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The map label for this gene is pepP [H]

Identifier: 89897871

GI number: 89897871

Start: 70748

End: 71818

Strand: Direct

Name: pepP [H]

Synonym: CF0064

Alternate gene names: 89897871

Gene position: 70748-71818 (Clockwise)

Preceding gene: 89897870

Following gene: 89897872

Centisome position: 6.07

GC content: 44.82

Gene sequence:

>1071_bases
ATGTTCCAGGATCGCATTGCAAGAGCGCAAGCAGCTCTAGCAGATTATGGTATAGACGGGTTTATTGTAGAAAGAAGTGA
GGATCTTGCGTACTTTCTTAATGATAAAGTGACTACAGGAACGCTTCTCATAGGTAAAGATGAGGTTGTGTTTTTTGTTT
ATCGTATGGATAAAGATCTCTATGCAGATCTTCAAGGCCCCTCCCTTGTGTTTTGTGATAGAAATATTGCAGAATTTCTT
CTTCCTTATCTTAAAACAACCACATATCAAACTATAGGATTTGATAGCCTCCACACTTCGTACCATAGATATCAAGAAAG
AGAAAATGCGGTGTGTTCTTGGGTGCCTACTACCCTATTTACAGAGAAGCTGCGTAGTGTAAAATCTGCAGATGAAATAG
AGAAAATGCGTCAGGCGGCGATTTTAGGCTCCGAGGGGTATGATCATGTTCTTTCCATACTGCAAGAGGGCATAACAGAA
CAAGAAGTTGTACGTCTCCTGCGCGTGTTTTGGGCAAAAGCTGGCGCCGAAGGTCCCTCTTTTTCACCCATTATTGCTTT
CGGTCATCATTCCGCTTTCCCTCATGCGGTTCCTACAAACAGGGCCCTACGTAAGGGAGATATCGTGCTTATTGATATAG
GGGTCCTGTACCACGGCTACTGCTCAGATATGACACGCACGGTGGCTTGGGGGCGTCCAGATTCGCTCCTTGTTGAGAGC
TATCCTGCGGTGGTAGAAGCTCAGCGAGCTGCTATGAAGCTTTGTTGTGCAGGGGCTGCATGTCTAGATATTCATGAAGA
GGCTGCTCGAGTCCTTAGGGGCTACGATCTCGAACAATATTTTTGTCATGGTGTTGGCCACGGTGTGGGAAGAAATATCC
ATGAATACCCCCAACTTTCTCCAAAATCTGGTTCAGCCACTCTAGAGACGGGAATGACAGTAACTGTCGAGCCCGGAGTT
TATTTCCCCGGAGTCGGAGGCATACGTATCGAGGATACAGTATTGATAGATGGGAATAAAAATTTTAGTTTAACAGATCG
TCCGGTGTCTTCAGATTTAGTTTTCTTATAA

Upstream 100 bases:

>100_bases
GCTTTCCTTGCTCTGGCAAATAGGTAAACCGGAAAAAGCCTTTGACGGCACTCAAATACGTCGGTTAGTTTTAGACGAGG
ATTTTATTAAGGAGTAAATT

Downstream 100 bases:

>100_bases
AAGCACTCTCTCTTTGTTTAATTATTTTTAATGTTAAACATAGTTGCTTTTGTTTGTATAAATTGATTTTTTTTCTCTAA
TCGGTTATCTTATAACTTTA

Product: aminopeptidase P

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MFQDRIARAQAALADYGIDGFIVERSEDLAYFLNDKVTTGTLLIGKDEVVFFVYRMDKDLYADLQGPSLVFCDRNIAEFL
LPYLKTTTYQTIGFDSLHTSYHRYQERENAVCSWVPTTLFTEKLRSVKSADEIEKMRQAAILGSEGYDHVLSILQEGITE
QEVVRLLRVFWAKAGAEGPSFSPIIAFGHHSAFPHAVPTNRALRKGDIVLIDIGVLYHGYCSDMTRTVAWGRPDSLLVES
YPAVVEAQRAAMKLCCAGAACLDIHEEAARVLRGYDLEQYFCHGVGHGVGRNIHEYPQLSPKSGSATLETGMTVTVEPGV
YFPGVGGIRIEDTVLIDGNKNFSLTDRPVSSDLVFL

Sequences:

>Translated_356_residues
MFQDRIARAQAALADYGIDGFIVERSEDLAYFLNDKVTTGTLLIGKDEVVFFVYRMDKDLYADLQGPSLVFCDRNIAEFL
LPYLKTTTYQTIGFDSLHTSYHRYQERENAVCSWVPTTLFTEKLRSVKSADEIEKMRQAAILGSEGYDHVLSILQEGITE
QEVVRLLRVFWAKAGAEGPSFSPIIAFGHHSAFPHAVPTNRALRKGDIVLIDIGVLYHGYCSDMTRTVAWGRPDSLLVES
YPAVVEAQRAAMKLCCAGAACLDIHEEAARVLRGYDLEQYFCHGVGHGVGRNIHEYPQLSPKSGSATLETGMTVTVEPGV
YFPGVGGIRIEDTVLIDGNKNFSLTDRPVSSDLVFL
>Mature_356_residues
MFQDRIARAQAALADYGIDGFIVERSEDLAYFLNDKVTTGTLLIGKDEVVFFVYRMDKDLYADLQGPSLVFCDRNIAEFL
LPYLKTTTYQTIGFDSLHTSYHRYQERENAVCSWVPTTLFTEKLRSVKSADEIEKMRQAAILGSEGYDHVLSILQEGITE
QEVVRLLRVFWAKAGAEGPSFSPIIAFGHHSAFPHAVPTNRALRKGDIVLIDIGVLYHGYCSDMTRTVAWGRPDSLLVES
YPAVVEAQRAAMKLCCAGAACLDIHEEAARVLRGYDLEQYFCHGVGHGVGRNIHEYPQLSPKSGSATLETGMTVTVEPGV
YFPGVGGIRIEDTVLIDGNKNFSLTDRPVSSDLVFL

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=257, Percent_Identity=28.4046692607004, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI93141226, Length=166, Percent_Identity=34.9397590361446, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI264681563, Length=249, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI149589008, Length=276, Percent_Identity=25, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI260593665, Length=276, Percent_Identity=25, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788728, Length=331, Percent_Identity=32.9305135951662, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1789275, Length=265, Percent_Identity=27.9245283018868, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1790282, Length=284, Percent_Identity=24.2957746478873, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786364, Length=209, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508215, Length=289, Percent_Identity=25.2595155709343, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17509539, Length=200, Percent_Identity=31.5, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320922, Length=256, Percent_Identity=25.78125, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6321118, Length=300, Percent_Identity=23.6666666666667, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323273, Length=201, Percent_Identity=27.363184079602, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357079, Length=291, Percent_Identity=28.8659793814433, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19920384, Length=261, Percent_Identity=27.9693486590038, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39533; Mature: 39533

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDRIARAQAALADYGIDGFIVERSEDLAYFLNDKVTTGTLLIGKDEVVFFVYRMDKDL
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCEEEEEEEECCCEEEEEEEECCHH
YADLQGPSLVFCDRNIAEFLLPYLKTTTYQTIGFDSLHTSYHRYQERENAVCSWVPTTLF
HCCCCCCEEEEECCCHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCCEEEECCHHHH
TEKLRSVKSADEIEKMRQAAILGSEGYDHVLSILQEGITEQEVVRLLRVFWAKAGAEGPS
HHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
FSPIIAFGHHSAFPHAVPTNRALRKGDIVLIDIGVLYHGYCSDMTRTVAWGRPDSLLVES
CCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHC
YPAVVEAQRAAMKLCCAGAACLDIHEEAARVLRGYDLEQYFCHGVGHGVGRNIHEYPQLS
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHCCCCC
PKSGSATLETGMTVTVEPGVYFPGVGGIRIEDTVLIDGNKNFSLTDRPVSSDLVFL
CCCCCEEEECCCEEEECCCEECCCCCCEEEEEEEEEECCCCCEECCCCCCCCCEEC
>Mature Secondary Structure
MFQDRIARAQAALADYGIDGFIVERSEDLAYFLNDKVTTGTLLIGKDEVVFFVYRMDKDL
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCEEEEEEEECCCEEEEEEEECCHH
YADLQGPSLVFCDRNIAEFLLPYLKTTTYQTIGFDSLHTSYHRYQERENAVCSWVPTTLF
HCCCCCCEEEEECCCHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCCEEEECCHHHH
TEKLRSVKSADEIEKMRQAAILGSEGYDHVLSILQEGITEQEVVRLLRVFWAKAGAEGPS
HHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
FSPIIAFGHHSAFPHAVPTNRALRKGDIVLIDIGVLYHGYCSDMTRTVAWGRPDSLLVES
CCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHC
YPAVVEAQRAAMKLCCAGAACLDIHEEAARVLRGYDLEQYFCHGVGHGVGRNIHEYPQLS
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHCCCCC
PKSGSATLETGMTVTVEPGVYFPGVGGIRIEDTVLIDGNKNFSLTDRPVSSDLVFL
CCCCCEEEECCCEEEECCCEECCCCCCEEEEEEEEEECCCCCEECCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]