Click here to switch to the map view.

The map label for this gene is parE [H]

Identifier: 89256995

GI number: 89256995

Start: 1657496

End: 1659379

Strand: Direct

Name: parE [H]

Synonym: FTL_1726

Alternate gene names: 89256995

Gene position: 1657496-1659379 (Clockwise)

Preceding gene: 89256994

Following gene: 89256997

Centisome position: 87.42

GC content: 34.5

Gene sequence:

>1884_bases
ATGCAAAACTATAATGCTAAATCTATCGAAGTTCTTACTGGTTTAGACCCTGTCAAGAAAAGACCAGGAATGTATACTAA
TATAGAAAATCCAAATCATCTCATCCAAGAAATTATTGATAATAGCGTTGATGAAGTTCTTGCTGGATTTGCTAGCAAAA
TAAATATCACATTATACGAAGATAACAGTATCGAAGTAGCTGATGATGGTCGTGGTATGCCTGTAGATATTCATCCTGAG
CATAAAATGTCTGGTATTGAACTTATCATGACCAAACTTCATTCTGGCGGCAAATTTAGTAACAAAAATTATACTCATTC
TGGCGGTCTTCATGGAGTTGGGGTATCTGTTGTTAATGCTTTATCAACTAGACTTGAGGCAGAGATTAAAAGAGATGGTA
ATGTTTATCATATAGTCTTTGAGGATGGTTTTAAAACTAAAGATCTGGAAATTATTGATAATGTAGGCAAGAAAAATACT
GGAACAAAAATTAGATTTTGGCCAAATAAAAAATATTTTGATGATATCAAAGTCAATTTTAAAGCTCTTAAAAATCTGCT
TGAAGCAAAAGCGATACTTTGTAAGGCTCTCACAATAAAATATTCAAATGAGATAAAAAAAGAGAAGCTTACATGGCATT
TTGAAACTGGACTTAAAGGCTATCTTGACCATAAACTAGAAGCTGAAACACTCCCAGCAGAACCGTTTATAATCGATAAT
TTCTCAAATGGCGACTCTTATTTAGATGCAGTATTTTGCTGGTGTGAAGATCTTAGTGAAAGTATCAAGAATAGCTATGT
AAACCTAATTCCAACACCTCAAGATGGTACACATGTCACCGGACTTAAAAATGGAATTTACGATGCGATTAAGGCGTATA
TAGAGAAAAACTCCCTTAGTGTGAAGAATATCAAAATTACTGCAAATGACTCTTTTGCTCAACTTAACTATGTAATATCA
GTAAAAATTACAAATCCACAATTTGCTGGACAAACCAAAGAAAAACTTTCTAATAAAGATGTTACTAACTTTGTTGCTAC
TGCTGTTAAAGACTTACTCACCATATGGCTAAACCAAAACCCTGATGAGGCACGTCAAATTGTTGAAAATATTAGTAAAG
TTGCACAAAAAAGAATTAATGCAGACAAAAAAACCACACGTAAACGCATAATGAACACAACTATTCGTTTGCCTGGTAAA
CTTACAGATTGTATTAGTTCTGATGTTAATTCTACTGAGCTTTTCATCGTTGAGGGGGATTCTGCTGGAGGTTCTGCTAA
ACAAGCACGTGATAAAAACTTTCAAGCTGTTCTACCTCTTAAAGGTAAGATTCTTAATAGTTGGGAACTAGATGCTGATA
CAATCATGAACTCTCAAGAAATCCACAATATTGCTACAGCAATTGGTGTTGATCCTGATAGTGATGATATTTCTGCTCTA
AGATACAATAAAATATGTATCCTCGCCGATGCCGACTCTGATGGATTGCATATCGCAACACTACTATGTGCAATGTTTCT
AAAGCACTTTAGAAAACTTATTGAGAATGGTCATATTTATATAGCTCAACCTCCGCTGTTTAGAATTGATATTGGTAAAA
GCACTTTCTACGCTCTTGATGAAAATGAAAGAGATACTATCTTGACTAAAAACTCTAAATTACCAGGTAAGGTAAATATC
ATGCGCTTTAAGGGTCTAGGGGAGATGAATCCTGCACAATTACGTGAGTCAGCTATGGATGTATCATCAAGAAGACTTTT
ACAACTTACCATTTCTGATGTATATGATGATACTGAAATGTTAGACATGCTTTTGGCTAAAAAGAGAGCCAAAGATCGCC
GTGATTGGCTCGAGAACTATGGTGATAGAGCCAGTGTTGAATAA

Upstream 100 bases:

>100_bases
TCAAGAAATAAAGCTTAGTGCTCAGCTAAATTTAGGATTAAAATAATTATATGGTAAAATCTAGATTAACTAATATAATT
TTATCGATCTTAAATTATCA

Downstream 100 bases:

>100_bases
TAGACTCTTTTACTTACTTTTATTTTTTTATCAATTAATTAGAATTTCTACCAGATAACCTTATTCCATTCAAAACATTT
ACCAGGATCAGTTTTTCTCT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MQNYNAKSIEVLTGLDPVKKRPGMYTNIENPNHLIQEIIDNSVDEVLAGFASKINITLYEDNSIEVADDGRGMPVDIHPE
HKMSGIELIMTKLHSGGKFSNKNYTHSGGLHGVGVSVVNALSTRLEAEIKRDGNVYHIVFEDGFKTKDLEIIDNVGKKNT
GTKIRFWPNKKYFDDIKVNFKALKNLLEAKAILCKALTIKYSNEIKKEKLTWHFETGLKGYLDHKLEAETLPAEPFIIDN
FSNGDSYLDAVFCWCEDLSESIKNSYVNLIPTPQDGTHVTGLKNGIYDAIKAYIEKNSLSVKNIKITANDSFAQLNYVIS
VKITNPQFAGQTKEKLSNKDVTNFVATAVKDLLTIWLNQNPDEARQIVENISKVAQKRINADKKTTRKRIMNTTIRLPGK
LTDCISSDVNSTELFIVEGDSAGGSAKQARDKNFQAVLPLKGKILNSWELDADTIMNSQEIHNIATAIGVDPDSDDISAL
RYNKICILADADSDGLHIATLLCAMFLKHFRKLIENGHIYIAQPPLFRIDIGKSTFYALDENERDTILTKNSKLPGKVNI
MRFKGLGEMNPAQLRESAMDVSSRRLLQLTISDVYDDTEMLDMLLAKKRAKDRRDWLENYGDRASVE

Sequences:

>Translated_627_residues
MQNYNAKSIEVLTGLDPVKKRPGMYTNIENPNHLIQEIIDNSVDEVLAGFASKINITLYEDNSIEVADDGRGMPVDIHPE
HKMSGIELIMTKLHSGGKFSNKNYTHSGGLHGVGVSVVNALSTRLEAEIKRDGNVYHIVFEDGFKTKDLEIIDNVGKKNT
GTKIRFWPNKKYFDDIKVNFKALKNLLEAKAILCKALTIKYSNEIKKEKLTWHFETGLKGYLDHKLEAETLPAEPFIIDN
FSNGDSYLDAVFCWCEDLSESIKNSYVNLIPTPQDGTHVTGLKNGIYDAIKAYIEKNSLSVKNIKITANDSFAQLNYVIS
VKITNPQFAGQTKEKLSNKDVTNFVATAVKDLLTIWLNQNPDEARQIVENISKVAQKRINADKKTTRKRIMNTTIRLPGK
LTDCISSDVNSTELFIVEGDSAGGSAKQARDKNFQAVLPLKGKILNSWELDADTIMNSQEIHNIATAIGVDPDSDDISAL
RYNKICILADADSDGLHIATLLCAMFLKHFRKLIENGHIYIAQPPLFRIDIGKSTFYALDENERDTILTKNSKLPGKVNI
MRFKGLGEMNPAQLRESAMDVSSRRLLQLTISDVYDDTEMLDMLLAKKRAKDRRDWLENYGDRASVE
>Mature_627_residues
MQNYNAKSIEVLTGLDPVKKRPGMYTNIENPNHLIQEIIDNSVDEVLAGFASKINITLYEDNSIEVADDGRGMPVDIHPE
HKMSGIELIMTKLHSGGKFSNKNYTHSGGLHGVGVSVVNALSTRLEAEIKRDGNVYHIVFEDGFKTKDLEIIDNVGKKNT
GTKIRFWPNKKYFDDIKVNFKALKNLLEAKAILCKALTIKYSNEIKKEKLTWHFETGLKGYLDHKLEAETLPAEPFIIDN
FSNGDSYLDAVFCWCEDLSESIKNSYVNLIPTPQDGTHVTGLKNGIYDAIKAYIEKNSLSVKNIKITANDSFAQLNYVIS
VKITNPQFAGQTKEKLSNKDVTNFVATAVKDLLTIWLNQNPDEARQIVENISKVAQKRINADKKTTRKRIMNTTIRLPGK
LTDCISSDVNSTELFIVEGDSAGGSAKQARDKNFQAVLPLKGKILNSWELDADTIMNSQEIHNIATAIGVDPDSDDISAL
RYNKICILADADSDGLHIATLLCAMFLKHFRKLIENGHIYIAQPPLFRIDIGKSTFYALDENERDTILTKNSKLPGKVNI
MRFKGLGEMNPAQLRESAMDVSSRRLLQLTISDVYDDTEMLDMLLAKKRAKDRRDWLENYGDRASVE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=645, Percent_Identity=25.4263565891473, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI19913408, Length=586, Percent_Identity=24.5733788395904, Blast_Score=106, Evalue=8e-23,
Organism=Escherichia coli, GI1789408, Length=629, Percent_Identity=54.2130365659777, Blast_Score=742, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=554, Percent_Identity=38.4476534296029, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=634, Percent_Identity=26.1829652996845, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI212645845, Length=592, Percent_Identity=26.0135135135135, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI212645657, Length=227, Percent_Identity=27.3127753303965, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=636, Percent_Identity=24.5283018867925, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136538, Length=584, Percent_Identity=25, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 70356; Mature: 70356

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNYNAKSIEVLTGLDPVKKRPGMYTNIENPNHLIQEIIDNSVDEVLAGFASKINITLYE
CCCCCCCCEEEEECCCHHHHCCCCEECCCCHHHHHHHHHCCCHHHHHHHHHCEEEEEEEE
DNSIEVADDGRGMPVDIHPEHKMSGIELIMTKLHSGGKFSNKNYTHSGGLHGVGVSVVNA
CCCEEECCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
LSTRLEAEIKRDGNVYHIVFEDGFKTKDLEIIDNVGKKNTGTKIRFWPNKKYFDDIKVNF
HHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCHHHEEEH
KALKNLLEAKAILCKALTIKYSNEIKKEKLTWHFETGLKGYLDHKLEAETLPAEPFIIDN
HHHHHHHHHHHHHHHHHEEECCCHHCHHHEEEEECCCCCHHHCCCCCCCCCCCCCEEEEC
FSNGDSYLDAVFCWCEDLSESIKNSYVNLIPTPQDGTHVTGLKNGIYDAIKAYIEKNSLS
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHHCCCE
VKNIKITANDSFAQLNYVISVKITNPQFAGQTKEKLSNKDVTNFVATAVKDLLTIWLNQN
EEEEEEEECCCEEEEEEEEEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
PDEARQIVENISKVAQKRINADKKTTRKRIMNTTIRLPGKLTDCISSDVNSTELFIVEGD
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCHHHHHHHCCCCCEEEEEEECC
SAGGSAKQARDKNFQAVLPLKGKILNSWELDADTIMNSQEIHNIATAIGVDPDSDDISAL
CCCCCHHHHCCCCCEEEECCCCEEECCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCEE
RYNKICILADADSDGLHIATLLCAMFLKHFRKLIENGHIYIAQPPLFRIDIGKSTFYALD
EECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCEEEEEC
ENERDTILTKNSKLPGKVNIMRFKGLGEMNPAQLRESAMDVSSRRLLQLTISDVYDDTEM
CCCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHCCCHHH
LDMLLAKKRAKDRRDWLENYGDRASVE
HHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQNYNAKSIEVLTGLDPVKKRPGMYTNIENPNHLIQEIIDNSVDEVLAGFASKINITLYE
CCCCCCCCEEEEECCCHHHHCCCCEECCCCHHHHHHHHHCCCHHHHHHHHHCEEEEEEEE
DNSIEVADDGRGMPVDIHPEHKMSGIELIMTKLHSGGKFSNKNYTHSGGLHGVGVSVVNA
CCCEEECCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
LSTRLEAEIKRDGNVYHIVFEDGFKTKDLEIIDNVGKKNTGTKIRFWPNKKYFDDIKVNF
HHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCHHHEEEH
KALKNLLEAKAILCKALTIKYSNEIKKEKLTWHFETGLKGYLDHKLEAETLPAEPFIIDN
HHHHHHHHHHHHHHHHHEEECCCHHCHHHEEEEECCCCCHHHCCCCCCCCCCCCCEEEEC
FSNGDSYLDAVFCWCEDLSESIKNSYVNLIPTPQDGTHVTGLKNGIYDAIKAYIEKNSLS
CCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHHCCCE
VKNIKITANDSFAQLNYVISVKITNPQFAGQTKEKLSNKDVTNFVATAVKDLLTIWLNQN
EEEEEEEECCCEEEEEEEEEEEECCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
PDEARQIVENISKVAQKRINADKKTTRKRIMNTTIRLPGKLTDCISSDVNSTELFIVEGD
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCHHHHHHHCCCCCEEEEEEECC
SAGGSAKQARDKNFQAVLPLKGKILNSWELDADTIMNSQEIHNIATAIGVDPDSDDISAL
CCCCCHHHHCCCCCEEEECCCCEEECCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCEE
RYNKICILADADSDGLHIATLLCAMFLKHFRKLIENGHIYIAQPPLFRIDIGKSTFYALD
EECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCEEEEEC
ENERDTILTKNSKLPGKVNIMRFKGLGEMNPAQLRESAMDVSSRRLLQLTISDVYDDTEM
CCCCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHCCCHHH
LDMLLAKKRAKDRRDWLENYGDRASVE
HHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]