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The map label for this gene is sdaC [H]

Identifier: 89255471

GI number: 89255471

Start: 23205

End: 24428

Strand: Reverse

Name: sdaC [H]

Synonym: FTL_0024

Alternate gene names: 89255471

Gene position: 24428-23205 (Counterclockwise)

Preceding gene: 89255472

Following gene: 89255469

Centisome position: 1.29

GC content: 29.82

Gene sequence:

>1224_bases
ATGAAAAAAAATGAAGATTTAATGTGGTCCCTTAGTCTGTATGGTACAGCTATCGGTGCCGGTGTACTATTTTTGCCAAT
TCAAACTGGAATTTCAGGAATTATACCAATATTAGTGATATTAGTATTTATCTTCCCAATGGTGTTTTTATCACATCGTG
CATTATGTAGATTTGTGATATCTAACCCAAATACTAACTCTGATATCACAGTAGTTGCTGATGACTATTTTGGTAAGCTT
GGTGGAATTATTTTCAACATTTTATATCTATTTGCTATCTTGCCAATACTACTGGTTTATAGTGTTGGTATAACAAATAC
TCTGGCTAGTTTTTTTAAGTATCAGTTTCATTACGATATTCAAAATAGATTTCTTTTGAGTTTTTTTACTATACTTTCGC
TAGTTTTTATCATTAACTTTGGTCAGAAGCTTATCATCCGTGTTATGAGCCTTCTAGTTTTTCCATTTATCATCGCTTTG
CTAGTACTTTCATTATGGATGATTCCATATTGGAATATTGAGATACTGCAAAAGAGCATTGAGTACAATCATAGTTTTTC
TGGTATTTTGATAGCTATCTGGATAATTATGCCAATATTGATATTTTCTTTTAACCACTCACCGATTATCTCTTCTTTAG
CCGTATATGCAAAAACCAAATACAAACAAAATGCCGACAAAAAAGCCTCTAAGATAATCGCTTTTAGTAATATTCTAATG
ATTATTACTGTAGTTATATTTGTAATTAGCTCAATGCTTACCCTCTCTCCAAAAGAGCTAATGATCGCAAAAGAAGAGAA
TATTTCTATACTATCTTATCTAGCAAGTCATTTTAATAATTATTCTCTTGATTATGTAGCTCCAATAGTAGCTCTAGTTG
CTATGAGTAAGTCTTTTTTTGGTCATTATTTAGGTTCAAAAGAAGGTATAGATGGTCTAGTTTATAAAGTTACAAAAAAT
AAAATTAGTGAAAAAACTATAAAACCAATTACATTATCAATAGTGTTTTTATCATGCTGGCTAGTTGCTTATTTAAACCC
AAATATCTTAGATATGATATCTAGTATAGGTGGTCTAGTTTTAGCGGTGATACTGTTTATTATGCCTATTTATAGTATCT
ATAAAATAAAATATCTAAAGCCTTATAAAAACCTATTAGCAGATAGTTTTATACTTTTTGTCGGTATTATTGCACTATCA
TCGGCAATTTATGTTTTGTTGTAG

Upstream 100 bases:

>100_bases
TTCTTTTTACATTAAACTTTATTAATTATTTTTGAACTTGGTTTATGGATCGCTAATTTTAGCTTTCTATATAGGCTATT
TTTTTATTTAGATATTTACT

Downstream 100 bases:

>100_bases
GGTTATACTTAAAATTTGACATTTGACATAATAAGGTATAAATTGTATCCACCCAAATGGGGGCGAATATGGTTTCGACA
TGAATGTCAAAATCTAAGGT

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKKNEDLMWSLSLYGTAIGAGVLFLPIQTGISGIIPILVILVFIFPMVFLSHRALCRFVISNPNTNSDITVVADDYFGKL
GGIIFNILYLFAILPILLVYSVGITNTLASFFKYQFHYDIQNRFLLSFFTILSLVFIINFGQKLIIRVMSLLVFPFIIAL
LVLSLWMIPYWNIEILQKSIEYNHSFSGILIAIWIIMPILIFSFNHSPIISSLAVYAKTKYKQNADKKASKIIAFSNILM
IITVVIFVISSMLTLSPKELMIAKEENISILSYLASHFNNYSLDYVAPIVALVAMSKSFFGHYLGSKEGIDGLVYKVTKN
KISEKTIKPITLSIVFLSCWLVAYLNPNILDMISSIGGLVLAVILFIMPIYSIYKIKYLKPYKNLLADSFILFVGIIALS
SAIYVLL

Sequences:

>Translated_407_residues
MKKNEDLMWSLSLYGTAIGAGVLFLPIQTGISGIIPILVILVFIFPMVFLSHRALCRFVISNPNTNSDITVVADDYFGKL
GGIIFNILYLFAILPILLVYSVGITNTLASFFKYQFHYDIQNRFLLSFFTILSLVFIINFGQKLIIRVMSLLVFPFIIAL
LVLSLWMIPYWNIEILQKSIEYNHSFSGILIAIWIIMPILIFSFNHSPIISSLAVYAKTKYKQNADKKASKIIAFSNILM
IITVVIFVISSMLTLSPKELMIAKEENISILSYLASHFNNYSLDYVAPIVALVAMSKSFFGHYLGSKEGIDGLVYKVTKN
KISEKTIKPITLSIVFLSCWLVAYLNPNILDMISSIGGLVLAVILFIMPIYSIYKIKYLKPYKNLLADSFILFVGIIALS
SAIYVLL
>Mature_407_residues
MKKNEDLMWSLSLYGTAIGAGVLFLPIQTGISGIIPILVILVFIFPMVFLSHRALCRFVISNPNTNSDITVVADDYFGKL
GGIIFNILYLFAILPILLVYSVGITNTLASFFKYQFHYDIQNRFLLSFFTILSLVFIINFGQKLIIRVMSLLVFPFIIAL
LVLSLWMIPYWNIEILQKSIEYNHSFSGILIAIWIIMPILIFSFNHSPIISSLAVYAKTKYKQNADKKASKIIAFSNILM
IITVVIFVISSMLTLSPKELMIAKEENISILSYLASHFNNYSLDYVAPIVALVAMSKSFFGHYLGSKEGIDGLVYKVTKN
KISEKTIKPITLSIVFLSCWLVAYLNPNILDMISSIGGLVLAVILFIMPIYSIYKIKYLKPYKNLLADSFILFVGIIALS
SAIYVLL

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=409, Percent_Identity=45.721271393643, Blast_Score=370, Evalue=1e-104,
Organism=Escherichia coli, GI1789504, Length=425, Percent_Identity=41.4117647058824, Blast_Score=331, Evalue=6e-92,
Organism=Escherichia coli, GI1789211, Length=404, Percent_Identity=37.3762376237624, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI145693183, Length=394, Percent_Identity=24.8730964467005, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1789961, Length=393, Percent_Identity=23.9185750636132, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 45843; Mature: 45843

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNEDLMWSLSLYGTAIGAGVLFLPIQTGISGIIPILVILVFIFPMVFLSHRALCRFVI
CCCCCCCEEEHHHHHHHHHCCHHEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNPNTNSDITVVADDYFGKLGGIIFNILYLFAILPILLVYSVGITNTLASFFKYQFHYDI
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECH
QNRFLLSFFTILSLVFIINFGQKLIIRVMSLLVFPFIIALLVLSLWMIPYWNIEILQKSI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EYNHSFSGILIAIWIIMPILIFSFNHSPIISSLAVYAKTKYKQNADKKASKIIAFSNILM
HCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IITVVIFVISSMLTLSPKELMIAKEENISILSYLASHFNNYSLDYVAPIVALVAMSKSFF
HHHHHHHHHHHHHHCCHHHHEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GHYLGSKEGIDGLVYKVTKNKISEKTIKPITLSIVFLSCWLVAYLNPNILDMISSIGGLV
HHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LAVILFIMPIYSIYKIKYLKPYKNLLADSFILFVGIIALSSAIYVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKNEDLMWSLSLYGTAIGAGVLFLPIQTGISGIIPILVILVFIFPMVFLSHRALCRFVI
CCCCCCCEEEHHHHHHHHHCCHHEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNPNTNSDITVVADDYFGKLGGIIFNILYLFAILPILLVYSVGITNTLASFFKYQFHYDI
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECH
QNRFLLSFFTILSLVFIINFGQKLIIRVMSLLVFPFIIALLVLSLWMIPYWNIEILQKSI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EYNHSFSGILIAIWIIMPILIFSFNHSPIISSLAVYAKTKYKQNADKKASKIIAFSNILM
HCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IITVVIFVISSMLTLSPKELMIAKEENISILSYLASHFNNYSLDYVAPIVALVAMSKSFF
HHHHHHHHHHHHHHCCHHHHEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GHYLGSKEGIDGLVYKVTKNKISEKTIKPITLSIVFLSCWLVAYLNPNILDMISSIGGLV
HHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LAVILFIMPIYSIYKIKYLKPYKNLLADSFILFVGIIALSSAIYVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]