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The map label for this gene is aas [H]

Identifier: 89897976

GI number: 89897976

Start: 199832

End: 201454

Strand: Direct

Name: aas [H]

Synonym: CF0169

Alternate gene names: 89897976

Gene position: 199832-201454 (Clockwise)

Preceding gene: 89897975

Following gene: 89897977

Centisome position: 17.13

GC content: 41.34

Gene sequence:

>1623_bases
ATGCATAAGCGTTGGAATTATTCTAAAAAGCGTCGTCTAGGTTTACGAGACGGGCGGACAGTTTTAGAGAAATTTTTAAA
ACTCTGTTCGGAAATGACATCAGATGCCTGTTGCTGGGATGAACAGCTGGGGGTTCTATCGTACGAGGATATGCGTAAGG
CTATAACAGCCTTATCTTTAAAAGTATCCGAATATCCCGAAAAAAATATTGGGATTATGATGCCTTCCTCTGCAGGTGCC
TATATTGCTTATTTCGCAGTATTATTAGCTGGAAAAGTTCCTGTTATGATCAACTGGAGTCAGGGACTTCGTGAAATGGA
AGCTTGTATTGAATTATCTCATGTAAAGCATATCCTGACTTCAAAACAACTTGTTGAGCATTTGCGGCAGATCCACGGTG
ATGGTATAGAGTACCCAGCACTGCTAATCTATATGGAAACTATCCGCAAGCACTTCACCCTTTGGGATAAAATACGTATA
GCTTTTTACCTATCTTTACCCTACACATGGGTAATTCGACTATTTAATATTTCGGGACAGAATAAGGAAGATTGTGCCGT
TATTTTGTTTACATCGGGGACGGAAAAACTCCCCAAAGGGGTTCCGTTAACCCACGCTAACCTCATAGCAAATCAAGAAG
CTTGTTTGAAGTTTTTCAATCCCTTAGAAACGGACATTATGATGTCGTTTCTTCCTCCGTTTCATGCCTATGGGTTTAAC
TGCTGCGCTCTTTTTCCCATACTCGCTGGTTTGCCAGTAGTTTTCTCTTACAACCCTCTACAGCCTAAAAAAATCGTTGA
GCTTATAGACGCAACACACGCGACCTTTTTAGGAGGAACACCCATATTTTTCGATTATATTTTGAAAACAGCTAAAAAAC
AGGGGTCTTCGCTAAGCTCCTTGCGCTTGGCGGTTATTGGTGGTGATGCTTTTAAAGACTCGTTAAGAAATGGGGTGCAA
AAAGATTTTCCACATATTGTTCCTTACCAGGGATACGGGACTACAGAGTGTTCTCCAGTGATTACAATTAATAATGAGAA
GAGCCCTAAAATTGAATCCTGCGTTGGTATCCCTATCGATGGTATGGATGTTATGGTAGTCTCTGAAGAGACTTATGTCC
CTGTATCTTCAGGCGAAGTCGGAGTGATTCTTATCCGTGGGACATCGCTCTTTTCTGGCTATTTAGGGAATGATCCTACT
TGTGGTTTTGTACGGCTTGGAGGAGAACTCTGGTATGTGACGGGAGACTTAGGTTGCTTGGATAACGAGGGGCAGTTATT
TTTAAAAGGTAGACTCAGCCGTTTTGTGAAAATCGGTAGCGAAATGATTAGTCTGCAAGCTTTAGAAAGCTTGCTCATTG
AAGGTTTTGGACTTCCCGAAGATCCAGGTAGCATTCCATTAGTTGTTTGTGGAATTCCGGGAGAGAGGGTAAAGCTTTGT
TTATTTACGACATTTTCTACGGATCTCAATGAAGTAAATGATATCCTAAAAAACTTAAAAACAAGTAGCATAATGAAGAT
ATCCTATCAGCATCAGGTAGAGTCTATACCGATGCTGGGGACAGGAAAGCCTGATTACCGAGCTTTAAACTCCTTAGCTC
TTTCTCTGTTTCAGGGGGACTAA

Upstream 100 bases:

>100_bases
CTACAAAACAGGATTTAAACACTTTTCTTTCTTCCTGGTTTAACGAAGAGAAGGAAAGTTTTCCTATAGAAGTTCCTTAT
GCCTAATGTAGGGGAGAGAT

Downstream 100 bases:

>100_bases
AAAGGCACTTGAATAATTAAAGATTCTAGATTGTAAGGAAAAGATCTTTAATGAGCGAATGTCCGATCGATTTTGTAACT
AACGATTTTCTTGGTTTTTC

Product: long chain fatty acid--[acyl-carrier-protein] ligase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MHKRWNYSKKRRLGLRDGRTVLEKFLKLCSEMTSDACCWDEQLGVLSYEDMRKAITALSLKVSEYPEKNIGIMMPSSAGA
YIAYFAVLLAGKVPVMINWSQGLREMEACIELSHVKHILTSKQLVEHLRQIHGDGIEYPALLIYMETIRKHFTLWDKIRI
AFYLSLPYTWVIRLFNISGQNKEDCAVILFTSGTEKLPKGVPLTHANLIANQEACLKFFNPLETDIMMSFLPPFHAYGFN
CCALFPILAGLPVVFSYNPLQPKKIVELIDATHATFLGGTPIFFDYILKTAKKQGSSLSSLRLAVIGGDAFKDSLRNGVQ
KDFPHIVPYQGYGTTECSPVITINNEKSPKIESCVGIPIDGMDVMVVSEETYVPVSSGEVGVILIRGTSLFSGYLGNDPT
CGFVRLGGELWYVTGDLGCLDNEGQLFLKGRLSRFVKIGSEMISLQALESLLIEGFGLPEDPGSIPLVVCGIPGERVKLC
LFTTFSTDLNEVNDILKNLKTSSIMKISYQHQVESIPMLGTGKPDYRALNSLALSLFQGD

Sequences:

>Translated_540_residues
MHKRWNYSKKRRLGLRDGRTVLEKFLKLCSEMTSDACCWDEQLGVLSYEDMRKAITALSLKVSEYPEKNIGIMMPSSAGA
YIAYFAVLLAGKVPVMINWSQGLREMEACIELSHVKHILTSKQLVEHLRQIHGDGIEYPALLIYMETIRKHFTLWDKIRI
AFYLSLPYTWVIRLFNISGQNKEDCAVILFTSGTEKLPKGVPLTHANLIANQEACLKFFNPLETDIMMSFLPPFHAYGFN
CCALFPILAGLPVVFSYNPLQPKKIVELIDATHATFLGGTPIFFDYILKTAKKQGSSLSSLRLAVIGGDAFKDSLRNGVQ
KDFPHIVPYQGYGTTECSPVITINNEKSPKIESCVGIPIDGMDVMVVSEETYVPVSSGEVGVILIRGTSLFSGYLGNDPT
CGFVRLGGELWYVTGDLGCLDNEGQLFLKGRLSRFVKIGSEMISLQALESLLIEGFGLPEDPGSIPLVVCGIPGERVKLC
LFTTFSTDLNEVNDILKNLKTSSIMKISYQHQVESIPMLGTGKPDYRALNSLALSLFQGD
>Mature_540_residues
MHKRWNYSKKRRLGLRDGRTVLEKFLKLCSEMTSDACCWDEQLGVLSYEDMRKAITALSLKVSEYPEKNIGIMMPSSAGA
YIAYFAVLLAGKVPVMINWSQGLREMEACIELSHVKHILTSKQLVEHLRQIHGDGIEYPALLIYMETIRKHFTLWDKIRI
AFYLSLPYTWVIRLFNISGQNKEDCAVILFTSGTEKLPKGVPLTHANLIANQEACLKFFNPLETDIMMSFLPPFHAYGFN
CCALFPILAGLPVVFSYNPLQPKKIVELIDATHATFLGGTPIFFDYILKTAKKQGSSLSSLRLAVIGGDAFKDSLRNGVQ
KDFPHIVPYQGYGTTECSPVITINNEKSPKIESCVGIPIDGMDVMVVSEETYVPVSSGEVGVILIRGTSLFSGYLGNDPT
CGFVRLGGELWYVTGDLGCLDNEGQLFLKGRLSRFVKIGSEMISLQALESLLIEGFGLPEDPGSIPLVVCGIPGERVKLC
LFTTFSTDLNEVNDILKNLKTSSIMKISYQHQVESIPMLGTGKPDYRALNSLALSLFQGD

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=272, Percent_Identity=26.8382352941176, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1789201, Length=550, Percent_Identity=28.9090909090909, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI145693145, Length=352, Percent_Identity=27.8409090909091, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788107, Length=441, Percent_Identity=24.2630385487528, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786810, Length=516, Percent_Identity=22.4806201550388, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=376, Percent_Identity=24.7340425531915, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=275, Percent_Identity=28.3636363636364, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17560308, Length=266, Percent_Identity=28.1954887218045, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71994703, Length=442, Percent_Identity=23.9819004524887, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994694, Length=442, Percent_Identity=23.9819004524887, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994690, Length=442, Percent_Identity=23.9819004524887, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559526, Length=362, Percent_Identity=25.9668508287293, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32563687, Length=278, Percent_Identity=24.8201438848921, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319699, Length=287, Percent_Identity=26.8292682926829, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355181, Length=437, Percent_Identity=23.5697940503432, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI18859661, Length=313, Percent_Identity=26.1980830670927, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24581924, Length=331, Percent_Identity=26.2839879154079, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24648260, Length=306, Percent_Identity=26.797385620915, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648676, Length=378, Percent_Identity=26.1904761904762, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130357, Length=278, Percent_Identity=25.5395683453237, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356441, Length=310, Percent_Identity=24.5161290322581, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24648253, Length=313, Percent_Identity=23.961661341853, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 59963; Mature: 59963

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKRWNYSKKRRLGLRDGRTVLEKFLKLCSEMTSDACCWDEQLGVLSYEDMRKAITALSL
CCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHE
KVSEYPEKNIGIMMPSSAGAYIAYFAVLLAGKVPVMINWSQGLREMEACIELSHVKHILT
EHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
SKQLVEHLRQIHGDGIEYPALLIYMETIRKHFTLWDKIRIAFYLSLPYTWVIRLFNISGQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEECCHHHHHHEEECCCC
NKEDCAVILFTSGTEKLPKGVPLTHANLIANQEACLKFFNPLETDIMMSFLPPFHAYGFN
CCCCEEEEEECCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHHCCCHHHCCCH
CCALFPILAGLPVVFSYNPLQPKKIVELIDATHATFLGGTPIFFDYILKTAKKQGSSLSS
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
LRLAVIGGDAFKDSLRNGVQKDFPHIVPYQGYGTTECSPVITINNEKSPKIESCVGIPID
EEEEEEECHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHCCCCCCC
GMDVMVVSEETYVPVSSGEVGVILIRGTSLFSGYLGNDPTCGFVRLGGELWYVTGDLGCL
CCEEEEEECCEEEEECCCCEEEEEEECCHHHHCCCCCCCCEEEEEECCEEEEEECCCCCC
DNEGQLFLKGRLSRFVKIGSEMISLQALESLLIEGFGLPEDPGSIPLVVCGIPGERVKLC
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEE
LFTTFSTDLNEVNDILKNLKTSSIMKISYQHQVESIPMLGTGKPDYRALNSLALSLFQGD
EEEECCCCHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHKRWNYSKKRRLGLRDGRTVLEKFLKLCSEMTSDACCWDEQLGVLSYEDMRKAITALSL
CCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHHE
KVSEYPEKNIGIMMPSSAGAYIAYFAVLLAGKVPVMINWSQGLREMEACIELSHVKHILT
EHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
SKQLVEHLRQIHGDGIEYPALLIYMETIRKHFTLWDKIRIAFYLSLPYTWVIRLFNISGQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEECCHHHHHHEEECCCC
NKEDCAVILFTSGTEKLPKGVPLTHANLIANQEACLKFFNPLETDIMMSFLPPFHAYGFN
CCCCEEEEEECCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCHHHHHHHHHCCCHHHCCCH
CCALFPILAGLPVVFSYNPLQPKKIVELIDATHATFLGGTPIFFDYILKTAKKQGSSLSS
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
LRLAVIGGDAFKDSLRNGVQKDFPHIVPYQGYGTTECSPVITINNEKSPKIESCVGIPID
EEEEEEECHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHCCCCCCC
GMDVMVVSEETYVPVSSGEVGVILIRGTSLFSGYLGNDPTCGFVRLGGELWYVTGDLGCL
CCEEEEEECCEEEEECCCCEEEEEEECCHHHHCCCCCCCCEEEEEECCEEEEEECCCCCC
DNEGQLFLKGRLSRFVKIGSEMISLQALESLLIEGFGLPEDPGSIPLVVCGIPGERVKLC
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEE
LFTTFSTDLNEVNDILKNLKTSSIMKISYQHQVESIPMLGTGKPDYRALNSLALSLFQGD
EEEECCCCHHHHHHHHHHCCCCCEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA