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The map label for this gene is accC [H]

Identifier: 89256868

GI number: 89256868

Start: 1519078

End: 1520433

Strand: Reverse

Name: accC [H]

Synonym: FTL_1591

Alternate gene names: 89256868

Gene position: 1520433-1519078 (Counterclockwise)

Preceding gene: 89256869

Following gene: 89256867

Centisome position: 80.19

GC content: 36.65

Gene sequence:

>1356_bases
ATGATTAAAAAAGTACTGATTGCCAATAGAGGTGAAATAGCTCTTAGAATTTTAAGAGCTTGTAGAGAGTTGGGAATTAA
GACAGTCGCTGTGTATTCTACAGCTGATGCTAACCTTATGCATGTCAAACTAGCTGATGAAGCAGTTTGTATAGGTCCTC
CTGCTCCTAATCTTAGTTATCTAAATATCCAAGCTATTATAACTGCCGCTGAAATTACTAATGCTGATGCGATACATCCA
GGTTATGGTTTCTTATCAGAAAATGCAAAATTTGCTAAAGCTGTTGAAGAAAGTGGCTTTATATTTATCGGTCCACGTGC
AGAAAGCATAGAGATAATGGGCGATAAAGTTGAAGCTATTAGATATATGAAAAAAGCTGGTGTTCCATGTGTGCCAGGTT
CAGGCGGTCCATTAGGCAGCGATGAAAAGAAAAACTTAGAAATTGCTGAAAAAATCGGCTATCCAGTTATTATTAAAGCT
GCTGGTGGCGGTGGCGGTCGCGGAATGAGTATCGTTAGAAAGAAAAAAGATCTTATTAGCGCTATTTCTATAACAAAGAG
TGAAGCGAGAATAGCTTTCAATAATGATATGGTTTATATGGAAAAATTCTTAGAAAACCCTCGCCATATTGAAATTCAAG
TTTTTGGTGATGGTGAAGGTAATGCCGTATATCTATTTGAAAGAGATTGTTCTACTCAAAGAAGACACCAAAAAGTTATT
GAAGAAGCTCCAGCAATCGGTCTTTCCGACGAGGAAAGAAAGCGTATTGGTGAGCAGTGTGTTAGCGCATGTAAGATATT
AAAATATCGTGGTGCTGGTACTTTTGAGTTCTTATATGAGAATGGTGAATTCTACTTTATTGAGATGAATACTAGAATTC
AAGTGGAGCATCCTGTTACTGAGTCAATAACTTCTACAGATCTTATCAAAGAGCAAATCAGAGTTGCTAATGGTGAAGGT
CTAAGTTGGAAACAAGAAGATATTGCTATAGTAGGTCATGCAATTGAGTGTAGAATAAACGCCGAAGATCCTGAAAGAAT
GATTCCTTCACCTGGTAAGATCGATATGTATCATCCGCCAGCAGGACCTAGAGTGCGTGTGGACTCACATATATATTCAG
GCTATGTTGTTCCGCCAAATTATGACTCAATGATAGCTAAAGTTATCGTACGTGGTCATAATAGAGAAACAGCATTACAG
AAAATGCGCGCAGCTTTAGAAGAGATGGTGATTAATGGTATTAAGACAAACATACCTCTTCATCAAGAAATTCTAAATAA
TGAAGATTTTATTAAGGGTAGAACTAATATCCATTTCTTAGAGAAATTCTTAGAACAAAAAAACAAAGCTAAATAA

Upstream 100 bases:

>100_bases
GTTCAATTTGATCAACCTCTATTTATTATTGAATAATAAGCAATAAGTGATAATTAAAAATAGAGACTTCAGGTATAAAC
TTTTTAAAAGGTAATACAAA

Downstream 100 bases:

>100_bases
CTAAGTCTATCTTTATATATATCTGCATTTAATTTTTACCTTTTTTCTTATATAATTTTGACTAGTATTAAATAACTAGT
TTATTGTAAAATTATGCATA

Product: Acetyl-CoA carboxylase, biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MIKKVLIANRGEIALRILRACRELGIKTVAVYSTADANLMHVKLADEAVCIGPPAPNLSYLNIQAIITAAEITNADAIHP
GYGFLSENAKFAKAVEESGFIFIGPRAESIEIMGDKVEAIRYMKKAGVPCVPGSGGPLGSDEKKNLEIAEKIGYPVIIKA
AGGGGGRGMSIVRKKKDLISAISITKSEARIAFNNDMVYMEKFLENPRHIEIQVFGDGEGNAVYLFERDCSTQRRHQKVI
EEAPAIGLSDEERKRIGEQCVSACKILKYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTESITSTDLIKEQIRVANGEG
LSWKQEDIAIVGHAIECRINAEDPERMIPSPGKIDMYHPPAGPRVRVDSHIYSGYVVPPNYDSMIAKVIVRGHNRETALQ
KMRAALEEMVINGIKTNIPLHQEILNNEDFIKGRTNIHFLEKFLEQKNKAK

Sequences:

>Translated_451_residues
MIKKVLIANRGEIALRILRACRELGIKTVAVYSTADANLMHVKLADEAVCIGPPAPNLSYLNIQAIITAAEITNADAIHP
GYGFLSENAKFAKAVEESGFIFIGPRAESIEIMGDKVEAIRYMKKAGVPCVPGSGGPLGSDEKKNLEIAEKIGYPVIIKA
AGGGGGRGMSIVRKKKDLISAISITKSEARIAFNNDMVYMEKFLENPRHIEIQVFGDGEGNAVYLFERDCSTQRRHQKVI
EEAPAIGLSDEERKRIGEQCVSACKILKYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTESITSTDLIKEQIRVANGEG
LSWKQEDIAIVGHAIECRINAEDPERMIPSPGKIDMYHPPAGPRVRVDSHIYSGYVVPPNYDSMIAKVIVRGHNRETALQ
KMRAALEEMVINGIKTNIPLHQEILNNEDFIKGRTNIHFLEKFLEQKNKAK
>Mature_451_residues
MIKKVLIANRGEIALRILRACRELGIKTVAVYSTADANLMHVKLADEAVCIGPPAPNLSYLNIQAIITAAEITNADAIHP
GYGFLSENAKFAKAVEESGFIFIGPRAESIEIMGDKVEAIRYMKKAGVPCVPGSGGPLGSDEKKNLEIAEKIGYPVIIKA
AGGGGGRGMSIVRKKKDLISAISITKSEARIAFNNDMVYMEKFLENPRHIEIQVFGDGEGNAVYLFERDCSTQRRHQKVI
EEAPAIGLSDEERKRIGEQCVSACKILKYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTESITSTDLIKEQIRVANGEG
LSWKQEDIAIVGHAIECRINAEDPERMIPSPGKIDMYHPPAGPRVRVDSHIYSGYVVPPNYDSMIAKVIVRGHNRETALQ
KMRAALEEMVINGIKTNIPLHQEILNNEDFIKGRTNIHFLEKFLEQKNKAK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=441, Percent_Identity=50.1133786848073, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI189095269, Length=441, Percent_Identity=50.1133786848073, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=441, Percent_Identity=50.1133786848073, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI116805327, Length=448, Percent_Identity=48.8839285714286, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=48.2142857142857, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=48.2142857142857, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=48.2142857142857, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI38679960, Length=518, Percent_Identity=31.0810810810811, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679977, Length=518, Percent_Identity=31.0810810810811, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679967, Length=518, Percent_Identity=31.0810810810811, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679974, Length=518, Percent_Identity=31.0810810810811, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI38679971, Length=518, Percent_Identity=31.0810810810811, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI134142062, Length=521, Percent_Identity=30.3262955854127, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=67.9287305122494, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1786216, Length=255, Percent_Identity=25.4901960784314, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.9638009049774, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567343, Length=441, Percent_Identity=46.2585034013605, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17562816, Length=461, Percent_Identity=43.8177874186551, Blast_Score=358, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=500, Percent_Identity=29.6, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71997168, Length=520, Percent_Identity=28.6538461538462, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=520, Percent_Identity=28.6538461538462, Blast_Score=194, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6319695, Length=463, Percent_Identity=44.9244060475162, Blast_Score=352, Evalue=6e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=463, Percent_Identity=46.0043196544276, Blast_Score=343, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=41.1633109619687, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6324343, Length=529, Percent_Identity=29.4896030245747, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6323863, Length=494, Percent_Identity=30.9716599190283, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=46.0674157303371, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI281363050, Length=463, Percent_Identity=47.0842332613391, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=463, Percent_Identity=47.0842332613391, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=463, Percent_Identity=47.0842332613391, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=463, Percent_Identity=47.0842332613391, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=463, Percent_Identity=47.0842332613391, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652212, Length=463, Percent_Identity=47.0842332613391, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=463, Percent_Identity=47.0842332613391, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=463, Percent_Identity=47.0842332613391, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=463, Percent_Identity=47.0842332613391, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=463, Percent_Identity=47.0842332613391, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=45.2088452088452, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI161076409, Length=514, Percent_Identity=28.7937743190661, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI161076407, Length=514, Percent_Identity=28.7937743190661, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24586460, Length=514, Percent_Identity=28.7937743190661, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI24586458, Length=510, Percent_Identity=29.0196078431373, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50051; Mature: 50051

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKVLIANRGEIALRILRACRELGIKTVAVYSTADANLMHVKLADEAVCIGPPAPNLSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCCCEE
LNIQAIITAAEITNADAIHPGYGFLSENAKFAKAVEESGFIFIGPRAESIEIMGDKVEAI
EEEEEEEEEEHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
RYMKKAGVPCVPGSGGPLGSDEKKNLEIAEKIGYPVIIKAAGGGGGRGMSIVRKKKDLIS
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHH
AISITKSEARIAFNNDMVYMEKFLENPRHIEIQVFGDGEGNAVYLFERDCSTQRRHQKVI
HHHCCCCCCEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
EEAPAIGLSDEERKRIGEQCVSACKILKYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCEEEECCCCH
ESITSTDLIKEQIRVANGEGLSWKQEDIAIVGHAIECRINAEDPERMIPSPGKIDMYHPP
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCCCCEEEECCC
AGPRVRVDSHIYSGYVVPPNYDSMIAKVIVRGHNRETALQKMRAALEEMVINGIKTNIPL
CCCEEEECCEEEECEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
HQEILNNEDFIKGRTNIHFLEKFLEQKNKAK
HHHHCCCCCEECCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKKVLIANRGEIALRILRACRELGIKTVAVYSTADANLMHVKLADEAVCIGPPAPNLSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCCCEE
LNIQAIITAAEITNADAIHPGYGFLSENAKFAKAVEESGFIFIGPRAESIEIMGDKVEAI
EEEEEEEEEEHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
RYMKKAGVPCVPGSGGPLGSDEKKNLEIAEKIGYPVIIKAAGGGGGRGMSIVRKKKDLIS
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHH
AISITKSEARIAFNNDMVYMEKFLENPRHIEIQVFGDGEGNAVYLFERDCSTQRRHQKVI
HHHCCCCCCEEEECCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
EEAPAIGLSDEERKRIGEQCVSACKILKYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEECCEEEECCCCH
ESITSTDLIKEQIRVANGEGLSWKQEDIAIVGHAIECRINAEDPERMIPSPGKIDMYHPP
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCCCCEEEECCC
AGPRVRVDSHIYSGYVVPPNYDSMIAKVIVRGHNRETALQKMRAALEEMVINGIKTNIPL
CCCEEEECCEEEECEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
HQEILNNEDFIKGRTNIHFLEKFLEQKNKAK
HHHHCCCCCEECCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]