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The map label for this gene is purH

Identifier: 89056533

GI number: 89056533

Start: 4145097

End: 4146695

Strand: Direct

Name: purH

Synonym: Jann_4042

Alternate gene names: 89056533

Gene position: 4145097-4146695 (Clockwise)

Preceding gene: 89056532

Following gene: 89056534

Centisome position: 96.0

GC content: 64.48

Gene sequence:

>1599_bases
ATGACCGATCCTGCCCCCCTCACCCGCGCGCTTCTGTCTGTCTCTGACAAGACCGGATTGATTGAGTTCGCCACCGACCT
GTCGTCCCGTGGGGTGGAGCTTCTGTCCACCGGTGGCACCGCGAAGGCCTTGCGCGAAGCCGGTCTGGATGTGCGCGATG
TGAGCGAGGTCACGGGCTTCCCGGAGATGATGGACGGACGGGTGAAGACATTGCATCCGATGATCCACGGCGGCCTGCTG
GCCCTGCGCGACAACGACGCCCATGTCGCGGCGATGAAAGAGCACGGGATCGGCGCGATCGATCTGCTGGTGGTGAACCT
TTACCCGTTTGAGGCGACGGTGGCCGCAGGCGCGGATTATGACACCTGTATCGAGAATATCGATATCGGCGGCCCCGCGA
TGATCCGGGCCGCCGCGAAAAACCATGGCGCGGTGACGGTGCTGACGGACTCCTCCCAATACGCCGGGTTGTTGAGCGAG
CTGGATGCTAATGCAAACAAGGGCGGTGGCACGTCGTTCCAGTTCCGCCAGCGGATGGCGCAGGCGGCTTACGGGCGCAC
GGCGGCCTATGACGCGGCGGTCTCCAGTTGGATGGCAGGTGCGGCTGAGATCAAAACTCCGCCACACCGCGCGTTCGCGG
GCAGCCTCGCACAGGAAATGCGCTACGGCGAGAACCCACACCAGAAAGCCGCATTCTATCTTGATGGATCGTCGCGCCCG
GGCGTGGCCACAGCGCAGCAACATCAGGGCAAAGCGCTGAGCTACAACAACATCAATGACACGGACGCCGCGTTTGAGCT
GGTCTCGGAATTCGCGCCCGACGATGGCCCGGCGGTTGCGATCATCAAGCACGCCAACCCGTCGGGCGTGGCCCGCGGCA
ACAGCCTTGCAGAGGCCTACAAAGCCGCGTTCGATTGCGACCGCACCAGCGCGTTTGGTGGCATCGTCGCATTGAACCAG
ACGTTGGACGCTGCCACGGCAGAAGAGATCGTGCAGATCTTCACAGAGGTGGTGATCGCGCCCGACGCTGACGAGGATGC
CAAGGCGATCTTCGCCGCCAAGAAAAACCTGCGCCTGCTGACAACCGGCGGCCTGCCGGACCCGCGCGCGCCAATGGTCG
CCTACAAGCAGGTCGCGGGCGGATTGTTGGTGCAGGACAAGGACACCGGCCATGTGGACCCGGAGTTGCTGGAGGTCGTG
ACCAAACGCGCGCCGTCAGCCCAGGAATTGGCCGATCTGCGCTTTGCCTGGACCGTGGCGAAACACACGAAATCCAACGC
GATCATCTACGCCAAGGGCGGTGCAACCGTGGGCATCGGCGCGGGGCAGATGAGCCGCGTGGACAGCTCCACCATCGCAG
CGTTGAAGGCGGCACGGATGGGCACGGAATGCGGAATGGCTGACACGCCCGCTAAGGGATCGGTCGTGGCGTCGGACGCG
TTCTTCCCGTTTGCGGACGGCTTGCTGGCGGCGGCAGAGGCAGGTGCCACGGCGGTGATCCAGCCCGGCGGCTCCATGCG
TGACGCAGATGTGATCGCTGCCGCCGACGAGGCAGGCCTGGCCATGGTCTTCACCGGCATGCGCCATTTCCGGCACTGA

Upstream 100 bases:

>100_bases
CAGTCAGCTGGTCCATCGCGCGCCCCTCGGCGCTGTTGCCCGCCCCCGACGACCTGTCTTTGTGAGCGATCATGGGGACG
CAGTATATGAGAGCCTGCCT

Downstream 100 bases:

>100_bases
TCGACACCAAGGAAAGCGACACCATGCGGCTTGTGTATCTGAGTGCAGCGTTCTGGTTCCTGATTGATCAGGGGTCGAAA
TATGGCGTGCTCTACGGCCT

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MTDPAPLTRALLSVSDKTGLIEFATDLSSRGVELLSTGGTAKALREAGLDVRDVSEVTGFPEMMDGRVKTLHPMIHGGLL
ALRDNDAHVAAMKEHGIGAIDLLVVNLYPFEATVAAGADYDTCIENIDIGGPAMIRAAAKNHGAVTVLTDSSQYAGLLSE
LDANANKGGGTSFQFRQRMAQAAYGRTAAYDAAVSSWMAGAAEIKTPPHRAFAGSLAQEMRYGENPHQKAAFYLDGSSRP
GVATAQQHQGKALSYNNINDTDAAFELVSEFAPDDGPAVAIIKHANPSGVARGNSLAEAYKAAFDCDRTSAFGGIVALNQ
TLDAATAEEIVQIFTEVVIAPDADEDAKAIFAAKKNLRLLTTGGLPDPRAPMVAYKQVAGGLLVQDKDTGHVDPELLEVV
TKRAPSAQELADLRFAWTVAKHTKSNAIIYAKGGATVGIGAGQMSRVDSSTIAALKAARMGTECGMADTPAKGSVVASDA
FFPFADGLLAAAEAGATAVIQPGGSMRDADVIAAADEAGLAMVFTGMRHFRH

Sequences:

>Translated_532_residues
MTDPAPLTRALLSVSDKTGLIEFATDLSSRGVELLSTGGTAKALREAGLDVRDVSEVTGFPEMMDGRVKTLHPMIHGGLL
ALRDNDAHVAAMKEHGIGAIDLLVVNLYPFEATVAAGADYDTCIENIDIGGPAMIRAAAKNHGAVTVLTDSSQYAGLLSE
LDANANKGGGTSFQFRQRMAQAAYGRTAAYDAAVSSWMAGAAEIKTPPHRAFAGSLAQEMRYGENPHQKAAFYLDGSSRP
GVATAQQHQGKALSYNNINDTDAAFELVSEFAPDDGPAVAIIKHANPSGVARGNSLAEAYKAAFDCDRTSAFGGIVALNQ
TLDAATAEEIVQIFTEVVIAPDADEDAKAIFAAKKNLRLLTTGGLPDPRAPMVAYKQVAGGLLVQDKDTGHVDPELLEVV
TKRAPSAQELADLRFAWTVAKHTKSNAIIYAKGGATVGIGAGQMSRVDSSTIAALKAARMGTECGMADTPAKGSVVASDA
FFPFADGLLAAAEAGATAVIQPGGSMRDADVIAAADEAGLAMVFTGMRHFRH
>Mature_531_residues
TDPAPLTRALLSVSDKTGLIEFATDLSSRGVELLSTGGTAKALREAGLDVRDVSEVTGFPEMMDGRVKTLHPMIHGGLLA
LRDNDAHVAAMKEHGIGAIDLLVVNLYPFEATVAAGADYDTCIENIDIGGPAMIRAAAKNHGAVTVLTDSSQYAGLLSEL
DANANKGGGTSFQFRQRMAQAAYGRTAAYDAAVSSWMAGAAEIKTPPHRAFAGSLAQEMRYGENPHQKAAFYLDGSSRPG
VATAQQHQGKALSYNNINDTDAAFELVSEFAPDDGPAVAIIKHANPSGVARGNSLAEAYKAAFDCDRTSAFGGIVALNQT
LDAATAEEIVQIFTEVVIAPDADEDAKAIFAAKKNLRLLTTGGLPDPRAPMVAYKQVAGGLLVQDKDTGHVDPELLEVVT
KRAPSAQELADLRFAWTVAKHTKSNAIIYAKGGATVGIGAGQMSRVDSSTIAALKAARMGTECGMADTPAKGSVVASDAF
FPFADGLLAAAEAGATAVIQPGGSMRDADVIAAADEAGLAMVFTGMRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=612, Percent_Identity=34.1503267973856, Blast_Score=273, Evalue=3e-73,
Organism=Escherichia coli, GI1790439, Length=545, Percent_Identity=55.4128440366973, Blast_Score=543, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI71985564, Length=617, Percent_Identity=33.063209076175, Blast_Score=276, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71985574, Length=304, Percent_Identity=29.2763157894737, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323768, Length=479, Percent_Identity=37.3695198329854, Blast_Score=263, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6323056, Length=475, Percent_Identity=37.4736842105263, Blast_Score=257, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24649832, Length=473, Percent_Identity=37.8435517970402, Blast_Score=264, Evalue=1e-70,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_JANSC (Q28K03)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_511984.1
- ProteinModelPortal:   Q28K03
- SMR:   Q28K03
- STRING:   Q28K03
- GeneID:   3936530
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_4042
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- PhylomeDB:   Q28K03
- ProtClustDB:   PRK00881
- BioCyc:   JSP290400:JANN_4042-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 55404; Mature: 55273

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPAPLTRALLSVSDKTGLIEFATDLSSRGVELLSTGGTAKALREAGLDVRDVSEVTGF
CCCCHHHHHHHHHHCCCCCEEHHHHHHHHCCEEEEECCCHHHHHHHCCCCHHHHHHHCCC
PEMMDGRVKTLHPMIHGGLLALRDNDAHVAAMKEHGIGAIDLLVVNLYPFEATVAAGADY
HHHHCCCHHHHHHHHHCCEEEEECCCCEEEEEHHCCCCEEEEEEEEEECCCEEEECCCCH
DTCIENIDIGGPAMIRAAAKNHGAVTVLTDSSQYAGLLSELDANANKGGGTSFQFRQRMA
HHHHHHCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
QAAYGRTAAYDAAVSSWMAGAAEIKTPPHRAFAGSLAQEMRYGENPHQKAAFYLDGSSRP
HHHCCCHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
GVATAQQHQGKALSYNNINDTDAAFELVSEFAPDDGPAVAIIKHANPSGVARGNSLAEAY
CCCCCHHHCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHH
KAAFDCDRTSAFGGIVALNQTLDAATAEEIVQIFTEVVIAPDADEDAKAIFAAKKNLRLL
HHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCEEEE
TTGGLPDPRAPMVAYKQVAGGLLVQDKDTGHVDPELLEVVTKRAPSAQELADLRFAWTVA
EECCCCCCCCHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHEEEH
KHTKSNAIIYAKGGATVGIGAGQMSRVDSSTIAALKAARMGTECGMADTPAKGSVVASDA
HCCCCCEEEEECCCCEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCC
FFPFADGLLAAAEAGATAVIQPGGSMRDADVIAAADEAGLAMVFTGMRHFRH
CCHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TDPAPLTRALLSVSDKTGLIEFATDLSSRGVELLSTGGTAKALREAGLDVRDVSEVTGF
CCCHHHHHHHHHHCCCCCEEHHHHHHHHCCEEEEECCCHHHHHHHCCCCHHHHHHHCCC
PEMMDGRVKTLHPMIHGGLLALRDNDAHVAAMKEHGIGAIDLLVVNLYPFEATVAAGADY
HHHHCCCHHHHHHHHHCCEEEEECCCCEEEEEHHCCCCEEEEEEEEEECCCEEEECCCCH
DTCIENIDIGGPAMIRAAAKNHGAVTVLTDSSQYAGLLSELDANANKGGGTSFQFRQRMA
HHHHHHCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
QAAYGRTAAYDAAVSSWMAGAAEIKTPPHRAFAGSLAQEMRYGENPHQKAAFYLDGSSRP
HHHCCCHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
GVATAQQHQGKALSYNNINDTDAAFELVSEFAPDDGPAVAIIKHANPSGVARGNSLAEAY
CCCCCHHHCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHH
KAAFDCDRTSAFGGIVALNQTLDAATAEEIVQIFTEVVIAPDADEDAKAIFAAKKNLRLL
HHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCEEEE
TTGGLPDPRAPMVAYKQVAGGLLVQDKDTGHVDPELLEVVTKRAPSAQELADLRFAWTVA
EECCCCCCCCHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHEEEH
KHTKSNAIIYAKGGATVGIGAGQMSRVDSSTIAALKAARMGTECGMADTPAKGSVVASDA
HCCCCCEEEEECCCCEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCC
FFPFADGLLAAAEAGATAVIQPGGSMRDADVIAAADEAGLAMVFTGMRHFRH
CCHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA