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The map label for this gene is trxA1 [H]

Identifier: 89897849

GI number: 89897849

Start: 40843

End: 43026

Strand: Direct

Name: trxA1 [H]

Synonym: CF0042

Alternate gene names: 89897849

Gene position: 40843-43026 (Clockwise)

Preceding gene: 89897841

Following gene: 89897850

Centisome position: 3.5

GC content: 43.77

Gene sequence:

>2184_bases
ATGTATAATTATCTACCTGATTTAGAAATAATTGGAGTTGTTTTGAATAAAATCAAAAAGCATTTTCAAACTATACTAGT
GGCTTTTCTATTTTCTTTACCTGCCTTTACTGAGTGTGGTCAGAAATTGCATGCCGCGGAGCCCGTAGTGGAACAGGTTG
CACCGGGAGCCACTCTAATTTCTGAGGGGACCCATATTCCCAAGGGTGAGGTGTTTAGAGTGGGGGTTCGGGTATCCGCT
CTTAAGGGAAGCCATATTTACTGGAAAAACCCTGGGGAAGAGGGTAGCCCGCTAAGAATTCATTGGAATTTACCCAAGGG
ATTCGTTGTTGAGGAGGAACACTGGCCTTCTCCAAAGGTTTTCGAAGAAGACGGCACAACATTCTTCGGTTATGACGATA
ACGCTCTTATTGTTGCCGATATTCGTGCTCCGAAAAACGGAGATGATCGAGAATCTGTTGTATTAAAGGTTCACGTTGAG
TGGTTGGCTTGTGGGGAAAGTTGCGTACCCGGAAATGCCGATTTGGAACTAGCTCTTCCGTATCGTGATGGTGCGGCTAC
TCTATATCCTGAAAAATCTGCAGAGTTTGCTCAAACGCTACAGGCTCAACCTCGTCTGTTGAAAGATGATCGTGCGATTA
CTTTAGGGCGCAGTCAGGAAGGCGAGATTATTTTAAATATTACTGGCCAGCAAAACCGTGCAGAGAAAGCCTGGTTTATC
TCAGAGAAAGCTGACAAAATTTTTGCATATTCAGAAGAAGCTATAAAAGAGGCTTCCGGGACGGCCTGGAAACTGAAAGT
AAAAACTCTAGCGGGAGTTCAGAAGAATCAGGAATTACAGGGAGTTCTATTACTTACAGATAGCGCCGGTCACGAGGTTG
AATCTTTTGCAGTTCGTGGTCAAATTAATGATTCTGGAGAATCGGCTTCCGATTTGTGGAATTACATAACGATTGTAGCT
ATGGCGTTCCTCGGGGGACTTCTTCTTAATATTATGCCCTGTGTTCTACCTTTAGTTACTCTAAAGGTGTATGGATTAAT
AAAATCGGCAGGAGAGCATCGTTCCTCTGTAATTATCAATGGACTGTGCTTTACTTTAGGAGTCGTCGGTTGTTTCTGGG
GATTGGCTGGAGTTGCTTTTCTCTTAAAAATGTTAGGACATAACATTGGATGGGGTTTCCAACTTCAAGAACCAATGTTT
GTGGCGACATTGATCATCGTATTCTTCCTGTTTGCTTTAAGCTCTTTAGGTTTATTTGAAACAGGCGCAATGTTTGCGAA
CTTAGGTGCGAAACTACGCCCTACAGGTTCTGGAGATTCTAGGAATAAAGCTGTGGGAGCTGTGTTTAACGGGGTATTGG
CTACGTTAGTAACTACTCCATGTACGGGACCGTTTTTGGGTTCTATTTTGGGGCTCGTAATGTCATTGTCGTTTATCAAG
CAGTTGACGATATTTACATCCATTGGTTTGGGAATGGCATCGCCATATCTTGTGTTTTCTGTATTTCCTAAGATGCTTTC
AGTTCTTCCTAAACCCGGAAGCTGGATGAGCACATTTAAACAGCTTACTGGATTTATGTTATTAGGAACGGTAACTTGGT
TAGCGTGGATCTTTGGTTCAGAAACAAGCACTACAGCGCTGATCATCCTTCTTGCGGGATTGTGGCTTGCAGGTATAGGC
GCTTGGATTTTAGGGAAATGGGGTTCTCCGGTTTCTCCGAAGAAACAAAGAATGGTTGTTTCAGCGTTGTTTTTCGGATG
TATAACAGGTGCCCTGTCTTTAAGTTTTGTTGCCTCCAGGCATTTCTCTGGAGAGGGAGAAACCGTTGTTATTCAAGAAA
ACAATGCTTGGCAACCGTTTTCCGCAACCAAACTTGCTCAGTTGCGTAAAGAAGGCCATGCGGTGTTTGTGAACTTCACA
GCTAAGTGGTGTTTGACATGCCAGATGAATAAACCTGTGTTGTACGCAAGTGCGGTACAGGAGATGTTTAAAGAACACGG
GGTAGTGACCCTAGAGGCTGATTGGACCCGCAAGGATCCGGGTATTACTGAGGAGCTGGCACGTTTAGGACGAGCAAGTG
TTCCCTCCTATGTCTATTATCCTGCGGATCAGTCTGATCCTATAGTACTTCCTGAGAAGATTACGCAATCAGTTCTTGAG
AGCATGGTTTTCTCAAAAAACTAA

Upstream 100 bases:

>100_bases
GATCGTACAAAAGACGATCCTATCAAAATTCTGCTATAGAGCCAAGTGGGTTTTGTTAAAGAGATTTACGAAATCGGTTG
TAAAAATAAAACTATAAATA

Downstream 100 bases:

>100_bases
TTTTACATAGATAACTCGTCTTATTTTTGGGGTGTATTTGTATAAATACACCCCTTTTTTGTCCCTTTGTATTAAGAAAA
ACTTCCCTCGAAGTCGATTC

Product: thioredoxin

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 727; Mature: 727

Protein sequence:

>727_residues
MYNYLPDLEIIGVVLNKIKKHFQTILVAFLFSLPAFTECGQKLHAAEPVVEQVAPGATLISEGTHIPKGEVFRVGVRVSA
LKGSHIYWKNPGEEGSPLRIHWNLPKGFVVEEEHWPSPKVFEEDGTTFFGYDDNALIVADIRAPKNGDDRESVVLKVHVE
WLACGESCVPGNADLELALPYRDGAATLYPEKSAEFAQTLQAQPRLLKDDRAITLGRSQEGEIILNITGQQNRAEKAWFI
SEKADKIFAYSEEAIKEASGTAWKLKVKTLAGVQKNQELQGVLLLTDSAGHEVESFAVRGQINDSGESASDLWNYITIVA
MAFLGGLLLNIMPCVLPLVTLKVYGLIKSAGEHRSSVIINGLCFTLGVVGCFWGLAGVAFLLKMLGHNIGWGFQLQEPMF
VATLIIVFFLFALSSLGLFETGAMFANLGAKLRPTGSGDSRNKAVGAVFNGVLATLVTTPCTGPFLGSILGLVMSLSFIK
QLTIFTSIGLGMASPYLVFSVFPKMLSVLPKPGSWMSTFKQLTGFMLLGTVTWLAWIFGSETSTTALIILLAGLWLAGIG
AWILGKWGSPVSPKKQRMVVSALFFGCITGALSLSFVASRHFSGEGETVVIQENNAWQPFSATKLAQLRKEGHAVFVNFT
AKWCLTCQMNKPVLYASAVQEMFKEHGVVTLEADWTRKDPGITEELARLGRASVPSYVYYPADQSDPIVLPEKITQSVLE
SMVFSKN

Sequences:

>Translated_727_residues
MYNYLPDLEIIGVVLNKIKKHFQTILVAFLFSLPAFTECGQKLHAAEPVVEQVAPGATLISEGTHIPKGEVFRVGVRVSA
LKGSHIYWKNPGEEGSPLRIHWNLPKGFVVEEEHWPSPKVFEEDGTTFFGYDDNALIVADIRAPKNGDDRESVVLKVHVE
WLACGESCVPGNADLELALPYRDGAATLYPEKSAEFAQTLQAQPRLLKDDRAITLGRSQEGEIILNITGQQNRAEKAWFI
SEKADKIFAYSEEAIKEASGTAWKLKVKTLAGVQKNQELQGVLLLTDSAGHEVESFAVRGQINDSGESASDLWNYITIVA
MAFLGGLLLNIMPCVLPLVTLKVYGLIKSAGEHRSSVIINGLCFTLGVVGCFWGLAGVAFLLKMLGHNIGWGFQLQEPMF
VATLIIVFFLFALSSLGLFETGAMFANLGAKLRPTGSGDSRNKAVGAVFNGVLATLVTTPCTGPFLGSILGLVMSLSFIK
QLTIFTSIGLGMASPYLVFSVFPKMLSVLPKPGSWMSTFKQLTGFMLLGTVTWLAWIFGSETSTTALIILLAGLWLAGIG
AWILGKWGSPVSPKKQRMVVSALFFGCITGALSLSFVASRHFSGEGETVVIQENNAWQPFSATKLAQLRKEGHAVFVNFT
AKWCLTCQMNKPVLYASAVQEMFKEHGVVTLEADWTRKDPGITEELARLGRASVPSYVYYPADQSDPIVLPEKITQSVLE
SMVFSKN
>Mature_727_residues
MYNYLPDLEIIGVVLNKIKKHFQTILVAFLFSLPAFTECGQKLHAAEPVVEQVAPGATLISEGTHIPKGEVFRVGVRVSA
LKGSHIYWKNPGEEGSPLRIHWNLPKGFVVEEEHWPSPKVFEEDGTTFFGYDDNALIVADIRAPKNGDDRESVVLKVHVE
WLACGESCVPGNADLELALPYRDGAATLYPEKSAEFAQTLQAQPRLLKDDRAITLGRSQEGEIILNITGQQNRAEKAWFI
SEKADKIFAYSEEAIKEASGTAWKLKVKTLAGVQKNQELQGVLLLTDSAGHEVESFAVRGQINDSGESASDLWNYITIVA
MAFLGGLLLNIMPCVLPLVTLKVYGLIKSAGEHRSSVIINGLCFTLGVVGCFWGLAGVAFLLKMLGHNIGWGFQLQEPMF
VATLIIVFFLFALSSLGLFETGAMFANLGAKLRPTGSGDSRNKAVGAVFNGVLATLVTTPCTGPFLGSILGLVMSLSFIK
QLTIFTSIGLGMASPYLVFSVFPKMLSVLPKPGSWMSTFKQLTGFMLLGTVTWLAWIFGSETSTTALIILLAGLWLAGIG
AWILGKWGSPVSPKKQRMVVSALFFGCITGALSLSFVASRHFSGEGETVVIQENNAWQPFSATKLAQLRKEGHAVFVNFT
AKWCLTCQMNKPVLYASAVQEMFKEHGVVTLEADWTRKDPGITEELARLGRASVPSYVYYPADQSDPIVLPEKITQSVLE
SMVFSKN

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=401, Percent_Identity=25.1870324189526, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 79275; Mature: 79275

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNYLPDLEIIGVVLNKIKKHFQTILVAFLFSLPAFTECGQKLHAAEPVVEQVAPGATLI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHCCCCEEE
SEGTHIPKGEVFRVGVRVSALKGSHIYWKNPGEEGSPLRIHWNLPKGFVVEEEHWPSPKV
CCCCCCCCCCEEEEEEEEEEECCCEEEECCCCCCCCCEEEEEECCCCCEEECCCCCCCCE
FEEDGTTFFGYDDNALIVADIRAPKNGDDRESVVLKVHVEWLACGESCVPGNADLELALP
ECCCCCEEEEECCCEEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCEEEEEE
YRDGAATLYPEKSAEFAQTLQAQPRLLKDDRAITLGRSQEGEIILNITGQQNRAEKAWFI
CCCCCEEECCCCHHHHHHHHHCCCCHHCCCCEEEECCCCCCCEEEEECCCCCCCCHHEEE
SEKADKIFAYSEEAIKEASGTAWKLKVKTLAGVQKNQELQGVLLLTDSAGHEVESFAVRG
CCCCCHHHHCCHHHHHHCCCCEEEEEEHHHHCCCCCCCCCEEEEEECCCCCCCHHEEEEC
QINDSGESASDLWNYITIVAMAFLGGLLLNIMPCVLPLVTLKVYGLIKSAGEHRSSVIIN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
GLCFTLGVVGCFWGLAGVAFLLKMLGHNIGWGFQLQEPMFVATLIIVFFLFALSSLGLFE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCHHH
TGAMFANLGAKLRPTGSGDSRNKAVGAVFNGVLATLVTTPCTGPFLGSILGLVMSLSFIK
HHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QLTIFTSIGLGMASPYLVFSVFPKMLSVLPKPGSWMSTFKQLTGFMLLGTVTWLAWIFGS
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
ETSTTALIILLAGLWLAGIGAWILGKWGSPVSPKKQRMVVSALFFGCITGALSLSFVASR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFSGEGETVVIQENNAWQPFSATKLAQLRKEGHAVFVNFTAKWCLTCQMNKPVLYASAVQ
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEEEEEEEEECCCCEEHHHHHH
EMFKEHGVVTLEADWTRKDPGITEELARLGRASVPSYVYYPADQSDPIVLPEKITQSVLE
HHHHHCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCCEECCHHHHHHHHH
SMVFSKN
HHHHCCC
>Mature Secondary Structure
MYNYLPDLEIIGVVLNKIKKHFQTILVAFLFSLPAFTECGQKLHAAEPVVEQVAPGATLI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHCCCCEEE
SEGTHIPKGEVFRVGVRVSALKGSHIYWKNPGEEGSPLRIHWNLPKGFVVEEEHWPSPKV
CCCCCCCCCCEEEEEEEEEEECCCEEEECCCCCCCCCEEEEEECCCCCEEECCCCCCCCE
FEEDGTTFFGYDDNALIVADIRAPKNGDDRESVVLKVHVEWLACGESCVPGNADLELALP
ECCCCCEEEEECCCEEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCEEEEEE
YRDGAATLYPEKSAEFAQTLQAQPRLLKDDRAITLGRSQEGEIILNITGQQNRAEKAWFI
CCCCCEEECCCCHHHHHHHHHCCCCHHCCCCEEEECCCCCCCEEEEECCCCCCCCHHEEE
SEKADKIFAYSEEAIKEASGTAWKLKVKTLAGVQKNQELQGVLLLTDSAGHEVESFAVRG
CCCCCHHHHCCHHHHHHCCCCEEEEEEHHHHCCCCCCCCCEEEEEECCCCCCCHHEEEEC
QINDSGESASDLWNYITIVAMAFLGGLLLNIMPCVLPLVTLKVYGLIKSAGEHRSSVIIN
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
GLCFTLGVVGCFWGLAGVAFLLKMLGHNIGWGFQLQEPMFVATLIIVFFLFALSSLGLFE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCHHH
TGAMFANLGAKLRPTGSGDSRNKAVGAVFNGVLATLVTTPCTGPFLGSILGLVMSLSFIK
HHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
QLTIFTSIGLGMASPYLVFSVFPKMLSVLPKPGSWMSTFKQLTGFMLLGTVTWLAWIFGS
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
ETSTTALIILLAGLWLAGIGAWILGKWGSPVSPKKQRMVVSALFFGCITGALSLSFVASR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFSGEGETVVIQENNAWQPFSATKLAQLRKEGHAVFVNFTAKWCLTCQMNKPVLYASAVQ
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEEEEEEEEECCCCEEHHHHHH
EMFKEHGVVTLEADWTRKDPGITEELARLGRASVPSYVYYPADQSDPIVLPEKITQSVLE
HHHHHCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEEECCCCCCCEECCHHHHHHHHH
SMVFSKN
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA