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The map label for this gene is hisA

Identifier: 89055283

GI number: 89055283

Start: 2809056

End: 2809772

Strand: Direct

Name: hisA

Synonym: Jann_2792

Alternate gene names: 89055283

Gene position: 2809056-2809772 (Clockwise)

Preceding gene: 89055281

Following gene: 89055284

Centisome position: 65.05

GC content: 65.83

Gene sequence:

>717_bases
ATGATCCTCTATCCCGCCATTGACCTCAAAGACGGCAACGCCGTGCGGCTCTTGCGCGGGGAAATGTCTGACGCCACCGT
CTTTAACACCGATCCCGCCGCACAGGCCCGCGCGTTTCAGGATGCGGGCTGCGACTGGCTGCATCTGGTCGACCTCAATG
GCGCATTCGCCGGGGAACCTGTGAATGGTGCCGCGGTGGAGGCGATCCTGGCCGCCACCTCTGTGCCGACGCAATTGGGT
GGCGGCATCCGCGACATGGCCACGATCGAGGGCTGGCTTACCCGTGGCATTGCCCGTGTGATACTGGGAACCGTGGCCGT
CGAAGATCCCGATCTGGTGCGCCAGGCCGCACGCGCCTTCCCGGGCCAGGTGGCCGTGGGTATCGACGCGCGCAAGGGTC
GCGTCGCCACCAAAGGATGGGCGGAAGAGACCGACGTGATGGTCACAGATCTGGCCCGAGCGTTCGAGGATGCGGGCGTG
GCCGCGATCATCTACACCGATATTGATCGCGATGGTGCGATGGGCGGCCCGAATGTCTCCGCGACCGCGGATCTCGCGCG
CGCCACATCCATCCCCGTGATCGCGTCGGGCGGTGTATCGTCGCTGGACGATCTGCACGCGCTGAAAACGACCGGCGTGA
TTTCTGGTGCGATCTCCGGGCGGGCGCTCTATGACGGGGCGCTTGACCTGTCCGAGGCGCTGCACGCCCTTGCCTGA

Upstream 100 bases:

>100_bases
GGCGCAAGGCAAGCGTGACGTGGCGGCGGCTGACCCTTGCGCTGCCTTGGGACATGGGGGAAAAGCCACGCGAGACCAGC
CCGCACAAGGACGCCGCCCG

Downstream 100 bases:

>100_bases
GTACGGGTTTTCCTGACGTTGCCGCTGCGGTCATCTGCGCATAGGTGCGGAGCGTATTTTGCAGGAGCAACCCCATGGGC
AGCGCATTCGTCGGCATCAT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MILYPAIDLKDGNAVRLLRGEMSDATVFNTDPAAQARAFQDAGCDWLHLVDLNGAFAGEPVNGAAVEAILAATSVPTQLG
GGIRDMATIEGWLTRGIARVILGTVAVEDPDLVRQAARAFPGQVAVGIDARKGRVATKGWAEETDVMVTDLARAFEDAGV
AAIIYTDIDRDGAMGGPNVSATADLARATSIPVIASGGVSSLDDLHALKTTGVISGAISGRALYDGALDLSEALHALA

Sequences:

>Translated_238_residues
MILYPAIDLKDGNAVRLLRGEMSDATVFNTDPAAQARAFQDAGCDWLHLVDLNGAFAGEPVNGAAVEAILAATSVPTQLG
GGIRDMATIEGWLTRGIARVILGTVAVEDPDLVRQAARAFPGQVAVGIDARKGRVATKGWAEETDVMVTDLARAFEDAGV
AAIIYTDIDRDGAMGGPNVSATADLARATSIPVIASGGVSSLDDLHALKTTGVISGAISGRALYDGALDLSEALHALA
>Mature_238_residues
MILYPAIDLKDGNAVRLLRGEMSDATVFNTDPAAQARAFQDAGCDWLHLVDLNGAFAGEPVNGAAVEAILAATSVPTQLG
GGIRDMATIEGWLTRGIARVILGTVAVEDPDLVRQAARAFPGQVAVGIDARKGRVATKGWAEETDVMVTDLARAFEDAGV
AAIIYTDIDRDGAMGGPNVSATADLARATSIPVIASGGVSSLDDLHALKTTGVISGAISGRALYDGALDLSEALHALA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=240, Percent_Identity=33.75, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788336, Length=247, Percent_Identity=21.4574898785425, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_JANSC (Q28NK3)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510734.1
- HSSP:   P16250
- ProteinModelPortal:   Q28NK3
- SMR:   Q28NK3
- STRING:   Q28NK3
- GeneID:   3935257
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2792
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   Q28NK3
- ProtClustDB:   PRK00748
- BioCyc:   JSP290400:JANN_2792-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 24451; Mature: 24451

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILYPAIDLKDGNAVRLLRGEMSDATVFNTDPAAQARAFQDAGCDWLHLVDLNGAFAGEP
CEEECEEECCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
VNGAAVEAILAATSVPTQLGGGIRDMATIEGWLTRGIARVILGTVAVEDPDLVRQAARAF
CCHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PGQVAVGIDARKGRVATKGWAEETDVMVTDLARAFEDAGVAAIIYTDIDRDGAMGGPNVS
CCEEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCC
ATADLARATSIPVIASGGVSSLDDLHALKTTGVISGAISGRALYDGALDLSEALHALA
HHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHCC
>Mature Secondary Structure
MILYPAIDLKDGNAVRLLRGEMSDATVFNTDPAAQARAFQDAGCDWLHLVDLNGAFAGEP
CEEECEEECCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
VNGAAVEAILAATSVPTQLGGGIRDMATIEGWLTRGIARVILGTVAVEDPDLVRQAARAF
CCHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PGQVAVGIDARKGRVATKGWAEETDVMVTDLARAFEDAGVAAIIYTDIDRDGAMGGPNVS
CCEEEEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCC
ATADLARATSIPVIASGGVSSLDDLHALKTTGVISGAISGRALYDGALDLSEALHALA
HHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA