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The map label for this gene is folP [H]

Identifier: 89897821

GI number: 89897821

Start: 13030

End: 14373

Strand: Direct

Name: folP [H]

Synonym: CF0014

Alternate gene names: 89897821

Gene position: 13030-14373 (Clockwise)

Preceding gene: 89897820

Following gene: 89897822

Centisome position: 1.12

GC content: 40.55

Gene sequence:

>1344_bases
ATGACAACACTCCACTCTGTTTGTTTGTCCCTGGGATCTAATCTGGGGAATCGCTTTGAAAATTTTCGCAAGGCATATTC
TTTATTAAAAGAATTAAATATAGAAGATTTGCAAAGTTCTGTGATTTTGGAGACAAAGGCCTTATTGTTGCCGGGTTCTC
CGAAAGAATGGGATTTACCTTTTTTTAATTCTGTACTTATTGGGAAAACAACACTCTCCCCTCAAGAGTTATTGTTGGGG
ATAAAACAAATAGAGCGCAGGCTTGGTAGAGATCTTGATGCCCCGGTTTGGTCTCCTCGAGTGTTGGATATTGACATTCT
CTTATATGGGGATGAAATTTGCCAACAGGACCATATAACTATTCCTCACAAGAGAATTTTAGAAAGGCCTTTTCTACTTT
CTCTTTTAGCGTCGCTTTGCCCTACTAGAAAACTTTATCAACCGGGTTCTGAGTGCCATTTAAAAACTTTTGGAGAAATC
TCTCATCTTATTCCATGTCCCCAAGAGATGATTCTCAACAGTTTTTCTCCAAGCACTTTATTGATGGGGATAGTTAATGT
TACTGATAACTCTATTTCAGATGGGGGACTGTATCTTGATCCAGAGAAAGCGGTTGCTCATGCTGAACAATTATTAGCTA
AAGGTGCCTCTGTTATAGATTTCGGAGCTCAAGCGACCAATCCTAAGGTAAAACATCTTCTGGATGTAGATCAAGAATGG
AAACGACTAGAGCCTGTCTTAAATCTTCTTGCTGACAAATGGTCAGGACGTAATCAGTATCCTGATATTTCATTAGATAC
ATTTTATCCTGAAATTATTCGGAGAGCTTTAGAAGTTTATCCTATTCGATGGATTAATGACGTCTCGGGTGGTTCGAAGG
AGATGGCAAAGATCGCTAGAGATGCGAATTTACGACTGGTTATCAATCATTCTTGTTCTCTTCCGCCGTGTCCAAATAAG
ACCCTGGAGCTTTCTACTTGTGCTGCTGAGCAATTGTTTAGTTGGGGAGAAAAACAGATAGAAGCCTTTACGGCTTTAGG
ATTAAACCTGGATCAAATTATTTTTGATCCAGGCATAGGCTTTGGGACAAGTCCAATACAAGCATTGCATGTATTACACA
GGATGAAAAAGTTTCGTGGGCTTGGTTGTGCTACGCTAGTAGGACACTCAAGGAAATCTTGTTTCTCGCTTTTAGGCAAG
CATGATGCTAAAGATCGTGACTGGGAAACGGTTAGCCTATCGGTTTTGTTGCAACAGCAAGGGGTGAATTTCTTGCGAGT
TCATGATGTTGAAGCCAACCAAAGGGTGTTATCTGCCGCAGCATGGCCTGGAGTTTATGTGTAA

Upstream 100 bases:

>100_bases
ACAAGGTGTCTAAAATAGATTTAGAGGTGCGTAAAGAGCGTCCTCTTGTTCCAAACTTGTTAAAGCCCATTTGCTTTAGG
ATAAGTAGGAAAATCTCGCC

Downstream 100 bases:

>100_bases
AATACTTGGTATTGTAGCTTGTAGTCCTAGTGGGGTGATTGGAAACCAAGGAAAGTTGCCTTGGAGCTATTCTAAGGACA
TTGAATTTTTCGCAAAAACG

Product: folate synthesis bifunctional protein

Products: NA

Alternate protein names: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; Dihydropteroate synthase; DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTTLHSVCLSLGSNLGNRFENFRKAYSLLKELNIEDLQSSVILETKALLLPGSPKEWDLPFFNSVLIGKTTLSPQELLLG
IKQIERRLGRDLDAPVWSPRVLDIDILLYGDEICQQDHITIPHKRILERPFLLSLLASLCPTRKLYQPGSECHLKTFGEI
SHLIPCPQEMILNSFSPSTLLMGIVNVTDNSISDGGLYLDPEKAVAHAEQLLAKGASVIDFGAQATNPKVKHLLDVDQEW
KRLEPVLNLLADKWSGRNQYPDISLDTFYPEIIRRALEVYPIRWINDVSGGSKEMAKIARDANLRLVINHSCSLPPCPNK
TLELSTCAAEQLFSWGEKQIEAFTALGLNLDQIIFDPGIGFGTSPIQALHVLHRMKKFRGLGCATLVGHSRKSCFSLLGK
HDAKDRDWETVSLSVLLQQQGVNFLRVHDVEANQRVLSAAAWPGVYV

Sequences:

>Translated_447_residues
MTTLHSVCLSLGSNLGNRFENFRKAYSLLKELNIEDLQSSVILETKALLLPGSPKEWDLPFFNSVLIGKTTLSPQELLLG
IKQIERRLGRDLDAPVWSPRVLDIDILLYGDEICQQDHITIPHKRILERPFLLSLLASLCPTRKLYQPGSECHLKTFGEI
SHLIPCPQEMILNSFSPSTLLMGIVNVTDNSISDGGLYLDPEKAVAHAEQLLAKGASVIDFGAQATNPKVKHLLDVDQEW
KRLEPVLNLLADKWSGRNQYPDISLDTFYPEIIRRALEVYPIRWINDVSGGSKEMAKIARDANLRLVINHSCSLPPCPNK
TLELSTCAAEQLFSWGEKQIEAFTALGLNLDQIIFDPGIGFGTSPIQALHVLHRMKKFRGLGCATLVGHSRKSCFSLLGK
HDAKDRDWETVSLSVLLQQQGVNFLRVHDVEANQRVLSAAAWPGVYV
>Mature_446_residues
TTLHSVCLSLGSNLGNRFENFRKAYSLLKELNIEDLQSSVILETKALLLPGSPKEWDLPFFNSVLIGKTTLSPQELLLGI
KQIERRLGRDLDAPVWSPRVLDIDILLYGDEICQQDHITIPHKRILERPFLLSLLASLCPTRKLYQPGSECHLKTFGEIS
HLIPCPQEMILNSFSPSTLLMGIVNVTDNSISDGGLYLDPEKAVAHAEQLLAKGASVIDFGAQATNPKVKHLLDVDQEWK
RLEPVLNLLADKWSGRNQYPDISLDTFYPEIIRRALEVYPIRWINDVSGGSKEMAKIARDANLRLVINHSCSLPPCPNKT
LELSTCAAEQLFSWGEKQIEAFTALGLNLDQIIFDPGIGFGTSPIQALHVLHRMKKFRGLGCATLVGHSRKSCFSLLGKH
DAKDRDWETVSLSVLLQQQGVNFLRVHDVEANQRVLSAAAWPGVYV

Specific function: Dhps Catalyzes The Formation Of The Immediate Precursor Of Folic Acid. It Is Implicated In Resistance To Sulfonamide. [C]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=255, Percent_Identity=30.5882352941176, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786335, Length=159, Percent_Identity=31.4465408805031, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324073, Length=514, Percent_Identity=24.9027237354086, Blast_Score=106, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000550
- InterPro:   IPR000489 [H]

Pfam domain/function: PF01288 HPPK; PF00809 Pterin_bind [H]

EC number: =2.7.6.3; =2.5.1.15 [H]

Molecular weight: Translated: 49898; Mature: 49767

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLHSVCLSLGSNLGNRFENFRKAYSLLKELNIEDLQSSVILETKALLLPGSPKEWDLP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCCCCC
FFNSVLIGKTTLSPQELLLGIKQIERRLGRDLDAPVWSPRVLDIDILLYGDEICQQDHIT
HHCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECHHHHCCCCCC
IPHKRILERPFLLSLLASLCPTRKLYQPGSECHLKTFGEISHLIPCPQEMILNSFSPSTL
CCHHHHHCCHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCHHH
LMGIVNVTDNSISDGGLYLDPEKAVAHAEQLLAKGASVIDFGAQATNPKVKHLLDVDQEW
HHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHCCHHHH
KRLEPVLNLLADKWSGRNQYPDISLDTFYPEIIRRALEVYPIRWINDVSGGSKEMAKIAR
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHH
DANLRLVINHSCSLPPCPNKTLELSTCAAEQLFSWGEKQIEAFTALGLNLDQIIFDPGIG
CCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHEECCCCC
FGTSPIQALHVLHRMKKFRGLGCATLVGHSRKSCFSLLGKHDAKDRDWETVSLSVLLQQQ
CCCCHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCEEHHHHHHHHC
GVNFLRVHDVEANQRVLSAAAWPGVYV
CCCEEEEECCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTLHSVCLSLGSNLGNRFENFRKAYSLLKELNIEDLQSSVILETKALLLPGSPKEWDLP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCCCCCCCC
FFNSVLIGKTTLSPQELLLGIKQIERRLGRDLDAPVWSPRVLDIDILLYGDEICQQDHIT
HHCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECHHHHCCCCCC
IPHKRILERPFLLSLLASLCPTRKLYQPGSECHLKTFGEISHLIPCPQEMILNSFSPSTL
CCHHHHHCCHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCHHH
LMGIVNVTDNSISDGGLYLDPEKAVAHAEQLLAKGASVIDFGAQATNPKVKHLLDVDQEW
HHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHCCHHHH
KRLEPVLNLLADKWSGRNQYPDISLDTFYPEIIRRALEVYPIRWINDVSGGSKEMAKIAR
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHH
DANLRLVINHSCSLPPCPNKTLELSTCAAEQLFSWGEKQIEAFTALGLNLDQIIFDPGIG
CCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHEECCCCC
FGTSPIQALHVLHRMKKFRGLGCATLVGHSRKSCFSLLGKHDAKDRDWETVSLSVLLQQQ
CCCCHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCEEHHHHHHHHC
GVNFLRVHDVEANQRVLSAAAWPGVYV
CCCEEEEECCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]