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The map label for this gene is hbpA [H]

Identifier: 89056307

GI number: 89056307

Start: 3905708

End: 3907276

Strand: Direct

Name: hbpA [H]

Synonym: Jann_3816

Alternate gene names: 89056307

Gene position: 3905708-3907276 (Clockwise)

Preceding gene: 89056306

Following gene: 89056308

Centisome position: 90.45

GC content: 63.22

Gene sequence:

>1569_bases
ATGAAACGATTGTCCAATATGGGCGGGATGAGCCGCCGAACGATGCTGCAAGGCACCGCCGCCGTCGGCACCGCCGCGCT
GATCACACCCTGGGGGACGCCGCTGCGCGCGCAGCCTGTGCAGGGCGGAACATTGCGGGTTGGCATGGCGCACGGCTCAA
CCACCGACGCGCTGGACCCGGGCACCTGGGAAGCAGATTTCATGATCTTTCAGGCCCATACCCGCAACAACTACCTGACC
GAGATCGCAGCAGACGGCTCCCTCGTGCCGGAACTGGCCGAAAGCTGGGAAGCGTCTGAGGATGCCGCGACCTGGACCTT
CACGATCCGCTCGGGCGTTGAATTCCATTCTGGCCACGTGCTGACGGCGGAAGACGTTGTCGCCTCCATCAACCACCACA
GGGGCGAAGACAGCACCTCTGCCGCTGCGCCTATCGTGTCGGCCATCACCGATATGACGGTGGATGGCATGAACGTCGTG
GTCACGCTGGCCTCCGGCAATGCGGACTTCCCGTTTGTGATGTCCGACTATCACCTGCCGATCCTGCCCGCCCAGGCCGA
TGGCACAATCGACCCCAACACCCAGGACGGCTGCGGCCCGTTCCGCATTGTTGAGATCGAATTCGGCGTTGGCGCCTCCT
ACGCGCGCCATGACGGCTATTGGAAAGAGGGTTTGCCCCATTTCGACGCGATTGAGCAGATCGTCATCTTCGACGATGCC
GCCCGCCAGAACGCGCTGATTTCTGGAGAGGTCGATTACATCGACACCGCCGACCTCAACACCGTGCACCTGCTGGAGCG
CGCGCCGGGGATCGAGATCCTGTCCGTGACCGGCACGCAGCACTATGGCCTGCCGATGGACACGCGGGCGGAGCCGTTCA
ATGATCCCAACGTCCGTCTGGCGCTGAAGTATTCGATTGACCGGACCCAGCTGGTGGACACGATCCTGAACGGCTACGGC
TCCATCGGCAACGACCACCCCATCGGCTCCGGCCAGCGGTTCTTCAACACCGAGTTGGAGCAGAAGGAATACGATCCGGA
TCGTGCGCGCTTCCACCTGGCCGAGGCCGGGATGGAAAGCCTCGACGTGGACATCCACCTGGCCGACGCCGCCTTCGCGG
GTGCGATGGACGCGGGCGTGTTGTTCTCGGAAAGTGCTGCGGCGTCCGGCATCAACCTTAACGTCGTGCGCGAACCCAAC
GACGGCTACTGGTCCAACGTCTGGATGCAGAAGCCCTTCGCGGGCACCTATTGGGGCGGTCGCCCGACCGAAGACCTGAT
GTTCGCGACGGCCTACGAGCGCGGCGTGCCATGGAACGAGACGTTCTGGGACAACGAGCGGTTCAACGACCTCCTGCTTC
AGGCCCGCTCCGAGCTGGATGAGGACCTGCGCCGCGACATGTATTTCGAGATGCAGCAGATCGTGTCCGACGATGGCGGG
ATCATCATCCCGATGTTCGCCAATTACGTCGGCGCCTACAGCGATGCCCTTGCCCATCCCGAGCAGGTCGCGTCGAACTG
GCGCAATGACGGCCACCGGATAGGCGAACGCTGGTGGTTCGCAGCTTAA

Upstream 100 bases:

>100_bases
GCAACTAACAGTTGAAACACAGGGGATTGTAGGCAGAATGCCCTGACAAATTCATAACGGGCCGGGCAAACCGACCTGAA
CGACAACAGTGGAGAGATAC

Downstream 100 bases:

>100_bases
GCCCATTGACCCCCGGCCAATGATTTGGTCGGGGGTTCTTCGTTCCGGAACGGGCACATAGGCCCGGGGAACCACAATCA
AGAACAAAGCGGCCCTCAGA

Product: twin-arginine translocation pathway signal

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MKRLSNMGGMSRRTMLQGTAAVGTAALITPWGTPLRAQPVQGGTLRVGMAHGSTTDALDPGTWEADFMIFQAHTRNNYLT
EIAADGSLVPELAESWEASEDAATWTFTIRSGVEFHSGHVLTAEDVVASINHHRGEDSTSAAAPIVSAITDMTVDGMNVV
VTLASGNADFPFVMSDYHLPILPAQADGTIDPNTQDGCGPFRIVEIEFGVGASYARHDGYWKEGLPHFDAIEQIVIFDDA
ARQNALISGEVDYIDTADLNTVHLLERAPGIEILSVTGTQHYGLPMDTRAEPFNDPNVRLALKYSIDRTQLVDTILNGYG
SIGNDHPIGSGQRFFNTELEQKEYDPDRARFHLAEAGMESLDVDIHLADAAFAGAMDAGVLFSESAAASGINLNVVREPN
DGYWSNVWMQKPFAGTYWGGRPTEDLMFATAYERGVPWNETFWDNERFNDLLLQARSELDEDLRRDMYFEMQQIVSDDGG
IIIPMFANYVGAYSDALAHPEQVASNWRNDGHRIGERWWFAA

Sequences:

>Translated_522_residues
MKRLSNMGGMSRRTMLQGTAAVGTAALITPWGTPLRAQPVQGGTLRVGMAHGSTTDALDPGTWEADFMIFQAHTRNNYLT
EIAADGSLVPELAESWEASEDAATWTFTIRSGVEFHSGHVLTAEDVVASINHHRGEDSTSAAAPIVSAITDMTVDGMNVV
VTLASGNADFPFVMSDYHLPILPAQADGTIDPNTQDGCGPFRIVEIEFGVGASYARHDGYWKEGLPHFDAIEQIVIFDDA
ARQNALISGEVDYIDTADLNTVHLLERAPGIEILSVTGTQHYGLPMDTRAEPFNDPNVRLALKYSIDRTQLVDTILNGYG
SIGNDHPIGSGQRFFNTELEQKEYDPDRARFHLAEAGMESLDVDIHLADAAFAGAMDAGVLFSESAAASGINLNVVREPN
DGYWSNVWMQKPFAGTYWGGRPTEDLMFATAYERGVPWNETFWDNERFNDLLLQARSELDEDLRRDMYFEMQQIVSDDGG
IIIPMFANYVGAYSDALAHPEQVASNWRNDGHRIGERWWFAA
>Mature_522_residues
MKRLSNMGGMSRRTMLQGTAAVGTAALITPWGTPLRAQPVQGGTLRVGMAHGSTTDALDPGTWEADFMIFQAHTRNNYLT
EIAADGSLVPELAESWEASEDAATWTFTIRSGVEFHSGHVLTAEDVVASINHHRGEDSTSAAAPIVSAITDMTVDGMNVV
VTLASGNADFPFVMSDYHLPILPAQADGTIDPNTQDGCGPFRIVEIEFGVGASYARHDGYWKEGLPHFDAIEQIVIFDDA
ARQNALISGEVDYIDTADLNTVHLLERAPGIEILSVTGTQHYGLPMDTRAEPFNDPNVRLALKYSIDRTQLVDTILNGYG
SIGNDHPIGSGQRFFNTELEQKEYDPDRARFHLAEAGMESLDVDIHLADAAFAGAMDAGVLFSESAAASGINLNVVREPN
DGYWSNVWMQKPFAGTYWGGRPTEDLMFATAYERGVPWNETFWDNERFNDLLLQARSELDEDLRRDMYFEMQQIVSDDGG
IIIPMFANYVGAYSDALAHPEQVASNWRNDGHRIGERWWFAA

Specific function: Important role in heme acquisition or metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=440, Percent_Identity=23.4090909090909, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789887, Length=313, Percent_Identity=27.4760383386581, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1787052, Length=495, Percent_Identity=25.2525252525253, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787762, Length=425, Percent_Identity=22.8235294117647, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1787551, Length=307, Percent_Identity=22.8013029315961, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 57421; Mature: 57421

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLSNMGGMSRRTMLQGTAAVGTAALITPWGTPLRAQPVQGGTLRVGMAHGSTTDALDP
CCCCHHCCCCCHHHHHHCCHHHCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
GTWEADFMIFQAHTRNNYLTEIAADGSLVPELAESWEASEDAATWTFTIRSGVEFHSGHV
CCCCEEEEEEEEECCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCEECCCCE
LTAEDVVASINHHRGEDSTSAAAPIVSAITDMTVDGMNVVVTLASGNADFPFVMSDYHLP
EEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEECCCCCE
ILPAQADGTIDPNTQDGCGPFRIVEIEFGVGASYARHDGYWKEGLPHFDAIEQIVIFDDA
EEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHCCCCHHHCCCCHHHHCEEEEEECC
ARQNALISGEVDYIDTADLNTVHLLERAPGIEILSVTGTQHYGLPMDTRAEPFNDPNVRL
CCCCCEEECCCCEEECCCCCEEEHHHCCCCCEEEEEECCEECCCCCCCCCCCCCCCCEEE
ALKYSIDRTQLVDTILNGYGSIGNDHPIGSGQRFFNTELEQKEYDPDRARFHLAEAGMES
EEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCHHHHCCCCHHHHEEHHHCCCCC
LDVDIHLADAAFAGAMDAGVLFSESAAASGINLNVVREPNDGYWSNVWMQKPFAGTYWGG
CEEEEEEECHHHHCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCC
RPTEDLMFATAYERGVPWNETFWDNERFNDLLLQARSELDEDLRRDMYFEMQQIVSDDGG
CCCHHHEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IIIPMFANYVGAYSDALAHPEQVASNWRNDGHRIGERWWFAA
EEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHCCEEECCC
>Mature Secondary Structure
MKRLSNMGGMSRRTMLQGTAAVGTAALITPWGTPLRAQPVQGGTLRVGMAHGSTTDALDP
CCCCHHCCCCCHHHHHHCCHHHCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCC
GTWEADFMIFQAHTRNNYLTEIAADGSLVPELAESWEASEDAATWTFTIRSGVEFHSGHV
CCCCEEEEEEEEECCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCEECCCCE
LTAEDVVASINHHRGEDSTSAAAPIVSAITDMTVDGMNVVVTLASGNADFPFVMSDYHLP
EEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEECCCCCE
ILPAQADGTIDPNTQDGCGPFRIVEIEFGVGASYARHDGYWKEGLPHFDAIEQIVIFDDA
EEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHCCCCHHHCCCCHHHHCEEEEEECC
ARQNALISGEVDYIDTADLNTVHLLERAPGIEILSVTGTQHYGLPMDTRAEPFNDPNVRL
CCCCCEEECCCCEEECCCCCEEEHHHCCCCCEEEEEECCEECCCCCCCCCCCCCCCCEEE
ALKYSIDRTQLVDTILNGYGSIGNDHPIGSGQRFFNTELEQKEYDPDRARFHLAEAGMES
EEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCHHHHCCCCHHHHEEHHHCCCCC
LDVDIHLADAAFAGAMDAGVLFSESAAASGINLNVVREPNDGYWSNVWMQKPFAGTYWGG
CEEEEEEECHHHHCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCC
RPTEDLMFATAYERGVPWNETFWDNERFNDLLLQARSELDEDLRRDMYFEMQQIVSDDGG
CCCHHHEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IIIPMFANYVGAYSDALAHPEQVASNWRNDGHRIGERWWFAA
EEEEHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]