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The map label for this gene is trpF

Identifier: 89056078

GI number: 89056078

Start: 3665091

End: 3665738

Strand: Direct

Name: trpF

Synonym: Jann_3587

Alternate gene names: 89056078

Gene position: 3665091-3665738 (Clockwise)

Preceding gene: 89056077

Following gene: 89056079

Centisome position: 84.88

GC content: 63.27

Gene sequence:

>648_bases
TTGTCTGAGGTGGCAATCAAGTTCTGCGGACTGAGCCGCCTGGAAGATGTGTCTGCCGCGGCAGAGGCCGGCGCGCGCTA
CGTGGGCTTTGTGTTCTTCCCAAAATCACCGCGCAACGTGTCCATCCCGCAGGCGCGAGAACTGGCTCTGGCCGTGCCCC
TCGGGATCGCCAAAGTGGCCCTCGTGGTGAATGCCGATGACGCGTTGCTTGACGAGATTGTTAGCCAGGTGCCGCTCGAT
ATGCTGCAGCTCCATGGGTCCGAGACGCCGGAGCGGGTGGCAGAGATCCGGGCGCGTTATGGCCTTCCCGTCATGAAAGC
CATCGGTGTGGCCGAGGCCGCAGACCTGGACGCCATCGACCTATATGCTCCGGTGGCCGATCAGCTTCTGATTGATACCA
AGAAGCCCAAGGGGGCCGAGCGCCCGGGGGGCAACGGCGCGACGTTTGATTGGTCGCTACTGGCGGCGCGGAAATATTGG
ACTGTGCCCTGGATGCTGGCGGGCGGTCTGACCGCCGATAATGTAACTGACGCAGTCCGCACCACGGGCGCGCGGCAGGT
GGACCTCAGCTCCGCCATTGAAAGCGCGCCGGGTGTGAAAGATGCGGCGCGGATGCAGGCTTTTTCGGCGGCGTTAACTG
ACGGATAA

Upstream 100 bases:

>100_bases
CGCCTGAACCAGGAAGTGGCCGCCATGAAGGGCCGCAAAAGCGACAGCCAGGATGATGTGCTGGCGATCCTGGACGACGC
AGACACCGCGCGCTGATTCC

Downstream 100 bases:

>100_bases
CCAAGTCGCGCCTAGGCTACGGCATGGCATATCAACTTCCAGACCACCTTACCCCTGAAATCTGGCTGAGCCAGGTCCTG
TCATCTCGGGAAGCCCAGGG

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MSEVAIKFCGLSRLEDVSAAAEAGARYVGFVFFPKSPRNVSIPQARELALAVPLGIAKVALVVNADDALLDEIVSQVPLD
MLQLHGSETPERVAEIRARYGLPVMKAIGVAEAADLDAIDLYAPVADQLLIDTKKPKGAERPGGNGATFDWSLLAARKYW
TVPWMLAGGLTADNVTDAVRTTGARQVDLSSAIESAPGVKDAARMQAFSAALTDG

Sequences:

>Translated_215_residues
MSEVAIKFCGLSRLEDVSAAAEAGARYVGFVFFPKSPRNVSIPQARELALAVPLGIAKVALVVNADDALLDEIVSQVPLD
MLQLHGSETPERVAEIRARYGLPVMKAIGVAEAADLDAIDLYAPVADQLLIDTKKPKGAERPGGNGATFDWSLLAARKYW
TVPWMLAGGLTADNVTDAVRTTGARQVDLSSAIESAPGVKDAARMQAFSAALTDG
>Mature_214_residues
SEVAIKFCGLSRLEDVSAAAEAGARYVGFVFFPKSPRNVSIPQARELALAVPLGIAKVALVVNADDALLDEIVSQVPLDM
LQLHGSETPERVAEIRARYGLPVMKAIGVAEAADLDAIDLYAPVADQLLIDTKKPKGAERPGGNGATFDWSLLAARKYWT
VPWMLAGGLTADNVTDAVRTTGARQVDLSSAIESAPGVKDAARMQAFSAALTDG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=203, Percent_Identity=37.4384236453202, Blast_Score=104, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320210, Length=222, Percent_Identity=27.9279279279279, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_JANSC (Q28LA8)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_511529.1
- ProteinModelPortal:   Q28LA8
- SMR:   Q28LA8
- STRING:   Q28LA8
- GeneID:   3936062
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_3587
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   Q28LA8
- ProtClustDB:   PRK01222
- BioCyc:   JSP290400:JANN_3587-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22677; Mature: 22546

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVAIKFCGLSRLEDVSAAAEAGARYVGFVFFPKSPRNVSIPQARELALAVPLGIAKVA
CCCCEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHHCCCCCEEEE
LVVNADDALLDEIVSQVPLDMLQLHGSETPERVAEIRARYGLPVMKAIGVAEAADLDAID
EEECCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHCCHHHCCCCHHH
LYAPVADQLLIDTKKPKGAERPGGNGATFDWSLLAARKYWTVPWMLAGGLTADNVTDAVR
HHHHHHHHHEEECCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCHHEECCCCCCHHHHHHH
TTGARQVDLSSAIESAPGVKDAARMQAFSAALTDG
HCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEVAIKFCGLSRLEDVSAAAEAGARYVGFVFFPKSPRNVSIPQARELALAVPLGIAKVA
CCCEEEECCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHHCCCCCEEEE
LVVNADDALLDEIVSQVPLDMLQLHGSETPERVAEIRARYGLPVMKAIGVAEAADLDAID
EEECCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHCCHHHCCCCHHH
LYAPVADQLLIDTKKPKGAERPGGNGATFDWSLLAARKYWTVPWMLAGGLTADNVTDAVR
HHHHHHHHHEEECCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCHHEECCCCCCHHHHHHH
TTGARQVDLSSAIESAPGVKDAARMQAFSAALTDG
HCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA