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The map label for this gene is ahpC [C]

Identifier: 89897841

GI number: 89897841

Start: 35248

End: 35865

Strand: Direct

Name: ahpC [C]

Synonym: CF0034

Alternate gene names: 89897841

Gene position: 35248-35865 (Clockwise)

Preceding gene: 89897840

Following gene: 89897849

Centisome position: 3.02

GC content: 38.03

Gene sequence:

>618_bases
ATGCATAATCATAAAAATAGGGTGGTAATGGGATCGCTTTTCGTTGGGAAAACTGCCCCAGATTTTTCTGCACAAGCAGT
AGTTGATGGTGAAGTAAAGAATATTTCCTTGAAAGATTATCGTGGTAAATACGTTATTCTTTTCTTTTATCCTAAAGATT
TTACATATGTTTGTCCTACCGAGCTTCATGCTTTTCAACATTCTTTAGAAGAATTCGAATCCCGCGGCGCACAAATTTTG
GGGTGCTCCGTTGACGATCTTGATACCCACAAGCGTTGGTTAGAAACTGATAAAAAAGCTGGTGGAGTTAAAGGTATTAC
CTATCCTCTAATTTCTGACACAACTCAGGAGCTTTCTAAACTCTATAGTGTTTTAGACTTACAGTCTGGATTATCATTCC
GTGGATCATTTCTGATCGATAAAGATGGGATAATTAGACATATGGTAATAAACGATCTTCCTTTAGGTCGTTCTATAGAT
GAAGAGCTTCGTGTATTAGACGCGTTAATTTTCTTCGAGAATCATGGATTAGTATGTCCTGCAAATTGGCAGCAAGGACA
GAAAGCTATGGCTCCCAATGAAGAAGGTTTGAAAGAGTACTTCGGAACTATCGATTAG

Upstream 100 bases:

>100_bases
GACTACACTTTTCATCGAAAGAGCTGTGCACCAGTAGCTCAGTGGATAGAGTACCTGGCTACGAACCAGGTGGTCAGAGG
TTCAAGTCCTCTCTGGTGCG

Downstream 100 bases:

>100_bases
AAAGCTTTGTTAAAAGTTAGTAAATCATAGAGATCTTGTTCGAAGAACAGAAGGAAACTTTTGTATTTTCGGCAGAGAGA
TTTAGAGGCCTCTATAATGT

Product: thio-specific antioxidant peroxidase

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MHNHKNRVVMGSLFVGKTAPDFSAQAVVDGEVKNISLKDYRGKYVILFFYPKDFTYVCPTELHAFQHSLEEFESRGAQIL
GCSVDDLDTHKRWLETDKKAGGVKGITYPLISDTTQELSKLYSVLDLQSGLSFRGSFLIDKDGIIRHMVINDLPLGRSID
EELRVLDALIFFENHGLVCPANWQQGQKAMAPNEEGLKEYFGTID

Sequences:

>Translated_205_residues
MHNHKNRVVMGSLFVGKTAPDFSAQAVVDGEVKNISLKDYRGKYVILFFYPKDFTYVCPTELHAFQHSLEEFESRGAQIL
GCSVDDLDTHKRWLETDKKAGGVKGITYPLISDTTQELSKLYSVLDLQSGLSFRGSFLIDKDGIIRHMVINDLPLGRSID
EELRVLDALIFFENHGLVCPANWQQGQKAMAPNEEGLKEYFGTID
>Mature_205_residues
MHNHKNRVVMGSLFVGKTAPDFSAQAVVDGEVKNISLKDYRGKYVILFFYPKDFTYVCPTELHAFQHSLEEFESRGAQIL
GCSVDDLDTHKRWLETDKKAGGVKGITYPLISDTTQELSKLYSVLDLQSGLSFRGSFLIDKDGIIRHMVINDLPLGRSID
EELRVLDALIFFENHGLVCPANWQQGQKAMAPNEEGLKEYFGTID

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=191, Percent_Identity=49.2146596858639, Blast_Score=211, Evalue=4e-55,
Organism=Homo sapiens, GI4505591, Length=192, Percent_Identity=48.4375, Blast_Score=200, Evalue=6e-52,
Organism=Homo sapiens, GI32455266, Length=192, Percent_Identity=48.4375, Blast_Score=200, Evalue=6e-52,
Organism=Homo sapiens, GI32455264, Length=192, Percent_Identity=48.4375, Blast_Score=200, Evalue=6e-52,
Organism=Homo sapiens, GI5453549, Length=191, Percent_Identity=46.5968586387435, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI5802974, Length=191, Percent_Identity=45.0261780104712, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI32483377, Length=187, Percent_Identity=45.4545454545455, Blast_Score=190, Evalue=9e-49,
Organism=Homo sapiens, GI33188454, Length=89, Percent_Identity=55.0561797752809, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4758638, Length=204, Percent_Identity=27.9411764705882, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1786822, Length=183, Percent_Identity=34.9726775956284, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1788825, Length=145, Percent_Identity=28.9655172413793, Blast_Score=64, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193204376, Length=192, Percent_Identity=46.875, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32565831, Length=192, Percent_Identity=46.875, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17554494, Length=188, Percent_Identity=46.8085106382979, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25153706, Length=188, Percent_Identity=27.6595744680851, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323613, Length=187, Percent_Identity=45.4545454545455, Blast_Score=178, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6320661, Length=187, Percent_Identity=42.7807486631016, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319407, Length=203, Percent_Identity=34.4827586206897, Blast_Score=117, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17738015, Length=195, Percent_Identity=47.6923076923077, Blast_Score=198, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17157991, Length=187, Percent_Identity=46.524064171123, Blast_Score=196, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24641739, Length=187, Percent_Identity=46.524064171123, Blast_Score=196, Evalue=7e-51,
Organism=Drosophila melanogaster, GI21357347, Length=192, Percent_Identity=43.75, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24656348, Length=188, Percent_Identity=44.6808510638298, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17864676, Length=188, Percent_Identity=44.6808510638298, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24581278, Length=186, Percent_Identity=32.258064516129, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24652434, Length=186, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24652436, Length=186, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17975518, Length=186, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=9e-20,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 23119; Mature: 23119

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNHKNRVVMGSLFVGKTAPDFSAQAVVDGEVKNISLKDYRGKYVILFFYPKDFTYVCPT
CCCCCCEEEEEEEEECCCCCCCCCEEEECCCEEEEEEEECCCCEEEEEEECCCCEEECCH
ELHAFQHSLEEFESRGAQILGCSVDDLDTHKRWLETDKKAGGVKGITYPLISDTTQELSK
HHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHH
LYSVLDLQSGLSFRGSFLIDKDGIIRHMVINDLPLGRSIDEELRVLDALIFFENHGLVCP
HHHHHHHHCCCCCCCEEEECCCCCEEEHHHCCCCCCCCHHHHHHHHHHHHEECCCCEEEC
ANWQQGQKAMAPNEEGLKEYFGTID
CCHHCCCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MHNHKNRVVMGSLFVGKTAPDFSAQAVVDGEVKNISLKDYRGKYVILFFYPKDFTYVCPT
CCCCCCEEEEEEEEECCCCCCCCCEEEECCCEEEEEEEECCCCEEEEEEECCCCEEECCH
ELHAFQHSLEEFESRGAQILGCSVDDLDTHKRWLETDKKAGGVKGITYPLISDTTQELSK
HHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHH
LYSVLDLQSGLSFRGSFLIDKDGIIRHMVINDLPLGRSIDEELRVLDALIFFENHGLVCP
HHHHHHHHCCCCCCCEEEECCCCCEEEHHHCCCCCCCCHHHHHHHHHHHHEECCCCEEEC
ANWQQGQKAMAPNEEGLKEYFGTID
CCHHCCCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]