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The map label for this gene is mtlK [H]

Identifier: 89055398

GI number: 89055398

Start: 2926818

End: 2928317

Strand: Direct

Name: mtlK [H]

Synonym: Jann_2907

Alternate gene names: 89055398

Gene position: 2926818-2928317 (Clockwise)

Preceding gene: 89055397

Following gene: 89055399

Centisome position: 67.78

GC content: 63.87

Gene sequence:

>1500_bases
ATGGGGACTGACATGAAAGATACGACCCCCGCCCTGCCCCTGCGGCTTGATACGCTGGAGGCCCTGCCCCATGGGATTGA
GCGGCCGACCTACTCCCGCGCCGATCTGACACCGGGCATCATGCATATCGGCCTGGGGAACTTTCACCGCGCCCATCAGG
CGTGGTATTTGCACCGCCTGATGCAGGCCGGAGAGGCCCACGATTGGGCGATCATCGGCGCGGGCGTGCGGGCCTATGAT
GCGGAAATGCGCGACCGTCTGGCTAAACAGGACTATCTGACGACGCTGATCGAACTCACGCCCACCAGCACCTCTGCCGA
GGTGATCGGACCGATGATTGACTATCTGCCGATTGAAGACGGCAACGGCGCGCTGATCGCGGCCATGACAGACCCGGCGA
TCCGCATCGTCTCGCTGACCGTGACGGAGGGCGGCTATTACATTGACCCCGCGACCCACGGGTTCGACGCCGCCCATCCG
GATATGGCCCATGACGCGGCCCACCCGGACAGCCCACACACCGCATTCGGGGCGATCATTGCGGCGTTGCGCGCGCGCCG
TGACGCCCGCGCGCCAGCCTTCACCGTGCAAAGTTGCGATAATCTGCAAGGCAATGGTGCCATCGTGCGTCAGACCGTCG
TGGGTCTTGCCCGGTTGGGGGACGCGGATCTTGCCGATTGGATCGAGGCAAATGCCAGCTTCCCCAATTCCATGGTCGAT
TGCATCGTGCCCGCCACGGGACCCGCGGAAATCGCCCTTGCCCGATCCTTCGGCATCGATGATGTGGCACCGGTCAGCCA
TGAGAACTACCGCCAATGGGTGATCGAGGACGCGTTTTGCCATGGACGCCCGGCCTGGGAAAAGGTCGGCGCGACCCTCA
CCGACGACGTTCATAGCTTTGAGGCCATGAAGATCCGCCTCCTCAACGGCGGGCATCAGGTGATCGCCAATGTCGGAGAG
CTTCTGTCCTGCGAGACCATCGCCGATTGCATGGCCGACCCGGATATCGCCGCCTTCTTCCGCAAGGTGGAACACGACGG
CATCGTGCCATACGTTCAGGCTGTCCCCGGCATGACGCCCCCGGCCTATGTGGAGTTGATCGAGCGGCGATTTGCGAATT
CTGCCATCAGGGACACCACCCGCCGCGTGGCCTTCGACGGCTCCTCTCGCCATACCGGGTTTATCCTGCCCATTGTACGC
GAGGCGTTGGCGGCAGGTGGCTCGGTCGACGCCTTGGCCTTGGTGGAGGCGTTGTGGGCACGGATGTGCGCGGGCACGCG
CGAAGATGGGACCATGATCGCGCCGAACGATCCGTTTTGGGACGACCTGCATGCTACCGCGCAGGCGGCCCGCACCCGCC
CCGCCGCGTGGTTAGAGCAGACGCATCTTTATGGCGACCTCGCGGATCACCCGGCCTTTGCGGAGGCGTTCACTGGCTGG
CTTTCCGACATCTGGAGCAACGGCAGCCGCGCCACCATCCATCGTTTCATTGCAGCTTAG

Upstream 100 bases:

>100_bases
GGCATGGCCGTCTTTCTGGCCAGCGACGAGGCGGAATATATCGTGTCGCAGACCTACAATGTGGACGGCGGACAATGGAT
GAGCTGACGGGAACGTGCTG

Downstream 100 bases:

>100_bases
CGCACTTTTCCCTGGGTCCCTTGACCGAACTTCTCAATTCGATAGTATGTATACTTACGATATGCTGGAGCGGACATGAC
ACAGCCCATTCTGATCGCCG

Product: mannitol dehydrogenase-like

Products: NA

Alternate protein names: M2DH; MDH [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MGTDMKDTTPALPLRLDTLEALPHGIERPTYSRADLTPGIMHIGLGNFHRAHQAWYLHRLMQAGEAHDWAIIGAGVRAYD
AEMRDRLAKQDYLTTLIELTPTSTSAEVIGPMIDYLPIEDGNGALIAAMTDPAIRIVSLTVTEGGYYIDPATHGFDAAHP
DMAHDAAHPDSPHTAFGAIIAALRARRDARAPAFTVQSCDNLQGNGAIVRQTVVGLARLGDADLADWIEANASFPNSMVD
CIVPATGPAEIALARSFGIDDVAPVSHENYRQWVIEDAFCHGRPAWEKVGATLTDDVHSFEAMKIRLLNGGHQVIANVGE
LLSCETIADCMADPDIAAFFRKVEHDGIVPYVQAVPGMTPPAYVELIERRFANSAIRDTTRRVAFDGSSRHTGFILPIVR
EALAAGGSVDALALVEALWARMCAGTREDGTMIAPNDPFWDDLHATAQAARTRPAAWLEQTHLYGDLADHPAFAEAFTGW
LSDIWSNGSRATIHRFIAA

Sequences:

>Translated_499_residues
MGTDMKDTTPALPLRLDTLEALPHGIERPTYSRADLTPGIMHIGLGNFHRAHQAWYLHRLMQAGEAHDWAIIGAGVRAYD
AEMRDRLAKQDYLTTLIELTPTSTSAEVIGPMIDYLPIEDGNGALIAAMTDPAIRIVSLTVTEGGYYIDPATHGFDAAHP
DMAHDAAHPDSPHTAFGAIIAALRARRDARAPAFTVQSCDNLQGNGAIVRQTVVGLARLGDADLADWIEANASFPNSMVD
CIVPATGPAEIALARSFGIDDVAPVSHENYRQWVIEDAFCHGRPAWEKVGATLTDDVHSFEAMKIRLLNGGHQVIANVGE
LLSCETIADCMADPDIAAFFRKVEHDGIVPYVQAVPGMTPPAYVELIERRFANSAIRDTTRRVAFDGSSRHTGFILPIVR
EALAAGGSVDALALVEALWARMCAGTREDGTMIAPNDPFWDDLHATAQAARTRPAAWLEQTHLYGDLADHPAFAEAFTGW
LSDIWSNGSRATIHRFIAA
>Mature_498_residues
GTDMKDTTPALPLRLDTLEALPHGIERPTYSRADLTPGIMHIGLGNFHRAHQAWYLHRLMQAGEAHDWAIIGAGVRAYDA
EMRDRLAKQDYLTTLIELTPTSTSAEVIGPMIDYLPIEDGNGALIAAMTDPAIRIVSLTVTEGGYYIDPATHGFDAAHPD
MAHDAAHPDSPHTAFGAIIAALRARRDARAPAFTVQSCDNLQGNGAIVRQTVVGLARLGDADLADWIEANASFPNSMVDC
IVPATGPAEIALARSFGIDDVAPVSHENYRQWVIEDAFCHGRPAWEKVGATLTDDVHSFEAMKIRLLNGGHQVIANVGEL
LSCETIADCMADPDIAAFFRKVEHDGIVPYVQAVPGMTPPAYVELIERRFANSAIRDTTRRVAFDGSSRHTGFILPIVRE
ALAAGGSVDALALVEALWARMCAGTREDGTMIAPNDPFWDDLHATAQAARTRPAAWLEQTHLYGDLADHPAFAEAFTGWL
SDIWSNGSRATIHRFIAA

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=477, Percent_Identity=38.7840670859539, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1787823, Length=476, Percent_Identity=37.1848739495798, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI1788497, Length=461, Percent_Identity=35.5748373101952, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI48994885, Length=495, Percent_Identity=22.4242424242424, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790028, Length=164, Percent_Identity=29.2682926829268, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324401, Length=495, Percent_Identity=36.3636363636364, Blast_Score=316, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6320765, Length=495, Percent_Identity=36.3636363636364, Blast_Score=316, Evalue=4e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.67 [H]

Molecular weight: Translated: 54091; Mature: 53960

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTDMKDTTPALPLRLDTLEALPHGIERPTYSRADLTPGIMHIGLGNFHRAHQAWYLHRL
CCCCCCCCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHH
MQAGEAHDWAIIGAGVRAYDAEMRDRLAKQDYLTTLIELTPTSTSAEVIGPMIDYLPIED
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEC
GNGALIAAMTDPAIRIVSLTVTEGGYYIDPATHGFDAAHPDMAHDAAHPDSPHTAFGAII
CCCEEEEEECCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHH
AALRARRDARAPAFTVQSCDNLQGNGAIVRQTVVGLARLGDADLADWIEANASFPNSMVD
HHHHHHHHCCCCEEEHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHH
CIVPATGPAEIALARSFGIDDVAPVSHENYRQWVIEDAFCHGRPAWEKVGATLTDDVHSF
EEECCCCCHHEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHH
EAMKIRLLNGGHQVIANVGELLSCETIADCMADPDIAAFFRKVEHDGIVPYVQAVPGMTP
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHCCCCCC
PAYVELIERRFANSAIRDTTRRVAFDGSSRHTGFILPIVREALAAGGSVDALALVEALWA
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
RMCAGTREDGTMIAPNDPFWDDLHATAQAARTRPAAWLEQTHLYGDLADHPAFAEAFTGW
HHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
LSDIWSNGSRATIHRFIAA
HHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
GTDMKDTTPALPLRLDTLEALPHGIERPTYSRADLTPGIMHIGLGNFHRAHQAWYLHRL
CCCCCCCCCCCCEEHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHH
MQAGEAHDWAIIGAGVRAYDAEMRDRLAKQDYLTTLIELTPTSTSAEVIGPMIDYLPIED
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEC
GNGALIAAMTDPAIRIVSLTVTEGGYYIDPATHGFDAAHPDMAHDAAHPDSPHTAFGAII
CCCEEEEEECCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHH
AALRARRDARAPAFTVQSCDNLQGNGAIVRQTVVGLARLGDADLADWIEANASFPNSMVD
HHHHHHHHCCCCEEEHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHH
CIVPATGPAEIALARSFGIDDVAPVSHENYRQWVIEDAFCHGRPAWEKVGATLTDDVHSF
EEECCCCCHHEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHH
EAMKIRLLNGGHQVIANVGELLSCETIADCMADPDIAAFFRKVEHDGIVPYVQAVPGMTP
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHCCCCCC
PAYVELIERRFANSAIRDTTRRVAFDGSSRHTGFILPIVREALAAGGSVDALALVEALWA
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
RMCAGTREDGTMIAPNDPFWDDLHATAQAARTRPAAWLEQTHLYGDLADHPAFAEAFTGW
HHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
LSDIWSNGSRATIHRFIAA
HHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8254318 [H]