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The map label for this gene is cynR [H]

Identifier: 89055431

GI number: 89055431

Start: 2962798

End: 2963703

Strand: Direct

Name: cynR [H]

Synonym: Jann_2940

Alternate gene names: 89055431

Gene position: 2962798-2963703 (Clockwise)

Preceding gene: 89055428

Following gene: 89055434

Centisome position: 68.62

GC content: 66.11

Gene sequence:

>906_bases
ATGGTGACCCTGCGCCAATTGCAATCGGTTGTGGCCGTGGTGGAGGAGCGGTCCTTCACCCGTGCCGCAGACCGCGAGAA
TGCGACCCAATCGGGGATCTCACAGCATGTGAAAGCGGTGGAGGCGAGCCTTGGCGTGGCGCTGTTTGAACGCACCAGCG
ACGGAGTCAAACCGACGCCTGCGGGCCAGCGATACTACCACCATTGCATCGACGTGCTGCGGACCCTGGACGTGGCGAAG
GATGAGGCGCGCGAGACCGGTATCGAGGTCACGGGCAAGATCCGCGCGGGGCTGATCCCGGCCTTCACCCGCGCTGCTCT
GGCCCCCGCATTGGAGCGGTTCACAGCGCAATACCCGGGCGTGGAGGTGGAGGTGATCGAAGGCTACAGCGGCGCGCTGA
CGGACCGGGTGCGCGCGCAGGCGCTGGACTTCGCGCTGGTGCCGGGGTTTGCGGGGGAGACCGGGTTGAAGCTGACGCAT
CTCAACCGGTCGCGCGAAATGCTGGTATCGGGCGCGCGGCGTGGTTTGACGCATCTGGAGCCGTTGCGCCTCGCCGATCA
GCCGCCCCTGAAACTGATCGTGCCGTCGCAGTCAAACGTGCGGCGCGCGAAGATCATGGAATACGCGGAAACCCACGGCG
TGCGCATTGACCGGGTGCTGGATATGGATGCGATGCTTGGGACGCTGGAACTGGTGGCGGCCAGTGACTGGGTCACGATC
CTGCCCTGGGTGATTTGCAGCGCCGACGCGGCGGGCGACGTTAGGCGGGTGTCGCCGCTGATTCATCCGGAACTGCATTC
GGATTTCGTGGTGATCGAGCCCGCGCGGCGTCCCCTTCCGCCGGAGGGGCACCTGTTTCTGGATGAGATCCGCGCGGAAC
TGGAGCGGCTGGAGGAGCCCGCCTAG

Upstream 100 bases:

>100_bases
TTTTTCGGAGTTACACTTTGCAATAGGGTAGAGCCGCAGTTGCCCGAGGGAAAATAATAATGAATAACACTTCCCATTAG
AAAAGTTGATGAGGCGGCCC

Downstream 100 bases:

>100_bases
AACATGATGTCCGGCAACCACGTTGCCAGCGACGGGATGAACAGCACGATCAGCGCCGCCAGAAGGATCAGCAGGAAGTA
GGGCGTGGAGCCCCAGAAGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MVTLRQLQSVVAVVEERSFTRAADRENATQSGISQHVKAVEASLGVALFERTSDGVKPTPAGQRYYHHCIDVLRTLDVAK
DEARETGIEVTGKIRAGLIPAFTRAALAPALERFTAQYPGVEVEVIEGYSGALTDRVRAQALDFALVPGFAGETGLKLTH
LNRSREMLVSGARRGLTHLEPLRLADQPPLKLIVPSQSNVRRAKIMEYAETHGVRIDRVLDMDAMLGTLELVAASDWVTI
LPWVICSADAAGDVRRVSPLIHPELHSDFVVIEPARRPLPPEGHLFLDEIRAELERLEEPA

Sequences:

>Translated_301_residues
MVTLRQLQSVVAVVEERSFTRAADRENATQSGISQHVKAVEASLGVALFERTSDGVKPTPAGQRYYHHCIDVLRTLDVAK
DEARETGIEVTGKIRAGLIPAFTRAALAPALERFTAQYPGVEVEVIEGYSGALTDRVRAQALDFALVPGFAGETGLKLTH
LNRSREMLVSGARRGLTHLEPLRLADQPPLKLIVPSQSNVRRAKIMEYAETHGVRIDRVLDMDAMLGTLELVAASDWVTI
LPWVICSADAAGDVRRVSPLIHPELHSDFVVIEPARRPLPPEGHLFLDEIRAELERLEEPA
>Mature_301_residues
MVTLRQLQSVVAVVEERSFTRAADRENATQSGISQHVKAVEASLGVALFERTSDGVKPTPAGQRYYHHCIDVLRTLDVAK
DEARETGIEVTGKIRAGLIPAFTRAALAPALERFTAQYPGVEVEVIEGYSGALTDRVRAQALDFALVPGFAGETGLKLTH
LNRSREMLVSGARRGLTHLEPLRLADQPPLKLIVPSQSNVRRAKIMEYAETHGVRIDRVLDMDAMLGTLELVAASDWVTI
LPWVICSADAAGDVRRVSPLIHPELHSDFVVIEPARRPLPPEGHLFLDEIRAELERLEEPA

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=243, Percent_Identity=26.3374485596708, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787601, Length=151, Percent_Identity=28.476821192053, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693193, Length=125, Percent_Identity=32.8, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790399, Length=263, Percent_Identity=25.4752851711027, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788297, Length=147, Percent_Identity=27.891156462585, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787589, Length=131, Percent_Identity=34.3511450381679, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI145693105, Length=171, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=192, Percent_Identity=29.6875, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789440, Length=119, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787879, Length=128, Percent_Identity=33.59375, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786401, Length=124, Percent_Identity=31.4516129032258, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787806, Length=240, Percent_Identity=23.75, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33096; Mature: 33096

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLRQLQSVVAVVEERSFTRAADRENATQSGISQHVKAVEASLGVALFERTSDGVKPTP
CCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AGQRYYHHCIDVLRTLDVAKDEARETGIEVTGKIRAGLIPAFTRAALAPALERFTAQYPG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHCHHHHHHHHHHHHHHHHHHHHCCC
VEVEVIEGYSGALTDRVRAQALDFALVPGFAGETGLKLTHLNRSREMLVSGARRGLTHLE
CEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCC
PLRLADQPPLKLIVPSQSNVRRAKIMEYAETHGVRIDRVLDMDAMLGTLELVAASDWVTI
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCHHHH
LPWVICSADAAGDVRRVSPLIHPELHSDFVVIEPARRPLPPEGHLFLDEIRAELERLEEP
HHHHHHCCCCCCCHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEHHHHHHHHHHHCCC
A
C
>Mature Secondary Structure
MVTLRQLQSVVAVVEERSFTRAADRENATQSGISQHVKAVEASLGVALFERTSDGVKPTP
CCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AGQRYYHHCIDVLRTLDVAKDEARETGIEVTGKIRAGLIPAFTRAALAPALERFTAQYPG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHCHHHHHHHHHHHHHHHHHHHHCCC
VEVEVIEGYSGALTDRVRAQALDFALVPGFAGETGLKLTHLNRSREMLVSGARRGLTHLE
CEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCC
PLRLADQPPLKLIVPSQSNVRRAKIMEYAETHGVRIDRVLDMDAMLGTLELVAASDWVTI
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCHHHH
LPWVICSADAAGDVRRVSPLIHPELHSDFVVIEPARRPLPPEGHLFLDEIRAELERLEEP
HHHHHHCCCCCCCHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEHHHHHHHHHHHCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]