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The map label for this gene is pepB [H]

Identifier: 89055883

GI number: 89055883

Start: 3444159

End: 3445982

Strand: Direct

Name: pepB [H]

Synonym: Jann_3392

Alternate gene names: 89055883

Gene position: 3444159-3445982 (Clockwise)

Preceding gene: 89055882

Following gene: 89055886

Centisome position: 79.76

GC content: 61.51

Gene sequence:

>1824_bases
ATGCGCTTGACCTACCCCGCCCCGCTCCGTGATGCCGCTGCTGAAACCGGGGGCGCACCGTTGGAGGGTTTGCCCGTGTG
GGATCTGAGCGATCTTTATGAGGGGCAGGATGCCGCGAGCCTGAAACGGGATCTGGACTGGCTGGAGGAGGCCTGTCAGT
CCTTCGCCGCGGACTATGAGGGCAAACTGGCCGATCTGGACGCCGATGGCCTGCTGGACTGCACCCTGCGCTATGAGAAG
ATCGACATGATCGCGGGCCGTATCATGTCGTTTGCCGGTCTGCGCTACTACCAGAAGACCACCGACGGCGAGCGCGCCAA
ATTCATGTCCGACATGCAGGACAAGATCACCACCTACACAACGCCGCTGGTGTTTTTCTCCCTCGAATTCAACCGGATCG
AGGATGCGCAGTATGATGCGATGATGGACAAGAACGCGGATCTTGCGCGCTACAAGCCCGTCTTTGACCGCATGCGCGCG
ATGAAGCCCTATCAGCTGAGCGATGAGTTGGAGAAATTCCTCCACGATACTTCCGTCGTGGGTGCGTCGGCGTGGAACAA
GCTCTTCGACGAGCAGATCGCGGGCCTGACCTTCGATGTGGACGGAGAGAGCCTGGGCATTGAGGCCACGCTGAACCTGA
TGACCGACAGTGACCGCGCGCGGCGCGAGGCCGGTGCAAAAGCGCTGGCTGAAAAGTTCGAAGACACCGCGCCGCTGTTT
GCGCGGGTGCACAACACGCTGGCGAAGGAAAAAGAGATCGGCGACCGGTGGCGGGGTCTGCCCTCACCGCAGGCGGGCCG
TCACCTCGCCAACCATGTGGAGCCCGAGGTGGTGGAGGCCCTGCGCAACGCCGTCGTGAAGGCCTACCCTCGCCTGTCCC
ACCGCTACTACAAGCTGAAGGCCAAATGGATGGGCCTTGAAAAGATGGAGGTCTGGGACCGCAACGCACCCCTGCCGATG
TCCGAGGACCGGATCGTCGGCTGGGACGAGGCGCGCCGCGTCGTGTCGGAGGCCTATGCGGGCTTTGATCCACGCATGGC
AGAATTGGCAGAGCCGTTCTTCACCGACGGCTGGATCGATGCGGGCGTGAAGGAAGGCAAAGCGCCCGGGGCCTTCGCCC
ACCCGACCGTCACGGATGTGCACCCCTATGTGATGCTCAACTACCTCGGCAAACCGCGCGACGTGATGACGTTGGCGCAC
GAATTGGGCCACGGCGTCCATCAACGCCTGGCCGCGGCGCAGGGCGAGATGTTGTCCTCTACGCCTCTGACACTGGCCGA
GACCGCCAGCGTGTTCGGCGAAATGCTAACCTTCCGCAAGATGCTGTCGGAAGCCAAGGACGACGCCACCCGCAAGGTCA
TGCTGGCCGGTAAGGTGGAGGATATGATCAACACTGTCGTGCGCCAGATCGCCTTCTATGATTTCGAATGCAAGCTGCAC
GATGCGCGACGTGGCGGAGAGCTGACGGTCGACGACATAAACGCCCTTTGGATGTCGGTGCAGGGCGAAAGCCTCGGGCC
CGTGTTCAATTTCATGGACGGGTATGAGACCTTCTGGGCCTATATCCCCCACTTCGTCCATTCGCCCTTCTACGTCTATG
CCTACGCCTTTGGCGACGGCCTCGTGAACGCCTTGTACGCGGTCTATGCGGAGGGCAACGAGGGCTTCGAGGAAAAGTAT
TTCGACATGCTGCGCGCGGGCGGATCGAAGCACCACAAGGAACTTCTCGCTCCCTTTGGGCTGGACGCCTCGGACCCTGC
ATTCTGGGACAAGGGCCTGAGCATGATCGAGGGCTTCATTGATGAGCTGGAAGCGATGGAGTGA

Upstream 100 bases:

>100_bases
ACTCGGCAAGGAATTGCCGAAAAATCAAAGGTTCCTGGGGTTGAGGCCCGGCACGCTCGGGCGCATATCTGTCACAACAG
TTTTGACACGAGGACGTCCC

Downstream 100 bases:

>100_bases
GTATGTGGCGGTGCTGTGCGGCGTTCACCGACTGGATCAGGCCACCCTTTTCGTGATGGATGGTCTGACCCGGTGCGCCA
AGCCTTAGACAACAACCTGG

Product: peptidase M3B, oligoendopeptidase-related clade 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MRLTYPAPLRDAAAETGGAPLEGLPVWDLSDLYEGQDAASLKRDLDWLEEACQSFAADYEGKLADLDADGLLDCTLRYEK
IDMIAGRIMSFAGLRYYQKTTDGERAKFMSDMQDKITTYTTPLVFFSLEFNRIEDAQYDAMMDKNADLARYKPVFDRMRA
MKPYQLSDELEKFLHDTSVVGASAWNKLFDEQIAGLTFDVDGESLGIEATLNLMTDSDRARREAGAKALAEKFEDTAPLF
ARVHNTLAKEKEIGDRWRGLPSPQAGRHLANHVEPEVVEALRNAVVKAYPRLSHRYYKLKAKWMGLEKMEVWDRNAPLPM
SEDRIVGWDEARRVVSEAYAGFDPRMAELAEPFFTDGWIDAGVKEGKAPGAFAHPTVTDVHPYVMLNYLGKPRDVMTLAH
ELGHGVHQRLAAAQGEMLSSTPLTLAETASVFGEMLTFRKMLSEAKDDATRKVMLAGKVEDMINTVVRQIAFYDFECKLH
DARRGGELTVDDINALWMSVQGESLGPVFNFMDGYETFWAYIPHFVHSPFYVYAYAFGDGLVNALYAVYAEGNEGFEEKY
FDMLRAGGSKHHKELLAPFGLDASDPAFWDKGLSMIEGFIDELEAME

Sequences:

>Translated_607_residues
MRLTYPAPLRDAAAETGGAPLEGLPVWDLSDLYEGQDAASLKRDLDWLEEACQSFAADYEGKLADLDADGLLDCTLRYEK
IDMIAGRIMSFAGLRYYQKTTDGERAKFMSDMQDKITTYTTPLVFFSLEFNRIEDAQYDAMMDKNADLARYKPVFDRMRA
MKPYQLSDELEKFLHDTSVVGASAWNKLFDEQIAGLTFDVDGESLGIEATLNLMTDSDRARREAGAKALAEKFEDTAPLF
ARVHNTLAKEKEIGDRWRGLPSPQAGRHLANHVEPEVVEALRNAVVKAYPRLSHRYYKLKAKWMGLEKMEVWDRNAPLPM
SEDRIVGWDEARRVVSEAYAGFDPRMAELAEPFFTDGWIDAGVKEGKAPGAFAHPTVTDVHPYVMLNYLGKPRDVMTLAH
ELGHGVHQRLAAAQGEMLSSTPLTLAETASVFGEMLTFRKMLSEAKDDATRKVMLAGKVEDMINTVVRQIAFYDFECKLH
DARRGGELTVDDINALWMSVQGESLGPVFNFMDGYETFWAYIPHFVHSPFYVYAYAFGDGLVNALYAVYAEGNEGFEEKY
FDMLRAGGSKHHKELLAPFGLDASDPAFWDKGLSMIEGFIDELEAME
>Mature_607_residues
MRLTYPAPLRDAAAETGGAPLEGLPVWDLSDLYEGQDAASLKRDLDWLEEACQSFAADYEGKLADLDADGLLDCTLRYEK
IDMIAGRIMSFAGLRYYQKTTDGERAKFMSDMQDKITTYTTPLVFFSLEFNRIEDAQYDAMMDKNADLARYKPVFDRMRA
MKPYQLSDELEKFLHDTSVVGASAWNKLFDEQIAGLTFDVDGESLGIEATLNLMTDSDRARREAGAKALAEKFEDTAPLF
ARVHNTLAKEKEIGDRWRGLPSPQAGRHLANHVEPEVVEALRNAVVKAYPRLSHRYYKLKAKWMGLEKMEVWDRNAPLPM
SEDRIVGWDEARRVVSEAYAGFDPRMAELAEPFFTDGWIDAGVKEGKAPGAFAHPTVTDVHPYVMLNYLGKPRDVMTLAH
ELGHGVHQRLAAAQGEMLSSTPLTLAETASVFGEMLTFRKMLSEAKDDATRKVMLAGKVEDMINTVVRQIAFYDFECKLH
DARRGGELTVDDINALWMSVQGESLGPVFNFMDGYETFWAYIPHFVHSPFYVYAYAFGDGLVNALYAVYAEGNEGFEEKY
FDMLRAGGSKHHKELLAPFGLDASDPAFWDKGLSMIEGFIDELEAME

Specific function: Has oligopeptidase activity and degrades a variety of small bioactive peptides, including bradykinin, neurotensin, and peptide fragments of substance P and adrenocorticotropin. Also hydrolyzes the synthetic collagen-like substrate N-(3-[2- furyl]acryloyl)

COG id: COG1164

COG function: function code E; Oligoendopeptidase F

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567
- InterPro:   IPR004438
- InterPro:   IPR013647 [H]

Pfam domain/function: PF01432 Peptidase_M3; PF08439 Peptidase_M3_N [H]

EC number: NA

Molecular weight: Translated: 68318; Mature: 68318

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTYPAPLRDAAAETGGAPLEGLPVWDLSDLYEGQDAASLKRDLDWLEEACQSFAADYE
CCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
GKLADLDADGLLDCTLRYEKIDMIAGRIMSFAGLRYYQKTTDGERAKFMSDMQDKITTYT
CCEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
TPLVFFSLEFNRIEDAQYDAMMDKNADLARYKPVFDRMRAMKPYQLSDELEKFLHDTSVV
CCEEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GASAWNKLFDEQIAGLTFDVDGESLGIEATLNLMTDSDRARREAGAKALAEKFEDTAPLF
HHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCHHHHH
ARVHNTLAKEKEIGDRWRGLPSPQAGRHLANHVEPEVVEALRNAVVKAYPRLSHRYYKLK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEH
AKWMGLEKMEVWDRNAPLPMSEDRIVGWDEARRVVSEAYAGFDPRMAELAEPFFTDGWID
HHHCCCHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHCCCCCHHHHHHCCHHCCCCHH
AGVKEGKAPGAFAHPTVTDVHPYVMLNYLGKPRDVMTLAHELGHGVHQRLAAAQGEMLSS
CCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCC
TPLTLAETASVFGEMLTFRKMLSEAKDDATRKVMLAGKVEDMINTVVRQIAFYDFECKLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DARRGGELTVDDINALWMSVQGESLGPVFNFMDGYETFWAYIPHFVHSPFYVYAYAFGDG
CCCCCCCEEHCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHH
LVNALYAVYAEGNEGFEEKYFDMLRAGGSKHHKELLAPFGLDASDPAFWDKGLSMIEGFI
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
DELEAME
HHHHCCC
>Mature Secondary Structure
MRLTYPAPLRDAAAETGGAPLEGLPVWDLSDLYEGQDAASLKRDLDWLEEACQSFAADYE
CCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
GKLADLDADGLLDCTLRYEKIDMIAGRIMSFAGLRYYQKTTDGERAKFMSDMQDKITTYT
CCEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
TPLVFFSLEFNRIEDAQYDAMMDKNADLARYKPVFDRMRAMKPYQLSDELEKFLHDTSVV
CCEEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GASAWNKLFDEQIAGLTFDVDGESLGIEATLNLMTDSDRARREAGAKALAEKFEDTAPLF
HHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCHHHHH
ARVHNTLAKEKEIGDRWRGLPSPQAGRHLANHVEPEVVEALRNAVVKAYPRLSHRYYKLK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHEEH
AKWMGLEKMEVWDRNAPLPMSEDRIVGWDEARRVVSEAYAGFDPRMAELAEPFFTDGWID
HHHCCCHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHCCCCCHHHHHHCCHHCCCCHH
AGVKEGKAPGAFAHPTVTDVHPYVMLNYLGKPRDVMTLAHELGHGVHQRLAAAQGEMLSS
CCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCC
TPLTLAETASVFGEMLTFRKMLSEAKDDATRKVMLAGKVEDMINTVVRQIAFYDFECKLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DARRGGELTVDDINALWMSVQGESLGPVFNFMDGYETFWAYIPHFVHSPFYVYAYAFGDG
CCCCCCCEEHCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHH
LVNALYAVYAEGNEGFEEKYFDMLRAGGSKHHKELLAPFGLDASDPAFWDKGLSMIEGFI
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
DELEAME
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757883; 12354221 [H]