATATTTTCAAAAGCCTTTTGGATTGAGTTCTCAGTGTTGTGGGCAACCCGTCTTTCTCA
GAGATTTTAATATGGATCTTCTTACCTCTATGTTAGATGAGGCAAACCTGCGCGTAGGATTAATGACTTTCGCTCACAGG
CCTTTCATCCGAGTGAATTTTCATGCGTATAATAATCACGATGAAGTTGATATTTTGGTCGCTATGCTACACAGCTATTT
AGAAAAATGTTGTTGTGGGATCGACGTCGATCATGAACTTTACTTTAGGAGAGAGTTTTGCCGATAA

Upstream 100 bases:

>100_bases
ATTACCGAGCTTTAAACTCCTTAGCTCTTTCTCTGTTTCAGGGGGACTAAAAAGGCACTTGAATAATTAAAGATTCTAGA
TTGTAAGGAAAAGATCTTTA

Downstream 100 bases:

>100_bases
CAAAGCTTCATGAAGCTTTTTATTTACCGGAAGAACTTGTTTGCTCTTTATTAGGAATTGATACCTAAACACATCTTTAA
TTTTAAAATGCCCACAGGGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSECPIDFVTNDFLGFSRSTILVNEVEKRYRAYCEQFSHAQLGASGSRAILGPSQIQQDLEEKIAKFHNSESAFVVHSGY
MANLGLCYHISKNTDIVFWDESVHISVAQSLRVISGEHQAFPHNDLCALESLLISHRAVSSGRIFIFVCSVYSFSGTLAP
LEELIALSKKYNAHLIVDEAHAMGILGEEGRGLCHKWGYENFYAVLVTYSKAMGAMGAALLSSLEVKTELMLSSPPLRYT
TALAPHALITIGASYDHLVLEGERARQKIFNLKAYFQKPFGLSSQCCGQPVFLRDFNMDLLTSMLDEANLRVGLMTFAHR
PFIRVNFHAYNNHDEVDILVAMLHSYLEKCCCGIDVDHELYFRREFCR

Sequences:

>Translated_368_residues
MSECPIDFVTNDFLGFSRSTILVNEVEKRYRAYCEQFSHAQLGASGSRAILGPSQIQQDLEEKIAKFHNSESAFVVHSGY
MANLGLCYHISKNTDIVFWDESVHISVAQSLRVISGEHQAFPHNDLCALESLLISHRAVSSGRIFIFVCSVYSFSGTLAP
LEELIALSKKYNAHLIVDEAHAMGILGEEGRGLCHKWGYENFYAVLVTYSKAMGAMGAALLSSLEVKTELMLSSPPLRYT
TALAPHALITIGASYDHLVLEGERARQKIFNLKAYFQKPFGLSSQCCGQPVFLRDFNMDLLTSMLDEANLRVGLMTFAHR
PFIRVNFHAYNNHDEVDILVAMLHSYLEKCCCGIDVDHELYFRREFCR
>Mature_367_residues
SECPIDFVTNDFLGFSRSTILVNEVEKRYRAYCEQFSHAQLGASGSRAILGPSQIQQDLEEKIAKFHNSESAFVVHSGYM
ANLGLCYHISKNTDIVFWDESVHISVAQSLRVISGEHQAFPHNDLCALESLLISHRAVSSGRIFIFVCSVYSFSGTLAPL
EELIALSKKYNAHLIVDEAHAMGILGEEGRGLCHKWGYENFYAVLVTYSKAMGAMGAALLSSLEVKTELMLSSPPLRYTT
ALAPHALITIGASYDHLVLEGERARQKIFNLKAYFQKPFGLSSQCCGQPVFLRDFNMDLLTSMLDEANLRVGLMTFAHRP
FIRVNFHAYNNHDEVDILVAMLHSYLEKCCCGIDVDHELYFRREFCR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4758668, Length=255, Percent_Identity=29.0196078431373, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI5454084, Length=205, Percent_Identity=31.7073170731707, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI83977444, Length=264, Percent_Identity=28.4090909090909, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI284448556, Length=365, Percent_Identity=26.8493150684932, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI83977440, Length=264, Percent_Identity=28.4090909090909, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI83977442, Length=264, Percent_Identity=28.4090909090909, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI7657118, Length=365, Percent_Identity=26.8493150684932, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI119220554, Length=215, Percent_Identity=30.2325581395349, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4502025, Length=262, Percent_Identity=27.0992366412214, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI40316939, Length=262, Percent_Identity=27.0992366412214, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786993, Length=355, Percent_Identity=27.887323943662, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790046, Length=269, Percent_Identity=28.2527881040892, Blast_Score=95, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71994529, Length=246, Percent_Identity=30.8943089430894, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17560914, Length=205, Percent_Identity=29.2682926829268, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560912, Length=205, Percent_Identity=29.2682926829268, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982617, Length=284, Percent_Identity=24.6478873239437, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=284, Percent_Identity=24.6478873239437, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI32566772, Length=290, Percent_Identity=25.8620689655172, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320267, Length=246, Percent_Identity=26.4227642276423, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320438, Length=299, Percent_Identity=25.4180602006689, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323954, Length=224, Percent_Identity=27.2321428571429, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24662918, Length=352, Percent_Identity=28.6931818181818, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653280, Length=365, Percent_Identity=24.1095890410959, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653276, Length=365, Percent_Identity=24.1095890410959, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653278, Length=365, Percent_Identity=24.1095890410959, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136286, Length=290, Percent_Identity=28.2758620689655, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137420, Length=270, Percent_Identity=28.5185185185185, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 41358; Mature: 41227

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSECPIDFVTNDFLGFSRSTILVNEVEKRYRAYCEQFSHAQLGASGSRAILGPSQIQQDL
CCCCCCCHHHCHHCCCCCCEEHHHHHHHHHHHHHHHHCCHHCCCCCCCEEECHHHHHHHH
EEKIAKFHNSESAFVVHSGYMANLGLCYHISKNTDIVFWDESVHISVAQSLRVISGEHQA
HHHHHHHCCCCCEEEEECCCEECCEEEEEECCCCEEEEECCCEEEEHHHHHHHHCCCCCC
FPHNDLCALESLLISHRAVSSGRIFIFVCSVYSFSGTLAPLEELIALSKKYNAHLIVDEA
CCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECH
HAMGILGEEGRGLCHKWGYENFYAVLVTYSKAMGAMGAALLSSLEVKTELMLSSPPLRYT
HHCCEECCCCCCHHHHCCCCHHEEHEEEHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEE
TALAPHALITIGASYDHLVLEGERARQKIFNLKAYFQKPFGLSSQCCGQPVFLRDFNMDL
HHCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEECCHHH
LTSMLDEANLRVGLMTFAHRPFIRVNFHAYNNHDEVDILVAMLHSYLEKCCCGIDVDHEL
HHHHHHHCCCEEEEEHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
YFRREFCR
HHHHHHCC
>Mature Secondary Structure 
SECPIDFVTNDFLGFSRSTILVNEVEKRYRAYCEQFSHAQLGASGSRAILGPSQIQQDL
CCCCCCHHHCHHCCCCCCEEHHHHHHHHHHHHHHHHCCHHCCCCCCCEEECHHHHHHHH
EEKIAKFHNSESAFVVHSGYMANLGLCYHISKNTDIVFWDESVHISVAQSLRVISGEHQA
HHHHHHHCCCCCEEEEECCCEECCEEEEEECCCCEEEEECCCEEEEHHHHHHHHCCCCCC
FPHNDLCALESLLISHRAVSSGRIFIFVCSVYSFSGTLAPLEELIALSKKYNAHLIVDEA
CCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECH
HAMGILGEEGRGLCHKWGYENFYAVLVTYSKAMGAMGAALLSSLEVKTELMLSSPPLRYT
HHCCEECCCCCCHHHHCCCCHHEEHEEEHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEE
TALAPHALITIGASYDHLVLEGERARQKIFNLKAYFQKPFGLSSQCCGQPVFLRDFNMDL
HHCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEECCHHH
LTSMLDEANLRVGLMTFAHRPFIRVNFHAYNNHDEVDILVAMLHSYLEKCCCGIDVDHEL
HHHHHHHCCCEEEEEHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
YFRREFCR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA