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The map label for this gene is gcvPB [H]

Identifier: 89255890

GI number: 89255890

Start: 458076

End: 459521

Strand: Direct

Name: gcvPB [H]

Synonym: FTL_0480

Alternate gene names: 89255890

Gene position: 458076-459521 (Clockwise)

Preceding gene: 89255889

Following gene: 89255894

Centisome position: 24.16

GC content: 37.83

Gene sequence:

>1446_bases
ATGGTTATTTTTGAAAAAACTAGAGGTAAAAACTCGCCATCTGTAATGCCTAGCAAAAAAGGAGATGTTTCAAATATCCC
TACAGATATGCTACGCACTAAGAAACCAATACTTCCAGAGCAAGCTGAGCTAGATGTTGTTAGACACTATACACAACTTT
CGCGCAAAAACTTTTGTATAGATACAAATTTCTATCCACTAGGTTCTTGTACTATGAAATACAATTCTAGAGCTGCTCAT
AAGTATGCTTCATTAGCAGGTTTTTTAGAAAGACATCCTTACGCAAGTGCTCAAAGTGTCCAAGGTACTCTTGAGTGTTT
ATATGACTTACAAAACTTAATCAAAGAGCTAACGGGTATGACAGGTGTATCATTAGCTCCTATGGCTGGTGCTCAAGGTG
AGTTTGCAGGTGTAGCTATGATTAAAGCATATCATCACAAACGCAGTGATTTTGAGCGTGATGAAATCATTGTACCAGAT
GCTGCTCATGGGACAAATCCAGCTACTGCAAAAGTTTGTGGTCTAAAAGTTATTGAGATACCTACCAAGAAGGATGGTGA
TATCGATATCGAGGCTCTTGATAAAGTACTTGGTCCAAAGACTGCGGGTATTATGTTGACAAATCCTTCAACAGTAGGTG
TATTTGAAAGAAATATCGCAGTTATCGCCAAGAAAGTTCATGAGGCTGGTGGTTTACTATACTATGATGGTGCTAACTTA
AATGCGATCATGGGTAAAGCACGTCCTGGTGATATGGGCTTTGATGTTTTACATATGAATTTGCATAAGACTTTTGCTAC
TCCTCATGGTGGTGGTGGTCCAGGTGCTGGTCCAGTTGCTGTTAATGATAAGCTAAAAGAGTTCTTGCCAGTACCAATGG
TTGGTAAAAAAGATGATAAATTTGTATGGCTAGAAGAAAAAGATGTATCAAATACTATCGGTAGATTATCAGCATTTAAT
GGTAATATTGGTGTATTAATTAGAGCATATATTTATGGTGCTATGCTTGGCGGTAATGGTTTAACAGAAGCATCTGAAAT
AGCAACTCTAAATGCTAACTATATGATGACTCGCTTAAAAGAAGAAGGCTTCACGATAGCATATCCTGATAGAAGAGCTT
CTCATGAGTTCATCGTAACTTTGAAGCCTGAATTCTTAAACTATGGAGTGACAGCTACTGATTTTGCTAAGTGCTTGATA
GATAAAGGTGTACACGCTCCTACTATGTACTTCCCGCTATTAGTACCAGAATGTTTACTAATAGAACCTACTGAAACTGA
AAATGTTGATAGTATGGAGAAATTTATCCAAGCAATGGTAGAAATCAGAGATATCGCTAAGAAAGATCCTCAGTATCTAA
AAGGTGCTCCTTATAATTTACCAGCGCGTCGTCTTGATGATGTCAAAGCCGCTAAAGAGCTTGATATAGTTTGGCAGCCT
AAGTAA

Upstream 100 bases:

>100_bases
CTATTATGGTTTGTGCTACAGAGATTCATACATCTGAAGATATCAAAGAGTATATAGAAGCTACTAAAAAAGTTTTAGCT
AGGATAGGAGGTTAATTTAA

Downstream 100 bases:

>100_bases
TAATCACACTGTTAAATTTGAACTTGATTCAGGATCTGATAAATATGTGGGCGAAGAGATTTCCGATCAATATCGGAATA
ACAACGTCGACAGTCGTCAG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MVIFEKTRGKNSPSVMPSKKGDVSNIPTDMLRTKKPILPEQAELDVVRHYTQLSRKNFCIDTNFYPLGSCTMKYNSRAAH
KYASLAGFLERHPYASAQSVQGTLECLYDLQNLIKELTGMTGVSLAPMAGAQGEFAGVAMIKAYHHKRSDFERDEIIVPD
AAHGTNPATAKVCGLKVIEIPTKKDGDIDIEALDKVLGPKTAGIMLTNPSTVGVFERNIAVIAKKVHEAGGLLYYDGANL
NAIMGKARPGDMGFDVLHMNLHKTFATPHGGGGPGAGPVAVNDKLKEFLPVPMVGKKDDKFVWLEEKDVSNTIGRLSAFN
GNIGVLIRAYIYGAMLGGNGLTEASEIATLNANYMMTRLKEEGFTIAYPDRRASHEFIVTLKPEFLNYGVTATDFAKCLI
DKGVHAPTMYFPLLVPECLLIEPTETENVDSMEKFIQAMVEIRDIAKKDPQYLKGAPYNLPARRLDDVKAAKELDIVWQP
K

Sequences:

>Translated_481_residues
MVIFEKTRGKNSPSVMPSKKGDVSNIPTDMLRTKKPILPEQAELDVVRHYTQLSRKNFCIDTNFYPLGSCTMKYNSRAAH
KYASLAGFLERHPYASAQSVQGTLECLYDLQNLIKELTGMTGVSLAPMAGAQGEFAGVAMIKAYHHKRSDFERDEIIVPD
AAHGTNPATAKVCGLKVIEIPTKKDGDIDIEALDKVLGPKTAGIMLTNPSTVGVFERNIAVIAKKVHEAGGLLYYDGANL
NAIMGKARPGDMGFDVLHMNLHKTFATPHGGGGPGAGPVAVNDKLKEFLPVPMVGKKDDKFVWLEEKDVSNTIGRLSAFN
GNIGVLIRAYIYGAMLGGNGLTEASEIATLNANYMMTRLKEEGFTIAYPDRRASHEFIVTLKPEFLNYGVTATDFAKCLI
DKGVHAPTMYFPLLVPECLLIEPTETENVDSMEKFIQAMVEIRDIAKKDPQYLKGAPYNLPARRLDDVKAAKELDIVWQP
K
>Mature_481_residues
MVIFEKTRGKNSPSVMPSKKGDVSNIPTDMLRTKKPILPEQAELDVVRHYTQLSRKNFCIDTNFYPLGSCTMKYNSRAAH
KYASLAGFLERHPYASAQSVQGTLECLYDLQNLIKELTGMTGVSLAPMAGAQGEFAGVAMIKAYHHKRSDFERDEIIVPD
AAHGTNPATAKVCGLKVIEIPTKKDGDIDIEALDKVLGPKTAGIMLTNPSTVGVFERNIAVIAKKVHEAGGLLYYDGANL
NAIMGKARPGDMGFDVLHMNLHKTFATPHGGGGPGAGPVAVNDKLKEFLPVPMVGKKDDKFVWLEEKDVSNTIGRLSAFN
GNIGVLIRAYIYGAMLGGNGLTEASEIATLNANYMMTRLKEEGFTIAYPDRRASHEFIVTLKPEFLNYGVTATDFAKCLI
DKGVHAPTMYFPLLVPECLLIEPTETENVDSMEKFIQAMVEIRDIAKKDPQYLKGAPYNLPARRLDDVKAAKELDIVWQP
K

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=466, Percent_Identity=38.412017167382, Blast_Score=268, Evalue=7e-72,
Organism=Escherichia coli, GI1789269, Length=445, Percent_Identity=37.752808988764, Blast_Score=265, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17535605, Length=414, Percent_Identity=40.8212560386473, Blast_Score=268, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI32564013, Length=363, Percent_Identity=42.1487603305785, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6323843, Length=460, Percent_Identity=39.1304347826087, Blast_Score=276, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24645648, Length=436, Percent_Identity=38.302752293578, Blast_Score=257, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 52783; Mature: 52783

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIFEKTRGKNSPSVMPSKKGDVSNIPTDMLRTKKPILPEQAELDVVRHYTQLSRKNFCI
CEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEE
DTNFYPLGSCTMKYNSRAAHKYASLAGFLERHPYASAQSVQGTLECLYDLQNLIKELTGM
ECCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
TGVSLAPMAGAQGEFAGVAMIKAYHHKRSDFERDEIIVPDAAHGTNPATAKVCGLKVIEI
CCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEC
PTKKDGDIDIEALDKVLGPKTAGIMLTNPSTVGVFERNIAVIAKKVHEAGGLLYYDGANL
CCCCCCCCCHHHHHHHHCCCCCCEEEECCCEECHHHHHHHHHHHHHHHHCCEEEECCCCC
NAIMGKARPGDMGFDVLHMNLHKTFATPHGGGGPGAGPVAVNDKLKEFLPVPMVGKKDDK
EEEECCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCEECHHHHHHCCCCCCCCCCCC
FVWLEEKDVSNTIGRLSAFNGNIGVLIRAYIYGAMLGGNGLTEASEIATLNANYMMTRLK
EEEEECCCHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCHHHEEEECCHHHHHHHH
EEGFTIAYPDRRASHEFIVTLKPEFLNYGVTATDFAKCLIDKGVHAPTMYFPLLVPECLL
HCCCEEECCCCCCCCEEEEEECHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEE
IEPTETENVDSMEKFIQAMVEIRDIAKKDPQYLKGAPYNLPARRLDDVKAAKELDIVWQP
ECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHCCEEECC
K
C
>Mature Secondary Structure
MVIFEKTRGKNSPSVMPSKKGDVSNIPTDMLRTKKPILPEQAELDVVRHYTQLSRKNFCI
CEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEE
DTNFYPLGSCTMKYNSRAAHKYASLAGFLERHPYASAQSVQGTLECLYDLQNLIKELTGM
ECCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
TGVSLAPMAGAQGEFAGVAMIKAYHHKRSDFERDEIIVPDAAHGTNPATAKVCGLKVIEI
CCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCCCEEEEEC
PTKKDGDIDIEALDKVLGPKTAGIMLTNPSTVGVFERNIAVIAKKVHEAGGLLYYDGANL
CCCCCCCCCHHHHHHHHCCCCCCEEEECCCEECHHHHHHHHHHHHHHHHCCEEEECCCCC
NAIMGKARPGDMGFDVLHMNLHKTFATPHGGGGPGAGPVAVNDKLKEFLPVPMVGKKDDK
EEEECCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCEECHHHHHHCCCCCCCCCCCC
FVWLEEKDVSNTIGRLSAFNGNIGVLIRAYIYGAMLGGNGLTEASEIATLNANYMMTRLK
EEEEECCCHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCHHHEEEECCHHHHHHHH
EEGFTIAYPDRRASHEFIVTLKPEFLNYGVTATDFAKCLIDKGVHAPTMYFPLLVPECLL
HCCCEEECCCCCCCCEEEEEECHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEE
IEPTETENVDSMEKFIQAMVEIRDIAKKDPQYLKGAPYNLPARRLDDVKAAKELDIVWQP
ECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHCCEEECC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA