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The map label for this gene is lysS [H]

Identifier: 89257151

GI number: 89257151

Start: 1834253

End: 1835935

Strand: Reverse

Name: lysS [H]

Synonym: FTL_1903

Alternate gene names: 89257151

Gene position: 1835935-1834253 (Counterclockwise)

Preceding gene: 89257152

Following gene: 89257145

Centisome position: 96.83

GC content: 35.83

Gene sequence:

>1683_bases
ATGAGTAGTAAATTAAAAGATTTGATAAAAACAACGATAAAAGAATATTTAGAAGCTAATGATATCACAGTTAAAGATGC
TATTAGAGGCAAGATTAGAGAGCAGATTAGTGAGTTTTTAGGCGAGGTAAGCGAGATAAATGAGCAGGTTAAAGAACAAA
TTTCAGCGCTTGTGAAAAAGCATGTAACAGAATTACAAGAAAGCTCACAAATTGCTTTAAGAAAAGAAAAGCTAAAAACT
TTAGCTCAGCAAAATAATGGCATAAGCCATCCAAATAGTTTCCGAAGAAATGCTGTTGCTATAGAGTTACAGGCTCGCTA
TACTGATAAGACTAAGCAAGAATTAGAAGAGCTAGATAATAAACAACAATATAGTTTGACAGGTAGAGTAGTTCTACGCC
GTGTCATGGGTAAAGCATCTTTTATAACACTACAAGATTATACTGGTAGAATCCAAGTTTATCTAAAAAAGAGTGACTTG
CCAGATGGGCAATATGAAACTTTTAAGAATCTATGTGACTTGGGTGATATAGTTGGTATTACTGGTACTATGTTTAAGAC
AAATACTGGTGAACTTTCTGTTGAAGCAAATCACTTTGAGATTTTGACAAAGGCAATTCGTCCTTTGCCTGATAAATTCC
ATGGTTTGGCAGATCAAGAAATGAGATATCGTCAAAGATATGTTGATTTAATTACAAATGAAAAGGCAAGAGAAGTCTTT
AAAGTACGCTCAAAAGTTGTGAGCTTTATCCGTAACTACTTTGATAGACTAGATTTTATGGAAGTAGAGACGCCGATGAT
GCATGTTTTGCAAGGTGGTGCTGCTGCTAAGCCATTTAAAACTCATCACAATGCTTTGGATATGCCTTTATATTTGCGTA
TTGCTCCAGAACTTTATCTAAAAAGACTAGTTGTTGGTGGTTTTGAGCGAGTTTATGAGATAAACCGTAATTTTAGAAAC
GAAGGTATATCTTCACGCCATAATCCAGAATTTACAATGCTAGAGTTCTATATGGCGTATGCTGATTATAATGACCTTAT
GGATCTAACAGAAGATATGCTATCTAAACTTGTACAGGAAGTAATTGGTAGCGAGATACTTGAGTATGGTGAGTATAAAA
TCAACTTTGGTGGTAAGTACGAACGAATCTCCATGGTTGACTCAATTGTTAAGTATAATGATGATATTACCAAAGAAGAT
TTAGTAACATTTGAATCTGCTAAAAAGATTGCTGAGAAACTAAAAATAAAAGTTGAAGCTTACCATGAACTTGGACATTT
GATAAACGAAATATTTGAAGAAACTGTCGAGCATCAGCTTATTCAACCGACATTTATTACAGATTATCCAGCTGTAGTTT
CACCATTGGCGCGTAGACAAGACGGTAACCCTGAGTTTACCGATAGATTTGAGTTCTTTATTGGAGCACGTGAAGTTGCT
AACGGCTTCTCTGAGCTAAATGATGCTGAAGATCAAGCAGAGCGTTTCAGAAAACAGGTTGAAGCTGCGGCATCTGGAGA
TGATGAAGCTATGCCTTATGACAAAGACTATATTCGCGCACTAGAGTATGGTATGCCTCCTACAGCGGGACAAGGAATCG
GTATTGATAGACTGGTAATGTATCTAACAAACTCTCAATCAATTAGAGATGTGATTCTATTTCCGCATATGAAGCCTGAG
TAA

Upstream 100 bases:

>100_bases
CGCCAATTTGAAAATTGATTCAGATAGTTTTATTTTCTAATCATTTGTTTTTTTGGGGCTACTAATTGCTAATGTGCAAC
AAATAATTACAGGGTTTAAA

Downstream 100 bases:

>100_bases
AATATGTCAAAAAAAATTACTAAAATTTTTATTTAAAAATATTTATAGTCCAGATATTGTTTCTAAAAAATTTATTCAAA
AGTTTGTACACGCAGATTAT

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MSSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKKHVTELQESSQIALRKEKLKT
LAQQNNGISHPNSFRRNAVAIELQARYTDKTKQELEELDNKQQYSLTGRVVLRRVMGKASFITLQDYTGRIQVYLKKSDL
PDGQYETFKNLCDLGDIVGITGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYRQRYVDLITNEKAREVF
KVRSKVVSFIRNYFDRLDFMEVETPMMHVLQGGAAAKPFKTHHNALDMPLYLRIAPELYLKRLVVGGFERVYEINRNFRN
EGISSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQEVIGSEILEYGEYKINFGGKYERISMVDSIVKYNDDITKED
LVTFESAKKIAEKLKIKVEAYHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNPEFTDRFEFFIGAREVA
NGFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVMYLTNSQSIRDVILFPHMKPE

Sequences:

>Translated_560_residues
MSSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKKHVTELQESSQIALRKEKLKT
LAQQNNGISHPNSFRRNAVAIELQARYTDKTKQELEELDNKQQYSLTGRVVLRRVMGKASFITLQDYTGRIQVYLKKSDL
PDGQYETFKNLCDLGDIVGITGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYRQRYVDLITNEKAREVF
KVRSKVVSFIRNYFDRLDFMEVETPMMHVLQGGAAAKPFKTHHNALDMPLYLRIAPELYLKRLVVGGFERVYEINRNFRN
EGISSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQEVIGSEILEYGEYKINFGGKYERISMVDSIVKYNDDITKED
LVTFESAKKIAEKLKIKVEAYHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNPEFTDRFEFFIGAREVA
NGFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVMYLTNSQSIRDVILFPHMKPE
>Mature_559_residues
SSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKKHVTELQESSQIALRKEKLKTL
AQQNNGISHPNSFRRNAVAIELQARYTDKTKQELEELDNKQQYSLTGRVVLRRVMGKASFITLQDYTGRIQVYLKKSDLP
DGQYETFKNLCDLGDIVGITGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYRQRYVDLITNEKAREVFK
VRSKVVSFIRNYFDRLDFMEVETPMMHVLQGGAAAKPFKTHHNALDMPLYLRIAPELYLKRLVVGGFERVYEINRNFRNE
GISSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQEVIGSEILEYGEYKINFGGKYERISMVDSIVKYNDDITKEDL
VTFESAKKIAEKLKIKVEAYHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNPEFTDRFEFFIGAREVAN
GFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVMYLTNSQSIRDVILFPHMKPE

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=449, Percent_Identity=43.652561247216, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI194272210, Length=449, Percent_Identity=43.652561247216, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI45439306, Length=481, Percent_Identity=23.4927234927235, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI40789249, Length=261, Percent_Identity=25.6704980842912, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI226491502, Length=339, Percent_Identity=24.4837758112094, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790571, Length=487, Percent_Identity=61.1909650924025, Blast_Score=627, Evalue=0.0,
Organism=Escherichia coli, GI1789256, Length=493, Percent_Identity=60.6490872210953, Blast_Score=619, Evalue=1e-178,
Organism=Escherichia coli, GI87082379, Length=321, Percent_Identity=30.8411214953271, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788173, Length=263, Percent_Identity=28.1368821292776, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17535925, Length=534, Percent_Identity=38.9513108614232, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17535927, Length=534, Percent_Identity=38.9513108614232, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71994340, Length=485, Percent_Identity=41.4432989690722, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17551876, Length=463, Percent_Identity=23.9740820734341, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI32566633, Length=281, Percent_Identity=26.6903914590747, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320242, Length=519, Percent_Identity=41.4258188824663, Blast_Score=380, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324256, Length=422, Percent_Identity=31.7535545023697, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6323011, Length=500, Percent_Identity=25.4, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321807, Length=451, Percent_Identity=24.1685144124169, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325153, Length=269, Percent_Identity=26.0223048327138, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640851, Length=511, Percent_Identity=41.2915851272016, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24640849, Length=511, Percent_Identity=41.2915851272016, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI17136276, Length=458, Percent_Identity=22.4890829694323, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24584738, Length=264, Percent_Identity=28.4090909090909, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 64573; Mature: 64442

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKK
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVTELQESSQIALRKEKLKTLAQQNNGISHPNSFRRNAVAIELQARYTDKTKQELEELDN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCEEEEEEEECCCCHHHHHHHHHCC
KQQYSLTGRVVLRRVMGKASFITLQDYTGRIQVYLKKSDLPDGQYETFKNLCDLGDIVGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
TGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYRQRYVDLITNEKAREVF
CCEEEECCCCCEEEECHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCHHHHHHH
KVRSKVVSFIRNYFDRLDFMEVETPMMHVLQGGAAAKPFKTHHNALDMPLYLRIAPELYL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCEEEEECHHHHH
KRLVVGGFERVYEINRNFRNEGISSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGSEILEYGEYKINFGGKYERISMVDSIVKYNDDITKEDLVTFESAKKIAEKLKIKVEA
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNPEFTDRFEFFIGAREVA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
NGFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVM
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHH
YLTNSQSIRDVILFPHMKPE
HHCCCCCHHHEEECCCCCCC
>Mature Secondary Structure 
SSKLKDLIKTTIKEYLEANDITVKDAIRGKIREQISEFLGEVSEINEQVKEQISALVKK
CHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVTELQESSQIALRKEKLKTLAQQNNGISHPNSFRRNAVAIELQARYTDKTKQELEELDN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCEEEEEEEECCCCHHHHHHHHHCC
KQQYSLTGRVVLRRVMGKASFITLQDYTGRIQVYLKKSDLPDGQYETFKNLCDLGDIVGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
TGTMFKTNTGELSVEANHFEILTKAIRPLPDKFHGLADQEMRYRQRYVDLITNEKAREVF
CCEEEECCCCCEEEECHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCHHHHHHH
KVRSKVVSFIRNYFDRLDFMEVETPMMHVLQGGAAAKPFKTHHNALDMPLYLRIAPELYL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCEEEEECHHHHH
KRLVVGGFERVYEINRNFRNEGISSRHNPEFTMLEFYMAYADYNDLMDLTEDMLSKLVQE
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGSEILEYGEYKINFGGKYERISMVDSIVKYNDDITKEDLVTFESAKKIAEKLKIKVEA
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YHELGHLINEIFEETVEHQLIQPTFITDYPAVVSPLARRQDGNPEFTDRFEFFIGAREVA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
NGFSELNDAEDQAERFRKQVEAAASGDDEAMPYDKDYIRALEYGMPPTAGQGIGIDRLVM
HHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHH
YLTNSQSIRDVILFPHMKPE
HHCCCCCHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA