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The map label for this gene is malS [H]

Identifier: 89255848

GI number: 89255848

Start: 404475

End: 406289

Strand: Direct

Name: malS [H]

Synonym: FTL_0438

Alternate gene names: 89255848

Gene position: 404475-406289 (Clockwise)

Preceding gene: 89255844

Following gene: 89255849

Centisome position: 21.33

GC content: 35.65

Gene sequence:

>1815_bases
ATGGAAAGACGTGAAAAAAGAATAAGAAAATTAAGAAATAAAAGCGGTAAAGTTTTTGCAATAGAAACTAACCTTACAGG
TAGACAACTATTAAACAATAGGGTTTTGAATAAGGATGTTGCTTTTAGCCAAGAAGAAAGAGTTGCTTTTGCTCTTATCG
GCTACCTACCAGAAAAAGTTGAAAGTCTCGAAGAGCAAGCTATCAGAGTAAGAAGACAGCTTGATTTGAAACCTAATTCT
CTTGAAAAATATGTATTTTTAAATAGGCTTCATGACTTAAACACCACGCTATTTTATCACTTTGTGCGTGAGAATTTAGA
AGAAATAATGCCGATTATATATACACCAACTGTGGGCGAAGCTGTCCAAAAATATAGTAGCTCATTTAGAAAGCAAAGTG
GTTTATTTATCTCTATAAGTCATAAAAAGCATATTGCTAGAATACTAGAGCGATATGAGTATAACAGTATTGACTTAGTG
CTTGTTACCGATGGTGAAGCAGTGCTTGGAATTGGTGACCAAGGGATTGGTGGTATGAATATCAGTATCGGTAAGATTAT
GGTTTATGTTGCTGCAAGTGGTATAGATCCAGCTAGAGTTTTGCCGGTACAGCTTGATATGGGTACAAATAATGATGCTT
TACTTAATGCTCCTGGTTATCTAGGTGTACGCTTGCCAAGAGTCTCTGGTGAAACCTATGATGAGTTTATTGAAGAATTT
GTTACCCAGGTTAAAGCTAGATTTCCAAATGTGTTTTTGCATTGGGAAGATTTAGGTCGTGATAATGCGACACGTATTTT
AGAAAAATACAAAGATAAGTTATGTACATTTAATGATGATATTGAGGGTACGGGCATTGTTGCAACAGCTAACTGTATAG
CTGGTGTGAAAACGGCAAGCACTATAAGAATAAACGCTGGTGAGATAACTGTTGAAGAGGCATTAAGTGGTATATGTGAT
ATCAAAGTAGTTATTTTTGGTGCTGGTAGTGCTGGTTGCGGTATCGCTAGACAGCTTGCTGATGTGATCGCTGATCGAGC
GGGGGTATCTATTGAGAAAGCCAGAAGTAGTATCTATCTAGTAGACAGATATGGTTTAGTTTGTGATAGATTAAGAGCAA
AAAGAATTATACCAGAGCAGAAATTATTTGTCAAAACTAGTGAAGAGATTGATAAATGGAAGGTTGAGGATTTTAACTAT
ATTACACTTGAAGAAACAGTTAAAAATACAAAATGTGATATTTTAATTGGGACATCTGGTCAACCAGGATCATTTACTAA
AGAAATTATAAAAACTATGGCAAAAAATAATAACTATCCTATTATTATGCCACTATCTAATCCTACATCTCTTTGTGAAG
CATTACCTGAAGACATTATTAAGTGGACAAATGGTAAGGCTCTAATTGCTGCAGGTAGTCCATTTCCAGATGTGACATAT
AATGGTCGTGATTACCGTATTTCTCAGGGGAATAACGCCTTTATATTCCCAGGTTTAGGTTTAGGCTCAGTAGCTGTGCA
TGCACGAGTTCTTACAAAAGGGATGATTAGAGCTGCTTGTTATAGATTAAGTGAGTTATCACCGATGGTAATAAATGAGG
ATATTACTCAGCCATTGTTAGCTAGGATAACAGATTTAGTTGATGTTACAAAAGAAATTACTAAAGCAGTAGCTAAACAA
GCAATTCTAGAGGGTGTTCATGGTGTTGATATAGATCTAGAAGATTTAACAGAAACTGAGCTTGATGAAGAGATTGAGAG
ACTAATTAACCTATCATCATGGACACCGACGTATGCACCATATATGCCAATTTAA

Upstream 100 bases:

>100_bases
GTATTCATTTTTTGTTGAAAAAAAGCAACTACTGATAGATACTTATTTGTTAGATGTTTTTGTCATCGTGTAATGTAAAA
TTTTATAAGTGGTTTGAGTC

Downstream 100 bases:

>100_bases
GTTGTTTTTTATTTTTGTTTCGGAAATAACTTTATATTAATTTTATAAGCGTTTTTATCTTTTCTTAAAGTATGAAATTT
ATTGAAACTAAGCGCGACTT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 3 [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MERREKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFALIGYLPEKVESLEEQAIRVRRQLDLKPNS
LEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGEAVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLV
LVTDGEAVLGIGDQGIGGMNISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEF
VTQVKARFPNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTASTIRINAGEITVEEALSGICD
IKVVIFGAGSAGCGIARQLADVIADRAGVSIEKARSSIYLVDRYGLVCDRLRAKRIIPEQKLFVKTSEEIDKWKVEDFNY
ITLEETVKNTKCDILIGTSGQPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY
NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAACYRLSELSPMVINEDITQPLLARITDLVDVTKEITKAVAKQ
AILEGVHGVDIDLEDLTETELDEEIERLINLSSWTPTYAPYMPI

Sequences:

>Translated_604_residues
MERREKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFALIGYLPEKVESLEEQAIRVRRQLDLKPNS
LEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGEAVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLV
LVTDGEAVLGIGDQGIGGMNISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEF
VTQVKARFPNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTASTIRINAGEITVEEALSGICD
IKVVIFGAGSAGCGIARQLADVIADRAGVSIEKARSSIYLVDRYGLVCDRLRAKRIIPEQKLFVKTSEEIDKWKVEDFNY
ITLEETVKNTKCDILIGTSGQPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY
NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAACYRLSELSPMVINEDITQPLLARITDLVDVTKEITKAVAKQ
AILEGVHGVDIDLEDLTETELDEEIERLINLSSWTPTYAPYMPI
>Mature_604_residues
MERREKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFALIGYLPEKVESLEEQAIRVRRQLDLKPNS
LEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGEAVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLV
LVTDGEAVLGIGDQGIGGMNISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEF
VTQVKARFPNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTASTIRINAGEITVEEALSGICD
IKVVIFGAGSAGCGIARQLADVIADRAGVSIEKARSSIYLVDRYGLVCDRLRAKRIIPEQKLFVKTSEEIDKWKVEDFNY
ITLEETVKNTKCDILIGTSGQPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY
NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAACYRLSELSPMVINEDITQPLLARITDLVDVTKEITKAVAKQ
AILEGVHGVDIDLEDLTETELDEEIERLINLSSWTPTYAPYMPI

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=546, Percent_Identity=38.2783882783883, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI62420882, Length=539, Percent_Identity=35.8070500927644, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI62420880, Length=539, Percent_Identity=35.8070500927644, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI239049447, Length=539, Percent_Identity=35.8070500927644, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI4505145, Length=526, Percent_Identity=37.0722433460076, Blast_Score=330, Evalue=3e-90,
Organism=Homo sapiens, GI270265879, Length=474, Percent_Identity=39.0295358649789, Blast_Score=322, Evalue=9e-88,
Organism=Escherichia coli, GI87081919, Length=553, Percent_Identity=43.7613019891501, Blast_Score=441, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17537199, Length=570, Percent_Identity=36.6666666666667, Blast_Score=314, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6322823, Length=594, Percent_Identity=40.0673400673401, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24646388, Length=549, Percent_Identity=36.6120218579235, Blast_Score=345, Evalue=6e-95,
Organism=Drosophila melanogaster, GI24646386, Length=549, Percent_Identity=36.6120218579235, Blast_Score=344, Evalue=8e-95,
Organism=Drosophila melanogaster, GI281363505, Length=552, Percent_Identity=35.1449275362319, Blast_Score=337, Evalue=2e-92,
Organism=Drosophila melanogaster, GI78707236, Length=552, Percent_Identity=35.1449275362319, Blast_Score=337, Evalue=2e-92,
Organism=Drosophila melanogaster, GI78707232, Length=539, Percent_Identity=35.621521335807, Blast_Score=337, Evalue=2e-92,
Organism=Drosophila melanogaster, GI21356279, Length=535, Percent_Identity=36.8224299065421, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI281362674, Length=534, Percent_Identity=37.0786516853933, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI281362672, Length=535, Percent_Identity=36.8224299065421, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI281363503, Length=541, Percent_Identity=35.3049907578558, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI78707242, Length=571, Percent_Identity=33.0998248686515, Blast_Score=289, Evalue=4e-78,
Organism=Drosophila melanogaster, GI78707238, Length=571, Percent_Identity=33.0998248686515, Blast_Score=289, Evalue=4e-78,
Organism=Drosophila melanogaster, GI78707240, Length=536, Percent_Identity=34.3283582089552, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI19922384, Length=491, Percent_Identity=28.5132382892057, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 67345; Mature: 67345

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERREKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFALIGYLPEKV
CCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCHHCCCCCCCCCHHHHHHHHHHHCHHHH
ESLEEQAIRVRRQLDLKPNSLEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHH
AVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLVLVTDGEAVLGIGDQGIGGMN
HHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCE
ISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEF
EEHHHEEEEEEECCCCCCEEEEEEEECCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHH
VTQVKARFPNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTAS
HHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHCCCCCC
TIRINAGEITVEEALSGICDIKVVIFGAGSAGCGIARQLADVIADRAGVSIEKARSSIYL
EEEEECCCEEHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCCEEE
VDRYGLVCDRLRAKRIIPEQKLFVKTSEEIDKWKVEDFNYITLEETVKNTKCDILIGTSG
EEHHHHHHHHHHHHHCCCCHHEEEECHHHHCCEECCCCCEEEHHHHCCCCEEEEEEECCC
QPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY
CCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAACYRLSELSPMVINEDITQPLL
CCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHH
ARITDLVDVTKEITKAVAKQAILEGVHGVDIDLEDLTETELDEEIERLINLSSWTPTYAP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
YMPI
CCCC
>Mature Secondary Structure
MERREKRIRKLRNKSGKVFAIETNLTGRQLLNNRVLNKDVAFSQEERVAFALIGYLPEKV
CCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCHHCCCCCCCCCHHHHHHHHHHHCHHHH
ESLEEQAIRVRRQLDLKPNSLEKYVFLNRLHDLNTTLFYHFVRENLEEIMPIIYTPTVGE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHH
AVQKYSSSFRKQSGLFISISHKKHIARILERYEYNSIDLVLVTDGEAVLGIGDQGIGGMN
HHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCE
ISIGKIMVYVAASGIDPARVLPVQLDMGTNNDALLNAPGYLGVRLPRVSGETYDEFIEEF
EEHHHEEEEEEECCCCCCEEEEEEEECCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHH
VTQVKARFPNVFLHWEDLGRDNATRILEKYKDKLCTFNDDIEGTGIVATANCIAGVKTAS
HHHHHHHCCCEEEEHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHCCCCCC
TIRINAGEITVEEALSGICDIKVVIFGAGSAGCGIARQLADVIADRAGVSIEKARSSIYL
EEEEECCCEEHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCCEEE
VDRYGLVCDRLRAKRIIPEQKLFVKTSEEIDKWKVEDFNYITLEETVKNTKCDILIGTSG
EEHHHHHHHHHHHHHCCCCHHEEEECHHHHCCEECCCCCEEEHHHHCCCCEEEEEEECCC
QPGSFTKEIIKTMAKNNNYPIIMPLSNPTSLCEALPEDIIKWTNGKALIAAGSPFPDVTY
CCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
NGRDYRISQGNNAFIFPGLGLGSVAVHARVLTKGMIRAACYRLSELSPMVINEDITQPLL
CCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHH
ARITDLVDVTKEITKAVAKQAILEGVHGVDIDLEDLTETELDEEIERLINLSSWTPTYAP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
YMPI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]