Click here to switch to the map view.

The map label for this gene is lysC [H]

Identifier: 89055682

GI number: 89055682

Start: 3232788

End: 3234026

Strand: Direct

Name: lysC [H]

Synonym: Jann_3191

Alternate gene names: 89055682

Gene position: 3232788-3234026 (Clockwise)

Preceding gene: 89055681

Following gene: 89055684

Centisome position: 74.87

GC content: 62.15

Gene sequence:

>1239_bases
ATGCCCCTCCTGGTGATGAAATTCGGCGGCACATCCGTCGCCACGCTCGACCGCATCCGTCGCGCCGCCAAGCGCGTGGG
GCGCGAGGTGGCCAATGGCTATGATGTGATCGTCATCGTCTCTGCCATGTCGGGAGAGACCAACAAACTTGTGGGCTTCG
TGGAAGAGACTGGGCCCTTCTATGACGCCCGCGAATATGATGCGGTGGTGTCGTCGGGAGAGAATGTCACCGCAGGCCTG
ATGGCCCTGACATTGCAAGAAATGGACGTGCCCGCGCGGTCCTGGCAGGGCTGGCAGGTGCCGCTTCTGACCACCGATGC
CCACGCCAGCGCCCGGATCGAAGAGATCCCGACGGACAACCTGAACGCCAAATTCGGCGAAGGCATGAAAGTGGCCGTTG
TCGCGGGTTTCCAGGGCATCTCGCCCGAGGGCCGCATTACCACGCTTGGCCGGGGTGGGTCGGACACCACGGCCGTGGCC
TTCGCCGCGTCGTTCGGGGCGGAGAGGTGCGATATCTACACGGACGTCGACGGCGTCTACACCACGGACCCGCGCATCAC
CACGAAGGCCCGCAAGCTCGACAAGATTTCGTTCGAGGAGATGTTGGAGTTGGCCTCGCTTGGCGCGAAGGTCCTGCAAA
CCCGCTCCGTTGAACTGGCGATGCGCTACCGGGTGCGCCTGCGGGTGTTGTCGAGTTTTGAAGAAATGTCAGATAATGCG
GGCACCTTGGTCTGCGCGGAGGAAGATATCGTGGAAAAGAACGTTGTGGCCGGTGTCGCCTATTCCCGCGATGAGGCGAA
AATGACCCTGCAAAGCGTGGAAGACCGCCCCGGCATCGCGGCGGCGATCTTCGGCCCCCTGGCCGAGGCCGGTGTGAATG
TCGACATGATCGTTCAGAACATCTCGGACGGTGGCATCACGGATATGACCTTCTCCTGCCCCGTGGGCGAAGTGGCGCGC
GCCGAGAAGGCCATGGGTGACGCAAAGGCATCGGGCGATATCGGTTTCGCCTCGCTGATTGCGGATACAGATGTGGCCAA
GGTGTCCATCGTCGGCATCGGGATGCGGTCCCACGCCGGCGTGGCCGCGAAAATGTTCCAGACGCTGCGCGACGAGGGGG
TGAACATCAAAGTCATCACCACGTCAGAGATCAAGGTCAGCGTGCTGATCGACCGCAAATATATGGAGTTGGCCGTGCAG
GCGCTCCACGATGCGTTCGGTCTGGAGAAAGCGGCCTGA

Upstream 100 bases:

>100_bases
TTCCTGAACTGGGACGGCAATCCGCAGGATTACTAAGCGTCCCTTGCCCCCGCGTCCGCCCCCGGGTAAGTCCGGGCGCG
ACTGAACAACGGGATCCTCC

Downstream 100 bases:

>100_bases
ACGCCGCTGAGCCAGGCAAAAGCTCTGACTGGCGACGGGTCAACAGGCAGCTACAGCACCAGGTTGATCAGGAACAGGAC
AACCGCCCCAACAAACAGCG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MPLLVMKFGGTSVATLDRIRRAAKRVGREVANGYDVIVIVSAMSGETNKLVGFVEETGPFYDAREYDAVVSSGENVTAGL
MALTLQEMDVPARSWQGWQVPLLTTDAHASARIEEIPTDNLNAKFGEGMKVAVVAGFQGISPEGRITTLGRGGSDTTAVA
FAASFGAERCDIYTDVDGVYTTDPRITTKARKLDKISFEEMLELASLGAKVLQTRSVELAMRYRVRLRVLSSFEEMSDNA
GTLVCAEEDIVEKNVVAGVAYSRDEAKMTLQSVEDRPGIAAAIFGPLAEAGVNVDMIVQNISDGGITDMTFSCPVGEVAR
AEKAMGDAKASGDIGFASLIADTDVAKVSIVGIGMRSHAGVAAKMFQTLRDEGVNIKVITTSEIKVSVLIDRKYMELAVQ
ALHDAFGLEKAA

Sequences:

>Translated_412_residues
MPLLVMKFGGTSVATLDRIRRAAKRVGREVANGYDVIVIVSAMSGETNKLVGFVEETGPFYDAREYDAVVSSGENVTAGL
MALTLQEMDVPARSWQGWQVPLLTTDAHASARIEEIPTDNLNAKFGEGMKVAVVAGFQGISPEGRITTLGRGGSDTTAVA
FAASFGAERCDIYTDVDGVYTTDPRITTKARKLDKISFEEMLELASLGAKVLQTRSVELAMRYRVRLRVLSSFEEMSDNA
GTLVCAEEDIVEKNVVAGVAYSRDEAKMTLQSVEDRPGIAAAIFGPLAEAGVNVDMIVQNISDGGITDMTFSCPVGEVAR
AEKAMGDAKASGDIGFASLIADTDVAKVSIVGIGMRSHAGVAAKMFQTLRDEGVNIKVITTSEIKVSVLIDRKYMELAVQ
ALHDAFGLEKAA
>Mature_411_residues
PLLVMKFGGTSVATLDRIRRAAKRVGREVANGYDVIVIVSAMSGETNKLVGFVEETGPFYDAREYDAVVSSGENVTAGLM
ALTLQEMDVPARSWQGWQVPLLTTDAHASARIEEIPTDNLNAKFGEGMKVAVVAGFQGISPEGRITTLGRGGSDTTAVAF
AASFGAERCDIYTDVDGVYTTDPRITTKARKLDKISFEEMLELASLGAKVLQTRSVELAMRYRVRLRVLSSFEEMSDNAG
TLVCAEEDIVEKNVVAGVAYSRDEAKMTLQSVEDRPGIAAAIFGPLAEAGVNVDMIVQNISDGGITDMTFSCPVGEVARA
EKAMGDAKASGDIGFASLIADTDVAKVSIVGIGMRSHAGVAAKMFQTLRDEGVNIKVITTSEIKVSVLIDRKYMELAVQA
LHDAFGLEKAA

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=305, Percent_Identity=31.1475409836066, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790455, Length=460, Percent_Identity=28.2608695652174, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790376, Length=364, Percent_Identity=25.8241758241758, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=308, Percent_Identity=26.6233766233766, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43983; Mature: 43852

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLVMKFGGTSVATLDRIRRAAKRVGREVANGYDVIVIVSAMSGETNKLVGFVEETGPF
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEECCCCC
YDAREYDAVVSSGENVTAGLMALTLQEMDVPARSWQGWQVPLLTTDAHASARIEEIPTDN
CCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCHHHHCCCCC
LNAKFGEGMKVAVVAGFQGISPEGRITTLGRGGSDTTAVAFAASFGAERCDIYTDVDGVY
CCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCHHEEEHHHCCCCCCEEEECCCCEE
TTDPRITTKARKLDKISFEEMLELASLGAKVLQTRSVELAMRYRVRLRVLSSFEEMSDNA
ECCCCEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTLVCAEEDIVEKNVVAGVAYSRDEAKMTLQSVEDRPGIAAAIFGPLAEAGVNVDMIVQN
CEEEECCHHHHHHHHHEEEEECCCHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCEEEEEE
ISDGGITDMTFSCPVGEVARAEKAMGDAKASGDIGFASLIADTDVAKVSIVGIGMRSHAG
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCC
VAAKMFQTLRDEGVNIKVITTSEIKVSVLIDRKYMELAVQALHDAFGLEKAA
HHHHHHHHHHHCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLLVMKFGGTSVATLDRIRRAAKRVGREVANGYDVIVIVSAMSGETNKLVGFVEETGPF
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEECCCCC
YDAREYDAVVSSGENVTAGLMALTLQEMDVPARSWQGWQVPLLTTDAHASARIEEIPTDN
CCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCHHHHCCCCC
LNAKFGEGMKVAVVAGFQGISPEGRITTLGRGGSDTTAVAFAASFGAERCDIYTDVDGVY
CCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCHHEEEHHHCCCCCCEEEECCCCEE
TTDPRITTKARKLDKISFEEMLELASLGAKVLQTRSVELAMRYRVRLRVLSSFEEMSDNA
ECCCCEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GTLVCAEEDIVEKNVVAGVAYSRDEAKMTLQSVEDRPGIAAAIFGPLAEAGVNVDMIVQN
CEEEECCHHHHHHHHHEEEEECCCHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCEEEEEE
ISDGGITDMTFSCPVGEVARAEKAMGDAKASGDIGFASLIADTDVAKVSIVGIGMRSHAG
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCCC
VAAKMFQTLRDEGVNIKVITTSEIKVSVLIDRKYMELAVQALHDAFGLEKAA
HHHHHHHHHHHCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]